Selective dysfunction of p53 for mitochondrial biogenesis induces cellular proliferation in bronchial smooth muscle from asthmatic patients
Increase of bronchial smooth muscle (BSM) mass is a crucial feature of asthma remodeling. The mechanisms of such an increased BSM mass are complex but involve enhanced mitochondrial biogenesis, leading to increased proliferation of BSM cells in asthmatic patients. The major tumor suppressor protein...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Trian, Thomas [verfasserIn] |
|---|
| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2016 |
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| Schlagwörter: |
peroxisome proliferator-activated receptor γ coactivator 1α |
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| Umfang: |
170897 |
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| Übergeordnetes Werk: |
Enthalten in: Antidiabetic treatment in elderly patients with low performance status admitted to internal medicine ward - Papakitsou, I. ELSEVIER, 2022, official publication of the American Academy of Allergy, Asthma and Immunology, Amsterdam [u.a.] |
|---|---|
| Übergeordnetes Werk: |
volume:137 ; year:2016 ; number:6 ; pages:1717-172613 ; extent:170897 |
| Links: |
|---|
| DOI / URN: |
10.1016/j.jaci.2015.10.031 |
|---|
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ELV013613553 |
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| 520 | |a Increase of bronchial smooth muscle (BSM) mass is a crucial feature of asthma remodeling. The mechanisms of such an increased BSM mass are complex but involve enhanced mitochondrial biogenesis, leading to increased proliferation of BSM cells in asthmatic patients. The major tumor suppressor protein p53 is a key cell regulator involved in cell proliferation and has also been implicated in mitochondrial biogenesis. However, the role of p53 in BSM cell proliferation and mitochondrial biogenesis has not been investigated thus far. | ||
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10.1016/j.jaci.2015.10.031 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001637.pica (DE-627)ELV013613553 (ELSEVIER)S0091-6749(15)01640-1 DE-627 ger DE-627 rakwb eng 610 VZ 44.85 bkl Trian, Thomas verfasserin aut Selective dysfunction of p53 for mitochondrial biogenesis induces cellular proliferation in bronchial smooth muscle from asthmatic patients 2016 170897 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Increase of bronchial smooth muscle (BSM) mass is a crucial feature of asthma remodeling. The mechanisms of such an increased BSM mass are complex but involve enhanced mitochondrial biogenesis, leading to increased proliferation of BSM cells in asthmatic patients. The major tumor suppressor protein p53 is a key cell regulator involved in cell proliferation and has also been implicated in mitochondrial biogenesis. However, the role of p53 in BSM cell proliferation and mitochondrial biogenesis has not been investigated thus far. peroxisome proliferator-activated receptor γ coactivator 1α Elsevier remodeling Elsevier mitochondrial transcription factor A Elsevier Asthma Elsevier lentivirus Elsevier Allard, Benoit oth Ozier, Annaig oth Maurat, Elise oth Dupin, Isabelle oth Thumerel, Matthieu oth Ousova, Olga oth Gillibert-Duplantier, Jennifer oth Le Morvan, Valérie oth Begueret, Hugues oth Girodet, Pierre-Olivier oth Marthan, Roger oth Berger, Patrick oth Enthalten in Elsevier Papakitsou, I. ELSEVIER Antidiabetic treatment in elderly patients with low performance status admitted to internal medicine ward 2022 official publication of the American Academy of Allergy, Asthma and Immunology Amsterdam [u.a.] (DE-627)ELV000021164 volume:137 year:2016 number:6 pages:1717-172613 extent:170897 https://doi.org/10.1016/j.jaci.2015.10.031 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.85 Kardiologie Angiologie VZ AR 137 2016 6 1717-172613 170897 |
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Selective dysfunction of p53 for mitochondrial biogenesis induces cellular proliferation in bronchial smooth muscle from asthmatic patients |
| author_sort |
Trian, Thomas |
| journal |
Antidiabetic treatment in elderly patients with low performance status admitted to internal medicine ward |
| journalStr |
Antidiabetic treatment in elderly patients with low performance status admitted to internal medicine ward |
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eng |
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600 - Technology |
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2016 |
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1717 |
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Trian, Thomas |
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137 |
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170897 |
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Elektronische Aufsätze |
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Trian, Thomas |
| doi_str_mv |
10.1016/j.jaci.2015.10.031 |
| dewey-full |
610 |
| title_sort |
selective dysfunction of p53 for mitochondrial biogenesis induces cellular proliferation in bronchial smooth muscle from asthmatic patients |
| title_auth |
Selective dysfunction of p53 for mitochondrial biogenesis induces cellular proliferation in bronchial smooth muscle from asthmatic patients |
| abstract |
Increase of bronchial smooth muscle (BSM) mass is a crucial feature of asthma remodeling. The mechanisms of such an increased BSM mass are complex but involve enhanced mitochondrial biogenesis, leading to increased proliferation of BSM cells in asthmatic patients. The major tumor suppressor protein p53 is a key cell regulator involved in cell proliferation and has also been implicated in mitochondrial biogenesis. However, the role of p53 in BSM cell proliferation and mitochondrial biogenesis has not been investigated thus far. |
| abstractGer |
Increase of bronchial smooth muscle (BSM) mass is a crucial feature of asthma remodeling. The mechanisms of such an increased BSM mass are complex but involve enhanced mitochondrial biogenesis, leading to increased proliferation of BSM cells in asthmatic patients. The major tumor suppressor protein p53 is a key cell regulator involved in cell proliferation and has also been implicated in mitochondrial biogenesis. However, the role of p53 in BSM cell proliferation and mitochondrial biogenesis has not been investigated thus far. |
| abstract_unstemmed |
Increase of bronchial smooth muscle (BSM) mass is a crucial feature of asthma remodeling. The mechanisms of such an increased BSM mass are complex but involve enhanced mitochondrial biogenesis, leading to increased proliferation of BSM cells in asthmatic patients. The major tumor suppressor protein p53 is a key cell regulator involved in cell proliferation and has also been implicated in mitochondrial biogenesis. However, the role of p53 in BSM cell proliferation and mitochondrial biogenesis has not been investigated thus far. |
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GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA |
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6 |
| title_short |
Selective dysfunction of p53 for mitochondrial biogenesis induces cellular proliferation in bronchial smooth muscle from asthmatic patients |
| url |
https://doi.org/10.1016/j.jaci.2015.10.031 |
| remote_bool |
true |
| author2 |
Allard, Benoit Ozier, Annaig Maurat, Elise Dupin, Isabelle Thumerel, Matthieu Ousova, Olga Gillibert-Duplantier, Jennifer Le Morvan, Valérie Begueret, Hugues Girodet, Pierre-Olivier Marthan, Roger Berger, Patrick |
| author2Str |
Allard, Benoit Ozier, Annaig Maurat, Elise Dupin, Isabelle Thumerel, Matthieu Ousova, Olga Gillibert-Duplantier, Jennifer Le Morvan, Valérie Begueret, Hugues Girodet, Pierre-Olivier Marthan, Roger Berger, Patrick |
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| doi_str |
10.1016/j.jaci.2015.10.031 |
| up_date |
2024-07-06T19:22:08.741Z |
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