Childhood lead exposure, childhood trauma, substance use and subclinical psychotic experiences–a longitudinal cohort study
This study examined the long-term associations between childhood lead exposure, childhood trauma and adult substance use, and subclinical psychotic experiences (SPEs) in the Port Pirie Cohort Study. Adult participants were initially 402 (175 males, 227 females) 25–29 year-olds followed up from the P...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Galletly, Cherrie [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2016transfer abstract |
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| Schlagwörter: |
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| Umfang: |
8 |
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| Übergeordnetes Werk: |
Enthalten in: No title available - 239(2016) vom: 30., Seite 54-61 |
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| Übergeordnetes Werk: |
volume:239 ; year:2016 ; day:30 ; month:05 ; pages:54-61 ; extent:8 |
| Links: |
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| DOI / URN: |
10.1016/j.psychres.2016.02.066 |
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ELV013760971 |
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| 520 | |a This study examined the long-term associations between childhood lead exposure, childhood trauma and adult substance use, and subclinical psychotic experiences (SPEs) in the Port Pirie Cohort Study. Adult participants were initially 402 (175 males, 227 females) 25–29 year-olds followed up from the Port Pirie Cohort Study that commenced in 1979 (55.6% of the original cohort). Multiple linear regression analyses were conducted on a sub-sample of 158 participants for which adequate data was available. Variables examined as correlates of positive, negative and depressive SPEs included socioeconomic status at birth, cumulative blood lead level at age 7, maternal mental health, family functioning and cognitive ability at age 11-13, and adverse childhood experiences, alcohol use and cannabis use assessed during adulthood. Cumulative blood lead levels at age 7 were bi-variately associated with the frequency of positive SPEs in adulthood; however this relationship was not significant when other variables were accounted for. Adverse childhood experiences and substance use (cannabis use in particular) were significant correlates of SPEs in adulthood. | ||
| 520 | |a This study examined the long-term associations between childhood lead exposure, childhood trauma and adult substance use, and subclinical psychotic experiences (SPEs) in the Port Pirie Cohort Study. Adult participants were initially 402 (175 males, 227 females) 25–29 year-olds followed up from the Port Pirie Cohort Study that commenced in 1979 (55.6% of the original cohort). Multiple linear regression analyses were conducted on a sub-sample of 158 participants for which adequate data was available. Variables examined as correlates of positive, negative and depressive SPEs included socioeconomic status at birth, cumulative blood lead level at age 7, maternal mental health, family functioning and cognitive ability at age 11-13, and adverse childhood experiences, alcohol use and cannabis use assessed during adulthood. Cumulative blood lead levels at age 7 were bi-variately associated with the frequency of positive SPEs in adulthood; however this relationship was not significant when other variables were accounted for. Adverse childhood experiences and substance use (cannabis use in particular) were significant correlates of SPEs in adulthood. | ||
| 650 | 7 | |a Psychosis |2 Elsevier | |
| 650 | 7 | |a Cannabis |2 Elsevier | |
| 650 | 7 | |a Cohort studies |2 Elsevier | |
| 650 | 7 | |a Lead |2 Elsevier | |
| 650 | 7 | |a Alcohol |2 Elsevier | |
| 650 | 7 | |a Adults |2 Elsevier | |
| 650 | 7 | |a Children |2 Elsevier | |
| 700 | 1 | |a Clark, Levina |4 oth | |
| 700 | 1 | |a McFarlane, Alexander |4 oth | |
| 700 | 1 | |a Searle, Amelia |4 oth | |
| 700 | 1 | |a Sawyer, Michael |4 oth | |
| 700 | 1 | |a Sim, Malcolm |4 oth | |
| 700 | 1 | |a Baghurst, Peter |4 oth | |
| 700 | 1 | |a van Hooff, Miranda |4 oth | |
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10.1016/j.psychres.2016.02.066 doi /export/home/cbs_olc/import_discovery/elsevier/convert/GBV-Archive_01_06_pica_neu/GBVA2016004000024.pica (DE-627)ELV013760971 (ELSEVIER)S0165-1781(16)30368-7 DE-627 ger DE-627 rakwb eng Galletly, Cherrie verfasserin aut Childhood lead exposure, childhood trauma, substance use and subclinical psychotic experiences–a longitudinal cohort study 2016transfer abstract 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier This study examined the long-term associations between childhood lead exposure, childhood trauma and adult substance use, and subclinical psychotic experiences (SPEs) in the Port Pirie Cohort Study. Adult participants were initially 402 (175 males, 227 females) 25–29 year-olds followed up from the Port Pirie Cohort Study that commenced in 1979 (55.6% of the original cohort). Multiple linear regression analyses were conducted on a sub-sample of 158 participants for which adequate data was available. Variables examined as correlates of positive, negative and depressive SPEs included socioeconomic status at birth, cumulative blood lead level at age 7, maternal mental health, family functioning and cognitive ability at age 11-13, and adverse childhood experiences, alcohol use and cannabis use assessed during adulthood. Cumulative blood lead levels at age 7 were bi-variately associated with the frequency of positive SPEs in adulthood; however this relationship was not significant when other variables were accounted for. Adverse childhood experiences and substance use (cannabis use in particular) were significant correlates of SPEs in adulthood. This study examined the long-term associations between childhood lead exposure, childhood trauma and adult substance use, and subclinical psychotic experiences (SPEs) in the Port Pirie Cohort Study. Adult participants were initially 402 (175 males, 227 females) 25–29 year-olds followed up from the Port Pirie Cohort Study that commenced in 1979 (55.6% of the original cohort). Multiple linear regression analyses were conducted on a sub-sample of 158 participants for which adequate data was available. Variables examined as correlates of positive, negative and depressive SPEs included socioeconomic status at birth, cumulative blood lead level at age 7, maternal mental health, family functioning and cognitive ability at age 11-13, and adverse childhood experiences, alcohol use and cannabis use assessed during adulthood. Cumulative blood lead levels at age 7 were bi-variately associated with the frequency of positive SPEs in adulthood; however this relationship was not significant when other variables were accounted for. Adverse childhood experiences and substance use (cannabis use in particular) were significant correlates of SPEs in adulthood. Psychosis Elsevier Cannabis Elsevier Cohort studies Elsevier Lead Elsevier Alcohol Elsevier Adults Elsevier Children Elsevier Clark, Levina oth McFarlane, Alexander oth Searle, Amelia oth Sawyer, Michael oth Sim, Malcolm oth Baghurst, Peter oth van Hooff, Miranda oth Enthalten in No title available 239(2016) vom: 30., Seite 54-61 (DE-627)ELV013759760 (DE-600)5-1781 nnns volume:239 year:2016 day:30 month:05 pages:54-61 extent:8 https://doi.org/10.1016/j.psychres.2016.02.066 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U AR 239 2016 30 0530 54-61 8 |
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10.1016/j.psychres.2016.02.066 doi /export/home/cbs_olc/import_discovery/elsevier/convert/GBV-Archive_01_06_pica_neu/GBVA2016004000024.pica (DE-627)ELV013760971 (ELSEVIER)S0165-1781(16)30368-7 DE-627 ger DE-627 rakwb eng Galletly, Cherrie verfasserin aut Childhood lead exposure, childhood trauma, substance use and subclinical psychotic experiences–a longitudinal cohort study 2016transfer abstract 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier This study examined the long-term associations between childhood lead exposure, childhood trauma and adult substance use, and subclinical psychotic experiences (SPEs) in the Port Pirie Cohort Study. Adult participants were initially 402 (175 males, 227 females) 25–29 year-olds followed up from the Port Pirie Cohort Study that commenced in 1979 (55.6% of the original cohort). Multiple linear regression analyses were conducted on a sub-sample of 158 participants for which adequate data was available. Variables examined as correlates of positive, negative and depressive SPEs included socioeconomic status at birth, cumulative blood lead level at age 7, maternal mental health, family functioning and cognitive ability at age 11-13, and adverse childhood experiences, alcohol use and cannabis use assessed during adulthood. Cumulative blood lead levels at age 7 were bi-variately associated with the frequency of positive SPEs in adulthood; however this relationship was not significant when other variables were accounted for. Adverse childhood experiences and substance use (cannabis use in particular) were significant correlates of SPEs in adulthood. This study examined the long-term associations between childhood lead exposure, childhood trauma and adult substance use, and subclinical psychotic experiences (SPEs) in the Port Pirie Cohort Study. Adult participants were initially 402 (175 males, 227 females) 25–29 year-olds followed up from the Port Pirie Cohort Study that commenced in 1979 (55.6% of the original cohort). Multiple linear regression analyses were conducted on a sub-sample of 158 participants for which adequate data was available. Variables examined as correlates of positive, negative and depressive SPEs included socioeconomic status at birth, cumulative blood lead level at age 7, maternal mental health, family functioning and cognitive ability at age 11-13, and adverse childhood experiences, alcohol use and cannabis use assessed during adulthood. Cumulative blood lead levels at age 7 were bi-variately associated with the frequency of positive SPEs in adulthood; however this relationship was not significant when other variables were accounted for. Adverse childhood experiences and substance use (cannabis use in particular) were significant correlates of SPEs in adulthood. Psychosis Elsevier Cannabis Elsevier Cohort studies Elsevier Lead Elsevier Alcohol Elsevier Adults Elsevier Children Elsevier Clark, Levina oth McFarlane, Alexander oth Searle, Amelia oth Sawyer, Michael oth Sim, Malcolm oth Baghurst, Peter oth van Hooff, Miranda oth Enthalten in No title available 239(2016) vom: 30., Seite 54-61 (DE-627)ELV013759760 (DE-600)5-1781 nnns volume:239 year:2016 day:30 month:05 pages:54-61 extent:8 https://doi.org/10.1016/j.psychres.2016.02.066 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U AR 239 2016 30 0530 54-61 8 |
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10.1016/j.psychres.2016.02.066 doi /export/home/cbs_olc/import_discovery/elsevier/convert/GBV-Archive_01_06_pica_neu/GBVA2016004000024.pica (DE-627)ELV013760971 (ELSEVIER)S0165-1781(16)30368-7 DE-627 ger DE-627 rakwb eng Galletly, Cherrie verfasserin aut Childhood lead exposure, childhood trauma, substance use and subclinical psychotic experiences–a longitudinal cohort study 2016transfer abstract 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier This study examined the long-term associations between childhood lead exposure, childhood trauma and adult substance use, and subclinical psychotic experiences (SPEs) in the Port Pirie Cohort Study. Adult participants were initially 402 (175 males, 227 females) 25–29 year-olds followed up from the Port Pirie Cohort Study that commenced in 1979 (55.6% of the original cohort). Multiple linear regression analyses were conducted on a sub-sample of 158 participants for which adequate data was available. Variables examined as correlates of positive, negative and depressive SPEs included socioeconomic status at birth, cumulative blood lead level at age 7, maternal mental health, family functioning and cognitive ability at age 11-13, and adverse childhood experiences, alcohol use and cannabis use assessed during adulthood. Cumulative blood lead levels at age 7 were bi-variately associated with the frequency of positive SPEs in adulthood; however this relationship was not significant when other variables were accounted for. Adverse childhood experiences and substance use (cannabis use in particular) were significant correlates of SPEs in adulthood. This study examined the long-term associations between childhood lead exposure, childhood trauma and adult substance use, and subclinical psychotic experiences (SPEs) in the Port Pirie Cohort Study. Adult participants were initially 402 (175 males, 227 females) 25–29 year-olds followed up from the Port Pirie Cohort Study that commenced in 1979 (55.6% of the original cohort). Multiple linear regression analyses were conducted on a sub-sample of 158 participants for which adequate data was available. Variables examined as correlates of positive, negative and depressive SPEs included socioeconomic status at birth, cumulative blood lead level at age 7, maternal mental health, family functioning and cognitive ability at age 11-13, and adverse childhood experiences, alcohol use and cannabis use assessed during adulthood. Cumulative blood lead levels at age 7 were bi-variately associated with the frequency of positive SPEs in adulthood; however this relationship was not significant when other variables were accounted for. Adverse childhood experiences and substance use (cannabis use in particular) were significant correlates of SPEs in adulthood. Psychosis Elsevier Cannabis Elsevier Cohort studies Elsevier Lead Elsevier Alcohol Elsevier Adults Elsevier Children Elsevier Clark, Levina oth McFarlane, Alexander oth Searle, Amelia oth Sawyer, Michael oth Sim, Malcolm oth Baghurst, Peter oth van Hooff, Miranda oth Enthalten in No title available 239(2016) vom: 30., Seite 54-61 (DE-627)ELV013759760 (DE-600)5-1781 nnns volume:239 year:2016 day:30 month:05 pages:54-61 extent:8 https://doi.org/10.1016/j.psychres.2016.02.066 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U AR 239 2016 30 0530 54-61 8 |
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10.1016/j.psychres.2016.02.066 doi /export/home/cbs_olc/import_discovery/elsevier/convert/GBV-Archive_01_06_pica_neu/GBVA2016004000024.pica (DE-627)ELV013760971 (ELSEVIER)S0165-1781(16)30368-7 DE-627 ger DE-627 rakwb eng Galletly, Cherrie verfasserin aut Childhood lead exposure, childhood trauma, substance use and subclinical psychotic experiences–a longitudinal cohort study 2016transfer abstract 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier This study examined the long-term associations between childhood lead exposure, childhood trauma and adult substance use, and subclinical psychotic experiences (SPEs) in the Port Pirie Cohort Study. Adult participants were initially 402 (175 males, 227 females) 25–29 year-olds followed up from the Port Pirie Cohort Study that commenced in 1979 (55.6% of the original cohort). Multiple linear regression analyses were conducted on a sub-sample of 158 participants for which adequate data was available. Variables examined as correlates of positive, negative and depressive SPEs included socioeconomic status at birth, cumulative blood lead level at age 7, maternal mental health, family functioning and cognitive ability at age 11-13, and adverse childhood experiences, alcohol use and cannabis use assessed during adulthood. Cumulative blood lead levels at age 7 were bi-variately associated with the frequency of positive SPEs in adulthood; however this relationship was not significant when other variables were accounted for. Adverse childhood experiences and substance use (cannabis use in particular) were significant correlates of SPEs in adulthood. This study examined the long-term associations between childhood lead exposure, childhood trauma and adult substance use, and subclinical psychotic experiences (SPEs) in the Port Pirie Cohort Study. Adult participants were initially 402 (175 males, 227 females) 25–29 year-olds followed up from the Port Pirie Cohort Study that commenced in 1979 (55.6% of the original cohort). Multiple linear regression analyses were conducted on a sub-sample of 158 participants for which adequate data was available. Variables examined as correlates of positive, negative and depressive SPEs included socioeconomic status at birth, cumulative blood lead level at age 7, maternal mental health, family functioning and cognitive ability at age 11-13, and adverse childhood experiences, alcohol use and cannabis use assessed during adulthood. Cumulative blood lead levels at age 7 were bi-variately associated with the frequency of positive SPEs in adulthood; however this relationship was not significant when other variables were accounted for. Adverse childhood experiences and substance use (cannabis use in particular) were significant correlates of SPEs in adulthood. Psychosis Elsevier Cannabis Elsevier Cohort studies Elsevier Lead Elsevier Alcohol Elsevier Adults Elsevier Children Elsevier Clark, Levina oth McFarlane, Alexander oth Searle, Amelia oth Sawyer, Michael oth Sim, Malcolm oth Baghurst, Peter oth van Hooff, Miranda oth Enthalten in No title available 239(2016) vom: 30., Seite 54-61 (DE-627)ELV013759760 (DE-600)5-1781 nnns volume:239 year:2016 day:30 month:05 pages:54-61 extent:8 https://doi.org/10.1016/j.psychres.2016.02.066 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U AR 239 2016 30 0530 54-61 8 |
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10.1016/j.psychres.2016.02.066 doi /export/home/cbs_olc/import_discovery/elsevier/convert/GBV-Archive_01_06_pica_neu/GBVA2016004000024.pica (DE-627)ELV013760971 (ELSEVIER)S0165-1781(16)30368-7 DE-627 ger DE-627 rakwb eng Galletly, Cherrie verfasserin aut Childhood lead exposure, childhood trauma, substance use and subclinical psychotic experiences–a longitudinal cohort study 2016transfer abstract 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier This study examined the long-term associations between childhood lead exposure, childhood trauma and adult substance use, and subclinical psychotic experiences (SPEs) in the Port Pirie Cohort Study. Adult participants were initially 402 (175 males, 227 females) 25–29 year-olds followed up from the Port Pirie Cohort Study that commenced in 1979 (55.6% of the original cohort). Multiple linear regression analyses were conducted on a sub-sample of 158 participants for which adequate data was available. Variables examined as correlates of positive, negative and depressive SPEs included socioeconomic status at birth, cumulative blood lead level at age 7, maternal mental health, family functioning and cognitive ability at age 11-13, and adverse childhood experiences, alcohol use and cannabis use assessed during adulthood. Cumulative blood lead levels at age 7 were bi-variately associated with the frequency of positive SPEs in adulthood; however this relationship was not significant when other variables were accounted for. Adverse childhood experiences and substance use (cannabis use in particular) were significant correlates of SPEs in adulthood. This study examined the long-term associations between childhood lead exposure, childhood trauma and adult substance use, and subclinical psychotic experiences (SPEs) in the Port Pirie Cohort Study. Adult participants were initially 402 (175 males, 227 females) 25–29 year-olds followed up from the Port Pirie Cohort Study that commenced in 1979 (55.6% of the original cohort). Multiple linear regression analyses were conducted on a sub-sample of 158 participants for which adequate data was available. Variables examined as correlates of positive, negative and depressive SPEs included socioeconomic status at birth, cumulative blood lead level at age 7, maternal mental health, family functioning and cognitive ability at age 11-13, and adverse childhood experiences, alcohol use and cannabis use assessed during adulthood. Cumulative blood lead levels at age 7 were bi-variately associated with the frequency of positive SPEs in adulthood; however this relationship was not significant when other variables were accounted for. Adverse childhood experiences and substance use (cannabis use in particular) were significant correlates of SPEs in adulthood. Psychosis Elsevier Cannabis Elsevier Cohort studies Elsevier Lead Elsevier Alcohol Elsevier Adults Elsevier Children Elsevier Clark, Levina oth McFarlane, Alexander oth Searle, Amelia oth Sawyer, Michael oth Sim, Malcolm oth Baghurst, Peter oth van Hooff, Miranda oth Enthalten in No title available 239(2016) vom: 30., Seite 54-61 (DE-627)ELV013759760 (DE-600)5-1781 nnns volume:239 year:2016 day:30 month:05 pages:54-61 extent:8 https://doi.org/10.1016/j.psychres.2016.02.066 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U AR 239 2016 30 0530 54-61 8 |
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Adult participants were initially 402 (175 males, 227 females) 25–29 year-olds followed up from the Port Pirie Cohort Study that commenced in 1979 (55.6% of the original cohort). Multiple linear regression analyses were conducted on a sub-sample of 158 participants for which adequate data was available. Variables examined as correlates of positive, negative and depressive SPEs included socioeconomic status at birth, cumulative blood lead level at age 7, maternal mental health, family functioning and cognitive ability at age 11-13, and adverse childhood experiences, alcohol use and cannabis use assessed during adulthood. Cumulative blood lead levels at age 7 were bi-variately associated with the frequency of positive SPEs in adulthood; however this relationship was not significant when other variables were accounted for. 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childhood lead exposure, childhood trauma, substance use and subclinical psychotic experiences–a longitudinal cohort study |
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Childhood lead exposure, childhood trauma, substance use and subclinical psychotic experiences–a longitudinal cohort study |
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This study examined the long-term associations between childhood lead exposure, childhood trauma and adult substance use, and subclinical psychotic experiences (SPEs) in the Port Pirie Cohort Study. Adult participants were initially 402 (175 males, 227 females) 25–29 year-olds followed up from the Port Pirie Cohort Study that commenced in 1979 (55.6% of the original cohort). Multiple linear regression analyses were conducted on a sub-sample of 158 participants for which adequate data was available. Variables examined as correlates of positive, negative and depressive SPEs included socioeconomic status at birth, cumulative blood lead level at age 7, maternal mental health, family functioning and cognitive ability at age 11-13, and adverse childhood experiences, alcohol use and cannabis use assessed during adulthood. Cumulative blood lead levels at age 7 were bi-variately associated with the frequency of positive SPEs in adulthood; however this relationship was not significant when other variables were accounted for. Adverse childhood experiences and substance use (cannabis use in particular) were significant correlates of SPEs in adulthood. |
| abstractGer |
This study examined the long-term associations between childhood lead exposure, childhood trauma and adult substance use, and subclinical psychotic experiences (SPEs) in the Port Pirie Cohort Study. Adult participants were initially 402 (175 males, 227 females) 25–29 year-olds followed up from the Port Pirie Cohort Study that commenced in 1979 (55.6% of the original cohort). Multiple linear regression analyses were conducted on a sub-sample of 158 participants for which adequate data was available. Variables examined as correlates of positive, negative and depressive SPEs included socioeconomic status at birth, cumulative blood lead level at age 7, maternal mental health, family functioning and cognitive ability at age 11-13, and adverse childhood experiences, alcohol use and cannabis use assessed during adulthood. Cumulative blood lead levels at age 7 were bi-variately associated with the frequency of positive SPEs in adulthood; however this relationship was not significant when other variables were accounted for. Adverse childhood experiences and substance use (cannabis use in particular) were significant correlates of SPEs in adulthood. |
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This study examined the long-term associations between childhood lead exposure, childhood trauma and adult substance use, and subclinical psychotic experiences (SPEs) in the Port Pirie Cohort Study. Adult participants were initially 402 (175 males, 227 females) 25–29 year-olds followed up from the Port Pirie Cohort Study that commenced in 1979 (55.6% of the original cohort). Multiple linear regression analyses were conducted on a sub-sample of 158 participants for which adequate data was available. Variables examined as correlates of positive, negative and depressive SPEs included socioeconomic status at birth, cumulative blood lead level at age 7, maternal mental health, family functioning and cognitive ability at age 11-13, and adverse childhood experiences, alcohol use and cannabis use assessed during adulthood. Cumulative blood lead levels at age 7 were bi-variately associated with the frequency of positive SPEs in adulthood; however this relationship was not significant when other variables were accounted for. Adverse childhood experiences and substance use (cannabis use in particular) were significant correlates of SPEs in adulthood. |
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