OBSESSIVE-COMPULSIVE DISORDER CLINICAL STAGING: FROM ENDOPHENOTYPE TO BEHAVIORAL ADDICTION (A THEORETICAL FRAMEWORK)
Up to date, no clinical staging models have been proposed or tested for obsessive-compulsive disorder (OCD). The last years’ research has clearly recognized the phenotypical and neurobiological heterogeneity of OCD and has focus on sub-typing OCD both in terms of symptom dimensions and comorbidity p...
Ausführliche Beschreibung
Autor*in: |
Grassi, Giacomo [verfasserIn] |
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Format: |
E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2016transfer abstract |
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Übergeordnetes Werk: |
Enthalten in: Temperature-dependence laws of absorption line shape parameters of the CO - Wilzewski, J.S. ELSEVIER, 2017, ENP : the journal of the European College of Neuropsychopharmacology, Amsterdam |
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Übergeordnetes Werk: |
volume:26 ; year:2016 ; number:5 ; pages:897 |
Links: |
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DOI / URN: |
10.1016/j.euroneuro.2015.06.031 |
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520 | |a Up to date, no clinical staging models have been proposed or tested for obsessive-compulsive disorder (OCD). The last years’ research has clearly recognized the phenotypical and neurobiological heterogeneity of OCD and has focus on sub-typing OCD both in terms of symptom dimensions and comorbidity patterns. However, there are several evidences supporting the idea that the illness course is responsible for neurobiological changes. Consequently, is reasonable to suppose that these neurobiological changes could be responsible for changes in the phenotypical and clinical expression of the disease [1]. Moreover, longitudinal studies showed that longer duration of illness is a significant predictor of poor long-term course, highlighting the critical importance of early detection and treatment of OCD. Thus, defining and testing a clinical staging model for OCD could be relevant both in the definition of its pathophisiology and in developing new strategies for an earlier intervention. | ||
520 | |a Up to date, no clinical staging models have been proposed or tested for obsessive-compulsive disorder (OCD). The last years’ research has clearly recognized the phenotypical and neurobiological heterogeneity of OCD and has focus on sub-typing OCD both in terms of symptom dimensions and comorbidity patterns. However, there are several evidences supporting the idea that the illness course is responsible for neurobiological changes. Consequently, is reasonable to suppose that these neurobiological changes could be responsible for changes in the phenotypical and clinical expression of the disease [1]. Moreover, longitudinal studies showed that longer duration of illness is a significant predictor of poor long-term course, highlighting the critical importance of early detection and treatment of OCD. Thus, defining and testing a clinical staging model for OCD could be relevant both in the definition of its pathophisiology and in developing new strategies for an earlier intervention. | ||
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10.1016/j.euroneuro.2015.06.031 doi GBVA2016014000027.pica (DE-627)ELV014234777 (ELSEVIER)S0924-977X(15)00201-1 DE-627 ger DE-627 rakwb eng 150 610 150 DE-600 610 DE-600 530 VZ 33.00 bkl Grassi, Giacomo verfasserin aut OBSESSIVE-COMPULSIVE DISORDER CLINICAL STAGING: FROM ENDOPHENOTYPE TO BEHAVIORAL ADDICTION (A THEORETICAL FRAMEWORK) 2016transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Up to date, no clinical staging models have been proposed or tested for obsessive-compulsive disorder (OCD). The last years’ research has clearly recognized the phenotypical and neurobiological heterogeneity of OCD and has focus on sub-typing OCD both in terms of symptom dimensions and comorbidity patterns. However, there are several evidences supporting the idea that the illness course is responsible for neurobiological changes. Consequently, is reasonable to suppose that these neurobiological changes could be responsible for changes in the phenotypical and clinical expression of the disease [1]. Moreover, longitudinal studies showed that longer duration of illness is a significant predictor of poor long-term course, highlighting the critical importance of early detection and treatment of OCD. Thus, defining and testing a clinical staging model for OCD could be relevant both in the definition of its pathophisiology and in developing new strategies for an earlier intervention. Up to date, no clinical staging models have been proposed or tested for obsessive-compulsive disorder (OCD). The last years’ research has clearly recognized the phenotypical and neurobiological heterogeneity of OCD and has focus on sub-typing OCD both in terms of symptom dimensions and comorbidity patterns. However, there are several evidences supporting the idea that the illness course is responsible for neurobiological changes. Consequently, is reasonable to suppose that these neurobiological changes could be responsible for changes in the phenotypical and clinical expression of the disease [1]. Moreover, longitudinal studies showed that longer duration of illness is a significant predictor of poor long-term course, highlighting the critical importance of early detection and treatment of OCD. Thus, defining and testing a clinical staging model for OCD could be relevant both in the definition of its pathophisiology and in developing new strategies for an earlier intervention. Enthalten in Elsevier Wilzewski, J.S. ELSEVIER Temperature-dependence laws of absorption line shape parameters of the CO 2017 ENP : the journal of the European College of Neuropsychopharmacology Amsterdam (DE-627)ELV000200816 volume:26 year:2016 number:5 pages:897 https://doi.org/10.1016/j.euroneuro.2015.06.031 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 33.00 Physik: Allgemeines VZ AR 26 2016 5 897 045F 150 |
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10.1016/j.euroneuro.2015.06.031 doi GBVA2016014000027.pica (DE-627)ELV014234777 (ELSEVIER)S0924-977X(15)00201-1 DE-627 ger DE-627 rakwb eng 150 610 150 DE-600 610 DE-600 530 VZ 33.00 bkl Grassi, Giacomo verfasserin aut OBSESSIVE-COMPULSIVE DISORDER CLINICAL STAGING: FROM ENDOPHENOTYPE TO BEHAVIORAL ADDICTION (A THEORETICAL FRAMEWORK) 2016transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Up to date, no clinical staging models have been proposed or tested for obsessive-compulsive disorder (OCD). The last years’ research has clearly recognized the phenotypical and neurobiological heterogeneity of OCD and has focus on sub-typing OCD both in terms of symptom dimensions and comorbidity patterns. However, there are several evidences supporting the idea that the illness course is responsible for neurobiological changes. Consequently, is reasonable to suppose that these neurobiological changes could be responsible for changes in the phenotypical and clinical expression of the disease [1]. Moreover, longitudinal studies showed that longer duration of illness is a significant predictor of poor long-term course, highlighting the critical importance of early detection and treatment of OCD. Thus, defining and testing a clinical staging model for OCD could be relevant both in the definition of its pathophisiology and in developing new strategies for an earlier intervention. Up to date, no clinical staging models have been proposed or tested for obsessive-compulsive disorder (OCD). The last years’ research has clearly recognized the phenotypical and neurobiological heterogeneity of OCD and has focus on sub-typing OCD both in terms of symptom dimensions and comorbidity patterns. However, there are several evidences supporting the idea that the illness course is responsible for neurobiological changes. Consequently, is reasonable to suppose that these neurobiological changes could be responsible for changes in the phenotypical and clinical expression of the disease [1]. Moreover, longitudinal studies showed that longer duration of illness is a significant predictor of poor long-term course, highlighting the critical importance of early detection and treatment of OCD. Thus, defining and testing a clinical staging model for OCD could be relevant both in the definition of its pathophisiology and in developing new strategies for an earlier intervention. Enthalten in Elsevier Wilzewski, J.S. ELSEVIER Temperature-dependence laws of absorption line shape parameters of the CO 2017 ENP : the journal of the European College of Neuropsychopharmacology Amsterdam (DE-627)ELV000200816 volume:26 year:2016 number:5 pages:897 https://doi.org/10.1016/j.euroneuro.2015.06.031 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 33.00 Physik: Allgemeines VZ AR 26 2016 5 897 045F 150 |
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10.1016/j.euroneuro.2015.06.031 doi GBVA2016014000027.pica (DE-627)ELV014234777 (ELSEVIER)S0924-977X(15)00201-1 DE-627 ger DE-627 rakwb eng 150 610 150 DE-600 610 DE-600 530 VZ 33.00 bkl Grassi, Giacomo verfasserin aut OBSESSIVE-COMPULSIVE DISORDER CLINICAL STAGING: FROM ENDOPHENOTYPE TO BEHAVIORAL ADDICTION (A THEORETICAL FRAMEWORK) 2016transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Up to date, no clinical staging models have been proposed or tested for obsessive-compulsive disorder (OCD). The last years’ research has clearly recognized the phenotypical and neurobiological heterogeneity of OCD and has focus on sub-typing OCD both in terms of symptom dimensions and comorbidity patterns. However, there are several evidences supporting the idea that the illness course is responsible for neurobiological changes. Consequently, is reasonable to suppose that these neurobiological changes could be responsible for changes in the phenotypical and clinical expression of the disease [1]. Moreover, longitudinal studies showed that longer duration of illness is a significant predictor of poor long-term course, highlighting the critical importance of early detection and treatment of OCD. Thus, defining and testing a clinical staging model for OCD could be relevant both in the definition of its pathophisiology and in developing new strategies for an earlier intervention. Up to date, no clinical staging models have been proposed or tested for obsessive-compulsive disorder (OCD). The last years’ research has clearly recognized the phenotypical and neurobiological heterogeneity of OCD and has focus on sub-typing OCD both in terms of symptom dimensions and comorbidity patterns. However, there are several evidences supporting the idea that the illness course is responsible for neurobiological changes. Consequently, is reasonable to suppose that these neurobiological changes could be responsible for changes in the phenotypical and clinical expression of the disease [1]. Moreover, longitudinal studies showed that longer duration of illness is a significant predictor of poor long-term course, highlighting the critical importance of early detection and treatment of OCD. Thus, defining and testing a clinical staging model for OCD could be relevant both in the definition of its pathophisiology and in developing new strategies for an earlier intervention. Enthalten in Elsevier Wilzewski, J.S. ELSEVIER Temperature-dependence laws of absorption line shape parameters of the CO 2017 ENP : the journal of the European College of Neuropsychopharmacology Amsterdam (DE-627)ELV000200816 volume:26 year:2016 number:5 pages:897 https://doi.org/10.1016/j.euroneuro.2015.06.031 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 33.00 Physik: Allgemeines VZ AR 26 2016 5 897 045F 150 |
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10.1016/j.euroneuro.2015.06.031 doi GBVA2016014000027.pica (DE-627)ELV014234777 (ELSEVIER)S0924-977X(15)00201-1 DE-627 ger DE-627 rakwb eng 150 610 150 DE-600 610 DE-600 530 VZ 33.00 bkl Grassi, Giacomo verfasserin aut OBSESSIVE-COMPULSIVE DISORDER CLINICAL STAGING: FROM ENDOPHENOTYPE TO BEHAVIORAL ADDICTION (A THEORETICAL FRAMEWORK) 2016transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Up to date, no clinical staging models have been proposed or tested for obsessive-compulsive disorder (OCD). The last years’ research has clearly recognized the phenotypical and neurobiological heterogeneity of OCD and has focus on sub-typing OCD both in terms of symptom dimensions and comorbidity patterns. However, there are several evidences supporting the idea that the illness course is responsible for neurobiological changes. Consequently, is reasonable to suppose that these neurobiological changes could be responsible for changes in the phenotypical and clinical expression of the disease [1]. Moreover, longitudinal studies showed that longer duration of illness is a significant predictor of poor long-term course, highlighting the critical importance of early detection and treatment of OCD. Thus, defining and testing a clinical staging model for OCD could be relevant both in the definition of its pathophisiology and in developing new strategies for an earlier intervention. Up to date, no clinical staging models have been proposed or tested for obsessive-compulsive disorder (OCD). The last years’ research has clearly recognized the phenotypical and neurobiological heterogeneity of OCD and has focus on sub-typing OCD both in terms of symptom dimensions and comorbidity patterns. However, there are several evidences supporting the idea that the illness course is responsible for neurobiological changes. Consequently, is reasonable to suppose that these neurobiological changes could be responsible for changes in the phenotypical and clinical expression of the disease [1]. Moreover, longitudinal studies showed that longer duration of illness is a significant predictor of poor long-term course, highlighting the critical importance of early detection and treatment of OCD. Thus, defining and testing a clinical staging model for OCD could be relevant both in the definition of its pathophisiology and in developing new strategies for an earlier intervention. Enthalten in Elsevier Wilzewski, J.S. ELSEVIER Temperature-dependence laws of absorption line shape parameters of the CO 2017 ENP : the journal of the European College of Neuropsychopharmacology Amsterdam (DE-627)ELV000200816 volume:26 year:2016 number:5 pages:897 https://doi.org/10.1016/j.euroneuro.2015.06.031 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 33.00 Physik: Allgemeines VZ AR 26 2016 5 897 045F 150 |
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Grassi, Giacomo |
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10.1016/j.euroneuro.2015.06.031 |
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obsessive-compulsive disorder clinical staging: from endophenotype to behavioral addiction (a theoretical framework) |
title_auth |
OBSESSIVE-COMPULSIVE DISORDER CLINICAL STAGING: FROM ENDOPHENOTYPE TO BEHAVIORAL ADDICTION (A THEORETICAL FRAMEWORK) |
abstract |
Up to date, no clinical staging models have been proposed or tested for obsessive-compulsive disorder (OCD). The last years’ research has clearly recognized the phenotypical and neurobiological heterogeneity of OCD and has focus on sub-typing OCD both in terms of symptom dimensions and comorbidity patterns. However, there are several evidences supporting the idea that the illness course is responsible for neurobiological changes. Consequently, is reasonable to suppose that these neurobiological changes could be responsible for changes in the phenotypical and clinical expression of the disease [1]. Moreover, longitudinal studies showed that longer duration of illness is a significant predictor of poor long-term course, highlighting the critical importance of early detection and treatment of OCD. Thus, defining and testing a clinical staging model for OCD could be relevant both in the definition of its pathophisiology and in developing new strategies for an earlier intervention. |
abstractGer |
Up to date, no clinical staging models have been proposed or tested for obsessive-compulsive disorder (OCD). The last years’ research has clearly recognized the phenotypical and neurobiological heterogeneity of OCD and has focus on sub-typing OCD both in terms of symptom dimensions and comorbidity patterns. However, there are several evidences supporting the idea that the illness course is responsible for neurobiological changes. Consequently, is reasonable to suppose that these neurobiological changes could be responsible for changes in the phenotypical and clinical expression of the disease [1]. Moreover, longitudinal studies showed that longer duration of illness is a significant predictor of poor long-term course, highlighting the critical importance of early detection and treatment of OCD. Thus, defining and testing a clinical staging model for OCD could be relevant both in the definition of its pathophisiology and in developing new strategies for an earlier intervention. |
abstract_unstemmed |
Up to date, no clinical staging models have been proposed or tested for obsessive-compulsive disorder (OCD). The last years’ research has clearly recognized the phenotypical and neurobiological heterogeneity of OCD and has focus on sub-typing OCD both in terms of symptom dimensions and comorbidity patterns. However, there are several evidences supporting the idea that the illness course is responsible for neurobiological changes. Consequently, is reasonable to suppose that these neurobiological changes could be responsible for changes in the phenotypical and clinical expression of the disease [1]. Moreover, longitudinal studies showed that longer duration of illness is a significant predictor of poor long-term course, highlighting the critical importance of early detection and treatment of OCD. Thus, defining and testing a clinical staging model for OCD could be relevant both in the definition of its pathophisiology and in developing new strategies for an earlier intervention. |
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title_short |
OBSESSIVE-COMPULSIVE DISORDER CLINICAL STAGING: FROM ENDOPHENOTYPE TO BEHAVIORAL ADDICTION (A THEORETICAL FRAMEWORK) |
url |
https://doi.org/10.1016/j.euroneuro.2015.06.031 |
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