Engineered porous scaffolds for periprosthetic infection prevention
Periprosthetic infection is a consequence of implant insertion procedures and strategies for its prevention involve either an increase in the rate of new bone formation or the release of antibiotics such as vancomycin. In this work we combined both strategies and developed a novel, multifunctional t...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Iviglia, Giorgio [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2016transfer abstract |
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| Umfang: |
15 |
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| Übergeordnetes Werk: |
Enthalten in: Adsorption of various metals by carboxymethyl-β-cyclodextrin-modified Zn - Kameda, Tomohito ELSEVIER, 2020, Amsterdam |
|---|---|
| Übergeordnetes Werk: |
volume:68 ; year:2016 ; day:1 ; month:11 ; pages:701-715 ; extent:15 |
| Links: |
|---|
| DOI / URN: |
10.1016/j.msec.2016.06.050 |
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ELV014352087 |
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| 520 | |a Periprosthetic infection is a consequence of implant insertion procedures and strategies for its prevention involve either an increase in the rate of new bone formation or the release of antibiotics such as vancomycin. In this work we combined both strategies and developed a novel, multifunctional three-dimensional porous scaffold that was produced using hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP), coupled with a pectin (PEC)-chitosan (CHIT) polyelectrolyte (PEI), and loaded with vancomycin (VCA). By this approach, a controlled vancomycin release was achieved and serial bacterial dilution test demonstrated that, after 1week, the engineered construct still inhibits the bacterial growth. Degradation tests show an excellent behavior in a physiological and acidic environment (<10% of mass loss). Furthermore, the PEI coating shows an anti-inflammatory response, and good cell proliferation and migration were demonstrated in vitro using osteoblast SAOS-2 cell line. This new engineered construct exhibits excellent properties both as an antibacterial material and as a stimulator of bone formation, which makes it a good candidate to contrast periprosthetic infection. | ||
| 520 | |a Periprosthetic infection is a consequence of implant insertion procedures and strategies for its prevention involve either an increase in the rate of new bone formation or the release of antibiotics such as vancomycin. In this work we combined both strategies and developed a novel, multifunctional three-dimensional porous scaffold that was produced using hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP), coupled with a pectin (PEC)-chitosan (CHIT) polyelectrolyte (PEI), and loaded with vancomycin (VCA). By this approach, a controlled vancomycin release was achieved and serial bacterial dilution test demonstrated that, after 1week, the engineered construct still inhibits the bacterial growth. Degradation tests show an excellent behavior in a physiological and acidic environment (<10% of mass loss). Furthermore, the PEI coating shows an anti-inflammatory response, and good cell proliferation and migration were demonstrated in vitro using osteoblast SAOS-2 cell line. This new engineered construct exhibits excellent properties both as an antibacterial material and as a stimulator of bone formation, which makes it a good candidate to contrast periprosthetic infection. | ||
| 700 | 1 | |a Cassinelli, Clara |4 oth | |
| 700 | 1 | |a Bollati, Daniele |4 oth | |
| 700 | 1 | |a Baino, Francesco |4 oth | |
| 700 | 1 | |a Torre, Elisa |4 oth | |
| 700 | 1 | |a Morra, Marco |4 oth | |
| 700 | 1 | |a Vitale-Brovarone, Chiara |4 oth | |
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10.1016/j.msec.2016.06.050 doi GBV00000000000165A.pica (DE-627)ELV014352087 (ELSEVIER)S0928-4931(16)30618-X DE-627 ger DE-627 rakwb eng 600 600 DE-600 550 VZ 38.30 bkl 58.45 bkl 38.69 bkl 56.20 bkl Iviglia, Giorgio verfasserin aut Engineered porous scaffolds for periprosthetic infection prevention 2016transfer abstract 15 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Periprosthetic infection is a consequence of implant insertion procedures and strategies for its prevention involve either an increase in the rate of new bone formation or the release of antibiotics such as vancomycin. In this work we combined both strategies and developed a novel, multifunctional three-dimensional porous scaffold that was produced using hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP), coupled with a pectin (PEC)-chitosan (CHIT) polyelectrolyte (PEI), and loaded with vancomycin (VCA). By this approach, a controlled vancomycin release was achieved and serial bacterial dilution test demonstrated that, after 1week, the engineered construct still inhibits the bacterial growth. Degradation tests show an excellent behavior in a physiological and acidic environment (<10% of mass loss). Furthermore, the PEI coating shows an anti-inflammatory response, and good cell proliferation and migration were demonstrated in vitro using osteoblast SAOS-2 cell line. This new engineered construct exhibits excellent properties both as an antibacterial material and as a stimulator of bone formation, which makes it a good candidate to contrast periprosthetic infection. Periprosthetic infection is a consequence of implant insertion procedures and strategies for its prevention involve either an increase in the rate of new bone formation or the release of antibiotics such as vancomycin. In this work we combined both strategies and developed a novel, multifunctional three-dimensional porous scaffold that was produced using hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP), coupled with a pectin (PEC)-chitosan (CHIT) polyelectrolyte (PEI), and loaded with vancomycin (VCA). By this approach, a controlled vancomycin release was achieved and serial bacterial dilution test demonstrated that, after 1week, the engineered construct still inhibits the bacterial growth. Degradation tests show an excellent behavior in a physiological and acidic environment (<10% of mass loss). Furthermore, the PEI coating shows an anti-inflammatory response, and good cell proliferation and migration were demonstrated in vitro using osteoblast SAOS-2 cell line. This new engineered construct exhibits excellent properties both as an antibacterial material and as a stimulator of bone formation, which makes it a good candidate to contrast periprosthetic infection. Cassinelli, Clara oth Bollati, Daniele oth Baino, Francesco oth Torre, Elisa oth Morra, Marco oth Vitale-Brovarone, Chiara oth Enthalten in Elsevier Kameda, Tomohito ELSEVIER Adsorption of various metals by carboxymethyl-β-cyclodextrin-modified Zn 2020 Amsterdam (DE-627)ELV003774007 volume:68 year:2016 day:1 month:11 pages:701-715 extent:15 https://doi.org/10.1016/j.msec.2016.06.050 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-GGO 38.30 Mineralogie VZ 58.45 Gesteinshüttenkunde VZ 38.69 Bodenkunde: Sonstiges Geowissenschaften VZ 56.20 Ingenieurgeologie Bodenmechanik VZ AR 68 2016 1 1101 701-715 15 045F 600 |
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10.1016/j.msec.2016.06.050 doi GBV00000000000165A.pica (DE-627)ELV014352087 (ELSEVIER)S0928-4931(16)30618-X DE-627 ger DE-627 rakwb eng 600 600 DE-600 550 VZ 38.30 bkl 58.45 bkl 38.69 bkl 56.20 bkl Iviglia, Giorgio verfasserin aut Engineered porous scaffolds for periprosthetic infection prevention 2016transfer abstract 15 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Periprosthetic infection is a consequence of implant insertion procedures and strategies for its prevention involve either an increase in the rate of new bone formation or the release of antibiotics such as vancomycin. In this work we combined both strategies and developed a novel, multifunctional three-dimensional porous scaffold that was produced using hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP), coupled with a pectin (PEC)-chitosan (CHIT) polyelectrolyte (PEI), and loaded with vancomycin (VCA). By this approach, a controlled vancomycin release was achieved and serial bacterial dilution test demonstrated that, after 1week, the engineered construct still inhibits the bacterial growth. Degradation tests show an excellent behavior in a physiological and acidic environment (<10% of mass loss). Furthermore, the PEI coating shows an anti-inflammatory response, and good cell proliferation and migration were demonstrated in vitro using osteoblast SAOS-2 cell line. This new engineered construct exhibits excellent properties both as an antibacterial material and as a stimulator of bone formation, which makes it a good candidate to contrast periprosthetic infection. Periprosthetic infection is a consequence of implant insertion procedures and strategies for its prevention involve either an increase in the rate of new bone formation or the release of antibiotics such as vancomycin. In this work we combined both strategies and developed a novel, multifunctional three-dimensional porous scaffold that was produced using hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP), coupled with a pectin (PEC)-chitosan (CHIT) polyelectrolyte (PEI), and loaded with vancomycin (VCA). By this approach, a controlled vancomycin release was achieved and serial bacterial dilution test demonstrated that, after 1week, the engineered construct still inhibits the bacterial growth. Degradation tests show an excellent behavior in a physiological and acidic environment (<10% of mass loss). Furthermore, the PEI coating shows an anti-inflammatory response, and good cell proliferation and migration were demonstrated in vitro using osteoblast SAOS-2 cell line. This new engineered construct exhibits excellent properties both as an antibacterial material and as a stimulator of bone formation, which makes it a good candidate to contrast periprosthetic infection. Cassinelli, Clara oth Bollati, Daniele oth Baino, Francesco oth Torre, Elisa oth Morra, Marco oth Vitale-Brovarone, Chiara oth Enthalten in Elsevier Kameda, Tomohito ELSEVIER Adsorption of various metals by carboxymethyl-β-cyclodextrin-modified Zn 2020 Amsterdam (DE-627)ELV003774007 volume:68 year:2016 day:1 month:11 pages:701-715 extent:15 https://doi.org/10.1016/j.msec.2016.06.050 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-GGO 38.30 Mineralogie VZ 58.45 Gesteinshüttenkunde VZ 38.69 Bodenkunde: Sonstiges Geowissenschaften VZ 56.20 Ingenieurgeologie Bodenmechanik VZ AR 68 2016 1 1101 701-715 15 045F 600 |
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10.1016/j.msec.2016.06.050 doi GBV00000000000165A.pica (DE-627)ELV014352087 (ELSEVIER)S0928-4931(16)30618-X DE-627 ger DE-627 rakwb eng 600 600 DE-600 550 VZ 38.30 bkl 58.45 bkl 38.69 bkl 56.20 bkl Iviglia, Giorgio verfasserin aut Engineered porous scaffolds for periprosthetic infection prevention 2016transfer abstract 15 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Periprosthetic infection is a consequence of implant insertion procedures and strategies for its prevention involve either an increase in the rate of new bone formation or the release of antibiotics such as vancomycin. In this work we combined both strategies and developed a novel, multifunctional three-dimensional porous scaffold that was produced using hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP), coupled with a pectin (PEC)-chitosan (CHIT) polyelectrolyte (PEI), and loaded with vancomycin (VCA). By this approach, a controlled vancomycin release was achieved and serial bacterial dilution test demonstrated that, after 1week, the engineered construct still inhibits the bacterial growth. Degradation tests show an excellent behavior in a physiological and acidic environment (<10% of mass loss). Furthermore, the PEI coating shows an anti-inflammatory response, and good cell proliferation and migration were demonstrated in vitro using osteoblast SAOS-2 cell line. This new engineered construct exhibits excellent properties both as an antibacterial material and as a stimulator of bone formation, which makes it a good candidate to contrast periprosthetic infection. Periprosthetic infection is a consequence of implant insertion procedures and strategies for its prevention involve either an increase in the rate of new bone formation or the release of antibiotics such as vancomycin. In this work we combined both strategies and developed a novel, multifunctional three-dimensional porous scaffold that was produced using hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP), coupled with a pectin (PEC)-chitosan (CHIT) polyelectrolyte (PEI), and loaded with vancomycin (VCA). By this approach, a controlled vancomycin release was achieved and serial bacterial dilution test demonstrated that, after 1week, the engineered construct still inhibits the bacterial growth. Degradation tests show an excellent behavior in a physiological and acidic environment (<10% of mass loss). Furthermore, the PEI coating shows an anti-inflammatory response, and good cell proliferation and migration were demonstrated in vitro using osteoblast SAOS-2 cell line. This new engineered construct exhibits excellent properties both as an antibacterial material and as a stimulator of bone formation, which makes it a good candidate to contrast periprosthetic infection. Cassinelli, Clara oth Bollati, Daniele oth Baino, Francesco oth Torre, Elisa oth Morra, Marco oth Vitale-Brovarone, Chiara oth Enthalten in Elsevier Kameda, Tomohito ELSEVIER Adsorption of various metals by carboxymethyl-β-cyclodextrin-modified Zn 2020 Amsterdam (DE-627)ELV003774007 volume:68 year:2016 day:1 month:11 pages:701-715 extent:15 https://doi.org/10.1016/j.msec.2016.06.050 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-GGO 38.30 Mineralogie VZ 58.45 Gesteinshüttenkunde VZ 38.69 Bodenkunde: Sonstiges Geowissenschaften VZ 56.20 Ingenieurgeologie Bodenmechanik VZ AR 68 2016 1 1101 701-715 15 045F 600 |
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10.1016/j.msec.2016.06.050 doi GBV00000000000165A.pica (DE-627)ELV014352087 (ELSEVIER)S0928-4931(16)30618-X DE-627 ger DE-627 rakwb eng 600 600 DE-600 550 VZ 38.30 bkl 58.45 bkl 38.69 bkl 56.20 bkl Iviglia, Giorgio verfasserin aut Engineered porous scaffolds for periprosthetic infection prevention 2016transfer abstract 15 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Periprosthetic infection is a consequence of implant insertion procedures and strategies for its prevention involve either an increase in the rate of new bone formation or the release of antibiotics such as vancomycin. In this work we combined both strategies and developed a novel, multifunctional three-dimensional porous scaffold that was produced using hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP), coupled with a pectin (PEC)-chitosan (CHIT) polyelectrolyte (PEI), and loaded with vancomycin (VCA). By this approach, a controlled vancomycin release was achieved and serial bacterial dilution test demonstrated that, after 1week, the engineered construct still inhibits the bacterial growth. Degradation tests show an excellent behavior in a physiological and acidic environment (<10% of mass loss). Furthermore, the PEI coating shows an anti-inflammatory response, and good cell proliferation and migration were demonstrated in vitro using osteoblast SAOS-2 cell line. This new engineered construct exhibits excellent properties both as an antibacterial material and as a stimulator of bone formation, which makes it a good candidate to contrast periprosthetic infection. Periprosthetic infection is a consequence of implant insertion procedures and strategies for its prevention involve either an increase in the rate of new bone formation or the release of antibiotics such as vancomycin. In this work we combined both strategies and developed a novel, multifunctional three-dimensional porous scaffold that was produced using hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP), coupled with a pectin (PEC)-chitosan (CHIT) polyelectrolyte (PEI), and loaded with vancomycin (VCA). By this approach, a controlled vancomycin release was achieved and serial bacterial dilution test demonstrated that, after 1week, the engineered construct still inhibits the bacterial growth. Degradation tests show an excellent behavior in a physiological and acidic environment (<10% of mass loss). Furthermore, the PEI coating shows an anti-inflammatory response, and good cell proliferation and migration were demonstrated in vitro using osteoblast SAOS-2 cell line. This new engineered construct exhibits excellent properties both as an antibacterial material and as a stimulator of bone formation, which makes it a good candidate to contrast periprosthetic infection. Cassinelli, Clara oth Bollati, Daniele oth Baino, Francesco oth Torre, Elisa oth Morra, Marco oth Vitale-Brovarone, Chiara oth Enthalten in Elsevier Kameda, Tomohito ELSEVIER Adsorption of various metals by carboxymethyl-β-cyclodextrin-modified Zn 2020 Amsterdam (DE-627)ELV003774007 volume:68 year:2016 day:1 month:11 pages:701-715 extent:15 https://doi.org/10.1016/j.msec.2016.06.050 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-GGO 38.30 Mineralogie VZ 58.45 Gesteinshüttenkunde VZ 38.69 Bodenkunde: Sonstiges Geowissenschaften VZ 56.20 Ingenieurgeologie Bodenmechanik VZ AR 68 2016 1 1101 701-715 15 045F 600 |
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10.1016/j.msec.2016.06.050 doi GBV00000000000165A.pica (DE-627)ELV014352087 (ELSEVIER)S0928-4931(16)30618-X DE-627 ger DE-627 rakwb eng 600 600 DE-600 550 VZ 38.30 bkl 58.45 bkl 38.69 bkl 56.20 bkl Iviglia, Giorgio verfasserin aut Engineered porous scaffolds for periprosthetic infection prevention 2016transfer abstract 15 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Periprosthetic infection is a consequence of implant insertion procedures and strategies for its prevention involve either an increase in the rate of new bone formation or the release of antibiotics such as vancomycin. In this work we combined both strategies and developed a novel, multifunctional three-dimensional porous scaffold that was produced using hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP), coupled with a pectin (PEC)-chitosan (CHIT) polyelectrolyte (PEI), and loaded with vancomycin (VCA). By this approach, a controlled vancomycin release was achieved and serial bacterial dilution test demonstrated that, after 1week, the engineered construct still inhibits the bacterial growth. Degradation tests show an excellent behavior in a physiological and acidic environment (<10% of mass loss). Furthermore, the PEI coating shows an anti-inflammatory response, and good cell proliferation and migration were demonstrated in vitro using osteoblast SAOS-2 cell line. This new engineered construct exhibits excellent properties both as an antibacterial material and as a stimulator of bone formation, which makes it a good candidate to contrast periprosthetic infection. Periprosthetic infection is a consequence of implant insertion procedures and strategies for its prevention involve either an increase in the rate of new bone formation or the release of antibiotics such as vancomycin. In this work we combined both strategies and developed a novel, multifunctional three-dimensional porous scaffold that was produced using hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP), coupled with a pectin (PEC)-chitosan (CHIT) polyelectrolyte (PEI), and loaded with vancomycin (VCA). By this approach, a controlled vancomycin release was achieved and serial bacterial dilution test demonstrated that, after 1week, the engineered construct still inhibits the bacterial growth. Degradation tests show an excellent behavior in a physiological and acidic environment (<10% of mass loss). Furthermore, the PEI coating shows an anti-inflammatory response, and good cell proliferation and migration were demonstrated in vitro using osteoblast SAOS-2 cell line. This new engineered construct exhibits excellent properties both as an antibacterial material and as a stimulator of bone formation, which makes it a good candidate to contrast periprosthetic infection. Cassinelli, Clara oth Bollati, Daniele oth Baino, Francesco oth Torre, Elisa oth Morra, Marco oth Vitale-Brovarone, Chiara oth Enthalten in Elsevier Kameda, Tomohito ELSEVIER Adsorption of various metals by carboxymethyl-β-cyclodextrin-modified Zn 2020 Amsterdam (DE-627)ELV003774007 volume:68 year:2016 day:1 month:11 pages:701-715 extent:15 https://doi.org/10.1016/j.msec.2016.06.050 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-GGO 38.30 Mineralogie VZ 58.45 Gesteinshüttenkunde VZ 38.69 Bodenkunde: Sonstiges Geowissenschaften VZ 56.20 Ingenieurgeologie Bodenmechanik VZ AR 68 2016 1 1101 701-715 15 045F 600 |
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Iviglia, Giorgio @@aut@@ Cassinelli, Clara @@oth@@ Bollati, Daniele @@oth@@ Baino, Francesco @@oth@@ Torre, Elisa @@oth@@ Morra, Marco @@oth@@ Vitale-Brovarone, Chiara @@oth@@ |
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Periprosthetic infection is a consequence of implant insertion procedures and strategies for its prevention involve either an increase in the rate of new bone formation or the release of antibiotics such as vancomycin. In this work we combined both strategies and developed a novel, multifunctional three-dimensional porous scaffold that was produced using hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP), coupled with a pectin (PEC)-chitosan (CHIT) polyelectrolyte (PEI), and loaded with vancomycin (VCA). By this approach, a controlled vancomycin release was achieved and serial bacterial dilution test demonstrated that, after 1week, the engineered construct still inhibits the bacterial growth. Degradation tests show an excellent behavior in a physiological and acidic environment (<10% of mass loss). Furthermore, the PEI coating shows an anti-inflammatory response, and good cell proliferation and migration were demonstrated in vitro using osteoblast SAOS-2 cell line. This new engineered construct exhibits excellent properties both as an antibacterial material and as a stimulator of bone formation, which makes it a good candidate to contrast periprosthetic infection. |
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Periprosthetic infection is a consequence of implant insertion procedures and strategies for its prevention involve either an increase in the rate of new bone formation or the release of antibiotics such as vancomycin. In this work we combined both strategies and developed a novel, multifunctional three-dimensional porous scaffold that was produced using hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP), coupled with a pectin (PEC)-chitosan (CHIT) polyelectrolyte (PEI), and loaded with vancomycin (VCA). By this approach, a controlled vancomycin release was achieved and serial bacterial dilution test demonstrated that, after 1week, the engineered construct still inhibits the bacterial growth. Degradation tests show an excellent behavior in a physiological and acidic environment (<10% of mass loss). Furthermore, the PEI coating shows an anti-inflammatory response, and good cell proliferation and migration were demonstrated in vitro using osteoblast SAOS-2 cell line. This new engineered construct exhibits excellent properties both as an antibacterial material and as a stimulator of bone formation, which makes it a good candidate to contrast periprosthetic infection. |
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Periprosthetic infection is a consequence of implant insertion procedures and strategies for its prevention involve either an increase in the rate of new bone formation or the release of antibiotics such as vancomycin. In this work we combined both strategies and developed a novel, multifunctional three-dimensional porous scaffold that was produced using hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP), coupled with a pectin (PEC)-chitosan (CHIT) polyelectrolyte (PEI), and loaded with vancomycin (VCA). By this approach, a controlled vancomycin release was achieved and serial bacterial dilution test demonstrated that, after 1week, the engineered construct still inhibits the bacterial growth. Degradation tests show an excellent behavior in a physiological and acidic environment (<10% of mass loss). Furthermore, the PEI coating shows an anti-inflammatory response, and good cell proliferation and migration were demonstrated in vitro using osteoblast SAOS-2 cell line. This new engineered construct exhibits excellent properties both as an antibacterial material and as a stimulator of bone formation, which makes it a good candidate to contrast periprosthetic infection. |
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