Electrochemical behavior of the cotinine at a boron-doped diamond electrode and its determination in saliva by multiple-pulse amperometry in an FIA system
Cotinine (CO) is the principal metabolite of nicotine, and it is used as a biomarker to monitor the exposure of an individual to tobacco. This paper sought to present the use of a boron-doped diamond (BDD) electrode for the electrochemical characterization of CO by voltammetric techniques and its qu...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Alecrim, Morgana F. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2016transfer abstract |
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| Umfang: |
7 |
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| Übergeordnetes Werk: |
Enthalten in: Computed tomographic morphometric analysis of lateral inclination C1 pedicle screw for atlantoaxial instability patients with a narrow C1 posterior arch - Zhang, Lei ELSEVIER, 2018, the journal of the International Society of Electrochemistry (ISE), New York, NY [u.a.] |
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| Übergeordnetes Werk: |
volume:222 ; year:2016 ; day:20 ; month:12 ; pages:331-337 ; extent:7 |
| Links: |
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| DOI / URN: |
10.1016/j.electacta.2016.10.177 |
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ELV014520648 |
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| 245 | 1 | 0 | |a Electrochemical behavior of the cotinine at a boron-doped diamond electrode and its determination in saliva by multiple-pulse amperometry in an FIA system |
| 264 | 1 | |c 2016transfer abstract | |
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| 520 | |a Cotinine (CO) is the principal metabolite of nicotine, and it is used as a biomarker to monitor the exposure of an individual to tobacco. This paper sought to present the use of a boron-doped diamond (BDD) electrode for the electrochemical characterization of CO by voltammetric techniques and its quantification in saliva samples by multiple-pulse amperometry (MPA) in a flow injection analysis (FIA) system. In phosphate buffer solution 0.1molL−1 (pH 7), the CO presented two electrochemical processes, one anodic at +1.8V and one cathodic at −1.2V (vs. Ag/AgCl). The second process was dependent on the first and both processes were irreversible. It was found that CO electrochemical processes are controlled by diffusion and that two-protons and two-electrons are involved in the oxidation reaction. In determination of CO in saliva samples, the MPA detection was used, applying four potential pulses: (1) at +1.8V/400ms, generator potential pulse for oxidation of CO; (2) at −1.0V/500ms, potential pulse for remove possible interferents; (3) at −1.2V/30ms, collector potential pulse for reduction of the product generated and CO quantification; (4) 1.45V/300ms, potential pulse for cleaning BDD electrode. The proposed method attained an analytical frequency of 36 determinations per hour with a relative standard deviation of 1.47% for 10 measurements of 1.0×10−5 molL−1 CO. A good linear range from 0.5 to 100μmolL−1 was obtained with a detection limit for CO estimated at 0.06μmolL−1. Approximately 100% of the CO added to saliva samples was recovered. Therefore, this work presents, for the first time, the electrochemical behavior of the CO at an electrode as well as a simple, fast and low-cost method for monitoring the degree of exposure to tobacco by CO determination in saliva samples using the FIA-MPA technique. | ||
| 520 | |a Cotinine (CO) is the principal metabolite of nicotine, and it is used as a biomarker to monitor the exposure of an individual to tobacco. This paper sought to present the use of a boron-doped diamond (BDD) electrode for the electrochemical characterization of CO by voltammetric techniques and its quantification in saliva samples by multiple-pulse amperometry (MPA) in a flow injection analysis (FIA) system. In phosphate buffer solution 0.1molL−1 (pH 7), the CO presented two electrochemical processes, one anodic at +1.8V and one cathodic at −1.2V (vs. Ag/AgCl). The second process was dependent on the first and both processes were irreversible. It was found that CO electrochemical processes are controlled by diffusion and that two-protons and two-electrons are involved in the oxidation reaction. In determination of CO in saliva samples, the MPA detection was used, applying four potential pulses: (1) at +1.8V/400ms, generator potential pulse for oxidation of CO; (2) at −1.0V/500ms, potential pulse for remove possible interferents; (3) at −1.2V/30ms, collector potential pulse for reduction of the product generated and CO quantification; (4) 1.45V/300ms, potential pulse for cleaning BDD electrode. The proposed method attained an analytical frequency of 36 determinations per hour with a relative standard deviation of 1.47% for 10 measurements of 1.0×10−5 molL−1 CO. A good linear range from 0.5 to 100μmolL−1 was obtained with a detection limit for CO estimated at 0.06μmolL−1. Approximately 100% of the CO added to saliva samples was recovered. Therefore, this work presents, for the first time, the electrochemical behavior of the CO at an electrode as well as a simple, fast and low-cost method for monitoring the degree of exposure to tobacco by CO determination in saliva samples using the FIA-MPA technique. | ||
| 650 | 7 | |a Tobacco |2 Elsevier | |
| 650 | 7 | |a Pulsed Amperometry |2 Elsevier | |
| 650 | 7 | |a Cotinine |2 Elsevier | |
| 650 | 7 | |a Boron-Doped Diamond |2 Elsevier | |
| 650 | 7 | |a FIA |2 Elsevier | |
| 700 | 1 | |a Oliveira, Fernando M. |4 oth | |
| 700 | 1 | |a Guedes, Tiago J. |4 oth | |
| 700 | 1 | |a Neves, Camila D.c. |4 oth | |
| 700 | 1 | |a Mendonça, Vanessa A. |4 oth | |
| 700 | 1 | |a Gil, Eric S. |4 oth | |
| 700 | 1 | |a Verly, Rodrigo M. |4 oth | |
| 700 | 1 | |a dos Santos, Wallans T.P. |4 oth | |
| 773 | 0 | 8 | |i Enthalten in |n Elsevier |a Zhang, Lei ELSEVIER |t Computed tomographic morphometric analysis of lateral inclination C1 pedicle screw for atlantoaxial instability patients with a narrow C1 posterior arch |d 2018 |d the journal of the International Society of Electrochemistry (ISE) |g New York, NY [u.a.] |w (DE-627)ELV001212419 |
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10.1016/j.electacta.2016.10.177 doi GBV00000000000122A.pica (DE-627)ELV014520648 (ELSEVIER)S0013-4686(16)32286-1 DE-627 ger DE-627 rakwb eng 540 540 DE-600 610 VZ 44.00 bkl Alecrim, Morgana F. verfasserin aut Electrochemical behavior of the cotinine at a boron-doped diamond electrode and its determination in saliva by multiple-pulse amperometry in an FIA system 2016transfer abstract 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Cotinine (CO) is the principal metabolite of nicotine, and it is used as a biomarker to monitor the exposure of an individual to tobacco. This paper sought to present the use of a boron-doped diamond (BDD) electrode for the electrochemical characterization of CO by voltammetric techniques and its quantification in saliva samples by multiple-pulse amperometry (MPA) in a flow injection analysis (FIA) system. In phosphate buffer solution 0.1molL−1 (pH 7), the CO presented two electrochemical processes, one anodic at +1.8V and one cathodic at −1.2V (vs. Ag/AgCl). The second process was dependent on the first and both processes were irreversible. It was found that CO electrochemical processes are controlled by diffusion and that two-protons and two-electrons are involved in the oxidation reaction. In determination of CO in saliva samples, the MPA detection was used, applying four potential pulses: (1) at +1.8V/400ms, generator potential pulse for oxidation of CO; (2) at −1.0V/500ms, potential pulse for remove possible interferents; (3) at −1.2V/30ms, collector potential pulse for reduction of the product generated and CO quantification; (4) 1.45V/300ms, potential pulse for cleaning BDD electrode. The proposed method attained an analytical frequency of 36 determinations per hour with a relative standard deviation of 1.47% for 10 measurements of 1.0×10−5 molL−1 CO. A good linear range from 0.5 to 100μmolL−1 was obtained with a detection limit for CO estimated at 0.06μmolL−1. Approximately 100% of the CO added to saliva samples was recovered. Therefore, this work presents, for the first time, the electrochemical behavior of the CO at an electrode as well as a simple, fast and low-cost method for monitoring the degree of exposure to tobacco by CO determination in saliva samples using the FIA-MPA technique. Cotinine (CO) is the principal metabolite of nicotine, and it is used as a biomarker to monitor the exposure of an individual to tobacco. This paper sought to present the use of a boron-doped diamond (BDD) electrode for the electrochemical characterization of CO by voltammetric techniques and its quantification in saliva samples by multiple-pulse amperometry (MPA) in a flow injection analysis (FIA) system. In phosphate buffer solution 0.1molL−1 (pH 7), the CO presented two electrochemical processes, one anodic at +1.8V and one cathodic at −1.2V (vs. Ag/AgCl). The second process was dependent on the first and both processes were irreversible. It was found that CO electrochemical processes are controlled by diffusion and that two-protons and two-electrons are involved in the oxidation reaction. In determination of CO in saliva samples, the MPA detection was used, applying four potential pulses: (1) at +1.8V/400ms, generator potential pulse for oxidation of CO; (2) at −1.0V/500ms, potential pulse for remove possible interferents; (3) at −1.2V/30ms, collector potential pulse for reduction of the product generated and CO quantification; (4) 1.45V/300ms, potential pulse for cleaning BDD electrode. The proposed method attained an analytical frequency of 36 determinations per hour with a relative standard deviation of 1.47% for 10 measurements of 1.0×10−5 molL−1 CO. A good linear range from 0.5 to 100μmolL−1 was obtained with a detection limit for CO estimated at 0.06μmolL−1. Approximately 100% of the CO added to saliva samples was recovered. Therefore, this work presents, for the first time, the electrochemical behavior of the CO at an electrode as well as a simple, fast and low-cost method for monitoring the degree of exposure to tobacco by CO determination in saliva samples using the FIA-MPA technique. Tobacco Elsevier Pulsed Amperometry Elsevier Cotinine Elsevier Boron-Doped Diamond Elsevier FIA Elsevier Oliveira, Fernando M. oth Guedes, Tiago J. oth Neves, Camila D.c. oth Mendonça, Vanessa A. oth Gil, Eric S. oth Verly, Rodrigo M. oth dos Santos, Wallans T.P. oth Enthalten in Elsevier Zhang, Lei ELSEVIER Computed tomographic morphometric analysis of lateral inclination C1 pedicle screw for atlantoaxial instability patients with a narrow C1 posterior arch 2018 the journal of the International Society of Electrochemistry (ISE) New York, NY [u.a.] (DE-627)ELV001212419 volume:222 year:2016 day:20 month:12 pages:331-337 extent:7 https://doi.org/10.1016/j.electacta.2016.10.177 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.00 Medizin: Allgemeines VZ AR 222 2016 20 1220 331-337 7 045F 540 |
| spelling |
10.1016/j.electacta.2016.10.177 doi GBV00000000000122A.pica (DE-627)ELV014520648 (ELSEVIER)S0013-4686(16)32286-1 DE-627 ger DE-627 rakwb eng 540 540 DE-600 610 VZ 44.00 bkl Alecrim, Morgana F. verfasserin aut Electrochemical behavior of the cotinine at a boron-doped diamond electrode and its determination in saliva by multiple-pulse amperometry in an FIA system 2016transfer abstract 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Cotinine (CO) is the principal metabolite of nicotine, and it is used as a biomarker to monitor the exposure of an individual to tobacco. This paper sought to present the use of a boron-doped diamond (BDD) electrode for the electrochemical characterization of CO by voltammetric techniques and its quantification in saliva samples by multiple-pulse amperometry (MPA) in a flow injection analysis (FIA) system. In phosphate buffer solution 0.1molL−1 (pH 7), the CO presented two electrochemical processes, one anodic at +1.8V and one cathodic at −1.2V (vs. Ag/AgCl). The second process was dependent on the first and both processes were irreversible. It was found that CO electrochemical processes are controlled by diffusion and that two-protons and two-electrons are involved in the oxidation reaction. In determination of CO in saliva samples, the MPA detection was used, applying four potential pulses: (1) at +1.8V/400ms, generator potential pulse for oxidation of CO; (2) at −1.0V/500ms, potential pulse for remove possible interferents; (3) at −1.2V/30ms, collector potential pulse for reduction of the product generated and CO quantification; (4) 1.45V/300ms, potential pulse for cleaning BDD electrode. The proposed method attained an analytical frequency of 36 determinations per hour with a relative standard deviation of 1.47% for 10 measurements of 1.0×10−5 molL−1 CO. A good linear range from 0.5 to 100μmolL−1 was obtained with a detection limit for CO estimated at 0.06μmolL−1. Approximately 100% of the CO added to saliva samples was recovered. Therefore, this work presents, for the first time, the electrochemical behavior of the CO at an electrode as well as a simple, fast and low-cost method for monitoring the degree of exposure to tobacco by CO determination in saliva samples using the FIA-MPA technique. Cotinine (CO) is the principal metabolite of nicotine, and it is used as a biomarker to monitor the exposure of an individual to tobacco. This paper sought to present the use of a boron-doped diamond (BDD) electrode for the electrochemical characterization of CO by voltammetric techniques and its quantification in saliva samples by multiple-pulse amperometry (MPA) in a flow injection analysis (FIA) system. In phosphate buffer solution 0.1molL−1 (pH 7), the CO presented two electrochemical processes, one anodic at +1.8V and one cathodic at −1.2V (vs. Ag/AgCl). The second process was dependent on the first and both processes were irreversible. It was found that CO electrochemical processes are controlled by diffusion and that two-protons and two-electrons are involved in the oxidation reaction. In determination of CO in saliva samples, the MPA detection was used, applying four potential pulses: (1) at +1.8V/400ms, generator potential pulse for oxidation of CO; (2) at −1.0V/500ms, potential pulse for remove possible interferents; (3) at −1.2V/30ms, collector potential pulse for reduction of the product generated and CO quantification; (4) 1.45V/300ms, potential pulse for cleaning BDD electrode. The proposed method attained an analytical frequency of 36 determinations per hour with a relative standard deviation of 1.47% for 10 measurements of 1.0×10−5 molL−1 CO. A good linear range from 0.5 to 100μmolL−1 was obtained with a detection limit for CO estimated at 0.06μmolL−1. Approximately 100% of the CO added to saliva samples was recovered. Therefore, this work presents, for the first time, the electrochemical behavior of the CO at an electrode as well as a simple, fast and low-cost method for monitoring the degree of exposure to tobacco by CO determination in saliva samples using the FIA-MPA technique. Tobacco Elsevier Pulsed Amperometry Elsevier Cotinine Elsevier Boron-Doped Diamond Elsevier FIA Elsevier Oliveira, Fernando M. oth Guedes, Tiago J. oth Neves, Camila D.c. oth Mendonça, Vanessa A. oth Gil, Eric S. oth Verly, Rodrigo M. oth dos Santos, Wallans T.P. oth Enthalten in Elsevier Zhang, Lei ELSEVIER Computed tomographic morphometric analysis of lateral inclination C1 pedicle screw for atlantoaxial instability patients with a narrow C1 posterior arch 2018 the journal of the International Society of Electrochemistry (ISE) New York, NY [u.a.] (DE-627)ELV001212419 volume:222 year:2016 day:20 month:12 pages:331-337 extent:7 https://doi.org/10.1016/j.electacta.2016.10.177 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.00 Medizin: Allgemeines VZ AR 222 2016 20 1220 331-337 7 045F 540 |
| allfields_unstemmed |
10.1016/j.electacta.2016.10.177 doi GBV00000000000122A.pica (DE-627)ELV014520648 (ELSEVIER)S0013-4686(16)32286-1 DE-627 ger DE-627 rakwb eng 540 540 DE-600 610 VZ 44.00 bkl Alecrim, Morgana F. verfasserin aut Electrochemical behavior of the cotinine at a boron-doped diamond electrode and its determination in saliva by multiple-pulse amperometry in an FIA system 2016transfer abstract 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Cotinine (CO) is the principal metabolite of nicotine, and it is used as a biomarker to monitor the exposure of an individual to tobacco. This paper sought to present the use of a boron-doped diamond (BDD) electrode for the electrochemical characterization of CO by voltammetric techniques and its quantification in saliva samples by multiple-pulse amperometry (MPA) in a flow injection analysis (FIA) system. In phosphate buffer solution 0.1molL−1 (pH 7), the CO presented two electrochemical processes, one anodic at +1.8V and one cathodic at −1.2V (vs. Ag/AgCl). The second process was dependent on the first and both processes were irreversible. It was found that CO electrochemical processes are controlled by diffusion and that two-protons and two-electrons are involved in the oxidation reaction. In determination of CO in saliva samples, the MPA detection was used, applying four potential pulses: (1) at +1.8V/400ms, generator potential pulse for oxidation of CO; (2) at −1.0V/500ms, potential pulse for remove possible interferents; (3) at −1.2V/30ms, collector potential pulse for reduction of the product generated and CO quantification; (4) 1.45V/300ms, potential pulse for cleaning BDD electrode. The proposed method attained an analytical frequency of 36 determinations per hour with a relative standard deviation of 1.47% for 10 measurements of 1.0×10−5 molL−1 CO. A good linear range from 0.5 to 100μmolL−1 was obtained with a detection limit for CO estimated at 0.06μmolL−1. Approximately 100% of the CO added to saliva samples was recovered. Therefore, this work presents, for the first time, the electrochemical behavior of the CO at an electrode as well as a simple, fast and low-cost method for monitoring the degree of exposure to tobacco by CO determination in saliva samples using the FIA-MPA technique. Cotinine (CO) is the principal metabolite of nicotine, and it is used as a biomarker to monitor the exposure of an individual to tobacco. This paper sought to present the use of a boron-doped diamond (BDD) electrode for the electrochemical characterization of CO by voltammetric techniques and its quantification in saliva samples by multiple-pulse amperometry (MPA) in a flow injection analysis (FIA) system. In phosphate buffer solution 0.1molL−1 (pH 7), the CO presented two electrochemical processes, one anodic at +1.8V and one cathodic at −1.2V (vs. Ag/AgCl). The second process was dependent on the first and both processes were irreversible. It was found that CO electrochemical processes are controlled by diffusion and that two-protons and two-electrons are involved in the oxidation reaction. In determination of CO in saliva samples, the MPA detection was used, applying four potential pulses: (1) at +1.8V/400ms, generator potential pulse for oxidation of CO; (2) at −1.0V/500ms, potential pulse for remove possible interferents; (3) at −1.2V/30ms, collector potential pulse for reduction of the product generated and CO quantification; (4) 1.45V/300ms, potential pulse for cleaning BDD electrode. The proposed method attained an analytical frequency of 36 determinations per hour with a relative standard deviation of 1.47% for 10 measurements of 1.0×10−5 molL−1 CO. A good linear range from 0.5 to 100μmolL−1 was obtained with a detection limit for CO estimated at 0.06μmolL−1. Approximately 100% of the CO added to saliva samples was recovered. Therefore, this work presents, for the first time, the electrochemical behavior of the CO at an electrode as well as a simple, fast and low-cost method for monitoring the degree of exposure to tobacco by CO determination in saliva samples using the FIA-MPA technique. Tobacco Elsevier Pulsed Amperometry Elsevier Cotinine Elsevier Boron-Doped Diamond Elsevier FIA Elsevier Oliveira, Fernando M. oth Guedes, Tiago J. oth Neves, Camila D.c. oth Mendonça, Vanessa A. oth Gil, Eric S. oth Verly, Rodrigo M. oth dos Santos, Wallans T.P. oth Enthalten in Elsevier Zhang, Lei ELSEVIER Computed tomographic morphometric analysis of lateral inclination C1 pedicle screw for atlantoaxial instability patients with a narrow C1 posterior arch 2018 the journal of the International Society of Electrochemistry (ISE) New York, NY [u.a.] (DE-627)ELV001212419 volume:222 year:2016 day:20 month:12 pages:331-337 extent:7 https://doi.org/10.1016/j.electacta.2016.10.177 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.00 Medizin: Allgemeines VZ AR 222 2016 20 1220 331-337 7 045F 540 |
| allfieldsGer |
10.1016/j.electacta.2016.10.177 doi GBV00000000000122A.pica (DE-627)ELV014520648 (ELSEVIER)S0013-4686(16)32286-1 DE-627 ger DE-627 rakwb eng 540 540 DE-600 610 VZ 44.00 bkl Alecrim, Morgana F. verfasserin aut Electrochemical behavior of the cotinine at a boron-doped diamond electrode and its determination in saliva by multiple-pulse amperometry in an FIA system 2016transfer abstract 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Cotinine (CO) is the principal metabolite of nicotine, and it is used as a biomarker to monitor the exposure of an individual to tobacco. This paper sought to present the use of a boron-doped diamond (BDD) electrode for the electrochemical characterization of CO by voltammetric techniques and its quantification in saliva samples by multiple-pulse amperometry (MPA) in a flow injection analysis (FIA) system. In phosphate buffer solution 0.1molL−1 (pH 7), the CO presented two electrochemical processes, one anodic at +1.8V and one cathodic at −1.2V (vs. Ag/AgCl). The second process was dependent on the first and both processes were irreversible. It was found that CO electrochemical processes are controlled by diffusion and that two-protons and two-electrons are involved in the oxidation reaction. In determination of CO in saliva samples, the MPA detection was used, applying four potential pulses: (1) at +1.8V/400ms, generator potential pulse for oxidation of CO; (2) at −1.0V/500ms, potential pulse for remove possible interferents; (3) at −1.2V/30ms, collector potential pulse for reduction of the product generated and CO quantification; (4) 1.45V/300ms, potential pulse for cleaning BDD electrode. The proposed method attained an analytical frequency of 36 determinations per hour with a relative standard deviation of 1.47% for 10 measurements of 1.0×10−5 molL−1 CO. A good linear range from 0.5 to 100μmolL−1 was obtained with a detection limit for CO estimated at 0.06μmolL−1. Approximately 100% of the CO added to saliva samples was recovered. Therefore, this work presents, for the first time, the electrochemical behavior of the CO at an electrode as well as a simple, fast and low-cost method for monitoring the degree of exposure to tobacco by CO determination in saliva samples using the FIA-MPA technique. Cotinine (CO) is the principal metabolite of nicotine, and it is used as a biomarker to monitor the exposure of an individual to tobacco. This paper sought to present the use of a boron-doped diamond (BDD) electrode for the electrochemical characterization of CO by voltammetric techniques and its quantification in saliva samples by multiple-pulse amperometry (MPA) in a flow injection analysis (FIA) system. In phosphate buffer solution 0.1molL−1 (pH 7), the CO presented two electrochemical processes, one anodic at +1.8V and one cathodic at −1.2V (vs. Ag/AgCl). The second process was dependent on the first and both processes were irreversible. It was found that CO electrochemical processes are controlled by diffusion and that two-protons and two-electrons are involved in the oxidation reaction. In determination of CO in saliva samples, the MPA detection was used, applying four potential pulses: (1) at +1.8V/400ms, generator potential pulse for oxidation of CO; (2) at −1.0V/500ms, potential pulse for remove possible interferents; (3) at −1.2V/30ms, collector potential pulse for reduction of the product generated and CO quantification; (4) 1.45V/300ms, potential pulse for cleaning BDD electrode. The proposed method attained an analytical frequency of 36 determinations per hour with a relative standard deviation of 1.47% for 10 measurements of 1.0×10−5 molL−1 CO. A good linear range from 0.5 to 100μmolL−1 was obtained with a detection limit for CO estimated at 0.06μmolL−1. Approximately 100% of the CO added to saliva samples was recovered. Therefore, this work presents, for the first time, the electrochemical behavior of the CO at an electrode as well as a simple, fast and low-cost method for monitoring the degree of exposure to tobacco by CO determination in saliva samples using the FIA-MPA technique. Tobacco Elsevier Pulsed Amperometry Elsevier Cotinine Elsevier Boron-Doped Diamond Elsevier FIA Elsevier Oliveira, Fernando M. oth Guedes, Tiago J. oth Neves, Camila D.c. oth Mendonça, Vanessa A. oth Gil, Eric S. oth Verly, Rodrigo M. oth dos Santos, Wallans T.P. oth Enthalten in Elsevier Zhang, Lei ELSEVIER Computed tomographic morphometric analysis of lateral inclination C1 pedicle screw for atlantoaxial instability patients with a narrow C1 posterior arch 2018 the journal of the International Society of Electrochemistry (ISE) New York, NY [u.a.] (DE-627)ELV001212419 volume:222 year:2016 day:20 month:12 pages:331-337 extent:7 https://doi.org/10.1016/j.electacta.2016.10.177 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.00 Medizin: Allgemeines VZ AR 222 2016 20 1220 331-337 7 045F 540 |
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10.1016/j.electacta.2016.10.177 doi GBV00000000000122A.pica (DE-627)ELV014520648 (ELSEVIER)S0013-4686(16)32286-1 DE-627 ger DE-627 rakwb eng 540 540 DE-600 610 VZ 44.00 bkl Alecrim, Morgana F. verfasserin aut Electrochemical behavior of the cotinine at a boron-doped diamond electrode and its determination in saliva by multiple-pulse amperometry in an FIA system 2016transfer abstract 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Cotinine (CO) is the principal metabolite of nicotine, and it is used as a biomarker to monitor the exposure of an individual to tobacco. This paper sought to present the use of a boron-doped diamond (BDD) electrode for the electrochemical characterization of CO by voltammetric techniques and its quantification in saliva samples by multiple-pulse amperometry (MPA) in a flow injection analysis (FIA) system. In phosphate buffer solution 0.1molL−1 (pH 7), the CO presented two electrochemical processes, one anodic at +1.8V and one cathodic at −1.2V (vs. Ag/AgCl). The second process was dependent on the first and both processes were irreversible. It was found that CO electrochemical processes are controlled by diffusion and that two-protons and two-electrons are involved in the oxidation reaction. In determination of CO in saliva samples, the MPA detection was used, applying four potential pulses: (1) at +1.8V/400ms, generator potential pulse for oxidation of CO; (2) at −1.0V/500ms, potential pulse for remove possible interferents; (3) at −1.2V/30ms, collector potential pulse for reduction of the product generated and CO quantification; (4) 1.45V/300ms, potential pulse for cleaning BDD electrode. The proposed method attained an analytical frequency of 36 determinations per hour with a relative standard deviation of 1.47% for 10 measurements of 1.0×10−5 molL−1 CO. A good linear range from 0.5 to 100μmolL−1 was obtained with a detection limit for CO estimated at 0.06μmolL−1. Approximately 100% of the CO added to saliva samples was recovered. Therefore, this work presents, for the first time, the electrochemical behavior of the CO at an electrode as well as a simple, fast and low-cost method for monitoring the degree of exposure to tobacco by CO determination in saliva samples using the FIA-MPA technique. Cotinine (CO) is the principal metabolite of nicotine, and it is used as a biomarker to monitor the exposure of an individual to tobacco. This paper sought to present the use of a boron-doped diamond (BDD) electrode for the electrochemical characterization of CO by voltammetric techniques and its quantification in saliva samples by multiple-pulse amperometry (MPA) in a flow injection analysis (FIA) system. In phosphate buffer solution 0.1molL−1 (pH 7), the CO presented two electrochemical processes, one anodic at +1.8V and one cathodic at −1.2V (vs. Ag/AgCl). The second process was dependent on the first and both processes were irreversible. It was found that CO electrochemical processes are controlled by diffusion and that two-protons and two-electrons are involved in the oxidation reaction. In determination of CO in saliva samples, the MPA detection was used, applying four potential pulses: (1) at +1.8V/400ms, generator potential pulse for oxidation of CO; (2) at −1.0V/500ms, potential pulse for remove possible interferents; (3) at −1.2V/30ms, collector potential pulse for reduction of the product generated and CO quantification; (4) 1.45V/300ms, potential pulse for cleaning BDD electrode. The proposed method attained an analytical frequency of 36 determinations per hour with a relative standard deviation of 1.47% for 10 measurements of 1.0×10−5 molL−1 CO. A good linear range from 0.5 to 100μmolL−1 was obtained with a detection limit for CO estimated at 0.06μmolL−1. Approximately 100% of the CO added to saliva samples was recovered. Therefore, this work presents, for the first time, the electrochemical behavior of the CO at an electrode as well as a simple, fast and low-cost method for monitoring the degree of exposure to tobacco by CO determination in saliva samples using the FIA-MPA technique. Tobacco Elsevier Pulsed Amperometry Elsevier Cotinine Elsevier Boron-Doped Diamond Elsevier FIA Elsevier Oliveira, Fernando M. oth Guedes, Tiago J. oth Neves, Camila D.c. oth Mendonça, Vanessa A. oth Gil, Eric S. oth Verly, Rodrigo M. oth dos Santos, Wallans T.P. oth Enthalten in Elsevier Zhang, Lei ELSEVIER Computed tomographic morphometric analysis of lateral inclination C1 pedicle screw for atlantoaxial instability patients with a narrow C1 posterior arch 2018 the journal of the International Society of Electrochemistry (ISE) New York, NY [u.a.] (DE-627)ELV001212419 volume:222 year:2016 day:20 month:12 pages:331-337 extent:7 https://doi.org/10.1016/j.electacta.2016.10.177 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.00 Medizin: Allgemeines VZ AR 222 2016 20 1220 331-337 7 045F 540 |
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Enthalten in Computed tomographic morphometric analysis of lateral inclination C1 pedicle screw for atlantoaxial instability patients with a narrow C1 posterior arch New York, NY [u.a.] volume:222 year:2016 day:20 month:12 pages:331-337 extent:7 |
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Alecrim, Morgana F. @@aut@@ Oliveira, Fernando M. @@oth@@ Guedes, Tiago J. @@oth@@ Neves, Camila D.c. @@oth@@ Mendonça, Vanessa A. @@oth@@ Gil, Eric S. @@oth@@ Verly, Rodrigo M. @@oth@@ dos Santos, Wallans T.P. @@oth@@ |
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Electrochemical behavior of the cotinine at a boron-doped diamond electrode and its determination in saliva by multiple-pulse amperometry in an FIA system |
| abstract |
Cotinine (CO) is the principal metabolite of nicotine, and it is used as a biomarker to monitor the exposure of an individual to tobacco. This paper sought to present the use of a boron-doped diamond (BDD) electrode for the electrochemical characterization of CO by voltammetric techniques and its quantification in saliva samples by multiple-pulse amperometry (MPA) in a flow injection analysis (FIA) system. In phosphate buffer solution 0.1molL−1 (pH 7), the CO presented two electrochemical processes, one anodic at +1.8V and one cathodic at −1.2V (vs. Ag/AgCl). The second process was dependent on the first and both processes were irreversible. It was found that CO electrochemical processes are controlled by diffusion and that two-protons and two-electrons are involved in the oxidation reaction. In determination of CO in saliva samples, the MPA detection was used, applying four potential pulses: (1) at +1.8V/400ms, generator potential pulse for oxidation of CO; (2) at −1.0V/500ms, potential pulse for remove possible interferents; (3) at −1.2V/30ms, collector potential pulse for reduction of the product generated and CO quantification; (4) 1.45V/300ms, potential pulse for cleaning BDD electrode. The proposed method attained an analytical frequency of 36 determinations per hour with a relative standard deviation of 1.47% for 10 measurements of 1.0×10−5 molL−1 CO. A good linear range from 0.5 to 100μmolL−1 was obtained with a detection limit for CO estimated at 0.06μmolL−1. Approximately 100% of the CO added to saliva samples was recovered. Therefore, this work presents, for the first time, the electrochemical behavior of the CO at an electrode as well as a simple, fast and low-cost method for monitoring the degree of exposure to tobacco by CO determination in saliva samples using the FIA-MPA technique. |
| abstractGer |
Cotinine (CO) is the principal metabolite of nicotine, and it is used as a biomarker to monitor the exposure of an individual to tobacco. This paper sought to present the use of a boron-doped diamond (BDD) electrode for the electrochemical characterization of CO by voltammetric techniques and its quantification in saliva samples by multiple-pulse amperometry (MPA) in a flow injection analysis (FIA) system. In phosphate buffer solution 0.1molL−1 (pH 7), the CO presented two electrochemical processes, one anodic at +1.8V and one cathodic at −1.2V (vs. Ag/AgCl). The second process was dependent on the first and both processes were irreversible. It was found that CO electrochemical processes are controlled by diffusion and that two-protons and two-electrons are involved in the oxidation reaction. In determination of CO in saliva samples, the MPA detection was used, applying four potential pulses: (1) at +1.8V/400ms, generator potential pulse for oxidation of CO; (2) at −1.0V/500ms, potential pulse for remove possible interferents; (3) at −1.2V/30ms, collector potential pulse for reduction of the product generated and CO quantification; (4) 1.45V/300ms, potential pulse for cleaning BDD electrode. The proposed method attained an analytical frequency of 36 determinations per hour with a relative standard deviation of 1.47% for 10 measurements of 1.0×10−5 molL−1 CO. A good linear range from 0.5 to 100μmolL−1 was obtained with a detection limit for CO estimated at 0.06μmolL−1. Approximately 100% of the CO added to saliva samples was recovered. Therefore, this work presents, for the first time, the electrochemical behavior of the CO at an electrode as well as a simple, fast and low-cost method for monitoring the degree of exposure to tobacco by CO determination in saliva samples using the FIA-MPA technique. |
| abstract_unstemmed |
Cotinine (CO) is the principal metabolite of nicotine, and it is used as a biomarker to monitor the exposure of an individual to tobacco. This paper sought to present the use of a boron-doped diamond (BDD) electrode for the electrochemical characterization of CO by voltammetric techniques and its quantification in saliva samples by multiple-pulse amperometry (MPA) in a flow injection analysis (FIA) system. In phosphate buffer solution 0.1molL−1 (pH 7), the CO presented two electrochemical processes, one anodic at +1.8V and one cathodic at −1.2V (vs. Ag/AgCl). The second process was dependent on the first and both processes were irreversible. It was found that CO electrochemical processes are controlled by diffusion and that two-protons and two-electrons are involved in the oxidation reaction. In determination of CO in saliva samples, the MPA detection was used, applying four potential pulses: (1) at +1.8V/400ms, generator potential pulse for oxidation of CO; (2) at −1.0V/500ms, potential pulse for remove possible interferents; (3) at −1.2V/30ms, collector potential pulse for reduction of the product generated and CO quantification; (4) 1.45V/300ms, potential pulse for cleaning BDD electrode. The proposed method attained an analytical frequency of 36 determinations per hour with a relative standard deviation of 1.47% for 10 measurements of 1.0×10−5 molL−1 CO. A good linear range from 0.5 to 100μmolL−1 was obtained with a detection limit for CO estimated at 0.06μmolL−1. Approximately 100% of the CO added to saliva samples was recovered. Therefore, this work presents, for the first time, the electrochemical behavior of the CO at an electrode as well as a simple, fast and low-cost method for monitoring the degree of exposure to tobacco by CO determination in saliva samples using the FIA-MPA technique. |
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| title_short |
Electrochemical behavior of the cotinine at a boron-doped diamond electrode and its determination in saliva by multiple-pulse amperometry in an FIA system |
| url |
https://doi.org/10.1016/j.electacta.2016.10.177 |
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Oliveira, Fernando M. Guedes, Tiago J. Neves, Camila D.c. Mendonça, Vanessa A. Gil, Eric S. Verly, Rodrigo M. dos Santos, Wallans T.P. |
| author2Str |
Oliveira, Fernando M. Guedes, Tiago J. Neves, Camila D.c. Mendonça, Vanessa A. Gil, Eric S. Verly, Rodrigo M. dos Santos, Wallans T.P. |
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| doi_str |
10.1016/j.electacta.2016.10.177 |
| up_date |
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