Heterozygosity for transmembrane activator and calcium modulator ligand interactor A144E causes haploinsufficiency and pneumococcal susceptibility in mice

The B-cell receptor transmembrane activator and calcium modulator ligand interactor (TACI) is important for T-independent antibody responses. One in 200 blood donors are heterozygous for the TACI A181E mutation.

Gespeichert in:
Autor*in:

Jabara, Haifa H. [verfasserIn]

Lee, John J.

Janssen, Erin

Ullas, Sumana

Liadaki, Kyriaki

Garibyan, Lilit

Benson, Halli

Sannikova, Tatyana

Bram, Richard

Hammarstrom, Lennart

Cruz, Anthony C.

Siegel, Richard

Manis, John

Malley, Richard

Geha, Raif S.

Format:

E-Artikel

Sprache:

Englisch

Erschienen:

2017

Schlagwörter:

pneumococcal susceptibility

B cells

Transmembrane activator and calcium modulator ligand interactor

common variable immunodeficiency

natural antibodies

Umfang:

11722

Übergeordnetes Werk:

Enthalten in: Antidiabetic treatment in elderly patients with low performance status admitted to internal medicine ward - Papakitsou, I. ELSEVIER, 2022, official publication of the American Academy of Allergy, Asthma and Immunology, Amsterdam [u.a.]

Übergeordnetes Werk:

volume:139 ; year:2017 ; number:4 ; pages:1293-13014 ; extent:11722

Links:

Volltext

DOI / URN:

10.1016/j.jaci.2016.07.028

Katalog-ID:

ELV01471776X

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