Estrogen-mediated protection of the organotin-degrading strain Metarhizium robertsii against oxidative stress promoted by monobutyltin
Dibutyltin (DBT) is a global pollutant characterized by pro-oxidative properties. The fungal strain Metarhizium robertsii can eliminate high levels of DBT efficiently. In this study, induction of oxidative stress as well as its alleviation through the application of natural estrogens during the elim...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Siewiera, Paulina [verfasserIn] |
|---|
| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2017transfer abstract |
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| Schlagwörter: |
Oxygen and nitrogen reactive species |
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| Umfang: |
9 |
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| Übergeordnetes Werk: |
Enthalten in: MPI vs Fortran coarrays beyond 100k cores: 3D cellular automata - Shterenlikht, Anton ELSEVIER, 2019, chemistry, biology and toxicology as related to environmental problems, Amsterdam [u.a.] |
|---|---|
| Übergeordnetes Werk: |
volume:185 ; year:2017 ; pages:96-104 ; extent:9 |
| Links: |
|---|
| DOI / URN: |
10.1016/j.chemosphere.2017.06.130 |
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ELV014752670 |
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| 520 | |a Dibutyltin (DBT) is a global pollutant characterized by pro-oxidative properties. The fungal strain Metarhizium robertsii can eliminate high levels of DBT efficiently. In this study, induction of oxidative stress as well as its alleviation through the application of natural estrogens during the elimination of DBT by M. robertsii were evaluated. During the first 24 h of incubation, the initial concentration of DBT (20 mg l−1) was reduced to 3.1 mg l−1, with simultaneous formation of a major byproduct – monobutyltin (MBT). In the presence of estrone (E1) or 17β-estradiol (E2), the amounts of dibutyltin residues in the fungal cultures were found to be approximately 2-fold higher compared to cultures without estrogens, which was associated with the simultaneous utilization of the compounds by cytochrome P450 enzymes. On the other hand, MBT levels were approximately 2.5 times lower in the fungal cultures with the addition of one of the estrogens. MBT (not DBT) promotes the generation of O2 –, H2O2, and NO at levels 65.89 ± 18.08, 4.04 ± 3.62, and 27.92 ± 1.95, respectively. Superoxide dismutase and catalase activities did not show any response of the M. robertsii strain against the overproduction of superoxide anion and hydrogen peroxide. Application of E1 as well as E2 ensured non-enzymatic defense against nitrosative and oxidative stress through scavenging of nitrogen and oxygen reactive species, and limited their levels from 1.5-fold to 21-fold, depending on the used estrogen. | ||
| 520 | |a Dibutyltin (DBT) is a global pollutant characterized by pro-oxidative properties. The fungal strain Metarhizium robertsii can eliminate high levels of DBT efficiently. In this study, induction of oxidative stress as well as its alleviation through the application of natural estrogens during the elimination of DBT by M. robertsii were evaluated. During the first 24 h of incubation, the initial concentration of DBT (20 mg l−1) was reduced to 3.1 mg l−1, with simultaneous formation of a major byproduct – monobutyltin (MBT). In the presence of estrone (E1) or 17β-estradiol (E2), the amounts of dibutyltin residues in the fungal cultures were found to be approximately 2-fold higher compared to cultures without estrogens, which was associated with the simultaneous utilization of the compounds by cytochrome P450 enzymes. On the other hand, MBT levels were approximately 2.5 times lower in the fungal cultures with the addition of one of the estrogens. MBT (not DBT) promotes the generation of O2 –, H2O2, and NO at levels 65.89 ± 18.08, 4.04 ± 3.62, and 27.92 ± 1.95, respectively. Superoxide dismutase and catalase activities did not show any response of the M. robertsii strain against the overproduction of superoxide anion and hydrogen peroxide. Application of E1 as well as E2 ensured non-enzymatic defense against nitrosative and oxidative stress through scavenging of nitrogen and oxygen reactive species, and limited their levels from 1.5-fold to 21-fold, depending on the used estrogen. | ||
| 650 | 7 | |a Monobutyltin |2 Elsevier | |
| 650 | 7 | |a Metarhizium robertsii |2 Elsevier | |
| 650 | 7 | |a Antioxidant enzymes |2 Elsevier | |
| 650 | 7 | |a Oxygen and nitrogen reactive species |2 Elsevier | |
| 650 | 7 | |a Cytochrome P450 monooxygenases |2 Elsevier | |
| 650 | 7 | |a Natural estrogens |2 Elsevier | |
| 700 | 1 | |a Różalska, Sylwia |4 oth | |
| 700 | 1 | |a Bernat, Przemysław |4 oth | |
| 773 | 0 | 8 | |i Enthalten in |n Elsevier Science |a Shterenlikht, Anton ELSEVIER |t MPI vs Fortran coarrays beyond 100k cores: 3D cellular automata |d 2019 |d chemistry, biology and toxicology as related to environmental problems |g Amsterdam [u.a.] |w (DE-627)ELV002112701 |
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10.1016/j.chemosphere.2017.06.130 doi GBV00000000000272A.pica (DE-627)ELV014752670 (ELSEVIER)S0045-6535(17)31036-6 DE-627 ger DE-627 rakwb eng 333.7 333.7 DE-600 004 620 VZ 54.25 bkl Siewiera, Paulina verfasserin aut Estrogen-mediated protection of the organotin-degrading strain Metarhizium robertsii against oxidative stress promoted by monobutyltin 2017transfer abstract 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Dibutyltin (DBT) is a global pollutant characterized by pro-oxidative properties. The fungal strain Metarhizium robertsii can eliminate high levels of DBT efficiently. In this study, induction of oxidative stress as well as its alleviation through the application of natural estrogens during the elimination of DBT by M. robertsii were evaluated. During the first 24 h of incubation, the initial concentration of DBT (20 mg l−1) was reduced to 3.1 mg l−1, with simultaneous formation of a major byproduct – monobutyltin (MBT). In the presence of estrone (E1) or 17β-estradiol (E2), the amounts of dibutyltin residues in the fungal cultures were found to be approximately 2-fold higher compared to cultures without estrogens, which was associated with the simultaneous utilization of the compounds by cytochrome P450 enzymes. On the other hand, MBT levels were approximately 2.5 times lower in the fungal cultures with the addition of one of the estrogens. MBT (not DBT) promotes the generation of O2 –, H2O2, and NO at levels 65.89 ± 18.08, 4.04 ± 3.62, and 27.92 ± 1.95, respectively. Superoxide dismutase and catalase activities did not show any response of the M. robertsii strain against the overproduction of superoxide anion and hydrogen peroxide. Application of E1 as well as E2 ensured non-enzymatic defense against nitrosative and oxidative stress through scavenging of nitrogen and oxygen reactive species, and limited their levels from 1.5-fold to 21-fold, depending on the used estrogen. Dibutyltin (DBT) is a global pollutant characterized by pro-oxidative properties. The fungal strain Metarhizium robertsii can eliminate high levels of DBT efficiently. In this study, induction of oxidative stress as well as its alleviation through the application of natural estrogens during the elimination of DBT by M. robertsii were evaluated. During the first 24 h of incubation, the initial concentration of DBT (20 mg l−1) was reduced to 3.1 mg l−1, with simultaneous formation of a major byproduct – monobutyltin (MBT). In the presence of estrone (E1) or 17β-estradiol (E2), the amounts of dibutyltin residues in the fungal cultures were found to be approximately 2-fold higher compared to cultures without estrogens, which was associated with the simultaneous utilization of the compounds by cytochrome P450 enzymes. On the other hand, MBT levels were approximately 2.5 times lower in the fungal cultures with the addition of one of the estrogens. MBT (not DBT) promotes the generation of O2 –, H2O2, and NO at levels 65.89 ± 18.08, 4.04 ± 3.62, and 27.92 ± 1.95, respectively. Superoxide dismutase and catalase activities did not show any response of the M. robertsii strain against the overproduction of superoxide anion and hydrogen peroxide. Application of E1 as well as E2 ensured non-enzymatic defense against nitrosative and oxidative stress through scavenging of nitrogen and oxygen reactive species, and limited their levels from 1.5-fold to 21-fold, depending on the used estrogen. Monobutyltin Elsevier Metarhizium robertsii Elsevier Antioxidant enzymes Elsevier Oxygen and nitrogen reactive species Elsevier Cytochrome P450 monooxygenases Elsevier Natural estrogens Elsevier Różalska, Sylwia oth Bernat, Przemysław oth Enthalten in Elsevier Science Shterenlikht, Anton ELSEVIER MPI vs Fortran coarrays beyond 100k cores: 3D cellular automata 2019 chemistry, biology and toxicology as related to environmental problems Amsterdam [u.a.] (DE-627)ELV002112701 volume:185 year:2017 pages:96-104 extent:9 https://doi.org/10.1016/j.chemosphere.2017.06.130 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 54.25 Parallele Datenverarbeitung VZ AR 185 2017 96-104 9 045F 333.7 |
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10.1016/j.chemosphere.2017.06.130 doi GBV00000000000272A.pica (DE-627)ELV014752670 (ELSEVIER)S0045-6535(17)31036-6 DE-627 ger DE-627 rakwb eng 333.7 333.7 DE-600 004 620 VZ 54.25 bkl Siewiera, Paulina verfasserin aut Estrogen-mediated protection of the organotin-degrading strain Metarhizium robertsii against oxidative stress promoted by monobutyltin 2017transfer abstract 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Dibutyltin (DBT) is a global pollutant characterized by pro-oxidative properties. The fungal strain Metarhizium robertsii can eliminate high levels of DBT efficiently. In this study, induction of oxidative stress as well as its alleviation through the application of natural estrogens during the elimination of DBT by M. robertsii were evaluated. During the first 24 h of incubation, the initial concentration of DBT (20 mg l−1) was reduced to 3.1 mg l−1, with simultaneous formation of a major byproduct – monobutyltin (MBT). In the presence of estrone (E1) or 17β-estradiol (E2), the amounts of dibutyltin residues in the fungal cultures were found to be approximately 2-fold higher compared to cultures without estrogens, which was associated with the simultaneous utilization of the compounds by cytochrome P450 enzymes. On the other hand, MBT levels were approximately 2.5 times lower in the fungal cultures with the addition of one of the estrogens. MBT (not DBT) promotes the generation of O2 –, H2O2, and NO at levels 65.89 ± 18.08, 4.04 ± 3.62, and 27.92 ± 1.95, respectively. Superoxide dismutase and catalase activities did not show any response of the M. robertsii strain against the overproduction of superoxide anion and hydrogen peroxide. Application of E1 as well as E2 ensured non-enzymatic defense against nitrosative and oxidative stress through scavenging of nitrogen and oxygen reactive species, and limited their levels from 1.5-fold to 21-fold, depending on the used estrogen. Dibutyltin (DBT) is a global pollutant characterized by pro-oxidative properties. The fungal strain Metarhizium robertsii can eliminate high levels of DBT efficiently. In this study, induction of oxidative stress as well as its alleviation through the application of natural estrogens during the elimination of DBT by M. robertsii were evaluated. During the first 24 h of incubation, the initial concentration of DBT (20 mg l−1) was reduced to 3.1 mg l−1, with simultaneous formation of a major byproduct – monobutyltin (MBT). In the presence of estrone (E1) or 17β-estradiol (E2), the amounts of dibutyltin residues in the fungal cultures were found to be approximately 2-fold higher compared to cultures without estrogens, which was associated with the simultaneous utilization of the compounds by cytochrome P450 enzymes. On the other hand, MBT levels were approximately 2.5 times lower in the fungal cultures with the addition of one of the estrogens. MBT (not DBT) promotes the generation of O2 –, H2O2, and NO at levels 65.89 ± 18.08, 4.04 ± 3.62, and 27.92 ± 1.95, respectively. Superoxide dismutase and catalase activities did not show any response of the M. robertsii strain against the overproduction of superoxide anion and hydrogen peroxide. Application of E1 as well as E2 ensured non-enzymatic defense against nitrosative and oxidative stress through scavenging of nitrogen and oxygen reactive species, and limited their levels from 1.5-fold to 21-fold, depending on the used estrogen. Monobutyltin Elsevier Metarhizium robertsii Elsevier Antioxidant enzymes Elsevier Oxygen and nitrogen reactive species Elsevier Cytochrome P450 monooxygenases Elsevier Natural estrogens Elsevier Różalska, Sylwia oth Bernat, Przemysław oth Enthalten in Elsevier Science Shterenlikht, Anton ELSEVIER MPI vs Fortran coarrays beyond 100k cores: 3D cellular automata 2019 chemistry, biology and toxicology as related to environmental problems Amsterdam [u.a.] (DE-627)ELV002112701 volume:185 year:2017 pages:96-104 extent:9 https://doi.org/10.1016/j.chemosphere.2017.06.130 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 54.25 Parallele Datenverarbeitung VZ AR 185 2017 96-104 9 045F 333.7 |
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10.1016/j.chemosphere.2017.06.130 doi GBV00000000000272A.pica (DE-627)ELV014752670 (ELSEVIER)S0045-6535(17)31036-6 DE-627 ger DE-627 rakwb eng 333.7 333.7 DE-600 004 620 VZ 54.25 bkl Siewiera, Paulina verfasserin aut Estrogen-mediated protection of the organotin-degrading strain Metarhizium robertsii against oxidative stress promoted by monobutyltin 2017transfer abstract 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Dibutyltin (DBT) is a global pollutant characterized by pro-oxidative properties. The fungal strain Metarhizium robertsii can eliminate high levels of DBT efficiently. In this study, induction of oxidative stress as well as its alleviation through the application of natural estrogens during the elimination of DBT by M. robertsii were evaluated. During the first 24 h of incubation, the initial concentration of DBT (20 mg l−1) was reduced to 3.1 mg l−1, with simultaneous formation of a major byproduct – monobutyltin (MBT). In the presence of estrone (E1) or 17β-estradiol (E2), the amounts of dibutyltin residues in the fungal cultures were found to be approximately 2-fold higher compared to cultures without estrogens, which was associated with the simultaneous utilization of the compounds by cytochrome P450 enzymes. On the other hand, MBT levels were approximately 2.5 times lower in the fungal cultures with the addition of one of the estrogens. MBT (not DBT) promotes the generation of O2 –, H2O2, and NO at levels 65.89 ± 18.08, 4.04 ± 3.62, and 27.92 ± 1.95, respectively. Superoxide dismutase and catalase activities did not show any response of the M. robertsii strain against the overproduction of superoxide anion and hydrogen peroxide. Application of E1 as well as E2 ensured non-enzymatic defense against nitrosative and oxidative stress through scavenging of nitrogen and oxygen reactive species, and limited their levels from 1.5-fold to 21-fold, depending on the used estrogen. Dibutyltin (DBT) is a global pollutant characterized by pro-oxidative properties. The fungal strain Metarhizium robertsii can eliminate high levels of DBT efficiently. In this study, induction of oxidative stress as well as its alleviation through the application of natural estrogens during the elimination of DBT by M. robertsii were evaluated. During the first 24 h of incubation, the initial concentration of DBT (20 mg l−1) was reduced to 3.1 mg l−1, with simultaneous formation of a major byproduct – monobutyltin (MBT). In the presence of estrone (E1) or 17β-estradiol (E2), the amounts of dibutyltin residues in the fungal cultures were found to be approximately 2-fold higher compared to cultures without estrogens, which was associated with the simultaneous utilization of the compounds by cytochrome P450 enzymes. On the other hand, MBT levels were approximately 2.5 times lower in the fungal cultures with the addition of one of the estrogens. MBT (not DBT) promotes the generation of O2 –, H2O2, and NO at levels 65.89 ± 18.08, 4.04 ± 3.62, and 27.92 ± 1.95, respectively. Superoxide dismutase and catalase activities did not show any response of the M. robertsii strain against the overproduction of superoxide anion and hydrogen peroxide. Application of E1 as well as E2 ensured non-enzymatic defense against nitrosative and oxidative stress through scavenging of nitrogen and oxygen reactive species, and limited their levels from 1.5-fold to 21-fold, depending on the used estrogen. Monobutyltin Elsevier Metarhizium robertsii Elsevier Antioxidant enzymes Elsevier Oxygen and nitrogen reactive species Elsevier Cytochrome P450 monooxygenases Elsevier Natural estrogens Elsevier Różalska, Sylwia oth Bernat, Przemysław oth Enthalten in Elsevier Science Shterenlikht, Anton ELSEVIER MPI vs Fortran coarrays beyond 100k cores: 3D cellular automata 2019 chemistry, biology and toxicology as related to environmental problems Amsterdam [u.a.] (DE-627)ELV002112701 volume:185 year:2017 pages:96-104 extent:9 https://doi.org/10.1016/j.chemosphere.2017.06.130 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 54.25 Parallele Datenverarbeitung VZ AR 185 2017 96-104 9 045F 333.7 |
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10.1016/j.chemosphere.2017.06.130 doi GBV00000000000272A.pica (DE-627)ELV014752670 (ELSEVIER)S0045-6535(17)31036-6 DE-627 ger DE-627 rakwb eng 333.7 333.7 DE-600 004 620 VZ 54.25 bkl Siewiera, Paulina verfasserin aut Estrogen-mediated protection of the organotin-degrading strain Metarhizium robertsii against oxidative stress promoted by monobutyltin 2017transfer abstract 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Dibutyltin (DBT) is a global pollutant characterized by pro-oxidative properties. The fungal strain Metarhizium robertsii can eliminate high levels of DBT efficiently. In this study, induction of oxidative stress as well as its alleviation through the application of natural estrogens during the elimination of DBT by M. robertsii were evaluated. During the first 24 h of incubation, the initial concentration of DBT (20 mg l−1) was reduced to 3.1 mg l−1, with simultaneous formation of a major byproduct – monobutyltin (MBT). In the presence of estrone (E1) or 17β-estradiol (E2), the amounts of dibutyltin residues in the fungal cultures were found to be approximately 2-fold higher compared to cultures without estrogens, which was associated with the simultaneous utilization of the compounds by cytochrome P450 enzymes. On the other hand, MBT levels were approximately 2.5 times lower in the fungal cultures with the addition of one of the estrogens. MBT (not DBT) promotes the generation of O2 –, H2O2, and NO at levels 65.89 ± 18.08, 4.04 ± 3.62, and 27.92 ± 1.95, respectively. Superoxide dismutase and catalase activities did not show any response of the M. robertsii strain against the overproduction of superoxide anion and hydrogen peroxide. Application of E1 as well as E2 ensured non-enzymatic defense against nitrosative and oxidative stress through scavenging of nitrogen and oxygen reactive species, and limited their levels from 1.5-fold to 21-fold, depending on the used estrogen. Dibutyltin (DBT) is a global pollutant characterized by pro-oxidative properties. The fungal strain Metarhizium robertsii can eliminate high levels of DBT efficiently. In this study, induction of oxidative stress as well as its alleviation through the application of natural estrogens during the elimination of DBT by M. robertsii were evaluated. During the first 24 h of incubation, the initial concentration of DBT (20 mg l−1) was reduced to 3.1 mg l−1, with simultaneous formation of a major byproduct – monobutyltin (MBT). In the presence of estrone (E1) or 17β-estradiol (E2), the amounts of dibutyltin residues in the fungal cultures were found to be approximately 2-fold higher compared to cultures without estrogens, which was associated with the simultaneous utilization of the compounds by cytochrome P450 enzymes. On the other hand, MBT levels were approximately 2.5 times lower in the fungal cultures with the addition of one of the estrogens. MBT (not DBT) promotes the generation of O2 –, H2O2, and NO at levels 65.89 ± 18.08, 4.04 ± 3.62, and 27.92 ± 1.95, respectively. Superoxide dismutase and catalase activities did not show any response of the M. robertsii strain against the overproduction of superoxide anion and hydrogen peroxide. Application of E1 as well as E2 ensured non-enzymatic defense against nitrosative and oxidative stress through scavenging of nitrogen and oxygen reactive species, and limited their levels from 1.5-fold to 21-fold, depending on the used estrogen. Monobutyltin Elsevier Metarhizium robertsii Elsevier Antioxidant enzymes Elsevier Oxygen and nitrogen reactive species Elsevier Cytochrome P450 monooxygenases Elsevier Natural estrogens Elsevier Różalska, Sylwia oth Bernat, Przemysław oth Enthalten in Elsevier Science Shterenlikht, Anton ELSEVIER MPI vs Fortran coarrays beyond 100k cores: 3D cellular automata 2019 chemistry, biology and toxicology as related to environmental problems Amsterdam [u.a.] (DE-627)ELV002112701 volume:185 year:2017 pages:96-104 extent:9 https://doi.org/10.1016/j.chemosphere.2017.06.130 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 54.25 Parallele Datenverarbeitung VZ AR 185 2017 96-104 9 045F 333.7 |
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10.1016/j.chemosphere.2017.06.130 doi GBV00000000000272A.pica (DE-627)ELV014752670 (ELSEVIER)S0045-6535(17)31036-6 DE-627 ger DE-627 rakwb eng 333.7 333.7 DE-600 004 620 VZ 54.25 bkl Siewiera, Paulina verfasserin aut Estrogen-mediated protection of the organotin-degrading strain Metarhizium robertsii against oxidative stress promoted by monobutyltin 2017transfer abstract 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Dibutyltin (DBT) is a global pollutant characterized by pro-oxidative properties. The fungal strain Metarhizium robertsii can eliminate high levels of DBT efficiently. In this study, induction of oxidative stress as well as its alleviation through the application of natural estrogens during the elimination of DBT by M. robertsii were evaluated. During the first 24 h of incubation, the initial concentration of DBT (20 mg l−1) was reduced to 3.1 mg l−1, with simultaneous formation of a major byproduct – monobutyltin (MBT). In the presence of estrone (E1) or 17β-estradiol (E2), the amounts of dibutyltin residues in the fungal cultures were found to be approximately 2-fold higher compared to cultures without estrogens, which was associated with the simultaneous utilization of the compounds by cytochrome P450 enzymes. On the other hand, MBT levels were approximately 2.5 times lower in the fungal cultures with the addition of one of the estrogens. MBT (not DBT) promotes the generation of O2 –, H2O2, and NO at levels 65.89 ± 18.08, 4.04 ± 3.62, and 27.92 ± 1.95, respectively. Superoxide dismutase and catalase activities did not show any response of the M. robertsii strain against the overproduction of superoxide anion and hydrogen peroxide. Application of E1 as well as E2 ensured non-enzymatic defense against nitrosative and oxidative stress through scavenging of nitrogen and oxygen reactive species, and limited their levels from 1.5-fold to 21-fold, depending on the used estrogen. Dibutyltin (DBT) is a global pollutant characterized by pro-oxidative properties. The fungal strain Metarhizium robertsii can eliminate high levels of DBT efficiently. In this study, induction of oxidative stress as well as its alleviation through the application of natural estrogens during the elimination of DBT by M. robertsii were evaluated. During the first 24 h of incubation, the initial concentration of DBT (20 mg l−1) was reduced to 3.1 mg l−1, with simultaneous formation of a major byproduct – monobutyltin (MBT). In the presence of estrone (E1) or 17β-estradiol (E2), the amounts of dibutyltin residues in the fungal cultures were found to be approximately 2-fold higher compared to cultures without estrogens, which was associated with the simultaneous utilization of the compounds by cytochrome P450 enzymes. On the other hand, MBT levels were approximately 2.5 times lower in the fungal cultures with the addition of one of the estrogens. MBT (not DBT) promotes the generation of O2 –, H2O2, and NO at levels 65.89 ± 18.08, 4.04 ± 3.62, and 27.92 ± 1.95, respectively. Superoxide dismutase and catalase activities did not show any response of the M. robertsii strain against the overproduction of superoxide anion and hydrogen peroxide. Application of E1 as well as E2 ensured non-enzymatic defense against nitrosative and oxidative stress through scavenging of nitrogen and oxygen reactive species, and limited their levels from 1.5-fold to 21-fold, depending on the used estrogen. Monobutyltin Elsevier Metarhizium robertsii Elsevier Antioxidant enzymes Elsevier Oxygen and nitrogen reactive species Elsevier Cytochrome P450 monooxygenases Elsevier Natural estrogens Elsevier Różalska, Sylwia oth Bernat, Przemysław oth Enthalten in Elsevier Science Shterenlikht, Anton ELSEVIER MPI vs Fortran coarrays beyond 100k cores: 3D cellular automata 2019 chemistry, biology and toxicology as related to environmental problems Amsterdam [u.a.] (DE-627)ELV002112701 volume:185 year:2017 pages:96-104 extent:9 https://doi.org/10.1016/j.chemosphere.2017.06.130 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 54.25 Parallele Datenverarbeitung VZ AR 185 2017 96-104 9 045F 333.7 |
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estrogen-mediated protection of the organotin-degrading strain metarhizium robertsii against oxidative stress promoted by monobutyltin |
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Estrogen-mediated protection of the organotin-degrading strain Metarhizium robertsii against oxidative stress promoted by monobutyltin |
| abstract |
Dibutyltin (DBT) is a global pollutant characterized by pro-oxidative properties. The fungal strain Metarhizium robertsii can eliminate high levels of DBT efficiently. In this study, induction of oxidative stress as well as its alleviation through the application of natural estrogens during the elimination of DBT by M. robertsii were evaluated. During the first 24 h of incubation, the initial concentration of DBT (20 mg l−1) was reduced to 3.1 mg l−1, with simultaneous formation of a major byproduct – monobutyltin (MBT). In the presence of estrone (E1) or 17β-estradiol (E2), the amounts of dibutyltin residues in the fungal cultures were found to be approximately 2-fold higher compared to cultures without estrogens, which was associated with the simultaneous utilization of the compounds by cytochrome P450 enzymes. On the other hand, MBT levels were approximately 2.5 times lower in the fungal cultures with the addition of one of the estrogens. MBT (not DBT) promotes the generation of O2 –, H2O2, and NO at levels 65.89 ± 18.08, 4.04 ± 3.62, and 27.92 ± 1.95, respectively. Superoxide dismutase and catalase activities did not show any response of the M. robertsii strain against the overproduction of superoxide anion and hydrogen peroxide. Application of E1 as well as E2 ensured non-enzymatic defense against nitrosative and oxidative stress through scavenging of nitrogen and oxygen reactive species, and limited their levels from 1.5-fold to 21-fold, depending on the used estrogen. |
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Dibutyltin (DBT) is a global pollutant characterized by pro-oxidative properties. The fungal strain Metarhizium robertsii can eliminate high levels of DBT efficiently. In this study, induction of oxidative stress as well as its alleviation through the application of natural estrogens during the elimination of DBT by M. robertsii were evaluated. During the first 24 h of incubation, the initial concentration of DBT (20 mg l−1) was reduced to 3.1 mg l−1, with simultaneous formation of a major byproduct – monobutyltin (MBT). In the presence of estrone (E1) or 17β-estradiol (E2), the amounts of dibutyltin residues in the fungal cultures were found to be approximately 2-fold higher compared to cultures without estrogens, which was associated with the simultaneous utilization of the compounds by cytochrome P450 enzymes. On the other hand, MBT levels were approximately 2.5 times lower in the fungal cultures with the addition of one of the estrogens. MBT (not DBT) promotes the generation of O2 –, H2O2, and NO at levels 65.89 ± 18.08, 4.04 ± 3.62, and 27.92 ± 1.95, respectively. Superoxide dismutase and catalase activities did not show any response of the M. robertsii strain against the overproduction of superoxide anion and hydrogen peroxide. Application of E1 as well as E2 ensured non-enzymatic defense against nitrosative and oxidative stress through scavenging of nitrogen and oxygen reactive species, and limited their levels from 1.5-fold to 21-fold, depending on the used estrogen. |
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Dibutyltin (DBT) is a global pollutant characterized by pro-oxidative properties. The fungal strain Metarhizium robertsii can eliminate high levels of DBT efficiently. In this study, induction of oxidative stress as well as its alleviation through the application of natural estrogens during the elimination of DBT by M. robertsii were evaluated. During the first 24 h of incubation, the initial concentration of DBT (20 mg l−1) was reduced to 3.1 mg l−1, with simultaneous formation of a major byproduct – monobutyltin (MBT). In the presence of estrone (E1) or 17β-estradiol (E2), the amounts of dibutyltin residues in the fungal cultures were found to be approximately 2-fold higher compared to cultures without estrogens, which was associated with the simultaneous utilization of the compounds by cytochrome P450 enzymes. On the other hand, MBT levels were approximately 2.5 times lower in the fungal cultures with the addition of one of the estrogens. MBT (not DBT) promotes the generation of O2 –, H2O2, and NO at levels 65.89 ± 18.08, 4.04 ± 3.62, and 27.92 ± 1.95, respectively. Superoxide dismutase and catalase activities did not show any response of the M. robertsii strain against the overproduction of superoxide anion and hydrogen peroxide. Application of E1 as well as E2 ensured non-enzymatic defense against nitrosative and oxidative stress through scavenging of nitrogen and oxygen reactive species, and limited their levels from 1.5-fold to 21-fold, depending on the used estrogen. |
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Estrogen-mediated protection of the organotin-degrading strain Metarhizium robertsii against oxidative stress promoted by monobutyltin |
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