P1-12. L-DOPA may modify function of the sensory cortex in Parkinson’s disease
Sensory disturbance is occasionally accompanied with parkinsonism and is sometimes improved by L-DOPA treatment. The abnormalities in cerebral somatosensory neurons were already revealed by neurophysiological methods. However, whether L-DOPA influences the cerebral somatosensory functions is unknown...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Ishii, Nobuyuki [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2017transfer abstract |
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| Übergeordnetes Werk: |
Enthalten in: Medical students' biomedical and clinical knowledge: Combining longitudinal design, eye tracking and comparison with residents' performance - Södervik, Ilona ELSEVIER, 2017, Amsterdam [u.a.] |
|---|---|
| Übergeordnetes Werk: |
volume:128 ; year:2017 ; number:9 ; pages:173 |
| Links: |
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| DOI / URN: |
10.1016/j.clinph.2017.06.015 |
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| 520 | |a Sensory disturbance is occasionally accompanied with parkinsonism and is sometimes improved by L-DOPA treatment. The abnormalities in cerebral somatosensory neurons were already revealed by neurophysiological methods. However, whether L-DOPA influences the cerebral somatosensory functions is unknown. We evaluated the effect of L-DOPA on the sensory cortex in Parkinson disease (PD) using neurophysiological technique such as high-frequency oscillations (HFOs) and somatosensory evoked potential recovery functions (SEP-Rs), which could detect slight functional abnormalities of cerebral somatosensory interneurons. We examined ten drug-naïve PD patients in pre- and post-L-DOPA treatment. HFOs were obtained by digitally filtering raw SEPs from 500 to 1000Hz. For SEP-Rs study, paired-pulse stimuli at various interstimulus intervals (ISIs; 20–200ms) were given. There were no significant differences in the HFO study. The SEP-Rs study demonstrated that patients with disease duration of more than one year (n =6) had a significant disinhibition (P =0.003) in P25-N33 of post-treatment compared with pre-treatment. L-DOPA may have some effects on the abnormal GABAergic interneuron function in sensory cortex, which could improve sensory disturbance by L-DOPA therapy in PD patients. | ||
| 520 | |a Sensory disturbance is occasionally accompanied with parkinsonism and is sometimes improved by L-DOPA treatment. The abnormalities in cerebral somatosensory neurons were already revealed by neurophysiological methods. However, whether L-DOPA influences the cerebral somatosensory functions is unknown. We evaluated the effect of L-DOPA on the sensory cortex in Parkinson disease (PD) using neurophysiological technique such as high-frequency oscillations (HFOs) and somatosensory evoked potential recovery functions (SEP-Rs), which could detect slight functional abnormalities of cerebral somatosensory interneurons. We examined ten drug-naïve PD patients in pre- and post-L-DOPA treatment. HFOs were obtained by digitally filtering raw SEPs from 500 to 1000Hz. For SEP-Rs study, paired-pulse stimuli at various interstimulus intervals (ISIs; 20–200ms) were given. There were no significant differences in the HFO study. The SEP-Rs study demonstrated that patients with disease duration of more than one year (n =6) had a significant disinhibition (P =0.003) in P25-N33 of post-treatment compared with pre-treatment. L-DOPA may have some effects on the abnormal GABAergic interneuron function in sensory cortex, which could improve sensory disturbance by L-DOPA therapy in PD patients. | ||
| 700 | 1 | |a Mochizuki, Hitoshi |4 oth | |
| 700 | 1 | |a Shiomi, Kazutaka |4 oth | |
| 700 | 1 | |a Nakazato, Masamitsu |4 oth | |
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10.1016/j.clinph.2017.06.015 doi GBV00000000000269A.pica (DE-627)ELV014817039 (ELSEVIER)S1388-2457(17)30231-6 DE-627 ger DE-627 rakwb eng 610 610 DE-600 370 VZ 5,3 ssgn 80.00 bkl Ishii, Nobuyuki verfasserin aut P1-12. L-DOPA may modify function of the sensory cortex in Parkinson’s disease 2017transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Sensory disturbance is occasionally accompanied with parkinsonism and is sometimes improved by L-DOPA treatment. The abnormalities in cerebral somatosensory neurons were already revealed by neurophysiological methods. However, whether L-DOPA influences the cerebral somatosensory functions is unknown. We evaluated the effect of L-DOPA on the sensory cortex in Parkinson disease (PD) using neurophysiological technique such as high-frequency oscillations (HFOs) and somatosensory evoked potential recovery functions (SEP-Rs), which could detect slight functional abnormalities of cerebral somatosensory interneurons. We examined ten drug-naïve PD patients in pre- and post-L-DOPA treatment. HFOs were obtained by digitally filtering raw SEPs from 500 to 1000Hz. For SEP-Rs study, paired-pulse stimuli at various interstimulus intervals (ISIs; 20–200ms) were given. There were no significant differences in the HFO study. The SEP-Rs study demonstrated that patients with disease duration of more than one year (n =6) had a significant disinhibition (P =0.003) in P25-N33 of post-treatment compared with pre-treatment. L-DOPA may have some effects on the abnormal GABAergic interneuron function in sensory cortex, which could improve sensory disturbance by L-DOPA therapy in PD patients. Sensory disturbance is occasionally accompanied with parkinsonism and is sometimes improved by L-DOPA treatment. The abnormalities in cerebral somatosensory neurons were already revealed by neurophysiological methods. However, whether L-DOPA influences the cerebral somatosensory functions is unknown. We evaluated the effect of L-DOPA on the sensory cortex in Parkinson disease (PD) using neurophysiological technique such as high-frequency oscillations (HFOs) and somatosensory evoked potential recovery functions (SEP-Rs), which could detect slight functional abnormalities of cerebral somatosensory interneurons. We examined ten drug-naïve PD patients in pre- and post-L-DOPA treatment. HFOs were obtained by digitally filtering raw SEPs from 500 to 1000Hz. For SEP-Rs study, paired-pulse stimuli at various interstimulus intervals (ISIs; 20–200ms) were given. There were no significant differences in the HFO study. The SEP-Rs study demonstrated that patients with disease duration of more than one year (n =6) had a significant disinhibition (P =0.003) in P25-N33 of post-treatment compared with pre-treatment. L-DOPA may have some effects on the abnormal GABAergic interneuron function in sensory cortex, which could improve sensory disturbance by L-DOPA therapy in PD patients. Mochizuki, Hitoshi oth Shiomi, Kazutaka oth Nakazato, Masamitsu oth Enthalten in Elsevier Science Södervik, Ilona ELSEVIER Medical students' biomedical and clinical knowledge: Combining longitudinal design, eye tracking and comparison with residents' performance 2017 Amsterdam [u.a.] (DE-627)ELV000764582 volume:128 year:2017 number:9 pages:173 https://doi.org/10.1016/j.clinph.2017.06.015 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 80.00 Pädagogik: Allgemeines VZ AR 128 2017 9 173 128.2017, 9, e173- 045F 610 |
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10.1016/j.clinph.2017.06.015 doi GBV00000000000269A.pica (DE-627)ELV014817039 (ELSEVIER)S1388-2457(17)30231-6 DE-627 ger DE-627 rakwb eng 610 610 DE-600 370 VZ 5,3 ssgn 80.00 bkl Ishii, Nobuyuki verfasserin aut P1-12. L-DOPA may modify function of the sensory cortex in Parkinson’s disease 2017transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Sensory disturbance is occasionally accompanied with parkinsonism and is sometimes improved by L-DOPA treatment. The abnormalities in cerebral somatosensory neurons were already revealed by neurophysiological methods. However, whether L-DOPA influences the cerebral somatosensory functions is unknown. We evaluated the effect of L-DOPA on the sensory cortex in Parkinson disease (PD) using neurophysiological technique such as high-frequency oscillations (HFOs) and somatosensory evoked potential recovery functions (SEP-Rs), which could detect slight functional abnormalities of cerebral somatosensory interneurons. We examined ten drug-naïve PD patients in pre- and post-L-DOPA treatment. HFOs were obtained by digitally filtering raw SEPs from 500 to 1000Hz. For SEP-Rs study, paired-pulse stimuli at various interstimulus intervals (ISIs; 20–200ms) were given. There were no significant differences in the HFO study. The SEP-Rs study demonstrated that patients with disease duration of more than one year (n =6) had a significant disinhibition (P =0.003) in P25-N33 of post-treatment compared with pre-treatment. L-DOPA may have some effects on the abnormal GABAergic interneuron function in sensory cortex, which could improve sensory disturbance by L-DOPA therapy in PD patients. Sensory disturbance is occasionally accompanied with parkinsonism and is sometimes improved by L-DOPA treatment. The abnormalities in cerebral somatosensory neurons were already revealed by neurophysiological methods. However, whether L-DOPA influences the cerebral somatosensory functions is unknown. We evaluated the effect of L-DOPA on the sensory cortex in Parkinson disease (PD) using neurophysiological technique such as high-frequency oscillations (HFOs) and somatosensory evoked potential recovery functions (SEP-Rs), which could detect slight functional abnormalities of cerebral somatosensory interneurons. We examined ten drug-naïve PD patients in pre- and post-L-DOPA treatment. HFOs were obtained by digitally filtering raw SEPs from 500 to 1000Hz. For SEP-Rs study, paired-pulse stimuli at various interstimulus intervals (ISIs; 20–200ms) were given. There were no significant differences in the HFO study. The SEP-Rs study demonstrated that patients with disease duration of more than one year (n =6) had a significant disinhibition (P =0.003) in P25-N33 of post-treatment compared with pre-treatment. L-DOPA may have some effects on the abnormal GABAergic interneuron function in sensory cortex, which could improve sensory disturbance by L-DOPA therapy in PD patients. Mochizuki, Hitoshi oth Shiomi, Kazutaka oth Nakazato, Masamitsu oth Enthalten in Elsevier Science Södervik, Ilona ELSEVIER Medical students' biomedical and clinical knowledge: Combining longitudinal design, eye tracking and comparison with residents' performance 2017 Amsterdam [u.a.] (DE-627)ELV000764582 volume:128 year:2017 number:9 pages:173 https://doi.org/10.1016/j.clinph.2017.06.015 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 80.00 Pädagogik: Allgemeines VZ AR 128 2017 9 173 128.2017, 9, e173- 045F 610 |
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10.1016/j.clinph.2017.06.015 doi GBV00000000000269A.pica (DE-627)ELV014817039 (ELSEVIER)S1388-2457(17)30231-6 DE-627 ger DE-627 rakwb eng 610 610 DE-600 370 VZ 5,3 ssgn 80.00 bkl Ishii, Nobuyuki verfasserin aut P1-12. L-DOPA may modify function of the sensory cortex in Parkinson’s disease 2017transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Sensory disturbance is occasionally accompanied with parkinsonism and is sometimes improved by L-DOPA treatment. The abnormalities in cerebral somatosensory neurons were already revealed by neurophysiological methods. However, whether L-DOPA influences the cerebral somatosensory functions is unknown. We evaluated the effect of L-DOPA on the sensory cortex in Parkinson disease (PD) using neurophysiological technique such as high-frequency oscillations (HFOs) and somatosensory evoked potential recovery functions (SEP-Rs), which could detect slight functional abnormalities of cerebral somatosensory interneurons. We examined ten drug-naïve PD patients in pre- and post-L-DOPA treatment. HFOs were obtained by digitally filtering raw SEPs from 500 to 1000Hz. For SEP-Rs study, paired-pulse stimuli at various interstimulus intervals (ISIs; 20–200ms) were given. There were no significant differences in the HFO study. The SEP-Rs study demonstrated that patients with disease duration of more than one year (n =6) had a significant disinhibition (P =0.003) in P25-N33 of post-treatment compared with pre-treatment. L-DOPA may have some effects on the abnormal GABAergic interneuron function in sensory cortex, which could improve sensory disturbance by L-DOPA therapy in PD patients. Sensory disturbance is occasionally accompanied with parkinsonism and is sometimes improved by L-DOPA treatment. The abnormalities in cerebral somatosensory neurons were already revealed by neurophysiological methods. However, whether L-DOPA influences the cerebral somatosensory functions is unknown. We evaluated the effect of L-DOPA on the sensory cortex in Parkinson disease (PD) using neurophysiological technique such as high-frequency oscillations (HFOs) and somatosensory evoked potential recovery functions (SEP-Rs), which could detect slight functional abnormalities of cerebral somatosensory interneurons. We examined ten drug-naïve PD patients in pre- and post-L-DOPA treatment. HFOs were obtained by digitally filtering raw SEPs from 500 to 1000Hz. For SEP-Rs study, paired-pulse stimuli at various interstimulus intervals (ISIs; 20–200ms) were given. There were no significant differences in the HFO study. The SEP-Rs study demonstrated that patients with disease duration of more than one year (n =6) had a significant disinhibition (P =0.003) in P25-N33 of post-treatment compared with pre-treatment. L-DOPA may have some effects on the abnormal GABAergic interneuron function in sensory cortex, which could improve sensory disturbance by L-DOPA therapy in PD patients. Mochizuki, Hitoshi oth Shiomi, Kazutaka oth Nakazato, Masamitsu oth Enthalten in Elsevier Science Södervik, Ilona ELSEVIER Medical students' biomedical and clinical knowledge: Combining longitudinal design, eye tracking and comparison with residents' performance 2017 Amsterdam [u.a.] (DE-627)ELV000764582 volume:128 year:2017 number:9 pages:173 https://doi.org/10.1016/j.clinph.2017.06.015 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 80.00 Pädagogik: Allgemeines VZ AR 128 2017 9 173 128.2017, 9, e173- 045F 610 |
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10.1016/j.clinph.2017.06.015 doi GBV00000000000269A.pica (DE-627)ELV014817039 (ELSEVIER)S1388-2457(17)30231-6 DE-627 ger DE-627 rakwb eng 610 610 DE-600 370 VZ 5,3 ssgn 80.00 bkl Ishii, Nobuyuki verfasserin aut P1-12. L-DOPA may modify function of the sensory cortex in Parkinson’s disease 2017transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Sensory disturbance is occasionally accompanied with parkinsonism and is sometimes improved by L-DOPA treatment. The abnormalities in cerebral somatosensory neurons were already revealed by neurophysiological methods. However, whether L-DOPA influences the cerebral somatosensory functions is unknown. We evaluated the effect of L-DOPA on the sensory cortex in Parkinson disease (PD) using neurophysiological technique such as high-frequency oscillations (HFOs) and somatosensory evoked potential recovery functions (SEP-Rs), which could detect slight functional abnormalities of cerebral somatosensory interneurons. We examined ten drug-naïve PD patients in pre- and post-L-DOPA treatment. HFOs were obtained by digitally filtering raw SEPs from 500 to 1000Hz. For SEP-Rs study, paired-pulse stimuli at various interstimulus intervals (ISIs; 20–200ms) were given. There were no significant differences in the HFO study. The SEP-Rs study demonstrated that patients with disease duration of more than one year (n =6) had a significant disinhibition (P =0.003) in P25-N33 of post-treatment compared with pre-treatment. L-DOPA may have some effects on the abnormal GABAergic interneuron function in sensory cortex, which could improve sensory disturbance by L-DOPA therapy in PD patients. Sensory disturbance is occasionally accompanied with parkinsonism and is sometimes improved by L-DOPA treatment. The abnormalities in cerebral somatosensory neurons were already revealed by neurophysiological methods. However, whether L-DOPA influences the cerebral somatosensory functions is unknown. We evaluated the effect of L-DOPA on the sensory cortex in Parkinson disease (PD) using neurophysiological technique such as high-frequency oscillations (HFOs) and somatosensory evoked potential recovery functions (SEP-Rs), which could detect slight functional abnormalities of cerebral somatosensory interneurons. We examined ten drug-naïve PD patients in pre- and post-L-DOPA treatment. HFOs were obtained by digitally filtering raw SEPs from 500 to 1000Hz. For SEP-Rs study, paired-pulse stimuli at various interstimulus intervals (ISIs; 20–200ms) were given. There were no significant differences in the HFO study. The SEP-Rs study demonstrated that patients with disease duration of more than one year (n =6) had a significant disinhibition (P =0.003) in P25-N33 of post-treatment compared with pre-treatment. L-DOPA may have some effects on the abnormal GABAergic interneuron function in sensory cortex, which could improve sensory disturbance by L-DOPA therapy in PD patients. Mochizuki, Hitoshi oth Shiomi, Kazutaka oth Nakazato, Masamitsu oth Enthalten in Elsevier Science Södervik, Ilona ELSEVIER Medical students' biomedical and clinical knowledge: Combining longitudinal design, eye tracking and comparison with residents' performance 2017 Amsterdam [u.a.] (DE-627)ELV000764582 volume:128 year:2017 number:9 pages:173 https://doi.org/10.1016/j.clinph.2017.06.015 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 80.00 Pädagogik: Allgemeines VZ AR 128 2017 9 173 128.2017, 9, e173- 045F 610 |
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10.1016/j.clinph.2017.06.015 doi GBV00000000000269A.pica (DE-627)ELV014817039 (ELSEVIER)S1388-2457(17)30231-6 DE-627 ger DE-627 rakwb eng 610 610 DE-600 370 VZ 5,3 ssgn 80.00 bkl Ishii, Nobuyuki verfasserin aut P1-12. L-DOPA may modify function of the sensory cortex in Parkinson’s disease 2017transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Sensory disturbance is occasionally accompanied with parkinsonism and is sometimes improved by L-DOPA treatment. The abnormalities in cerebral somatosensory neurons were already revealed by neurophysiological methods. However, whether L-DOPA influences the cerebral somatosensory functions is unknown. We evaluated the effect of L-DOPA on the sensory cortex in Parkinson disease (PD) using neurophysiological technique such as high-frequency oscillations (HFOs) and somatosensory evoked potential recovery functions (SEP-Rs), which could detect slight functional abnormalities of cerebral somatosensory interneurons. We examined ten drug-naïve PD patients in pre- and post-L-DOPA treatment. HFOs were obtained by digitally filtering raw SEPs from 500 to 1000Hz. For SEP-Rs study, paired-pulse stimuli at various interstimulus intervals (ISIs; 20–200ms) were given. There were no significant differences in the HFO study. The SEP-Rs study demonstrated that patients with disease duration of more than one year (n =6) had a significant disinhibition (P =0.003) in P25-N33 of post-treatment compared with pre-treatment. L-DOPA may have some effects on the abnormal GABAergic interneuron function in sensory cortex, which could improve sensory disturbance by L-DOPA therapy in PD patients. Sensory disturbance is occasionally accompanied with parkinsonism and is sometimes improved by L-DOPA treatment. The abnormalities in cerebral somatosensory neurons were already revealed by neurophysiological methods. However, whether L-DOPA influences the cerebral somatosensory functions is unknown. We evaluated the effect of L-DOPA on the sensory cortex in Parkinson disease (PD) using neurophysiological technique such as high-frequency oscillations (HFOs) and somatosensory evoked potential recovery functions (SEP-Rs), which could detect slight functional abnormalities of cerebral somatosensory interneurons. We examined ten drug-naïve PD patients in pre- and post-L-DOPA treatment. HFOs were obtained by digitally filtering raw SEPs from 500 to 1000Hz. For SEP-Rs study, paired-pulse stimuli at various interstimulus intervals (ISIs; 20–200ms) were given. There were no significant differences in the HFO study. The SEP-Rs study demonstrated that patients with disease duration of more than one year (n =6) had a significant disinhibition (P =0.003) in P25-N33 of post-treatment compared with pre-treatment. L-DOPA may have some effects on the abnormal GABAergic interneuron function in sensory cortex, which could improve sensory disturbance by L-DOPA therapy in PD patients. Mochizuki, Hitoshi oth Shiomi, Kazutaka oth Nakazato, Masamitsu oth Enthalten in Elsevier Science Södervik, Ilona ELSEVIER Medical students' biomedical and clinical knowledge: Combining longitudinal design, eye tracking and comparison with residents' performance 2017 Amsterdam [u.a.] (DE-627)ELV000764582 volume:128 year:2017 number:9 pages:173 https://doi.org/10.1016/j.clinph.2017.06.015 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 80.00 Pädagogik: Allgemeines VZ AR 128 2017 9 173 128.2017, 9, e173- 045F 610 |
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Enthalten in Medical students' biomedical and clinical knowledge: Combining longitudinal design, eye tracking and comparison with residents' performance Amsterdam [u.a.] volume:128 year:2017 number:9 pages:173 |
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P1-12. L-DOPA may modify function of the sensory cortex in Parkinson’s disease |
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Sensory disturbance is occasionally accompanied with parkinsonism and is sometimes improved by L-DOPA treatment. The abnormalities in cerebral somatosensory neurons were already revealed by neurophysiological methods. However, whether L-DOPA influences the cerebral somatosensory functions is unknown. We evaluated the effect of L-DOPA on the sensory cortex in Parkinson disease (PD) using neurophysiological technique such as high-frequency oscillations (HFOs) and somatosensory evoked potential recovery functions (SEP-Rs), which could detect slight functional abnormalities of cerebral somatosensory interneurons. We examined ten drug-naïve PD patients in pre- and post-L-DOPA treatment. HFOs were obtained by digitally filtering raw SEPs from 500 to 1000Hz. For SEP-Rs study, paired-pulse stimuli at various interstimulus intervals (ISIs; 20–200ms) were given. There were no significant differences in the HFO study. The SEP-Rs study demonstrated that patients with disease duration of more than one year (n =6) had a significant disinhibition (P =0.003) in P25-N33 of post-treatment compared with pre-treatment. L-DOPA may have some effects on the abnormal GABAergic interneuron function in sensory cortex, which could improve sensory disturbance by L-DOPA therapy in PD patients. |
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Sensory disturbance is occasionally accompanied with parkinsonism and is sometimes improved by L-DOPA treatment. The abnormalities in cerebral somatosensory neurons were already revealed by neurophysiological methods. However, whether L-DOPA influences the cerebral somatosensory functions is unknown. We evaluated the effect of L-DOPA on the sensory cortex in Parkinson disease (PD) using neurophysiological technique such as high-frequency oscillations (HFOs) and somatosensory evoked potential recovery functions (SEP-Rs), which could detect slight functional abnormalities of cerebral somatosensory interneurons. We examined ten drug-naïve PD patients in pre- and post-L-DOPA treatment. HFOs were obtained by digitally filtering raw SEPs from 500 to 1000Hz. For SEP-Rs study, paired-pulse stimuli at various interstimulus intervals (ISIs; 20–200ms) were given. There were no significant differences in the HFO study. The SEP-Rs study demonstrated that patients with disease duration of more than one year (n =6) had a significant disinhibition (P =0.003) in P25-N33 of post-treatment compared with pre-treatment. L-DOPA may have some effects on the abnormal GABAergic interneuron function in sensory cortex, which could improve sensory disturbance by L-DOPA therapy in PD patients. |
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Sensory disturbance is occasionally accompanied with parkinsonism and is sometimes improved by L-DOPA treatment. The abnormalities in cerebral somatosensory neurons were already revealed by neurophysiological methods. However, whether L-DOPA influences the cerebral somatosensory functions is unknown. We evaluated the effect of L-DOPA on the sensory cortex in Parkinson disease (PD) using neurophysiological technique such as high-frequency oscillations (HFOs) and somatosensory evoked potential recovery functions (SEP-Rs), which could detect slight functional abnormalities of cerebral somatosensory interneurons. We examined ten drug-naïve PD patients in pre- and post-L-DOPA treatment. HFOs were obtained by digitally filtering raw SEPs from 500 to 1000Hz. For SEP-Rs study, paired-pulse stimuli at various interstimulus intervals (ISIs; 20–200ms) were given. There were no significant differences in the HFO study. The SEP-Rs study demonstrated that patients with disease duration of more than one year (n =6) had a significant disinhibition (P =0.003) in P25-N33 of post-treatment compared with pre-treatment. L-DOPA may have some effects on the abnormal GABAergic interneuron function in sensory cortex, which could improve sensory disturbance by L-DOPA therapy in PD patients. |
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