Porous hydroxyapatite scaffolds containing dual microspheres based on poly(lactide-co-glycolide) and chitosan for bone regeneration
The strategy of incorporating both scaffold and drug delivery systems to promote tissue growth, has attracted increasing attention in the field of bone tissue engineering. The aim of this study was to incorporate dual microspheres with different diameters, based on chitosan (CS) and poly(lactide-co-...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Wang, Qin [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2017transfer abstract |
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| Schlagwörter: |
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| Umfang: |
5 |
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| Übergeordnetes Werk: |
Enthalten in: New associations and host status: Infestability of kiwifruit by the fruit fly species - Follett, Peter A. ELSEVIER, 2018, an interdisciplinary journal affiliated with the Materials Research Society and the Materials Society Japan, devoted to the rapid publication of short communications on the science, applications and processing of materials, New York, NY [u.a.] |
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| Übergeordnetes Werk: |
volume:188 ; year:2017 ; day:1 ; month:02 ; pages:387-391 ; extent:5 |
| Links: |
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| DOI / URN: |
10.1016/j.matlet.2016.11.098 |
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| 520 | |a The strategy of incorporating both scaffold and drug delivery systems to promote tissue growth, has attracted increasing attention in the field of bone tissue engineering. The aim of this study was to incorporate dual microspheres with different diameters, based on chitosan (CS) and poly(lactide-co-glycolide) (PLGA), onto the porous surface of hydroxyapatite scaffolds (HAs). The scaffolds and microspheres were prepared by the sphere-leaching method and emulsion technique, respectively. Through electrostatic interactions, the CS and PLGA microspheres were successfully immobilized onto the porous surface of alginate-precoated HAs. The CS microspheres were homogeneously and solidly immobilized onto the surface of the HAs, whereas the PLGA microspheres were attached to the surface of the CS microspheres. Additionally, the compressive strength of the scaffolds was obviously improved by the alginate coating. Such HAs combined with two types of microspheres to build a dual delivery system would be a promising and suitable vehicle for the repair of bone tissue defects. | ||
| 520 | |a The strategy of incorporating both scaffold and drug delivery systems to promote tissue growth, has attracted increasing attention in the field of bone tissue engineering. The aim of this study was to incorporate dual microspheres with different diameters, based on chitosan (CS) and poly(lactide-co-glycolide) (PLGA), onto the porous surface of hydroxyapatite scaffolds (HAs). The scaffolds and microspheres were prepared by the sphere-leaching method and emulsion technique, respectively. Through electrostatic interactions, the CS and PLGA microspheres were successfully immobilized onto the porous surface of alginate-precoated HAs. The CS microspheres were homogeneously and solidly immobilized onto the surface of the HAs, whereas the PLGA microspheres were attached to the surface of the CS microspheres. Additionally, the compressive strength of the scaffolds was obviously improved by the alginate coating. Such HAs combined with two types of microspheres to build a dual delivery system would be a promising and suitable vehicle for the repair of bone tissue defects. | ||
| 650 | 7 | |a Poly(lactide-co-glycolide) microspheres |2 Elsevier | |
| 650 | 7 | |a Porous materials |2 Elsevier | |
| 650 | 7 | |a Dual delivery system |2 Elsevier | |
| 650 | 7 | |a Bioceramics |2 Elsevier | |
| 650 | 7 | |a Chitosan microspheres |2 Elsevier | |
| 650 | 7 | |a Surface |2 Elsevier | |
| 700 | 1 | |a Li, Jinyu |4 oth | |
| 700 | 1 | |a Xu, Taotao |4 oth | |
| 700 | 1 | |a Lu, Xiaoying |4 oth | |
| 700 | 1 | |a Zhi, Wei |4 oth | |
| 700 | 1 | |a Weng, Jie |4 oth | |
| 773 | 0 | 8 | |i Enthalten in |n Elsevier |a Follett, Peter A. ELSEVIER |t New associations and host status: Infestability of kiwifruit by the fruit fly species |d 2018 |d an interdisciplinary journal affiliated with the Materials Research Society and the Materials Society Japan, devoted to the rapid publication of short communications on the science, applications and processing of materials |g New York, NY [u.a.] |w (DE-627)ELV000885371 |
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10.1016/j.matlet.2016.11.098 doi GBV00000000000056A.pica (DE-627)ELV014940795 (ELSEVIER)S0167-577X(16)31851-1 DE-627 ger DE-627 rakwb eng 530 600 670 530 DE-600 600 DE-600 670 DE-600 630 580 VZ BIODIV DE-30 fid 48.00 bkl Wang, Qin verfasserin aut Porous hydroxyapatite scaffolds containing dual microspheres based on poly(lactide-co-glycolide) and chitosan for bone regeneration 2017transfer abstract 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The strategy of incorporating both scaffold and drug delivery systems to promote tissue growth, has attracted increasing attention in the field of bone tissue engineering. The aim of this study was to incorporate dual microspheres with different diameters, based on chitosan (CS) and poly(lactide-co-glycolide) (PLGA), onto the porous surface of hydroxyapatite scaffolds (HAs). The scaffolds and microspheres were prepared by the sphere-leaching method and emulsion technique, respectively. Through electrostatic interactions, the CS and PLGA microspheres were successfully immobilized onto the porous surface of alginate-precoated HAs. The CS microspheres were homogeneously and solidly immobilized onto the surface of the HAs, whereas the PLGA microspheres were attached to the surface of the CS microspheres. Additionally, the compressive strength of the scaffolds was obviously improved by the alginate coating. Such HAs combined with two types of microspheres to build a dual delivery system would be a promising and suitable vehicle for the repair of bone tissue defects. The strategy of incorporating both scaffold and drug delivery systems to promote tissue growth, has attracted increasing attention in the field of bone tissue engineering. The aim of this study was to incorporate dual microspheres with different diameters, based on chitosan (CS) and poly(lactide-co-glycolide) (PLGA), onto the porous surface of hydroxyapatite scaffolds (HAs). The scaffolds and microspheres were prepared by the sphere-leaching method and emulsion technique, respectively. Through electrostatic interactions, the CS and PLGA microspheres were successfully immobilized onto the porous surface of alginate-precoated HAs. The CS microspheres were homogeneously and solidly immobilized onto the surface of the HAs, whereas the PLGA microspheres were attached to the surface of the CS microspheres. Additionally, the compressive strength of the scaffolds was obviously improved by the alginate coating. Such HAs combined with two types of microspheres to build a dual delivery system would be a promising and suitable vehicle for the repair of bone tissue defects. Poly(lactide-co-glycolide) microspheres Elsevier Porous materials Elsevier Dual delivery system Elsevier Bioceramics Elsevier Chitosan microspheres Elsevier Surface Elsevier Li, Jinyu oth Xu, Taotao oth Lu, Xiaoying oth Zhi, Wei oth Weng, Jie oth Enthalten in Elsevier Follett, Peter A. ELSEVIER New associations and host status: Infestability of kiwifruit by the fruit fly species 2018 an interdisciplinary journal affiliated with the Materials Research Society and the Materials Society Japan, devoted to the rapid publication of short communications on the science, applications and processing of materials New York, NY [u.a.] (DE-627)ELV000885371 volume:188 year:2017 day:1 month:02 pages:387-391 extent:5 https://doi.org/10.1016/j.matlet.2016.11.098 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV SSG-OLC-PHA SSG-OPC-FOR 48.00 Land- und Forstwirtschaft: Allgemeines VZ AR 188 2017 1 0201 387-391 5 045F 530 |
| spelling |
10.1016/j.matlet.2016.11.098 doi GBV00000000000056A.pica (DE-627)ELV014940795 (ELSEVIER)S0167-577X(16)31851-1 DE-627 ger DE-627 rakwb eng 530 600 670 530 DE-600 600 DE-600 670 DE-600 630 580 VZ BIODIV DE-30 fid 48.00 bkl Wang, Qin verfasserin aut Porous hydroxyapatite scaffolds containing dual microspheres based on poly(lactide-co-glycolide) and chitosan for bone regeneration 2017transfer abstract 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The strategy of incorporating both scaffold and drug delivery systems to promote tissue growth, has attracted increasing attention in the field of bone tissue engineering. The aim of this study was to incorporate dual microspheres with different diameters, based on chitosan (CS) and poly(lactide-co-glycolide) (PLGA), onto the porous surface of hydroxyapatite scaffolds (HAs). The scaffolds and microspheres were prepared by the sphere-leaching method and emulsion technique, respectively. Through electrostatic interactions, the CS and PLGA microspheres were successfully immobilized onto the porous surface of alginate-precoated HAs. The CS microspheres were homogeneously and solidly immobilized onto the surface of the HAs, whereas the PLGA microspheres were attached to the surface of the CS microspheres. Additionally, the compressive strength of the scaffolds was obviously improved by the alginate coating. Such HAs combined with two types of microspheres to build a dual delivery system would be a promising and suitable vehicle for the repair of bone tissue defects. The strategy of incorporating both scaffold and drug delivery systems to promote tissue growth, has attracted increasing attention in the field of bone tissue engineering. The aim of this study was to incorporate dual microspheres with different diameters, based on chitosan (CS) and poly(lactide-co-glycolide) (PLGA), onto the porous surface of hydroxyapatite scaffolds (HAs). The scaffolds and microspheres were prepared by the sphere-leaching method and emulsion technique, respectively. Through electrostatic interactions, the CS and PLGA microspheres were successfully immobilized onto the porous surface of alginate-precoated HAs. The CS microspheres were homogeneously and solidly immobilized onto the surface of the HAs, whereas the PLGA microspheres were attached to the surface of the CS microspheres. Additionally, the compressive strength of the scaffolds was obviously improved by the alginate coating. Such HAs combined with two types of microspheres to build a dual delivery system would be a promising and suitable vehicle for the repair of bone tissue defects. Poly(lactide-co-glycolide) microspheres Elsevier Porous materials Elsevier Dual delivery system Elsevier Bioceramics Elsevier Chitosan microspheres Elsevier Surface Elsevier Li, Jinyu oth Xu, Taotao oth Lu, Xiaoying oth Zhi, Wei oth Weng, Jie oth Enthalten in Elsevier Follett, Peter A. ELSEVIER New associations and host status: Infestability of kiwifruit by the fruit fly species 2018 an interdisciplinary journal affiliated with the Materials Research Society and the Materials Society Japan, devoted to the rapid publication of short communications on the science, applications and processing of materials New York, NY [u.a.] (DE-627)ELV000885371 volume:188 year:2017 day:1 month:02 pages:387-391 extent:5 https://doi.org/10.1016/j.matlet.2016.11.098 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV SSG-OLC-PHA SSG-OPC-FOR 48.00 Land- und Forstwirtschaft: Allgemeines VZ AR 188 2017 1 0201 387-391 5 045F 530 |
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10.1016/j.matlet.2016.11.098 doi GBV00000000000056A.pica (DE-627)ELV014940795 (ELSEVIER)S0167-577X(16)31851-1 DE-627 ger DE-627 rakwb eng 530 600 670 530 DE-600 600 DE-600 670 DE-600 630 580 VZ BIODIV DE-30 fid 48.00 bkl Wang, Qin verfasserin aut Porous hydroxyapatite scaffolds containing dual microspheres based on poly(lactide-co-glycolide) and chitosan for bone regeneration 2017transfer abstract 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The strategy of incorporating both scaffold and drug delivery systems to promote tissue growth, has attracted increasing attention in the field of bone tissue engineering. The aim of this study was to incorporate dual microspheres with different diameters, based on chitosan (CS) and poly(lactide-co-glycolide) (PLGA), onto the porous surface of hydroxyapatite scaffolds (HAs). The scaffolds and microspheres were prepared by the sphere-leaching method and emulsion technique, respectively. Through electrostatic interactions, the CS and PLGA microspheres were successfully immobilized onto the porous surface of alginate-precoated HAs. The CS microspheres were homogeneously and solidly immobilized onto the surface of the HAs, whereas the PLGA microspheres were attached to the surface of the CS microspheres. Additionally, the compressive strength of the scaffolds was obviously improved by the alginate coating. Such HAs combined with two types of microspheres to build a dual delivery system would be a promising and suitable vehicle for the repair of bone tissue defects. The strategy of incorporating both scaffold and drug delivery systems to promote tissue growth, has attracted increasing attention in the field of bone tissue engineering. The aim of this study was to incorporate dual microspheres with different diameters, based on chitosan (CS) and poly(lactide-co-glycolide) (PLGA), onto the porous surface of hydroxyapatite scaffolds (HAs). The scaffolds and microspheres were prepared by the sphere-leaching method and emulsion technique, respectively. Through electrostatic interactions, the CS and PLGA microspheres were successfully immobilized onto the porous surface of alginate-precoated HAs. The CS microspheres were homogeneously and solidly immobilized onto the surface of the HAs, whereas the PLGA microspheres were attached to the surface of the CS microspheres. Additionally, the compressive strength of the scaffolds was obviously improved by the alginate coating. Such HAs combined with two types of microspheres to build a dual delivery system would be a promising and suitable vehicle for the repair of bone tissue defects. Poly(lactide-co-glycolide) microspheres Elsevier Porous materials Elsevier Dual delivery system Elsevier Bioceramics Elsevier Chitosan microspheres Elsevier Surface Elsevier Li, Jinyu oth Xu, Taotao oth Lu, Xiaoying oth Zhi, Wei oth Weng, Jie oth Enthalten in Elsevier Follett, Peter A. ELSEVIER New associations and host status: Infestability of kiwifruit by the fruit fly species 2018 an interdisciplinary journal affiliated with the Materials Research Society and the Materials Society Japan, devoted to the rapid publication of short communications on the science, applications and processing of materials New York, NY [u.a.] (DE-627)ELV000885371 volume:188 year:2017 day:1 month:02 pages:387-391 extent:5 https://doi.org/10.1016/j.matlet.2016.11.098 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV SSG-OLC-PHA SSG-OPC-FOR 48.00 Land- und Forstwirtschaft: Allgemeines VZ AR 188 2017 1 0201 387-391 5 045F 530 |
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10.1016/j.matlet.2016.11.098 doi GBV00000000000056A.pica (DE-627)ELV014940795 (ELSEVIER)S0167-577X(16)31851-1 DE-627 ger DE-627 rakwb eng 530 600 670 530 DE-600 600 DE-600 670 DE-600 630 580 VZ BIODIV DE-30 fid 48.00 bkl Wang, Qin verfasserin aut Porous hydroxyapatite scaffolds containing dual microspheres based on poly(lactide-co-glycolide) and chitosan for bone regeneration 2017transfer abstract 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The strategy of incorporating both scaffold and drug delivery systems to promote tissue growth, has attracted increasing attention in the field of bone tissue engineering. The aim of this study was to incorporate dual microspheres with different diameters, based on chitosan (CS) and poly(lactide-co-glycolide) (PLGA), onto the porous surface of hydroxyapatite scaffolds (HAs). The scaffolds and microspheres were prepared by the sphere-leaching method and emulsion technique, respectively. Through electrostatic interactions, the CS and PLGA microspheres were successfully immobilized onto the porous surface of alginate-precoated HAs. The CS microspheres were homogeneously and solidly immobilized onto the surface of the HAs, whereas the PLGA microspheres were attached to the surface of the CS microspheres. Additionally, the compressive strength of the scaffolds was obviously improved by the alginate coating. Such HAs combined with two types of microspheres to build a dual delivery system would be a promising and suitable vehicle for the repair of bone tissue defects. The strategy of incorporating both scaffold and drug delivery systems to promote tissue growth, has attracted increasing attention in the field of bone tissue engineering. The aim of this study was to incorporate dual microspheres with different diameters, based on chitosan (CS) and poly(lactide-co-glycolide) (PLGA), onto the porous surface of hydroxyapatite scaffolds (HAs). The scaffolds and microspheres were prepared by the sphere-leaching method and emulsion technique, respectively. Through electrostatic interactions, the CS and PLGA microspheres were successfully immobilized onto the porous surface of alginate-precoated HAs. The CS microspheres were homogeneously and solidly immobilized onto the surface of the HAs, whereas the PLGA microspheres were attached to the surface of the CS microspheres. Additionally, the compressive strength of the scaffolds was obviously improved by the alginate coating. Such HAs combined with two types of microspheres to build a dual delivery system would be a promising and suitable vehicle for the repair of bone tissue defects. Poly(lactide-co-glycolide) microspheres Elsevier Porous materials Elsevier Dual delivery system Elsevier Bioceramics Elsevier Chitosan microspheres Elsevier Surface Elsevier Li, Jinyu oth Xu, Taotao oth Lu, Xiaoying oth Zhi, Wei oth Weng, Jie oth Enthalten in Elsevier Follett, Peter A. ELSEVIER New associations and host status: Infestability of kiwifruit by the fruit fly species 2018 an interdisciplinary journal affiliated with the Materials Research Society and the Materials Society Japan, devoted to the rapid publication of short communications on the science, applications and processing of materials New York, NY [u.a.] (DE-627)ELV000885371 volume:188 year:2017 day:1 month:02 pages:387-391 extent:5 https://doi.org/10.1016/j.matlet.2016.11.098 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV SSG-OLC-PHA SSG-OPC-FOR 48.00 Land- und Forstwirtschaft: Allgemeines VZ AR 188 2017 1 0201 387-391 5 045F 530 |
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10.1016/j.matlet.2016.11.098 doi GBV00000000000056A.pica (DE-627)ELV014940795 (ELSEVIER)S0167-577X(16)31851-1 DE-627 ger DE-627 rakwb eng 530 600 670 530 DE-600 600 DE-600 670 DE-600 630 580 VZ BIODIV DE-30 fid 48.00 bkl Wang, Qin verfasserin aut Porous hydroxyapatite scaffolds containing dual microspheres based on poly(lactide-co-glycolide) and chitosan for bone regeneration 2017transfer abstract 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The strategy of incorporating both scaffold and drug delivery systems to promote tissue growth, has attracted increasing attention in the field of bone tissue engineering. The aim of this study was to incorporate dual microspheres with different diameters, based on chitosan (CS) and poly(lactide-co-glycolide) (PLGA), onto the porous surface of hydroxyapatite scaffolds (HAs). The scaffolds and microspheres were prepared by the sphere-leaching method and emulsion technique, respectively. Through electrostatic interactions, the CS and PLGA microspheres were successfully immobilized onto the porous surface of alginate-precoated HAs. The CS microspheres were homogeneously and solidly immobilized onto the surface of the HAs, whereas the PLGA microspheres were attached to the surface of the CS microspheres. Additionally, the compressive strength of the scaffolds was obviously improved by the alginate coating. Such HAs combined with two types of microspheres to build a dual delivery system would be a promising and suitable vehicle for the repair of bone tissue defects. The strategy of incorporating both scaffold and drug delivery systems to promote tissue growth, has attracted increasing attention in the field of bone tissue engineering. The aim of this study was to incorporate dual microspheres with different diameters, based on chitosan (CS) and poly(lactide-co-glycolide) (PLGA), onto the porous surface of hydroxyapatite scaffolds (HAs). The scaffolds and microspheres were prepared by the sphere-leaching method and emulsion technique, respectively. Through electrostatic interactions, the CS and PLGA microspheres were successfully immobilized onto the porous surface of alginate-precoated HAs. The CS microspheres were homogeneously and solidly immobilized onto the surface of the HAs, whereas the PLGA microspheres were attached to the surface of the CS microspheres. Additionally, the compressive strength of the scaffolds was obviously improved by the alginate coating. Such HAs combined with two types of microspheres to build a dual delivery system would be a promising and suitable vehicle for the repair of bone tissue defects. Poly(lactide-co-glycolide) microspheres Elsevier Porous materials Elsevier Dual delivery system Elsevier Bioceramics Elsevier Chitosan microspheres Elsevier Surface Elsevier Li, Jinyu oth Xu, Taotao oth Lu, Xiaoying oth Zhi, Wei oth Weng, Jie oth Enthalten in Elsevier Follett, Peter A. ELSEVIER New associations and host status: Infestability of kiwifruit by the fruit fly species 2018 an interdisciplinary journal affiliated with the Materials Research Society and the Materials Society Japan, devoted to the rapid publication of short communications on the science, applications and processing of materials New York, NY [u.a.] (DE-627)ELV000885371 volume:188 year:2017 day:1 month:02 pages:387-391 extent:5 https://doi.org/10.1016/j.matlet.2016.11.098 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV SSG-OLC-PHA SSG-OPC-FOR 48.00 Land- und Forstwirtschaft: Allgemeines VZ AR 188 2017 1 0201 387-391 5 045F 530 |
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Enthalten in New associations and host status: Infestability of kiwifruit by the fruit fly species New York, NY [u.a.] volume:188 year:2017 day:1 month:02 pages:387-391 extent:5 |
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Enthalten in New associations and host status: Infestability of kiwifruit by the fruit fly species New York, NY [u.a.] volume:188 year:2017 day:1 month:02 pages:387-391 extent:5 |
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New associations and host status: Infestability of kiwifruit by the fruit fly species |
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Wang, Qin @@aut@@ Li, Jinyu @@oth@@ Xu, Taotao @@oth@@ Lu, Xiaoying @@oth@@ Zhi, Wei @@oth@@ Weng, Jie @@oth@@ |
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porous hydroxyapatite scaffolds containing dual microspheres based on poly(lactide-co-glycolide) and chitosan for bone regeneration |
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Porous hydroxyapatite scaffolds containing dual microspheres based on poly(lactide-co-glycolide) and chitosan for bone regeneration |
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The strategy of incorporating both scaffold and drug delivery systems to promote tissue growth, has attracted increasing attention in the field of bone tissue engineering. The aim of this study was to incorporate dual microspheres with different diameters, based on chitosan (CS) and poly(lactide-co-glycolide) (PLGA), onto the porous surface of hydroxyapatite scaffolds (HAs). The scaffolds and microspheres were prepared by the sphere-leaching method and emulsion technique, respectively. Through electrostatic interactions, the CS and PLGA microspheres were successfully immobilized onto the porous surface of alginate-precoated HAs. The CS microspheres were homogeneously and solidly immobilized onto the surface of the HAs, whereas the PLGA microspheres were attached to the surface of the CS microspheres. Additionally, the compressive strength of the scaffolds was obviously improved by the alginate coating. Such HAs combined with two types of microspheres to build a dual delivery system would be a promising and suitable vehicle for the repair of bone tissue defects. |
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The strategy of incorporating both scaffold and drug delivery systems to promote tissue growth, has attracted increasing attention in the field of bone tissue engineering. The aim of this study was to incorporate dual microspheres with different diameters, based on chitosan (CS) and poly(lactide-co-glycolide) (PLGA), onto the porous surface of hydroxyapatite scaffolds (HAs). The scaffolds and microspheres were prepared by the sphere-leaching method and emulsion technique, respectively. Through electrostatic interactions, the CS and PLGA microspheres were successfully immobilized onto the porous surface of alginate-precoated HAs. The CS microspheres were homogeneously and solidly immobilized onto the surface of the HAs, whereas the PLGA microspheres were attached to the surface of the CS microspheres. Additionally, the compressive strength of the scaffolds was obviously improved by the alginate coating. Such HAs combined with two types of microspheres to build a dual delivery system would be a promising and suitable vehicle for the repair of bone tissue defects. |
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The strategy of incorporating both scaffold and drug delivery systems to promote tissue growth, has attracted increasing attention in the field of bone tissue engineering. The aim of this study was to incorporate dual microspheres with different diameters, based on chitosan (CS) and poly(lactide-co-glycolide) (PLGA), onto the porous surface of hydroxyapatite scaffolds (HAs). The scaffolds and microspheres were prepared by the sphere-leaching method and emulsion technique, respectively. Through electrostatic interactions, the CS and PLGA microspheres were successfully immobilized onto the porous surface of alginate-precoated HAs. The CS microspheres were homogeneously and solidly immobilized onto the surface of the HAs, whereas the PLGA microspheres were attached to the surface of the CS microspheres. Additionally, the compressive strength of the scaffolds was obviously improved by the alginate coating. Such HAs combined with two types of microspheres to build a dual delivery system would be a promising and suitable vehicle for the repair of bone tissue defects. |
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