Olea europaea leaf extract and bevacizumab synergistically exhibit beneficial efficacy upon human glioblastoma cancer stem cells through reducing angiogenesis and invasion in vitro
Patients with glioblastoma multiforme (GBM) that are cancer stem-cell-positive (GSC [+]) essentially cannot benefit from anti-angiogenic or anti-invasive therapy. In the present study, the potential anti-angiogenic and anti-invasive effects of Olea europaea (olive) leaf extract (OLE) were tested usi...
Ausführliche Beschreibung
Autor*in: |
Tezcan, Gulcin [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
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2017transfer abstract |
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Umfang: |
11 |
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Übergeordnetes Werk: |
Enthalten in: A Scoping Review of Registered Clinical Trials of Cellular Therapy for COVID-19 and a - Liao, Gary ELSEVIER, 2020, Amsterdam [u.a.] |
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Übergeordnetes Werk: |
volume:90 ; year:2017 ; pages:713-723 ; extent:11 |
Links: |
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DOI / URN: |
10.1016/j.biopha.2017.04.022 |
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ELV015178218 |
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520 | |a Patients with glioblastoma multiforme (GBM) that are cancer stem-cell-positive (GSC [+]) essentially cannot benefit from anti-angiogenic or anti-invasive therapy. In the present study, the potential anti-angiogenic and anti-invasive effects of Olea europaea (olive) leaf extract (OLE) were tested using GSC (+) tumours. OLE (2mg/mL) caused a significant reduction in tumour weight, vascularisation, invasiveness and migration (p =0.0001, p< 0.001, p =0.004; respectively) that was associated with reducing the expression of VEGFA, MMP-2 and MMP-9. This effect was synergistically increased in combination with bevacizumab. Therefore, our current findings may contribute to research on drugs that inhibit the invasiveness of GBM. | ||
650 | 7 | |a VEGFA |2 Elsevier | |
650 | 7 | |a Angiogenesis |2 Elsevier | |
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650 | 7 | |a Olea europaea leaf extract |2 Elsevier | |
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650 | 7 | |a Glioblastoma cancer stem cell |2 Elsevier | |
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700 | 1 | |a Kocaeli, Hasan |4 oth | |
700 | 1 | |a Aksoy, Secil Ak |4 oth | |
700 | 1 | |a Egeli, Unal |4 oth | |
700 | 1 | |a Cecener, Gulsah |4 oth | |
700 | 1 | |a Tolunay, Sahsine |4 oth | |
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10.1016/j.biopha.2017.04.022 doi GBV00000000000092A.pica (DE-627)ELV015178218 (ELSEVIER)S0753-3322(17)30781-3 DE-627 ger DE-627 rakwb eng 610 610 DE-600 610 VZ 44.86 bkl Tezcan, Gulcin verfasserin aut Olea europaea leaf extract and bevacizumab synergistically exhibit beneficial efficacy upon human glioblastoma cancer stem cells through reducing angiogenesis and invasion in vitro 2017transfer abstract 11 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Patients with glioblastoma multiforme (GBM) that are cancer stem-cell-positive (GSC [+]) essentially cannot benefit from anti-angiogenic or anti-invasive therapy. In the present study, the potential anti-angiogenic and anti-invasive effects of Olea europaea (olive) leaf extract (OLE) were tested using GSC (+) tumours. OLE (2mg/mL) caused a significant reduction in tumour weight, vascularisation, invasiveness and migration (p =0.0001, p< 0.001, p =0.004; respectively) that was associated with reducing the expression of VEGFA, MMP-2 and MMP-9. This effect was synergistically increased in combination with bevacizumab. Therefore, our current findings may contribute to research on drugs that inhibit the invasiveness of GBM. Patients with glioblastoma multiforme (GBM) that are cancer stem-cell-positive (GSC [+]) essentially cannot benefit from anti-angiogenic or anti-invasive therapy. In the present study, the potential anti-angiogenic and anti-invasive effects of Olea europaea (olive) leaf extract (OLE) were tested using GSC (+) tumours. OLE (2mg/mL) caused a significant reduction in tumour weight, vascularisation, invasiveness and migration (p =0.0001, p< 0.001, p =0.004; respectively) that was associated with reducing the expression of VEGFA, MMP-2 and MMP-9. This effect was synergistically increased in combination with bevacizumab. Therefore, our current findings may contribute to research on drugs that inhibit the invasiveness of GBM. VEGFA Elsevier Angiogenesis Elsevier MMP2 Elsevier Olea europaea leaf extract Elsevier MMP9 Elsevier Invasion Elsevier Glioblastoma cancer stem cell Elsevier Taskapilioglu, Mevlut Ozgur oth Tunca, Berrin oth Bekar, Ahmet oth Demirci, Hilal oth Kocaeli, Hasan oth Aksoy, Secil Ak oth Egeli, Unal oth Cecener, Gulsah oth Tolunay, Sahsine oth Enthalten in Elsevier Science Liao, Gary ELSEVIER A Scoping Review of Registered Clinical Trials of Cellular Therapy for COVID-19 and a 2020 Amsterdam [u.a.] (DE-627)ELV004620771 volume:90 year:2017 pages:713-723 extent:11 https://doi.org/10.1016/j.biopha.2017.04.022 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.86 Hämatologie VZ AR 90 2017 713-723 11 045F 610 |
spelling |
10.1016/j.biopha.2017.04.022 doi GBV00000000000092A.pica (DE-627)ELV015178218 (ELSEVIER)S0753-3322(17)30781-3 DE-627 ger DE-627 rakwb eng 610 610 DE-600 610 VZ 44.86 bkl Tezcan, Gulcin verfasserin aut Olea europaea leaf extract and bevacizumab synergistically exhibit beneficial efficacy upon human glioblastoma cancer stem cells through reducing angiogenesis and invasion in vitro 2017transfer abstract 11 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Patients with glioblastoma multiforme (GBM) that are cancer stem-cell-positive (GSC [+]) essentially cannot benefit from anti-angiogenic or anti-invasive therapy. In the present study, the potential anti-angiogenic and anti-invasive effects of Olea europaea (olive) leaf extract (OLE) were tested using GSC (+) tumours. OLE (2mg/mL) caused a significant reduction in tumour weight, vascularisation, invasiveness and migration (p =0.0001, p< 0.001, p =0.004; respectively) that was associated with reducing the expression of VEGFA, MMP-2 and MMP-9. This effect was synergistically increased in combination with bevacizumab. Therefore, our current findings may contribute to research on drugs that inhibit the invasiveness of GBM. Patients with glioblastoma multiforme (GBM) that are cancer stem-cell-positive (GSC [+]) essentially cannot benefit from anti-angiogenic or anti-invasive therapy. In the present study, the potential anti-angiogenic and anti-invasive effects of Olea europaea (olive) leaf extract (OLE) were tested using GSC (+) tumours. OLE (2mg/mL) caused a significant reduction in tumour weight, vascularisation, invasiveness and migration (p =0.0001, p< 0.001, p =0.004; respectively) that was associated with reducing the expression of VEGFA, MMP-2 and MMP-9. This effect was synergistically increased in combination with bevacizumab. Therefore, our current findings may contribute to research on drugs that inhibit the invasiveness of GBM. VEGFA Elsevier Angiogenesis Elsevier MMP2 Elsevier Olea europaea leaf extract Elsevier MMP9 Elsevier Invasion Elsevier Glioblastoma cancer stem cell Elsevier Taskapilioglu, Mevlut Ozgur oth Tunca, Berrin oth Bekar, Ahmet oth Demirci, Hilal oth Kocaeli, Hasan oth Aksoy, Secil Ak oth Egeli, Unal oth Cecener, Gulsah oth Tolunay, Sahsine oth Enthalten in Elsevier Science Liao, Gary ELSEVIER A Scoping Review of Registered Clinical Trials of Cellular Therapy for COVID-19 and a 2020 Amsterdam [u.a.] (DE-627)ELV004620771 volume:90 year:2017 pages:713-723 extent:11 https://doi.org/10.1016/j.biopha.2017.04.022 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.86 Hämatologie VZ AR 90 2017 713-723 11 045F 610 |
allfields_unstemmed |
10.1016/j.biopha.2017.04.022 doi GBV00000000000092A.pica (DE-627)ELV015178218 (ELSEVIER)S0753-3322(17)30781-3 DE-627 ger DE-627 rakwb eng 610 610 DE-600 610 VZ 44.86 bkl Tezcan, Gulcin verfasserin aut Olea europaea leaf extract and bevacizumab synergistically exhibit beneficial efficacy upon human glioblastoma cancer stem cells through reducing angiogenesis and invasion in vitro 2017transfer abstract 11 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Patients with glioblastoma multiforme (GBM) that are cancer stem-cell-positive (GSC [+]) essentially cannot benefit from anti-angiogenic or anti-invasive therapy. In the present study, the potential anti-angiogenic and anti-invasive effects of Olea europaea (olive) leaf extract (OLE) were tested using GSC (+) tumours. OLE (2mg/mL) caused a significant reduction in tumour weight, vascularisation, invasiveness and migration (p =0.0001, p< 0.001, p =0.004; respectively) that was associated with reducing the expression of VEGFA, MMP-2 and MMP-9. This effect was synergistically increased in combination with bevacizumab. Therefore, our current findings may contribute to research on drugs that inhibit the invasiveness of GBM. Patients with glioblastoma multiforme (GBM) that are cancer stem-cell-positive (GSC [+]) essentially cannot benefit from anti-angiogenic or anti-invasive therapy. In the present study, the potential anti-angiogenic and anti-invasive effects of Olea europaea (olive) leaf extract (OLE) were tested using GSC (+) tumours. OLE (2mg/mL) caused a significant reduction in tumour weight, vascularisation, invasiveness and migration (p =0.0001, p< 0.001, p =0.004; respectively) that was associated with reducing the expression of VEGFA, MMP-2 and MMP-9. This effect was synergistically increased in combination with bevacizumab. Therefore, our current findings may contribute to research on drugs that inhibit the invasiveness of GBM. VEGFA Elsevier Angiogenesis Elsevier MMP2 Elsevier Olea europaea leaf extract Elsevier MMP9 Elsevier Invasion Elsevier Glioblastoma cancer stem cell Elsevier Taskapilioglu, Mevlut Ozgur oth Tunca, Berrin oth Bekar, Ahmet oth Demirci, Hilal oth Kocaeli, Hasan oth Aksoy, Secil Ak oth Egeli, Unal oth Cecener, Gulsah oth Tolunay, Sahsine oth Enthalten in Elsevier Science Liao, Gary ELSEVIER A Scoping Review of Registered Clinical Trials of Cellular Therapy for COVID-19 and a 2020 Amsterdam [u.a.] (DE-627)ELV004620771 volume:90 year:2017 pages:713-723 extent:11 https://doi.org/10.1016/j.biopha.2017.04.022 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.86 Hämatologie VZ AR 90 2017 713-723 11 045F 610 |
allfieldsGer |
10.1016/j.biopha.2017.04.022 doi GBV00000000000092A.pica (DE-627)ELV015178218 (ELSEVIER)S0753-3322(17)30781-3 DE-627 ger DE-627 rakwb eng 610 610 DE-600 610 VZ 44.86 bkl Tezcan, Gulcin verfasserin aut Olea europaea leaf extract and bevacizumab synergistically exhibit beneficial efficacy upon human glioblastoma cancer stem cells through reducing angiogenesis and invasion in vitro 2017transfer abstract 11 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Patients with glioblastoma multiforme (GBM) that are cancer stem-cell-positive (GSC [+]) essentially cannot benefit from anti-angiogenic or anti-invasive therapy. In the present study, the potential anti-angiogenic and anti-invasive effects of Olea europaea (olive) leaf extract (OLE) were tested using GSC (+) tumours. OLE (2mg/mL) caused a significant reduction in tumour weight, vascularisation, invasiveness and migration (p =0.0001, p< 0.001, p =0.004; respectively) that was associated with reducing the expression of VEGFA, MMP-2 and MMP-9. This effect was synergistically increased in combination with bevacizumab. Therefore, our current findings may contribute to research on drugs that inhibit the invasiveness of GBM. Patients with glioblastoma multiforme (GBM) that are cancer stem-cell-positive (GSC [+]) essentially cannot benefit from anti-angiogenic or anti-invasive therapy. In the present study, the potential anti-angiogenic and anti-invasive effects of Olea europaea (olive) leaf extract (OLE) were tested using GSC (+) tumours. OLE (2mg/mL) caused a significant reduction in tumour weight, vascularisation, invasiveness and migration (p =0.0001, p< 0.001, p =0.004; respectively) that was associated with reducing the expression of VEGFA, MMP-2 and MMP-9. This effect was synergistically increased in combination with bevacizumab. Therefore, our current findings may contribute to research on drugs that inhibit the invasiveness of GBM. VEGFA Elsevier Angiogenesis Elsevier MMP2 Elsevier Olea europaea leaf extract Elsevier MMP9 Elsevier Invasion Elsevier Glioblastoma cancer stem cell Elsevier Taskapilioglu, Mevlut Ozgur oth Tunca, Berrin oth Bekar, Ahmet oth Demirci, Hilal oth Kocaeli, Hasan oth Aksoy, Secil Ak oth Egeli, Unal oth Cecener, Gulsah oth Tolunay, Sahsine oth Enthalten in Elsevier Science Liao, Gary ELSEVIER A Scoping Review of Registered Clinical Trials of Cellular Therapy for COVID-19 and a 2020 Amsterdam [u.a.] (DE-627)ELV004620771 volume:90 year:2017 pages:713-723 extent:11 https://doi.org/10.1016/j.biopha.2017.04.022 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.86 Hämatologie VZ AR 90 2017 713-723 11 045F 610 |
allfieldsSound |
10.1016/j.biopha.2017.04.022 doi GBV00000000000092A.pica (DE-627)ELV015178218 (ELSEVIER)S0753-3322(17)30781-3 DE-627 ger DE-627 rakwb eng 610 610 DE-600 610 VZ 44.86 bkl Tezcan, Gulcin verfasserin aut Olea europaea leaf extract and bevacizumab synergistically exhibit beneficial efficacy upon human glioblastoma cancer stem cells through reducing angiogenesis and invasion in vitro 2017transfer abstract 11 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Patients with glioblastoma multiforme (GBM) that are cancer stem-cell-positive (GSC [+]) essentially cannot benefit from anti-angiogenic or anti-invasive therapy. In the present study, the potential anti-angiogenic and anti-invasive effects of Olea europaea (olive) leaf extract (OLE) were tested using GSC (+) tumours. OLE (2mg/mL) caused a significant reduction in tumour weight, vascularisation, invasiveness and migration (p =0.0001, p< 0.001, p =0.004; respectively) that was associated with reducing the expression of VEGFA, MMP-2 and MMP-9. This effect was synergistically increased in combination with bevacizumab. Therefore, our current findings may contribute to research on drugs that inhibit the invasiveness of GBM. Patients with glioblastoma multiforme (GBM) that are cancer stem-cell-positive (GSC [+]) essentially cannot benefit from anti-angiogenic or anti-invasive therapy. In the present study, the potential anti-angiogenic and anti-invasive effects of Olea europaea (olive) leaf extract (OLE) were tested using GSC (+) tumours. OLE (2mg/mL) caused a significant reduction in tumour weight, vascularisation, invasiveness and migration (p =0.0001, p< 0.001, p =0.004; respectively) that was associated with reducing the expression of VEGFA, MMP-2 and MMP-9. This effect was synergistically increased in combination with bevacizumab. Therefore, our current findings may contribute to research on drugs that inhibit the invasiveness of GBM. VEGFA Elsevier Angiogenesis Elsevier MMP2 Elsevier Olea europaea leaf extract Elsevier MMP9 Elsevier Invasion Elsevier Glioblastoma cancer stem cell Elsevier Taskapilioglu, Mevlut Ozgur oth Tunca, Berrin oth Bekar, Ahmet oth Demirci, Hilal oth Kocaeli, Hasan oth Aksoy, Secil Ak oth Egeli, Unal oth Cecener, Gulsah oth Tolunay, Sahsine oth Enthalten in Elsevier Science Liao, Gary ELSEVIER A Scoping Review of Registered Clinical Trials of Cellular Therapy for COVID-19 and a 2020 Amsterdam [u.a.] (DE-627)ELV004620771 volume:90 year:2017 pages:713-723 extent:11 https://doi.org/10.1016/j.biopha.2017.04.022 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.86 Hämatologie VZ AR 90 2017 713-723 11 045F 610 |
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olea europaea leaf extract and bevacizumab synergistically exhibit beneficial efficacy upon human glioblastoma cancer stem cells through reducing angiogenesis and invasion in vitro |
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Olea europaea leaf extract and bevacizumab synergistically exhibit beneficial efficacy upon human glioblastoma cancer stem cells through reducing angiogenesis and invasion in vitro |
abstract |
Patients with glioblastoma multiforme (GBM) that are cancer stem-cell-positive (GSC [+]) essentially cannot benefit from anti-angiogenic or anti-invasive therapy. In the present study, the potential anti-angiogenic and anti-invasive effects of Olea europaea (olive) leaf extract (OLE) were tested using GSC (+) tumours. OLE (2mg/mL) caused a significant reduction in tumour weight, vascularisation, invasiveness and migration (p =0.0001, p< 0.001, p =0.004; respectively) that was associated with reducing the expression of VEGFA, MMP-2 and MMP-9. This effect was synergistically increased in combination with bevacizumab. Therefore, our current findings may contribute to research on drugs that inhibit the invasiveness of GBM. |
abstractGer |
Patients with glioblastoma multiforme (GBM) that are cancer stem-cell-positive (GSC [+]) essentially cannot benefit from anti-angiogenic or anti-invasive therapy. In the present study, the potential anti-angiogenic and anti-invasive effects of Olea europaea (olive) leaf extract (OLE) were tested using GSC (+) tumours. OLE (2mg/mL) caused a significant reduction in tumour weight, vascularisation, invasiveness and migration (p =0.0001, p< 0.001, p =0.004; respectively) that was associated with reducing the expression of VEGFA, MMP-2 and MMP-9. This effect was synergistically increased in combination with bevacizumab. Therefore, our current findings may contribute to research on drugs that inhibit the invasiveness of GBM. |
abstract_unstemmed |
Patients with glioblastoma multiforme (GBM) that are cancer stem-cell-positive (GSC [+]) essentially cannot benefit from anti-angiogenic or anti-invasive therapy. In the present study, the potential anti-angiogenic and anti-invasive effects of Olea europaea (olive) leaf extract (OLE) were tested using GSC (+) tumours. OLE (2mg/mL) caused a significant reduction in tumour weight, vascularisation, invasiveness and migration (p =0.0001, p< 0.001, p =0.004; respectively) that was associated with reducing the expression of VEGFA, MMP-2 and MMP-9. This effect was synergistically increased in combination with bevacizumab. Therefore, our current findings may contribute to research on drugs that inhibit the invasiveness of GBM. |
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Olea europaea leaf extract and bevacizumab synergistically exhibit beneficial efficacy upon human glioblastoma cancer stem cells through reducing angiogenesis and invasion in vitro |
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https://doi.org/10.1016/j.biopha.2017.04.022 |
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