Structure-based design of pyridopyrimidinediones as dipeptidyl peptidase IV inhibitors
Abstract Dipeptidyl peptidase IV (DPP-4) inhibitors have been shown to enhance GLP-1 levels and thereby improve hyperglycemia in type II diabetes. From a small fragment hit, using structure-based design, we have discovered a new class of non-covalent, potent and selective DPP-4 inhibitors.
Gespeichert in:
| Autor*in: |
Lam, Betty [verfasserIn] |
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E-Artikel |
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| Sprache: |
Englisch |
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2012 |
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| Schlagwörter: |
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4 |
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| Übergeordnetes Werk: |
Enthalten in: Feeding European sea bass ( - Torrecillas, S. ELSEVIER, 2018, a Tetrahedron publication for rapid dissemination of preliminary communications on all aspects of bioorganic chemistry, medicinal chemistry, bioinorganic chemistry and related disciplines, Amsterdam [u.a.] |
|---|---|
| Übergeordnetes Werk: |
volume:22 ; year:2012 ; number:21 ; day:1 ; month:11 ; pages:6628-6631 ; extent:4 |
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| DOI / URN: |
10.1016/j.bmcl.2012.08.110 |
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| 520 | |a Abstract Dipeptidyl peptidase IV (DPP-4) inhibitors have been shown to enhance GLP-1 levels and thereby improve hyperglycemia in type II diabetes. From a small fragment hit, using structure-based design, we have discovered a new class of non-covalent, potent and selective DPP-4 inhibitors. | ||
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Abstract Dipeptidyl peptidase IV (DPP-4) inhibitors have been shown to enhance GLP-1 levels and thereby improve hyperglycemia in type II diabetes. From a small fragment hit, using structure-based design, we have discovered a new class of non-covalent, potent and selective DPP-4 inhibitors. |
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