PTPRD expression regulates sleep consolidation in Drosophila
Restless legs syndrome/Willis-Ekbom Disease (RLS/WED) is a common sleep disorder, yet its underlying pathophysiology is poorly understood. Genome-wide association studies (GWAS) point to allelic variants in multiple genes that confer susceptibility to RLS/WED. They offer potential insights into mole...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Freeman, A. [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
2013transfer abstract |
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| Übergeordnetes Werk: |
Enthalten in: On the probability of finding nonphysical solutions through shadowing - Chandramoorthy, Nisha ELSEVIER, 2021, Amsterdam [u.a.] |
|---|---|
| Übergeordnetes Werk: |
volume:14 ; year:2013 ; pages:40 |
| Links: |
|---|
| DOI / URN: |
10.1016/j.sleep.2013.11.058 |
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ELV016604148 |
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| 520 | |a Restless legs syndrome/Willis-Ekbom Disease (RLS/WED) is a common sleep disorder, yet its underlying pathophysiology is poorly understood. Genome-wide association studies (GWAS) point to allelic variants in multiple genes that confer susceptibility to RLS/WED. They offer potential insights into molecular pathways that govern expressivity of symptoms and signs. We used Drosophila melanogaster to explore sleep related physiology of two genes harboring at-risk alleles for RLS which also have highly conserved fly homologs, BTBD9 and PTPRD. Here, we complement our recent report of RLS phenotypes in BTBD9 mutants by exploring whether similar phenotypes exist in PTPRD mutants and probe whether sleep phenotypes are mimicked by dual mutants (i.e., suggesting a common molecular pathway) or are more severely disrupted (i.e., consistent with parallel pathways). | ||
| 520 | |a Restless legs syndrome/Willis-Ekbom Disease (RLS/WED) is a common sleep disorder, yet its underlying pathophysiology is poorly understood. Genome-wide association studies (GWAS) point to allelic variants in multiple genes that confer susceptibility to RLS/WED. They offer potential insights into molecular pathways that govern expressivity of symptoms and signs. We used Drosophila melanogaster to explore sleep related physiology of two genes harboring at-risk alleles for RLS which also have highly conserved fly homologs, BTBD9 and PTPRD. Here, we complement our recent report of RLS phenotypes in BTBD9 mutants by exploring whether similar phenotypes exist in PTPRD mutants and probe whether sleep phenotypes are mimicked by dual mutants (i.e., suggesting a common molecular pathway) or are more severely disrupted (i.e., consistent with parallel pathways). | ||
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10.1016/j.sleep.2013.11.058 doi GBVA2013003000009.pica (DE-627)ELV016604148 (ELSEVIER)S1389-9457(13)01273-2 DE-627 ger DE-627 rakwb eng 610 610 DE-600 530 510 000 VZ 33.06 bkl Freeman, A. verfasserin aut PTPRD expression regulates sleep consolidation in Drosophila 2013transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Restless legs syndrome/Willis-Ekbom Disease (RLS/WED) is a common sleep disorder, yet its underlying pathophysiology is poorly understood. Genome-wide association studies (GWAS) point to allelic variants in multiple genes that confer susceptibility to RLS/WED. They offer potential insights into molecular pathways that govern expressivity of symptoms and signs. We used Drosophila melanogaster to explore sleep related physiology of two genes harboring at-risk alleles for RLS which also have highly conserved fly homologs, BTBD9 and PTPRD. Here, we complement our recent report of RLS phenotypes in BTBD9 mutants by exploring whether similar phenotypes exist in PTPRD mutants and probe whether sleep phenotypes are mimicked by dual mutants (i.e., suggesting a common molecular pathway) or are more severely disrupted (i.e., consistent with parallel pathways). Restless legs syndrome/Willis-Ekbom Disease (RLS/WED) is a common sleep disorder, yet its underlying pathophysiology is poorly understood. Genome-wide association studies (GWAS) point to allelic variants in multiple genes that confer susceptibility to RLS/WED. They offer potential insights into molecular pathways that govern expressivity of symptoms and signs. We used Drosophila melanogaster to explore sleep related physiology of two genes harboring at-risk alleles for RLS which also have highly conserved fly homologs, BTBD9 and PTPRD. Here, we complement our recent report of RLS phenotypes in BTBD9 mutants by exploring whether similar phenotypes exist in PTPRD mutants and probe whether sleep phenotypes are mimicked by dual mutants (i.e., suggesting a common molecular pathway) or are more severely disrupted (i.e., consistent with parallel pathways). Rye, D. oth Sanyal, S. oth Enthalten in Elsevier Chandramoorthy, Nisha ELSEVIER On the probability of finding nonphysical solutions through shadowing 2021 Amsterdam [u.a.] (DE-627)ELV006103790 volume:14 year:2013 pages:40 https://doi.org/10.1016/j.sleep.2013.11.058 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-MAT 33.06 Mathematische Methoden der Physik VZ AR 14 2013 40 14.2013, e40- 045F 610 |
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10.1016/j.sleep.2013.11.058 doi GBVA2013003000009.pica (DE-627)ELV016604148 (ELSEVIER)S1389-9457(13)01273-2 DE-627 ger DE-627 rakwb eng 610 610 DE-600 530 510 000 VZ 33.06 bkl Freeman, A. verfasserin aut PTPRD expression regulates sleep consolidation in Drosophila 2013transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Restless legs syndrome/Willis-Ekbom Disease (RLS/WED) is a common sleep disorder, yet its underlying pathophysiology is poorly understood. Genome-wide association studies (GWAS) point to allelic variants in multiple genes that confer susceptibility to RLS/WED. They offer potential insights into molecular pathways that govern expressivity of symptoms and signs. We used Drosophila melanogaster to explore sleep related physiology of two genes harboring at-risk alleles for RLS which also have highly conserved fly homologs, BTBD9 and PTPRD. Here, we complement our recent report of RLS phenotypes in BTBD9 mutants by exploring whether similar phenotypes exist in PTPRD mutants and probe whether sleep phenotypes are mimicked by dual mutants (i.e., suggesting a common molecular pathway) or are more severely disrupted (i.e., consistent with parallel pathways). Restless legs syndrome/Willis-Ekbom Disease (RLS/WED) is a common sleep disorder, yet its underlying pathophysiology is poorly understood. Genome-wide association studies (GWAS) point to allelic variants in multiple genes that confer susceptibility to RLS/WED. They offer potential insights into molecular pathways that govern expressivity of symptoms and signs. We used Drosophila melanogaster to explore sleep related physiology of two genes harboring at-risk alleles for RLS which also have highly conserved fly homologs, BTBD9 and PTPRD. Here, we complement our recent report of RLS phenotypes in BTBD9 mutants by exploring whether similar phenotypes exist in PTPRD mutants and probe whether sleep phenotypes are mimicked by dual mutants (i.e., suggesting a common molecular pathway) or are more severely disrupted (i.e., consistent with parallel pathways). Rye, D. oth Sanyal, S. oth Enthalten in Elsevier Chandramoorthy, Nisha ELSEVIER On the probability of finding nonphysical solutions through shadowing 2021 Amsterdam [u.a.] (DE-627)ELV006103790 volume:14 year:2013 pages:40 https://doi.org/10.1016/j.sleep.2013.11.058 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-MAT 33.06 Mathematische Methoden der Physik VZ AR 14 2013 40 14.2013, e40- 045F 610 |
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10.1016/j.sleep.2013.11.058 doi GBVA2013003000009.pica (DE-627)ELV016604148 (ELSEVIER)S1389-9457(13)01273-2 DE-627 ger DE-627 rakwb eng 610 610 DE-600 530 510 000 VZ 33.06 bkl Freeman, A. verfasserin aut PTPRD expression regulates sleep consolidation in Drosophila 2013transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Restless legs syndrome/Willis-Ekbom Disease (RLS/WED) is a common sleep disorder, yet its underlying pathophysiology is poorly understood. Genome-wide association studies (GWAS) point to allelic variants in multiple genes that confer susceptibility to RLS/WED. They offer potential insights into molecular pathways that govern expressivity of symptoms and signs. We used Drosophila melanogaster to explore sleep related physiology of two genes harboring at-risk alleles for RLS which also have highly conserved fly homologs, BTBD9 and PTPRD. Here, we complement our recent report of RLS phenotypes in BTBD9 mutants by exploring whether similar phenotypes exist in PTPRD mutants and probe whether sleep phenotypes are mimicked by dual mutants (i.e., suggesting a common molecular pathway) or are more severely disrupted (i.e., consistent with parallel pathways). Restless legs syndrome/Willis-Ekbom Disease (RLS/WED) is a common sleep disorder, yet its underlying pathophysiology is poorly understood. Genome-wide association studies (GWAS) point to allelic variants in multiple genes that confer susceptibility to RLS/WED. They offer potential insights into molecular pathways that govern expressivity of symptoms and signs. We used Drosophila melanogaster to explore sleep related physiology of two genes harboring at-risk alleles for RLS which also have highly conserved fly homologs, BTBD9 and PTPRD. Here, we complement our recent report of RLS phenotypes in BTBD9 mutants by exploring whether similar phenotypes exist in PTPRD mutants and probe whether sleep phenotypes are mimicked by dual mutants (i.e., suggesting a common molecular pathway) or are more severely disrupted (i.e., consistent with parallel pathways). Rye, D. oth Sanyal, S. oth Enthalten in Elsevier Chandramoorthy, Nisha ELSEVIER On the probability of finding nonphysical solutions through shadowing 2021 Amsterdam [u.a.] (DE-627)ELV006103790 volume:14 year:2013 pages:40 https://doi.org/10.1016/j.sleep.2013.11.058 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-MAT 33.06 Mathematische Methoden der Physik VZ AR 14 2013 40 14.2013, e40- 045F 610 |
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10.1016/j.sleep.2013.11.058 doi GBVA2013003000009.pica (DE-627)ELV016604148 (ELSEVIER)S1389-9457(13)01273-2 DE-627 ger DE-627 rakwb eng 610 610 DE-600 530 510 000 VZ 33.06 bkl Freeman, A. verfasserin aut PTPRD expression regulates sleep consolidation in Drosophila 2013transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Restless legs syndrome/Willis-Ekbom Disease (RLS/WED) is a common sleep disorder, yet its underlying pathophysiology is poorly understood. Genome-wide association studies (GWAS) point to allelic variants in multiple genes that confer susceptibility to RLS/WED. They offer potential insights into molecular pathways that govern expressivity of symptoms and signs. We used Drosophila melanogaster to explore sleep related physiology of two genes harboring at-risk alleles for RLS which also have highly conserved fly homologs, BTBD9 and PTPRD. Here, we complement our recent report of RLS phenotypes in BTBD9 mutants by exploring whether similar phenotypes exist in PTPRD mutants and probe whether sleep phenotypes are mimicked by dual mutants (i.e., suggesting a common molecular pathway) or are more severely disrupted (i.e., consistent with parallel pathways). Restless legs syndrome/Willis-Ekbom Disease (RLS/WED) is a common sleep disorder, yet its underlying pathophysiology is poorly understood. Genome-wide association studies (GWAS) point to allelic variants in multiple genes that confer susceptibility to RLS/WED. They offer potential insights into molecular pathways that govern expressivity of symptoms and signs. We used Drosophila melanogaster to explore sleep related physiology of two genes harboring at-risk alleles for RLS which also have highly conserved fly homologs, BTBD9 and PTPRD. Here, we complement our recent report of RLS phenotypes in BTBD9 mutants by exploring whether similar phenotypes exist in PTPRD mutants and probe whether sleep phenotypes are mimicked by dual mutants (i.e., suggesting a common molecular pathway) or are more severely disrupted (i.e., consistent with parallel pathways). Rye, D. oth Sanyal, S. oth Enthalten in Elsevier Chandramoorthy, Nisha ELSEVIER On the probability of finding nonphysical solutions through shadowing 2021 Amsterdam [u.a.] (DE-627)ELV006103790 volume:14 year:2013 pages:40 https://doi.org/10.1016/j.sleep.2013.11.058 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-MAT 33.06 Mathematische Methoden der Physik VZ AR 14 2013 40 14.2013, e40- 045F 610 |
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PTPRD expression regulates sleep consolidation in Drosophila |
| abstract |
Restless legs syndrome/Willis-Ekbom Disease (RLS/WED) is a common sleep disorder, yet its underlying pathophysiology is poorly understood. Genome-wide association studies (GWAS) point to allelic variants in multiple genes that confer susceptibility to RLS/WED. They offer potential insights into molecular pathways that govern expressivity of symptoms and signs. We used Drosophila melanogaster to explore sleep related physiology of two genes harboring at-risk alleles for RLS which also have highly conserved fly homologs, BTBD9 and PTPRD. Here, we complement our recent report of RLS phenotypes in BTBD9 mutants by exploring whether similar phenotypes exist in PTPRD mutants and probe whether sleep phenotypes are mimicked by dual mutants (i.e., suggesting a common molecular pathway) or are more severely disrupted (i.e., consistent with parallel pathways). |
| abstractGer |
Restless legs syndrome/Willis-Ekbom Disease (RLS/WED) is a common sleep disorder, yet its underlying pathophysiology is poorly understood. Genome-wide association studies (GWAS) point to allelic variants in multiple genes that confer susceptibility to RLS/WED. They offer potential insights into molecular pathways that govern expressivity of symptoms and signs. We used Drosophila melanogaster to explore sleep related physiology of two genes harboring at-risk alleles for RLS which also have highly conserved fly homologs, BTBD9 and PTPRD. Here, we complement our recent report of RLS phenotypes in BTBD9 mutants by exploring whether similar phenotypes exist in PTPRD mutants and probe whether sleep phenotypes are mimicked by dual mutants (i.e., suggesting a common molecular pathway) or are more severely disrupted (i.e., consistent with parallel pathways). |
| abstract_unstemmed |
Restless legs syndrome/Willis-Ekbom Disease (RLS/WED) is a common sleep disorder, yet its underlying pathophysiology is poorly understood. Genome-wide association studies (GWAS) point to allelic variants in multiple genes that confer susceptibility to RLS/WED. They offer potential insights into molecular pathways that govern expressivity of symptoms and signs. We used Drosophila melanogaster to explore sleep related physiology of two genes harboring at-risk alleles for RLS which also have highly conserved fly homologs, BTBD9 and PTPRD. Here, we complement our recent report of RLS phenotypes in BTBD9 mutants by exploring whether similar phenotypes exist in PTPRD mutants and probe whether sleep phenotypes are mimicked by dual mutants (i.e., suggesting a common molecular pathway) or are more severely disrupted (i.e., consistent with parallel pathways). |
| collection_details |
GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-MAT |
| title_short |
PTPRD expression regulates sleep consolidation in Drosophila |
| url |
https://doi.org/10.1016/j.sleep.2013.11.058 |
| remote_bool |
true |
| author2 |
Rye, D. Sanyal, S. |
| author2Str |
Rye, D. Sanyal, S. |
| ppnlink |
ELV006103790 |
| mediatype_str_mv |
z |
| isOA_txt |
false |
| hochschulschrift_bool |
false |
| author2_role |
oth oth |
| doi_str |
10.1016/j.sleep.2013.11.058 |
| up_date |
2024-07-06T19:58:58.917Z |
| _version_ |
1803861034446880768 |
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|
| score |
7.402316 |