5q− syndrome and multiple myeloma diagnosed simultaneously and successful treated with lenalidomide
A 72-year-old woman was diagnosed with 5q− myelodysplastic syndrome in the course of an indolent multiple myeloma (MM). Bone marrow (BM) cytogenetics disclosed two unrelated clones: 46,XX,del(5)(q13q33), and [47,X,-X,der(1;21)(q10;q10),−4,−4,+5,del(5)(q13q31),+7,der(7)t(1;7)(p34.2;p22),add(8)(p23),−...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Ortega, Margarita [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2013transfer abstract |
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| Schlagwörter: |
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| Umfang: |
3 |
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| Übergeordnetes Werk: |
Enthalten in: N - Li, Danyang ELSEVIER, 2019, clinical and laboratory studies, Amsterdam [u.a.] |
|---|---|
| Übergeordnetes Werk: |
volume:37 ; year:2013 ; number:10 ; pages:1248-1250 ; extent:3 |
| Links: |
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| DOI / URN: |
10.1016/j.leukres.2013.06.021 |
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ELV016626176 |
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| 245 | 1 | 0 | |a 5q− syndrome and multiple myeloma diagnosed simultaneously and successful treated with lenalidomide |
| 264 | 1 | |c 2013transfer abstract | |
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| 520 | |a A 72-year-old woman was diagnosed with 5q− myelodysplastic syndrome in the course of an indolent multiple myeloma (MM). Bone marrow (BM) cytogenetics disclosed two unrelated clones: 46,XX,del(5)(q13q33), and [47,X,-X,der(1;21)(q10;q10),−4,−4,+5,del(5)(q13q31),+7,der(7)t(1;7)(p34.2;p22),add(8)(p23),−13,+15,der(16) t(1;16)(q23;q12.2),+19,−21,+mar1,+mar2]. The last complex karyotype belonged to malignant plasma cells. FISH and SKY techniques demonstrated different 5q deletions. EGR1 gene (on 5q31) lost in 5q− syndrome remained in 5q− plasma cells. Biclonal evolution was noted: myeloid 5q− cells added a deletion 13q and plasma cells showed monosomy 13. Patient achieved complete cytogenetic response of 5q− syndrome with low-dose of lenalidomide, and a partial remission of MM with high-dose of lenalidomide/dexamethasone combination. | ||
| 520 | |a A 72-year-old woman was diagnosed with 5q− myelodysplastic syndrome in the course of an indolent multiple myeloma (MM). Bone marrow (BM) cytogenetics disclosed two unrelated clones: 46,XX,del(5)(q13q33), and [47,X,-X,der(1;21)(q10;q10),−4,−4,+5,del(5)(q13q31),+7,der(7)t(1;7)(p34.2;p22),add(8)(p23),−13,+15,der(16) t(1;16)(q23;q12.2),+19,−21,+mar1,+mar2]. The last complex karyotype belonged to malignant plasma cells. FISH and SKY techniques demonstrated different 5q deletions. EGR1 gene (on 5q31) lost in 5q− syndrome remained in 5q− plasma cells. Biclonal evolution was noted: myeloid 5q− cells added a deletion 13q and plasma cells showed monosomy 13. Patient achieved complete cytogenetic response of 5q− syndrome with low-dose of lenalidomide, and a partial remission of MM with high-dose of lenalidomide/dexamethasone combination. | ||
| 650 | 7 | |a SKY |2 Elsevier | |
| 650 | 7 | |a Lenalidomide |2 Elsevier | |
| 650 | 7 | |a 5q− |2 Elsevier | |
| 650 | 7 | |a Multiple myeloma |2 Elsevier | |
| 650 | 7 | |a Unrelated clones |2 Elsevier | |
| 650 | 7 | |a BM |2 Elsevier | |
| 700 | 1 | |a Mallo, Mar |4 oth | |
| 700 | 1 | |a Solé, Francesc |4 oth | |
| 700 | 1 | |a Sánchez-Morata, Carmen |4 oth | |
| 700 | 1 | |a López-Andreoni, Laura |4 oth | |
| 700 | 1 | |a Martínez-Morgado, Noemí |4 oth | |
| 700 | 1 | |a Gironella, Mercedes |4 oth | |
| 700 | 1 | |a Valcárcel, David |4 oth | |
| 700 | 1 | |a Vallespí, Teresa |4 oth | |
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2013 |
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10.1016/j.leukres.2013.06.021 doi GBVA2013003000024.pica (DE-627)ELV016626176 (ELSEVIER)S0145-2126(13)00219-1 DE-627 ger DE-627 rakwb eng 610 610 DE-600 333.7 610 VZ 43.12 bkl 43.13 bkl 44.13 bkl Ortega, Margarita verfasserin aut 5q− syndrome and multiple myeloma diagnosed simultaneously and successful treated with lenalidomide 2013transfer abstract 3 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier A 72-year-old woman was diagnosed with 5q− myelodysplastic syndrome in the course of an indolent multiple myeloma (MM). Bone marrow (BM) cytogenetics disclosed two unrelated clones: 46,XX,del(5)(q13q33), and [47,X,-X,der(1;21)(q10;q10),−4,−4,+5,del(5)(q13q31),+7,der(7)t(1;7)(p34.2;p22),add(8)(p23),−13,+15,der(16) t(1;16)(q23;q12.2),+19,−21,+mar1,+mar2]. The last complex karyotype belonged to malignant plasma cells. FISH and SKY techniques demonstrated different 5q deletions. EGR1 gene (on 5q31) lost in 5q− syndrome remained in 5q− plasma cells. Biclonal evolution was noted: myeloid 5q− cells added a deletion 13q and plasma cells showed monosomy 13. Patient achieved complete cytogenetic response of 5q− syndrome with low-dose of lenalidomide, and a partial remission of MM with high-dose of lenalidomide/dexamethasone combination. A 72-year-old woman was diagnosed with 5q− myelodysplastic syndrome in the course of an indolent multiple myeloma (MM). Bone marrow (BM) cytogenetics disclosed two unrelated clones: 46,XX,del(5)(q13q33), and [47,X,-X,der(1;21)(q10;q10),−4,−4,+5,del(5)(q13q31),+7,der(7)t(1;7)(p34.2;p22),add(8)(p23),−13,+15,der(16) t(1;16)(q23;q12.2),+19,−21,+mar1,+mar2]. The last complex karyotype belonged to malignant plasma cells. FISH and SKY techniques demonstrated different 5q deletions. EGR1 gene (on 5q31) lost in 5q− syndrome remained in 5q− plasma cells. Biclonal evolution was noted: myeloid 5q− cells added a deletion 13q and plasma cells showed monosomy 13. Patient achieved complete cytogenetic response of 5q− syndrome with low-dose of lenalidomide, and a partial remission of MM with high-dose of lenalidomide/dexamethasone combination. SKY Elsevier Lenalidomide Elsevier 5q− Elsevier Multiple myeloma Elsevier Unrelated clones Elsevier BM Elsevier Mallo, Mar oth Solé, Francesc oth Sánchez-Morata, Carmen oth López-Andreoni, Laura oth Martínez-Morgado, Noemí oth Gironella, Mercedes oth Valcárcel, David oth Vallespí, Teresa oth Enthalten in Elsevier Science Li, Danyang ELSEVIER N 2019 clinical and laboratory studies Amsterdam [u.a.] (DE-627)ELV002185202 volume:37 year:2013 number:10 pages:1248-1250 extent:3 https://doi.org/10.1016/j.leukres.2013.06.021 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA SSG-OPC-GGO 43.12 Umweltchemie VZ 43.13 Umwelttoxikologie VZ 44.13 Medizinische Ökologie VZ AR 37 2013 10 1248-1250 3 045F 610 |
| spelling |
10.1016/j.leukres.2013.06.021 doi GBVA2013003000024.pica (DE-627)ELV016626176 (ELSEVIER)S0145-2126(13)00219-1 DE-627 ger DE-627 rakwb eng 610 610 DE-600 333.7 610 VZ 43.12 bkl 43.13 bkl 44.13 bkl Ortega, Margarita verfasserin aut 5q− syndrome and multiple myeloma diagnosed simultaneously and successful treated with lenalidomide 2013transfer abstract 3 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier A 72-year-old woman was diagnosed with 5q− myelodysplastic syndrome in the course of an indolent multiple myeloma (MM). Bone marrow (BM) cytogenetics disclosed two unrelated clones: 46,XX,del(5)(q13q33), and [47,X,-X,der(1;21)(q10;q10),−4,−4,+5,del(5)(q13q31),+7,der(7)t(1;7)(p34.2;p22),add(8)(p23),−13,+15,der(16) t(1;16)(q23;q12.2),+19,−21,+mar1,+mar2]. The last complex karyotype belonged to malignant plasma cells. FISH and SKY techniques demonstrated different 5q deletions. EGR1 gene (on 5q31) lost in 5q− syndrome remained in 5q− plasma cells. Biclonal evolution was noted: myeloid 5q− cells added a deletion 13q and plasma cells showed monosomy 13. Patient achieved complete cytogenetic response of 5q− syndrome with low-dose of lenalidomide, and a partial remission of MM with high-dose of lenalidomide/dexamethasone combination. A 72-year-old woman was diagnosed with 5q− myelodysplastic syndrome in the course of an indolent multiple myeloma (MM). Bone marrow (BM) cytogenetics disclosed two unrelated clones: 46,XX,del(5)(q13q33), and [47,X,-X,der(1;21)(q10;q10),−4,−4,+5,del(5)(q13q31),+7,der(7)t(1;7)(p34.2;p22),add(8)(p23),−13,+15,der(16) t(1;16)(q23;q12.2),+19,−21,+mar1,+mar2]. The last complex karyotype belonged to malignant plasma cells. FISH and SKY techniques demonstrated different 5q deletions. EGR1 gene (on 5q31) lost in 5q− syndrome remained in 5q− plasma cells. Biclonal evolution was noted: myeloid 5q− cells added a deletion 13q and plasma cells showed monosomy 13. Patient achieved complete cytogenetic response of 5q− syndrome with low-dose of lenalidomide, and a partial remission of MM with high-dose of lenalidomide/dexamethasone combination. SKY Elsevier Lenalidomide Elsevier 5q− Elsevier Multiple myeloma Elsevier Unrelated clones Elsevier BM Elsevier Mallo, Mar oth Solé, Francesc oth Sánchez-Morata, Carmen oth López-Andreoni, Laura oth Martínez-Morgado, Noemí oth Gironella, Mercedes oth Valcárcel, David oth Vallespí, Teresa oth Enthalten in Elsevier Science Li, Danyang ELSEVIER N 2019 clinical and laboratory studies Amsterdam [u.a.] (DE-627)ELV002185202 volume:37 year:2013 number:10 pages:1248-1250 extent:3 https://doi.org/10.1016/j.leukres.2013.06.021 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA SSG-OPC-GGO 43.12 Umweltchemie VZ 43.13 Umwelttoxikologie VZ 44.13 Medizinische Ökologie VZ AR 37 2013 10 1248-1250 3 045F 610 |
| allfields_unstemmed |
10.1016/j.leukres.2013.06.021 doi GBVA2013003000024.pica (DE-627)ELV016626176 (ELSEVIER)S0145-2126(13)00219-1 DE-627 ger DE-627 rakwb eng 610 610 DE-600 333.7 610 VZ 43.12 bkl 43.13 bkl 44.13 bkl Ortega, Margarita verfasserin aut 5q− syndrome and multiple myeloma diagnosed simultaneously and successful treated with lenalidomide 2013transfer abstract 3 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier A 72-year-old woman was diagnosed with 5q− myelodysplastic syndrome in the course of an indolent multiple myeloma (MM). Bone marrow (BM) cytogenetics disclosed two unrelated clones: 46,XX,del(5)(q13q33), and [47,X,-X,der(1;21)(q10;q10),−4,−4,+5,del(5)(q13q31),+7,der(7)t(1;7)(p34.2;p22),add(8)(p23),−13,+15,der(16) t(1;16)(q23;q12.2),+19,−21,+mar1,+mar2]. The last complex karyotype belonged to malignant plasma cells. FISH and SKY techniques demonstrated different 5q deletions. EGR1 gene (on 5q31) lost in 5q− syndrome remained in 5q− plasma cells. Biclonal evolution was noted: myeloid 5q− cells added a deletion 13q and plasma cells showed monosomy 13. Patient achieved complete cytogenetic response of 5q− syndrome with low-dose of lenalidomide, and a partial remission of MM with high-dose of lenalidomide/dexamethasone combination. A 72-year-old woman was diagnosed with 5q− myelodysplastic syndrome in the course of an indolent multiple myeloma (MM). Bone marrow (BM) cytogenetics disclosed two unrelated clones: 46,XX,del(5)(q13q33), and [47,X,-X,der(1;21)(q10;q10),−4,−4,+5,del(5)(q13q31),+7,der(7)t(1;7)(p34.2;p22),add(8)(p23),−13,+15,der(16) t(1;16)(q23;q12.2),+19,−21,+mar1,+mar2]. The last complex karyotype belonged to malignant plasma cells. FISH and SKY techniques demonstrated different 5q deletions. EGR1 gene (on 5q31) lost in 5q− syndrome remained in 5q− plasma cells. Biclonal evolution was noted: myeloid 5q− cells added a deletion 13q and plasma cells showed monosomy 13. Patient achieved complete cytogenetic response of 5q− syndrome with low-dose of lenalidomide, and a partial remission of MM with high-dose of lenalidomide/dexamethasone combination. SKY Elsevier Lenalidomide Elsevier 5q− Elsevier Multiple myeloma Elsevier Unrelated clones Elsevier BM Elsevier Mallo, Mar oth Solé, Francesc oth Sánchez-Morata, Carmen oth López-Andreoni, Laura oth Martínez-Morgado, Noemí oth Gironella, Mercedes oth Valcárcel, David oth Vallespí, Teresa oth Enthalten in Elsevier Science Li, Danyang ELSEVIER N 2019 clinical and laboratory studies Amsterdam [u.a.] (DE-627)ELV002185202 volume:37 year:2013 number:10 pages:1248-1250 extent:3 https://doi.org/10.1016/j.leukres.2013.06.021 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA SSG-OPC-GGO 43.12 Umweltchemie VZ 43.13 Umwelttoxikologie VZ 44.13 Medizinische Ökologie VZ AR 37 2013 10 1248-1250 3 045F 610 |
| allfieldsGer |
10.1016/j.leukres.2013.06.021 doi GBVA2013003000024.pica (DE-627)ELV016626176 (ELSEVIER)S0145-2126(13)00219-1 DE-627 ger DE-627 rakwb eng 610 610 DE-600 333.7 610 VZ 43.12 bkl 43.13 bkl 44.13 bkl Ortega, Margarita verfasserin aut 5q− syndrome and multiple myeloma diagnosed simultaneously and successful treated with lenalidomide 2013transfer abstract 3 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier A 72-year-old woman was diagnosed with 5q− myelodysplastic syndrome in the course of an indolent multiple myeloma (MM). Bone marrow (BM) cytogenetics disclosed two unrelated clones: 46,XX,del(5)(q13q33), and [47,X,-X,der(1;21)(q10;q10),−4,−4,+5,del(5)(q13q31),+7,der(7)t(1;7)(p34.2;p22),add(8)(p23),−13,+15,der(16) t(1;16)(q23;q12.2),+19,−21,+mar1,+mar2]. The last complex karyotype belonged to malignant plasma cells. FISH and SKY techniques demonstrated different 5q deletions. EGR1 gene (on 5q31) lost in 5q− syndrome remained in 5q− plasma cells. Biclonal evolution was noted: myeloid 5q− cells added a deletion 13q and plasma cells showed monosomy 13. Patient achieved complete cytogenetic response of 5q− syndrome with low-dose of lenalidomide, and a partial remission of MM with high-dose of lenalidomide/dexamethasone combination. A 72-year-old woman was diagnosed with 5q− myelodysplastic syndrome in the course of an indolent multiple myeloma (MM). Bone marrow (BM) cytogenetics disclosed two unrelated clones: 46,XX,del(5)(q13q33), and [47,X,-X,der(1;21)(q10;q10),−4,−4,+5,del(5)(q13q31),+7,der(7)t(1;7)(p34.2;p22),add(8)(p23),−13,+15,der(16) t(1;16)(q23;q12.2),+19,−21,+mar1,+mar2]. The last complex karyotype belonged to malignant plasma cells. FISH and SKY techniques demonstrated different 5q deletions. EGR1 gene (on 5q31) lost in 5q− syndrome remained in 5q− plasma cells. Biclonal evolution was noted: myeloid 5q− cells added a deletion 13q and plasma cells showed monosomy 13. Patient achieved complete cytogenetic response of 5q− syndrome with low-dose of lenalidomide, and a partial remission of MM with high-dose of lenalidomide/dexamethasone combination. SKY Elsevier Lenalidomide Elsevier 5q− Elsevier Multiple myeloma Elsevier Unrelated clones Elsevier BM Elsevier Mallo, Mar oth Solé, Francesc oth Sánchez-Morata, Carmen oth López-Andreoni, Laura oth Martínez-Morgado, Noemí oth Gironella, Mercedes oth Valcárcel, David oth Vallespí, Teresa oth Enthalten in Elsevier Science Li, Danyang ELSEVIER N 2019 clinical and laboratory studies Amsterdam [u.a.] (DE-627)ELV002185202 volume:37 year:2013 number:10 pages:1248-1250 extent:3 https://doi.org/10.1016/j.leukres.2013.06.021 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA SSG-OPC-GGO 43.12 Umweltchemie VZ 43.13 Umwelttoxikologie VZ 44.13 Medizinische Ökologie VZ AR 37 2013 10 1248-1250 3 045F 610 |
| allfieldsSound |
10.1016/j.leukres.2013.06.021 doi GBVA2013003000024.pica (DE-627)ELV016626176 (ELSEVIER)S0145-2126(13)00219-1 DE-627 ger DE-627 rakwb eng 610 610 DE-600 333.7 610 VZ 43.12 bkl 43.13 bkl 44.13 bkl Ortega, Margarita verfasserin aut 5q− syndrome and multiple myeloma diagnosed simultaneously and successful treated with lenalidomide 2013transfer abstract 3 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier A 72-year-old woman was diagnosed with 5q− myelodysplastic syndrome in the course of an indolent multiple myeloma (MM). Bone marrow (BM) cytogenetics disclosed two unrelated clones: 46,XX,del(5)(q13q33), and [47,X,-X,der(1;21)(q10;q10),−4,−4,+5,del(5)(q13q31),+7,der(7)t(1;7)(p34.2;p22),add(8)(p23),−13,+15,der(16) t(1;16)(q23;q12.2),+19,−21,+mar1,+mar2]. The last complex karyotype belonged to malignant plasma cells. FISH and SKY techniques demonstrated different 5q deletions. EGR1 gene (on 5q31) lost in 5q− syndrome remained in 5q− plasma cells. Biclonal evolution was noted: myeloid 5q− cells added a deletion 13q and plasma cells showed monosomy 13. Patient achieved complete cytogenetic response of 5q− syndrome with low-dose of lenalidomide, and a partial remission of MM with high-dose of lenalidomide/dexamethasone combination. A 72-year-old woman was diagnosed with 5q− myelodysplastic syndrome in the course of an indolent multiple myeloma (MM). Bone marrow (BM) cytogenetics disclosed two unrelated clones: 46,XX,del(5)(q13q33), and [47,X,-X,der(1;21)(q10;q10),−4,−4,+5,del(5)(q13q31),+7,der(7)t(1;7)(p34.2;p22),add(8)(p23),−13,+15,der(16) t(1;16)(q23;q12.2),+19,−21,+mar1,+mar2]. The last complex karyotype belonged to malignant plasma cells. FISH and SKY techniques demonstrated different 5q deletions. EGR1 gene (on 5q31) lost in 5q− syndrome remained in 5q− plasma cells. Biclonal evolution was noted: myeloid 5q− cells added a deletion 13q and plasma cells showed monosomy 13. Patient achieved complete cytogenetic response of 5q− syndrome with low-dose of lenalidomide, and a partial remission of MM with high-dose of lenalidomide/dexamethasone combination. SKY Elsevier Lenalidomide Elsevier 5q− Elsevier Multiple myeloma Elsevier Unrelated clones Elsevier BM Elsevier Mallo, Mar oth Solé, Francesc oth Sánchez-Morata, Carmen oth López-Andreoni, Laura oth Martínez-Morgado, Noemí oth Gironella, Mercedes oth Valcárcel, David oth Vallespí, Teresa oth Enthalten in Elsevier Science Li, Danyang ELSEVIER N 2019 clinical and laboratory studies Amsterdam [u.a.] (DE-627)ELV002185202 volume:37 year:2013 number:10 pages:1248-1250 extent:3 https://doi.org/10.1016/j.leukres.2013.06.021 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA SSG-OPC-GGO 43.12 Umweltchemie VZ 43.13 Umwelttoxikologie VZ 44.13 Medizinische Ökologie VZ AR 37 2013 10 1248-1250 3 045F 610 |
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Ortega, Margarita @@aut@@ Mallo, Mar @@oth@@ Solé, Francesc @@oth@@ Sánchez-Morata, Carmen @@oth@@ López-Andreoni, Laura @@oth@@ Martínez-Morgado, Noemí @@oth@@ Gironella, Mercedes @@oth@@ Valcárcel, David @@oth@@ Vallespí, Teresa @@oth@@ |
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5q− syndrome and multiple myeloma diagnosed simultaneously and successful treated with lenalidomide |
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5q− syndrome and multiple myeloma diagnosed simultaneously and successful treated with lenalidomide |
| abstract |
A 72-year-old woman was diagnosed with 5q− myelodysplastic syndrome in the course of an indolent multiple myeloma (MM). Bone marrow (BM) cytogenetics disclosed two unrelated clones: 46,XX,del(5)(q13q33), and [47,X,-X,der(1;21)(q10;q10),−4,−4,+5,del(5)(q13q31),+7,der(7)t(1;7)(p34.2;p22),add(8)(p23),−13,+15,der(16) t(1;16)(q23;q12.2),+19,−21,+mar1,+mar2]. The last complex karyotype belonged to malignant plasma cells. FISH and SKY techniques demonstrated different 5q deletions. EGR1 gene (on 5q31) lost in 5q− syndrome remained in 5q− plasma cells. Biclonal evolution was noted: myeloid 5q− cells added a deletion 13q and plasma cells showed monosomy 13. Patient achieved complete cytogenetic response of 5q− syndrome with low-dose of lenalidomide, and a partial remission of MM with high-dose of lenalidomide/dexamethasone combination. |
| abstractGer |
A 72-year-old woman was diagnosed with 5q− myelodysplastic syndrome in the course of an indolent multiple myeloma (MM). Bone marrow (BM) cytogenetics disclosed two unrelated clones: 46,XX,del(5)(q13q33), and [47,X,-X,der(1;21)(q10;q10),−4,−4,+5,del(5)(q13q31),+7,der(7)t(1;7)(p34.2;p22),add(8)(p23),−13,+15,der(16) t(1;16)(q23;q12.2),+19,−21,+mar1,+mar2]. The last complex karyotype belonged to malignant plasma cells. FISH and SKY techniques demonstrated different 5q deletions. EGR1 gene (on 5q31) lost in 5q− syndrome remained in 5q− plasma cells. Biclonal evolution was noted: myeloid 5q− cells added a deletion 13q and plasma cells showed monosomy 13. Patient achieved complete cytogenetic response of 5q− syndrome with low-dose of lenalidomide, and a partial remission of MM with high-dose of lenalidomide/dexamethasone combination. |
| abstract_unstemmed |
A 72-year-old woman was diagnosed with 5q− myelodysplastic syndrome in the course of an indolent multiple myeloma (MM). Bone marrow (BM) cytogenetics disclosed two unrelated clones: 46,XX,del(5)(q13q33), and [47,X,-X,der(1;21)(q10;q10),−4,−4,+5,del(5)(q13q31),+7,der(7)t(1;7)(p34.2;p22),add(8)(p23),−13,+15,der(16) t(1;16)(q23;q12.2),+19,−21,+mar1,+mar2]. The last complex karyotype belonged to malignant plasma cells. FISH and SKY techniques demonstrated different 5q deletions. EGR1 gene (on 5q31) lost in 5q− syndrome remained in 5q− plasma cells. Biclonal evolution was noted: myeloid 5q− cells added a deletion 13q and plasma cells showed monosomy 13. Patient achieved complete cytogenetic response of 5q− syndrome with low-dose of lenalidomide, and a partial remission of MM with high-dose of lenalidomide/dexamethasone combination. |
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Bone marrow (BM) cytogenetics disclosed two unrelated clones: 46,XX,del(5)(q13q33), and [47,X,-X,der(1;21)(q10;q10),−4,−4,+5,del(5)(q13q31),+7,der(7)t(1;7)(p34.2;p22),add(8)(p23),−13,+15,der(16) t(1;16)(q23;q12.2),+19,−21,+mar1,+mar2]. The last complex karyotype belonged to malignant plasma cells. FISH and SKY techniques demonstrated different 5q deletions. EGR1 gene (on 5q31) lost in 5q− syndrome remained in 5q− plasma cells. Biclonal evolution was noted: myeloid 5q− cells added a deletion 13q and plasma cells showed monosomy 13. Patient achieved complete cytogenetic response of 5q− syndrome with low-dose of lenalidomide, and a partial remission of MM with high-dose of lenalidomide/dexamethasone combination.</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">A 72-year-old woman was diagnosed with 5q− myelodysplastic syndrome in the course of an indolent multiple myeloma (MM). Bone marrow (BM) cytogenetics disclosed two unrelated clones: 46,XX,del(5)(q13q33), and [47,X,-X,der(1;21)(q10;q10),−4,−4,+5,del(5)(q13q31),+7,der(7)t(1;7)(p34.2;p22),add(8)(p23),−13,+15,der(16) t(1;16)(q23;q12.2),+19,−21,+mar1,+mar2]. The last complex karyotype belonged to malignant plasma cells. FISH and SKY techniques demonstrated different 5q deletions. EGR1 gene (on 5q31) lost in 5q− syndrome remained in 5q− plasma cells. Biclonal evolution was noted: myeloid 5q− cells added a deletion 13q and plasma cells showed monosomy 13. Patient achieved complete cytogenetic response of 5q− syndrome with low-dose of lenalidomide, and a partial remission of MM with high-dose of lenalidomide/dexamethasone combination.</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">SKY</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Lenalidomide</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">5q−</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Multiple myeloma</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Unrelated clones</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">BM</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Mallo, Mar</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Solé, Francesc</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Sánchez-Morata, Carmen</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">López-Andreoni, Laura</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Martínez-Morgado, Noemí</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Gironella, Mercedes</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Valcárcel, David</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Vallespí, Teresa</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="n">Elsevier Science</subfield><subfield code="a">Li, Danyang ELSEVIER</subfield><subfield code="t">N</subfield><subfield code="d">2019</subfield><subfield code="d">clinical and laboratory studies</subfield><subfield code="g">Amsterdam [u.a.]</subfield><subfield code="w">(DE-627)ELV002185202</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:37</subfield><subfield code="g">year:2013</subfield><subfield code="g">number:10</subfield><subfield code="g">pages:1248-1250</subfield><subfield code="g">extent:3</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1016/j.leukres.2013.06.021</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ELV</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-PHA</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OPC-GGO</subfield></datafield><datafield tag="936" ind1="b" ind2="k"><subfield code="a">43.12</subfield><subfield code="j">Umweltchemie</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="936" ind1="b" ind2="k"><subfield code="a">43.13</subfield><subfield code="j">Umwelttoxikologie</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="936" ind1="b" ind2="k"><subfield code="a">44.13</subfield><subfield code="j">Medizinische Ökologie</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">37</subfield><subfield code="j">2013</subfield><subfield code="e">10</subfield><subfield code="h">1248-1250</subfield><subfield code="g">3</subfield></datafield><datafield tag="953" ind1=" " ind2=" "><subfield code="2">045F</subfield><subfield code="a">610</subfield></datafield></record></collection>
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