The relationship between FCN2 genotypes and serum ficolin-2 (L-ficolin) protein concentrations from a large cohort of neonates
The human FCN2 gene codes for ficolin-2 (L-ficolin), a major pattern recognition molecule and activator of the lectin pathway of complement. Seven single nucleotide polymorphisms of this gene were investigated in a large series of cord blood DNA samples. Mutations from the majority to the minority a...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Kilpatrick, David C. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2013transfer abstract |
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| Umfang: |
5 |
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| Übergeordnetes Werk: |
Enthalten in: Towards a Dynamic Understanding of Cadherin-Based Mechanobiology - Hoffman, Brenton D. ELSEVIER, 2015, official journal of the American Society for Histocompatibility and Immunogenetics (ASHI), Amsterdam [u.a.] |
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| Übergeordnetes Werk: |
volume:74 ; year:2013 ; number:7 ; pages:867-871 ; extent:5 |
| Links: |
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| DOI / URN: |
10.1016/j.humimm.2013.04.011 |
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| 245 | 1 | 4 | |a The relationship between FCN2 genotypes and serum ficolin-2 (L-ficolin) protein concentrations from a large cohort of neonates |
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| 520 | |a The human FCN2 gene codes for ficolin-2 (L-ficolin), a major pattern recognition molecule and activator of the lectin pathway of complement. Seven single nucleotide polymorphisms of this gene were investigated in a large series of cord blood DNA samples. Mutations from the majority to the minority alleles at −602, −4 and +6359 were associated with an increase, while mutations at −986, −557, −64 and +6424 were associated with a decrease, in protein concentration. Full (7loci) genotypes were obtained for 1229 unrelated neonates, 12 sets of twin siblings and one set of triplets. Forty-four separate genotypes were detected. Four genotypes accounted for more than half the unrelated neonates, and >90% had one of the 12 commonest genotypes. Genotypes were associated with significant differences in mean serum ficolin-2, but the intra-genotype concentration ranges were large and greater than the inter-genotype differences. Consequently, there were no associations between genotypes and low birthweight babies or perinatal infections, and only a weak relationship with preterm deliveries, despite all three adverse pregnancy features being significantly associated with serum ficolin-2 protein. FCN2 genotyping may be of value in clinical studies, but not as a substitute for total serum ficolin-2 protein measurement. | ||
| 520 | |a The human FCN2 gene codes for ficolin-2 (L-ficolin), a major pattern recognition molecule and activator of the lectin pathway of complement. Seven single nucleotide polymorphisms of this gene were investigated in a large series of cord blood DNA samples. Mutations from the majority to the minority alleles at −602, −4 and +6359 were associated with an increase, while mutations at −986, −557, −64 and +6424 were associated with a decrease, in protein concentration. Full (7loci) genotypes were obtained for 1229 unrelated neonates, 12 sets of twin siblings and one set of triplets. Forty-four separate genotypes were detected. Four genotypes accounted for more than half the unrelated neonates, and >90% had one of the 12 commonest genotypes. Genotypes were associated with significant differences in mean serum ficolin-2, but the intra-genotype concentration ranges were large and greater than the inter-genotype differences. Consequently, there were no associations between genotypes and low birthweight babies or perinatal infections, and only a weak relationship with preterm deliveries, despite all three adverse pregnancy features being significantly associated with serum ficolin-2 protein. FCN2 genotyping may be of value in clinical studies, but not as a substitute for total serum ficolin-2 protein measurement. | ||
| 700 | 1 | |a Swierzko, Anna St. |4 oth | |
| 700 | 1 | |a Matsushita, Misao |4 oth | |
| 700 | 1 | |a Domzalska-Popadiuk, Iwona |4 oth | |
| 700 | 1 | |a Borkowska-Klos, Monika |4 oth | |
| 700 | 1 | |a Szczapa, Jerzy |4 oth | |
| 700 | 1 | |a Cedzynski, Maciej |4 oth | |
| 773 | 0 | 8 | |i Enthalten in |n Elsevier Science |a Hoffman, Brenton D. ELSEVIER |t Towards a Dynamic Understanding of Cadherin-Based Mechanobiology |d 2015 |d official journal of the American Society for Histocompatibility and Immunogenetics (ASHI) |g Amsterdam [u.a.] |w (DE-627)ELV000456578 |
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10.1016/j.humimm.2013.04.011 doi GBVA2013007000025.pica (DE-627)ELV01672531X (ELSEVIER)S0198-8859(13)00097-9 DE-627 ger DE-627 rakwb eng 610 610 DE-600 570 VZ BIODIV DE-30 fid Kilpatrick, David C. verfasserin aut The relationship between FCN2 genotypes and serum ficolin-2 (L-ficolin) protein concentrations from a large cohort of neonates 2013transfer abstract 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The human FCN2 gene codes for ficolin-2 (L-ficolin), a major pattern recognition molecule and activator of the lectin pathway of complement. Seven single nucleotide polymorphisms of this gene were investigated in a large series of cord blood DNA samples. Mutations from the majority to the minority alleles at −602, −4 and +6359 were associated with an increase, while mutations at −986, −557, −64 and +6424 were associated with a decrease, in protein concentration. Full (7loci) genotypes were obtained for 1229 unrelated neonates, 12 sets of twin siblings and one set of triplets. Forty-four separate genotypes were detected. Four genotypes accounted for more than half the unrelated neonates, and >90% had one of the 12 commonest genotypes. Genotypes were associated with significant differences in mean serum ficolin-2, but the intra-genotype concentration ranges were large and greater than the inter-genotype differences. Consequently, there were no associations between genotypes and low birthweight babies or perinatal infections, and only a weak relationship with preterm deliveries, despite all three adverse pregnancy features being significantly associated with serum ficolin-2 protein. FCN2 genotyping may be of value in clinical studies, but not as a substitute for total serum ficolin-2 protein measurement. The human FCN2 gene codes for ficolin-2 (L-ficolin), a major pattern recognition molecule and activator of the lectin pathway of complement. Seven single nucleotide polymorphisms of this gene were investigated in a large series of cord blood DNA samples. Mutations from the majority to the minority alleles at −602, −4 and +6359 were associated with an increase, while mutations at −986, −557, −64 and +6424 were associated with a decrease, in protein concentration. Full (7loci) genotypes were obtained for 1229 unrelated neonates, 12 sets of twin siblings and one set of triplets. Forty-four separate genotypes were detected. Four genotypes accounted for more than half the unrelated neonates, and >90% had one of the 12 commonest genotypes. Genotypes were associated with significant differences in mean serum ficolin-2, but the intra-genotype concentration ranges were large and greater than the inter-genotype differences. Consequently, there were no associations between genotypes and low birthweight babies or perinatal infections, and only a weak relationship with preterm deliveries, despite all three adverse pregnancy features being significantly associated with serum ficolin-2 protein. FCN2 genotyping may be of value in clinical studies, but not as a substitute for total serum ficolin-2 protein measurement. Swierzko, Anna St. oth Matsushita, Misao oth Domzalska-Popadiuk, Iwona oth Borkowska-Klos, Monika oth Szczapa, Jerzy oth Cedzynski, Maciej oth Enthalten in Elsevier Science Hoffman, Brenton D. ELSEVIER Towards a Dynamic Understanding of Cadherin-Based Mechanobiology 2015 official journal of the American Society for Histocompatibility and Immunogenetics (ASHI) Amsterdam [u.a.] (DE-627)ELV000456578 volume:74 year:2013 number:7 pages:867-871 extent:5 https://doi.org/10.1016/j.humimm.2013.04.011 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV SSG-OLC-PHA AR 74 2013 7 867-871 5 045F 610 |
| spelling |
10.1016/j.humimm.2013.04.011 doi GBVA2013007000025.pica (DE-627)ELV01672531X (ELSEVIER)S0198-8859(13)00097-9 DE-627 ger DE-627 rakwb eng 610 610 DE-600 570 VZ BIODIV DE-30 fid Kilpatrick, David C. verfasserin aut The relationship between FCN2 genotypes and serum ficolin-2 (L-ficolin) protein concentrations from a large cohort of neonates 2013transfer abstract 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The human FCN2 gene codes for ficolin-2 (L-ficolin), a major pattern recognition molecule and activator of the lectin pathway of complement. Seven single nucleotide polymorphisms of this gene were investigated in a large series of cord blood DNA samples. Mutations from the majority to the minority alleles at −602, −4 and +6359 were associated with an increase, while mutations at −986, −557, −64 and +6424 were associated with a decrease, in protein concentration. Full (7loci) genotypes were obtained for 1229 unrelated neonates, 12 sets of twin siblings and one set of triplets. Forty-four separate genotypes were detected. Four genotypes accounted for more than half the unrelated neonates, and >90% had one of the 12 commonest genotypes. Genotypes were associated with significant differences in mean serum ficolin-2, but the intra-genotype concentration ranges were large and greater than the inter-genotype differences. Consequently, there were no associations between genotypes and low birthweight babies or perinatal infections, and only a weak relationship with preterm deliveries, despite all three adverse pregnancy features being significantly associated with serum ficolin-2 protein. FCN2 genotyping may be of value in clinical studies, but not as a substitute for total serum ficolin-2 protein measurement. The human FCN2 gene codes for ficolin-2 (L-ficolin), a major pattern recognition molecule and activator of the lectin pathway of complement. Seven single nucleotide polymorphisms of this gene were investigated in a large series of cord blood DNA samples. Mutations from the majority to the minority alleles at −602, −4 and +6359 were associated with an increase, while mutations at −986, −557, −64 and +6424 were associated with a decrease, in protein concentration. Full (7loci) genotypes were obtained for 1229 unrelated neonates, 12 sets of twin siblings and one set of triplets. Forty-four separate genotypes were detected. Four genotypes accounted for more than half the unrelated neonates, and >90% had one of the 12 commonest genotypes. Genotypes were associated with significant differences in mean serum ficolin-2, but the intra-genotype concentration ranges were large and greater than the inter-genotype differences. Consequently, there were no associations between genotypes and low birthweight babies or perinatal infections, and only a weak relationship with preterm deliveries, despite all three adverse pregnancy features being significantly associated with serum ficolin-2 protein. FCN2 genotyping may be of value in clinical studies, but not as a substitute for total serum ficolin-2 protein measurement. Swierzko, Anna St. oth Matsushita, Misao oth Domzalska-Popadiuk, Iwona oth Borkowska-Klos, Monika oth Szczapa, Jerzy oth Cedzynski, Maciej oth Enthalten in Elsevier Science Hoffman, Brenton D. ELSEVIER Towards a Dynamic Understanding of Cadherin-Based Mechanobiology 2015 official journal of the American Society for Histocompatibility and Immunogenetics (ASHI) Amsterdam [u.a.] (DE-627)ELV000456578 volume:74 year:2013 number:7 pages:867-871 extent:5 https://doi.org/10.1016/j.humimm.2013.04.011 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV SSG-OLC-PHA AR 74 2013 7 867-871 5 045F 610 |
| allfields_unstemmed |
10.1016/j.humimm.2013.04.011 doi GBVA2013007000025.pica (DE-627)ELV01672531X (ELSEVIER)S0198-8859(13)00097-9 DE-627 ger DE-627 rakwb eng 610 610 DE-600 570 VZ BIODIV DE-30 fid Kilpatrick, David C. verfasserin aut The relationship between FCN2 genotypes and serum ficolin-2 (L-ficolin) protein concentrations from a large cohort of neonates 2013transfer abstract 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The human FCN2 gene codes for ficolin-2 (L-ficolin), a major pattern recognition molecule and activator of the lectin pathway of complement. Seven single nucleotide polymorphisms of this gene were investigated in a large series of cord blood DNA samples. Mutations from the majority to the minority alleles at −602, −4 and +6359 were associated with an increase, while mutations at −986, −557, −64 and +6424 were associated with a decrease, in protein concentration. Full (7loci) genotypes were obtained for 1229 unrelated neonates, 12 sets of twin siblings and one set of triplets. Forty-four separate genotypes were detected. Four genotypes accounted for more than half the unrelated neonates, and >90% had one of the 12 commonest genotypes. Genotypes were associated with significant differences in mean serum ficolin-2, but the intra-genotype concentration ranges were large and greater than the inter-genotype differences. Consequently, there were no associations between genotypes and low birthweight babies or perinatal infections, and only a weak relationship with preterm deliveries, despite all three adverse pregnancy features being significantly associated with serum ficolin-2 protein. FCN2 genotyping may be of value in clinical studies, but not as a substitute for total serum ficolin-2 protein measurement. The human FCN2 gene codes for ficolin-2 (L-ficolin), a major pattern recognition molecule and activator of the lectin pathway of complement. Seven single nucleotide polymorphisms of this gene were investigated in a large series of cord blood DNA samples. Mutations from the majority to the minority alleles at −602, −4 and +6359 were associated with an increase, while mutations at −986, −557, −64 and +6424 were associated with a decrease, in protein concentration. Full (7loci) genotypes were obtained for 1229 unrelated neonates, 12 sets of twin siblings and one set of triplets. Forty-four separate genotypes were detected. Four genotypes accounted for more than half the unrelated neonates, and >90% had one of the 12 commonest genotypes. Genotypes were associated with significant differences in mean serum ficolin-2, but the intra-genotype concentration ranges were large and greater than the inter-genotype differences. Consequently, there were no associations between genotypes and low birthweight babies or perinatal infections, and only a weak relationship with preterm deliveries, despite all three adverse pregnancy features being significantly associated with serum ficolin-2 protein. FCN2 genotyping may be of value in clinical studies, but not as a substitute for total serum ficolin-2 protein measurement. Swierzko, Anna St. oth Matsushita, Misao oth Domzalska-Popadiuk, Iwona oth Borkowska-Klos, Monika oth Szczapa, Jerzy oth Cedzynski, Maciej oth Enthalten in Elsevier Science Hoffman, Brenton D. ELSEVIER Towards a Dynamic Understanding of Cadherin-Based Mechanobiology 2015 official journal of the American Society for Histocompatibility and Immunogenetics (ASHI) Amsterdam [u.a.] (DE-627)ELV000456578 volume:74 year:2013 number:7 pages:867-871 extent:5 https://doi.org/10.1016/j.humimm.2013.04.011 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV SSG-OLC-PHA AR 74 2013 7 867-871 5 045F 610 |
| allfieldsGer |
10.1016/j.humimm.2013.04.011 doi GBVA2013007000025.pica (DE-627)ELV01672531X (ELSEVIER)S0198-8859(13)00097-9 DE-627 ger DE-627 rakwb eng 610 610 DE-600 570 VZ BIODIV DE-30 fid Kilpatrick, David C. verfasserin aut The relationship between FCN2 genotypes and serum ficolin-2 (L-ficolin) protein concentrations from a large cohort of neonates 2013transfer abstract 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The human FCN2 gene codes for ficolin-2 (L-ficolin), a major pattern recognition molecule and activator of the lectin pathway of complement. Seven single nucleotide polymorphisms of this gene were investigated in a large series of cord blood DNA samples. Mutations from the majority to the minority alleles at −602, −4 and +6359 were associated with an increase, while mutations at −986, −557, −64 and +6424 were associated with a decrease, in protein concentration. Full (7loci) genotypes were obtained for 1229 unrelated neonates, 12 sets of twin siblings and one set of triplets. Forty-four separate genotypes were detected. Four genotypes accounted for more than half the unrelated neonates, and >90% had one of the 12 commonest genotypes. Genotypes were associated with significant differences in mean serum ficolin-2, but the intra-genotype concentration ranges were large and greater than the inter-genotype differences. Consequently, there were no associations between genotypes and low birthweight babies or perinatal infections, and only a weak relationship with preterm deliveries, despite all three adverse pregnancy features being significantly associated with serum ficolin-2 protein. FCN2 genotyping may be of value in clinical studies, but not as a substitute for total serum ficolin-2 protein measurement. The human FCN2 gene codes for ficolin-2 (L-ficolin), a major pattern recognition molecule and activator of the lectin pathway of complement. Seven single nucleotide polymorphisms of this gene were investigated in a large series of cord blood DNA samples. Mutations from the majority to the minority alleles at −602, −4 and +6359 were associated with an increase, while mutations at −986, −557, −64 and +6424 were associated with a decrease, in protein concentration. Full (7loci) genotypes were obtained for 1229 unrelated neonates, 12 sets of twin siblings and one set of triplets. Forty-four separate genotypes were detected. Four genotypes accounted for more than half the unrelated neonates, and >90% had one of the 12 commonest genotypes. Genotypes were associated with significant differences in mean serum ficolin-2, but the intra-genotype concentration ranges were large and greater than the inter-genotype differences. Consequently, there were no associations between genotypes and low birthweight babies or perinatal infections, and only a weak relationship with preterm deliveries, despite all three adverse pregnancy features being significantly associated with serum ficolin-2 protein. FCN2 genotyping may be of value in clinical studies, but not as a substitute for total serum ficolin-2 protein measurement. Swierzko, Anna St. oth Matsushita, Misao oth Domzalska-Popadiuk, Iwona oth Borkowska-Klos, Monika oth Szczapa, Jerzy oth Cedzynski, Maciej oth Enthalten in Elsevier Science Hoffman, Brenton D. ELSEVIER Towards a Dynamic Understanding of Cadherin-Based Mechanobiology 2015 official journal of the American Society for Histocompatibility and Immunogenetics (ASHI) Amsterdam [u.a.] (DE-627)ELV000456578 volume:74 year:2013 number:7 pages:867-871 extent:5 https://doi.org/10.1016/j.humimm.2013.04.011 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV SSG-OLC-PHA AR 74 2013 7 867-871 5 045F 610 |
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10.1016/j.humimm.2013.04.011 doi GBVA2013007000025.pica (DE-627)ELV01672531X (ELSEVIER)S0198-8859(13)00097-9 DE-627 ger DE-627 rakwb eng 610 610 DE-600 570 VZ BIODIV DE-30 fid Kilpatrick, David C. verfasserin aut The relationship between FCN2 genotypes and serum ficolin-2 (L-ficolin) protein concentrations from a large cohort of neonates 2013transfer abstract 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The human FCN2 gene codes for ficolin-2 (L-ficolin), a major pattern recognition molecule and activator of the lectin pathway of complement. Seven single nucleotide polymorphisms of this gene were investigated in a large series of cord blood DNA samples. Mutations from the majority to the minority alleles at −602, −4 and +6359 were associated with an increase, while mutations at −986, −557, −64 and +6424 were associated with a decrease, in protein concentration. Full (7loci) genotypes were obtained for 1229 unrelated neonates, 12 sets of twin siblings and one set of triplets. Forty-four separate genotypes were detected. Four genotypes accounted for more than half the unrelated neonates, and >90% had one of the 12 commonest genotypes. Genotypes were associated with significant differences in mean serum ficolin-2, but the intra-genotype concentration ranges were large and greater than the inter-genotype differences. Consequently, there were no associations between genotypes and low birthweight babies or perinatal infections, and only a weak relationship with preterm deliveries, despite all three adverse pregnancy features being significantly associated with serum ficolin-2 protein. FCN2 genotyping may be of value in clinical studies, but not as a substitute for total serum ficolin-2 protein measurement. The human FCN2 gene codes for ficolin-2 (L-ficolin), a major pattern recognition molecule and activator of the lectin pathway of complement. Seven single nucleotide polymorphisms of this gene were investigated in a large series of cord blood DNA samples. Mutations from the majority to the minority alleles at −602, −4 and +6359 were associated with an increase, while mutations at −986, −557, −64 and +6424 were associated with a decrease, in protein concentration. Full (7loci) genotypes were obtained for 1229 unrelated neonates, 12 sets of twin siblings and one set of triplets. Forty-four separate genotypes were detected. Four genotypes accounted for more than half the unrelated neonates, and >90% had one of the 12 commonest genotypes. Genotypes were associated with significant differences in mean serum ficolin-2, but the intra-genotype concentration ranges were large and greater than the inter-genotype differences. Consequently, there were no associations between genotypes and low birthweight babies or perinatal infections, and only a weak relationship with preterm deliveries, despite all three adverse pregnancy features being significantly associated with serum ficolin-2 protein. FCN2 genotyping may be of value in clinical studies, but not as a substitute for total serum ficolin-2 protein measurement. Swierzko, Anna St. oth Matsushita, Misao oth Domzalska-Popadiuk, Iwona oth Borkowska-Klos, Monika oth Szczapa, Jerzy oth Cedzynski, Maciej oth Enthalten in Elsevier Science Hoffman, Brenton D. ELSEVIER Towards a Dynamic Understanding of Cadherin-Based Mechanobiology 2015 official journal of the American Society for Histocompatibility and Immunogenetics (ASHI) Amsterdam [u.a.] (DE-627)ELV000456578 volume:74 year:2013 number:7 pages:867-871 extent:5 https://doi.org/10.1016/j.humimm.2013.04.011 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV SSG-OLC-PHA AR 74 2013 7 867-871 5 045F 610 |
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relationship between fcn2 genotypes and serum ficolin-2 (l-ficolin) protein concentrations from a large cohort of neonates |
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The relationship between FCN2 genotypes and serum ficolin-2 (L-ficolin) protein concentrations from a large cohort of neonates |
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The human FCN2 gene codes for ficolin-2 (L-ficolin), a major pattern recognition molecule and activator of the lectin pathway of complement. Seven single nucleotide polymorphisms of this gene were investigated in a large series of cord blood DNA samples. Mutations from the majority to the minority alleles at −602, −4 and +6359 were associated with an increase, while mutations at −986, −557, −64 and +6424 were associated with a decrease, in protein concentration. Full (7loci) genotypes were obtained for 1229 unrelated neonates, 12 sets of twin siblings and one set of triplets. Forty-four separate genotypes were detected. Four genotypes accounted for more than half the unrelated neonates, and >90% had one of the 12 commonest genotypes. Genotypes were associated with significant differences in mean serum ficolin-2, but the intra-genotype concentration ranges were large and greater than the inter-genotype differences. Consequently, there were no associations between genotypes and low birthweight babies or perinatal infections, and only a weak relationship with preterm deliveries, despite all three adverse pregnancy features being significantly associated with serum ficolin-2 protein. FCN2 genotyping may be of value in clinical studies, but not as a substitute for total serum ficolin-2 protein measurement. |
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The human FCN2 gene codes for ficolin-2 (L-ficolin), a major pattern recognition molecule and activator of the lectin pathway of complement. Seven single nucleotide polymorphisms of this gene were investigated in a large series of cord blood DNA samples. Mutations from the majority to the minority alleles at −602, −4 and +6359 were associated with an increase, while mutations at −986, −557, −64 and +6424 were associated with a decrease, in protein concentration. Full (7loci) genotypes were obtained for 1229 unrelated neonates, 12 sets of twin siblings and one set of triplets. Forty-four separate genotypes were detected. Four genotypes accounted for more than half the unrelated neonates, and >90% had one of the 12 commonest genotypes. Genotypes were associated with significant differences in mean serum ficolin-2, but the intra-genotype concentration ranges were large and greater than the inter-genotype differences. Consequently, there were no associations between genotypes and low birthweight babies or perinatal infections, and only a weak relationship with preterm deliveries, despite all three adverse pregnancy features being significantly associated with serum ficolin-2 protein. FCN2 genotyping may be of value in clinical studies, but not as a substitute for total serum ficolin-2 protein measurement. |
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The human FCN2 gene codes for ficolin-2 (L-ficolin), a major pattern recognition molecule and activator of the lectin pathway of complement. Seven single nucleotide polymorphisms of this gene were investigated in a large series of cord blood DNA samples. Mutations from the majority to the minority alleles at −602, −4 and +6359 were associated with an increase, while mutations at −986, −557, −64 and +6424 were associated with a decrease, in protein concentration. Full (7loci) genotypes were obtained for 1229 unrelated neonates, 12 sets of twin siblings and one set of triplets. Forty-four separate genotypes were detected. Four genotypes accounted for more than half the unrelated neonates, and >90% had one of the 12 commonest genotypes. Genotypes were associated with significant differences in mean serum ficolin-2, but the intra-genotype concentration ranges were large and greater than the inter-genotype differences. Consequently, there were no associations between genotypes and low birthweight babies or perinatal infections, and only a weak relationship with preterm deliveries, despite all three adverse pregnancy features being significantly associated with serum ficolin-2 protein. FCN2 genotyping may be of value in clinical studies, but not as a substitute for total serum ficolin-2 protein measurement. |
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The relationship between FCN2 genotypes and serum ficolin-2 (L-ficolin) protein concentrations from a large cohort of neonates |
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