Cyclooxygenase and cytokine regulation in lung fibroblasts activated with viral versus bacterial pathogen associated molecular patterns
• Human lung fibroblasts are particularly sensitive to activation of Toll-like receptor 3. • Cyclooxygenase inhibition abolishes PGE2 and enhances IL-8 and IP-10 release from human lung fibroblasts. • Cyclooxygenase-1 or cyclooxygenase-2 activity limit mouse lung fibroblast KC levels. • PGE2 levels...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Wright, William R. [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
2013 |
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| Schlagwörter: |
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| Umfang: |
9 |
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| Übergeordnetes Werk: |
Enthalten in: Radial growth response of trees to seasonal soil humidity in a subtropical forest - Gheyret, Gheyur ELSEVIER, 2021, an international journal, New York, NY |
|---|---|
| Übergeordnetes Werk: |
volume:107 ; year:2013 ; pages:4-12 ; extent:9 |
| Links: |
|---|
| DOI / URN: |
10.1016/j.prostaglandins.2013.05.006 |
|---|
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cyclooxygenase and cytokine regulation in lung fibroblasts activated with viral versus bacterial pathogen associated molecular patterns |
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Cyclooxygenase and cytokine regulation in lung fibroblasts activated with viral versus bacterial pathogen associated molecular patterns |
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• Human lung fibroblasts are particularly sensitive to activation of Toll-like receptor 3. • Cyclooxygenase inhibition abolishes PGE2 and enhances IL-8 and IP-10 release from human lung fibroblasts. • Cyclooxygenase-1 or cyclooxygenase-2 activity limit mouse lung fibroblast KC levels. • PGE2 levels correlate to KC and IP-10 release from human lung fibroblasts, but not mouse lung fibroblasts. |
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• Human lung fibroblasts are particularly sensitive to activation of Toll-like receptor 3. • Cyclooxygenase inhibition abolishes PGE2 and enhances IL-8 and IP-10 release from human lung fibroblasts. • Cyclooxygenase-1 or cyclooxygenase-2 activity limit mouse lung fibroblast KC levels. • PGE2 levels correlate to KC and IP-10 release from human lung fibroblasts, but not mouse lung fibroblasts. |
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• Human lung fibroblasts are particularly sensitive to activation of Toll-like receptor 3. • Cyclooxygenase inhibition abolishes PGE2 and enhances IL-8 and IP-10 release from human lung fibroblasts. • Cyclooxygenase-1 or cyclooxygenase-2 activity limit mouse lung fibroblast KC levels. • PGE2 levels correlate to KC and IP-10 release from human lung fibroblasts, but not mouse lung fibroblasts. |
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| doi_str |
10.1016/j.prostaglandins.2013.05.006 |
| up_date |
2024-07-06T21:00:41.724Z |
| _version_ |
1803864917120385024 |
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