Gas6 induces cancer cell migration and epithelial–mesenchymal transition through upregulation of MAPK and Slug
• We investigated the molecular mechanisms underlying Gas6-mediated cancer cell migration. • Gas6 treatment and subsequent Axl activation induce cell migration and EMT via upregulation of Slug. • Slug expression mediated by Gas6 is mainly through c-Jun and ATF-2 in an ERK1/2 and JNK-dependent manner...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Lee, Yunhee [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
2013 |
|---|
| Schlagwörter: |
|---|
| Umfang: |
7 |
|---|
| Übergeordnetes Werk: |
Enthalten in: Preparation and characterization of glass-ceramics via co-sintering of coal fly ash and oil shale ash-derived amorphous slag - Zhang, Zhikun ELSEVIER, 2019, BBRC, Orlando, Fla |
|---|---|
| Übergeordnetes Werk: |
volume:434 ; year:2013 ; number:1 ; day:26 ; month:04 ; pages:8-14 ; extent:7 |
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| DOI / URN: |
10.1016/j.bbrc.2013.03.082 |
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Gas6 induces cancer cell migration and epithelial–mesenchymal transition through upregulation of MAPK and Slug |
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• We investigated the molecular mechanisms underlying Gas6-mediated cancer cell migration. • Gas6 treatment and subsequent Axl activation induce cell migration and EMT via upregulation of Slug. • Slug expression mediated by Gas6 is mainly through c-Jun and ATF-2 in an ERK1/2 and JNK-dependent manner. • The Gas6/Axl-Slug axis may be exploited as a target for anti-cancer metastasis therapy. |
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• We investigated the molecular mechanisms underlying Gas6-mediated cancer cell migration. • Gas6 treatment and subsequent Axl activation induce cell migration and EMT via upregulation of Slug. • Slug expression mediated by Gas6 is mainly through c-Jun and ATF-2 in an ERK1/2 and JNK-dependent manner. • The Gas6/Axl-Slug axis may be exploited as a target for anti-cancer metastasis therapy. |
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• We investigated the molecular mechanisms underlying Gas6-mediated cancer cell migration. • Gas6 treatment and subsequent Axl activation induce cell migration and EMT via upregulation of Slug. • Slug expression mediated by Gas6 is mainly through c-Jun and ATF-2 in an ERK1/2 and JNK-dependent manner. • The Gas6/Axl-Slug axis may be exploited as a target for anti-cancer metastasis therapy. |
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