Cytoreductive Nephrectomy in Patients with Synchronous Metastases from Renal Cell Carcinoma: Results from the International Metastatic Renal Cell Carcinoma Database Consortium
Background: The benefit of cytoreductive nephrectomy (CN) for overall survival (OS) is unclear in patients with synchronous metastatic renal cell carcinoma (mRCC) in the era of targeted therapy.Objective: To determine OS benefit of CN compared with no CN in mRCC patients treated with targeted therap...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Heng, Daniel Y.C. [verfasserIn] Wells, J. Connor [verfasserIn] Rini, Brian I. [verfasserIn] Beuselinck, Benoit [verfasserIn] Lee, Jae-Lyun [verfasserIn] Knox, Jennifer J. [verfasserIn] Bjarnason, Georg A. [verfasserIn] Pal, Sumanta Kumar [verfasserIn] Kollmannsberger, Christian K. [verfasserIn] Yuasa, Takeshi [verfasserIn] Srinivas, Sandy [verfasserIn] Donskov, Frede [verfasserIn] Bamias, Aristotelis [verfasserIn] Wood, Lori A. [verfasserIn] Ernst, D. Scott [verfasserIn] Agarwal, Neeraj [verfasserIn] Vaishampayan, Ulka N. [verfasserIn] Rha, Sun Young [verfasserIn] Kim, Jenny J. [verfasserIn] Choueiri, Toni K. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2014 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: European urology - Amsterdam [u.a.] : Elsevier Science, 1976, 66 |
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| Übergeordnetes Werk: |
volume:66 |
| DOI / URN: |
10.1016/j.eururo.2014.05.034 |
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| Katalog-ID: |
ELV017488257 |
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| 024 | 7 | |a 10.1016/j.eururo.2014.05.034 |2 doi | |
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| 100 | 1 | |a Heng, Daniel Y.C. |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Cytoreductive Nephrectomy in Patients with Synchronous Metastases from Renal Cell Carcinoma: Results from the International Metastatic Renal Cell Carcinoma Database Consortium |
| 264 | 1 | |c 2014 | |
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| 520 | |a Background: The benefit of cytoreductive nephrectomy (CN) for overall survival (OS) is unclear in patients with synchronous metastatic renal cell carcinoma (mRCC) in the era of targeted therapy.Objective: To determine OS benefit of CN compared with no CN in mRCC patients treated with targeted therapies.Design, setting, and participants: Retrospective data from patients with synchronous mRCC (n =1658) from the International Metastatic Renal Cell Carcinoma Database Consortium (IMDC) were used to compare 982 mRCC patients who had a CN with 676 mRCC patients who did not.Outcome measurements and statistical analysis: OS was compared and hazard ratios (HRs) adjusted for IMDC poor prognostic criteria.Results and limitations: Patients who had CN had better IMDC prognostic profiles versus those without (favorable, intermediate, or poor in 9%, 63%, and 28% vs 1%, 45%, and 54%, respectively). The median OS of patients with CN versus without CN was 20.6 versus 9.5 mo (p <0.0001). When adjusted for IMDC criteria to correct for imbalances, the HR of death was 0.60 (95% confidence interval, 0.52–0.69; p <0.0001). Patients estimated to survive <12 mo may receive marginal benefit from CN. Patients who have four or more of the IMDC prognostic criteria did not benefit from CN. Data were collected retrospectively.Conclusions: CN is beneficial in synchronous mRCC patients treated with targeted therapy, even after adjusting for prognostic factors. Patients with estimated survival times <12 mo or four or more IMDC prognostic factors may not benefit from CN. This information may aid in patient selection as we await results from randomized controlled trials.Patient summary: We looked at the survival outcomes of metastatic renal cell carcinoma patients who did or did not have the primary tumor removed. We found that most patients benefited from tumor removal, except for those with four or more IMDC risk factors. | ||
| 650 | 4 | |a Cytoreductive nephrectomy | |
| 650 | 4 | |a Metastatic renal cell carcinoma | |
| 650 | 4 | |a Targeted therapy | |
| 700 | 1 | |a Wells, J. Connor |e verfasserin |4 aut | |
| 700 | 1 | |a Rini, Brian I. |e verfasserin |4 aut | |
| 700 | 1 | |a Beuselinck, Benoit |e verfasserin |4 aut | |
| 700 | 1 | |a Lee, Jae-Lyun |e verfasserin |4 aut | |
| 700 | 1 | |a Knox, Jennifer J. |e verfasserin |4 aut | |
| 700 | 1 | |a Bjarnason, Georg A. |e verfasserin |4 aut | |
| 700 | 1 | |a Pal, Sumanta Kumar |e verfasserin |4 aut | |
| 700 | 1 | |a Kollmannsberger, Christian K. |e verfasserin |4 aut | |
| 700 | 1 | |a Yuasa, Takeshi |e verfasserin |4 aut | |
| 700 | 1 | |a Srinivas, Sandy |e verfasserin |4 aut | |
| 700 | 1 | |a Donskov, Frede |e verfasserin |4 aut | |
| 700 | 1 | |a Bamias, Aristotelis |e verfasserin |4 aut | |
| 700 | 1 | |a Wood, Lori A. |e verfasserin |4 aut | |
| 700 | 1 | |a Ernst, D. Scott |e verfasserin |4 aut | |
| 700 | 1 | |a Agarwal, Neeraj |e verfasserin |4 aut | |
| 700 | 1 | |a Vaishampayan, Ulka N. |e verfasserin |4 aut | |
| 700 | 1 | |a Rha, Sun Young |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Jenny J. |e verfasserin |4 aut | |
| 700 | 1 | |a Choueiri, Toni K. |e verfasserin |4 aut | |
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2014 |
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2014 |
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10.1016/j.eururo.2014.05.034 doi (DE-627)ELV017488257 (ELSEVIER)S0302-2838(14)00494-1 DE-627 ger DE-627 rda eng 610 VZ 44.88 bkl Heng, Daniel Y.C. verfasserin aut Cytoreductive Nephrectomy in Patients with Synchronous Metastases from Renal Cell Carcinoma: Results from the International Metastatic Renal Cell Carcinoma Database Consortium 2014 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: The benefit of cytoreductive nephrectomy (CN) for overall survival (OS) is unclear in patients with synchronous metastatic renal cell carcinoma (mRCC) in the era of targeted therapy.Objective: To determine OS benefit of CN compared with no CN in mRCC patients treated with targeted therapies.Design, setting, and participants: Retrospective data from patients with synchronous mRCC (n =1658) from the International Metastatic Renal Cell Carcinoma Database Consortium (IMDC) were used to compare 982 mRCC patients who had a CN with 676 mRCC patients who did not.Outcome measurements and statistical analysis: OS was compared and hazard ratios (HRs) adjusted for IMDC poor prognostic criteria.Results and limitations: Patients who had CN had better IMDC prognostic profiles versus those without (favorable, intermediate, or poor in 9%, 63%, and 28% vs 1%, 45%, and 54%, respectively). The median OS of patients with CN versus without CN was 20.6 versus 9.5 mo (p <0.0001). When adjusted for IMDC criteria to correct for imbalances, the HR of death was 0.60 (95% confidence interval, 0.52–0.69; p <0.0001). Patients estimated to survive <12 mo may receive marginal benefit from CN. Patients who have four or more of the IMDC prognostic criteria did not benefit from CN. Data were collected retrospectively.Conclusions: CN is beneficial in synchronous mRCC patients treated with targeted therapy, even after adjusting for prognostic factors. Patients with estimated survival times <12 mo or four or more IMDC prognostic factors may not benefit from CN. This information may aid in patient selection as we await results from randomized controlled trials.Patient summary: We looked at the survival outcomes of metastatic renal cell carcinoma patients who did or did not have the primary tumor removed. We found that most patients benefited from tumor removal, except for those with four or more IMDC risk factors. Cytoreductive nephrectomy Metastatic renal cell carcinoma Targeted therapy Wells, J. Connor verfasserin aut Rini, Brian I. verfasserin aut Beuselinck, Benoit verfasserin aut Lee, Jae-Lyun verfasserin aut Knox, Jennifer J. verfasserin aut Bjarnason, Georg A. verfasserin aut Pal, Sumanta Kumar verfasserin aut Kollmannsberger, Christian K. verfasserin aut Yuasa, Takeshi verfasserin aut Srinivas, Sandy verfasserin aut Donskov, Frede verfasserin aut Bamias, Aristotelis verfasserin aut Wood, Lori A. verfasserin aut Ernst, D. Scott verfasserin aut Agarwal, Neeraj verfasserin aut Vaishampayan, Ulka N. verfasserin aut Rha, Sun Young verfasserin aut Kim, Jenny J. verfasserin aut Choueiri, Toni K. verfasserin aut Enthalten in European urology Amsterdam [u.a.] : Elsevier Science, 1976 66 Online-Ressource (DE-627)300191596 (DE-600)1482253-2 (DE-576)099718103 1873-7560 nnns volume:66 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.88 Urologie Nephrologie VZ AR 66 |
| spelling |
10.1016/j.eururo.2014.05.034 doi (DE-627)ELV017488257 (ELSEVIER)S0302-2838(14)00494-1 DE-627 ger DE-627 rda eng 610 VZ 44.88 bkl Heng, Daniel Y.C. verfasserin aut Cytoreductive Nephrectomy in Patients with Synchronous Metastases from Renal Cell Carcinoma: Results from the International Metastatic Renal Cell Carcinoma Database Consortium 2014 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: The benefit of cytoreductive nephrectomy (CN) for overall survival (OS) is unclear in patients with synchronous metastatic renal cell carcinoma (mRCC) in the era of targeted therapy.Objective: To determine OS benefit of CN compared with no CN in mRCC patients treated with targeted therapies.Design, setting, and participants: Retrospective data from patients with synchronous mRCC (n =1658) from the International Metastatic Renal Cell Carcinoma Database Consortium (IMDC) were used to compare 982 mRCC patients who had a CN with 676 mRCC patients who did not.Outcome measurements and statistical analysis: OS was compared and hazard ratios (HRs) adjusted for IMDC poor prognostic criteria.Results and limitations: Patients who had CN had better IMDC prognostic profiles versus those without (favorable, intermediate, or poor in 9%, 63%, and 28% vs 1%, 45%, and 54%, respectively). The median OS of patients with CN versus without CN was 20.6 versus 9.5 mo (p <0.0001). When adjusted for IMDC criteria to correct for imbalances, the HR of death was 0.60 (95% confidence interval, 0.52–0.69; p <0.0001). Patients estimated to survive <12 mo may receive marginal benefit from CN. Patients who have four or more of the IMDC prognostic criteria did not benefit from CN. Data were collected retrospectively.Conclusions: CN is beneficial in synchronous mRCC patients treated with targeted therapy, even after adjusting for prognostic factors. Patients with estimated survival times <12 mo or four or more IMDC prognostic factors may not benefit from CN. This information may aid in patient selection as we await results from randomized controlled trials.Patient summary: We looked at the survival outcomes of metastatic renal cell carcinoma patients who did or did not have the primary tumor removed. We found that most patients benefited from tumor removal, except for those with four or more IMDC risk factors. Cytoreductive nephrectomy Metastatic renal cell carcinoma Targeted therapy Wells, J. Connor verfasserin aut Rini, Brian I. verfasserin aut Beuselinck, Benoit verfasserin aut Lee, Jae-Lyun verfasserin aut Knox, Jennifer J. verfasserin aut Bjarnason, Georg A. verfasserin aut Pal, Sumanta Kumar verfasserin aut Kollmannsberger, Christian K. verfasserin aut Yuasa, Takeshi verfasserin aut Srinivas, Sandy verfasserin aut Donskov, Frede verfasserin aut Bamias, Aristotelis verfasserin aut Wood, Lori A. verfasserin aut Ernst, D. Scott verfasserin aut Agarwal, Neeraj verfasserin aut Vaishampayan, Ulka N. verfasserin aut Rha, Sun Young verfasserin aut Kim, Jenny J. verfasserin aut Choueiri, Toni K. verfasserin aut Enthalten in European urology Amsterdam [u.a.] : Elsevier Science, 1976 66 Online-Ressource (DE-627)300191596 (DE-600)1482253-2 (DE-576)099718103 1873-7560 nnns volume:66 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.88 Urologie Nephrologie VZ AR 66 |
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10.1016/j.eururo.2014.05.034 doi (DE-627)ELV017488257 (ELSEVIER)S0302-2838(14)00494-1 DE-627 ger DE-627 rda eng 610 VZ 44.88 bkl Heng, Daniel Y.C. verfasserin aut Cytoreductive Nephrectomy in Patients with Synchronous Metastases from Renal Cell Carcinoma: Results from the International Metastatic Renal Cell Carcinoma Database Consortium 2014 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: The benefit of cytoreductive nephrectomy (CN) for overall survival (OS) is unclear in patients with synchronous metastatic renal cell carcinoma (mRCC) in the era of targeted therapy.Objective: To determine OS benefit of CN compared with no CN in mRCC patients treated with targeted therapies.Design, setting, and participants: Retrospective data from patients with synchronous mRCC (n =1658) from the International Metastatic Renal Cell Carcinoma Database Consortium (IMDC) were used to compare 982 mRCC patients who had a CN with 676 mRCC patients who did not.Outcome measurements and statistical analysis: OS was compared and hazard ratios (HRs) adjusted for IMDC poor prognostic criteria.Results and limitations: Patients who had CN had better IMDC prognostic profiles versus those without (favorable, intermediate, or poor in 9%, 63%, and 28% vs 1%, 45%, and 54%, respectively). The median OS of patients with CN versus without CN was 20.6 versus 9.5 mo (p <0.0001). When adjusted for IMDC criteria to correct for imbalances, the HR of death was 0.60 (95% confidence interval, 0.52–0.69; p <0.0001). Patients estimated to survive <12 mo may receive marginal benefit from CN. Patients who have four or more of the IMDC prognostic criteria did not benefit from CN. Data were collected retrospectively.Conclusions: CN is beneficial in synchronous mRCC patients treated with targeted therapy, even after adjusting for prognostic factors. Patients with estimated survival times <12 mo or four or more IMDC prognostic factors may not benefit from CN. This information may aid in patient selection as we await results from randomized controlled trials.Patient summary: We looked at the survival outcomes of metastatic renal cell carcinoma patients who did or did not have the primary tumor removed. We found that most patients benefited from tumor removal, except for those with four or more IMDC risk factors. Cytoreductive nephrectomy Metastatic renal cell carcinoma Targeted therapy Wells, J. Connor verfasserin aut Rini, Brian I. verfasserin aut Beuselinck, Benoit verfasserin aut Lee, Jae-Lyun verfasserin aut Knox, Jennifer J. verfasserin aut Bjarnason, Georg A. verfasserin aut Pal, Sumanta Kumar verfasserin aut Kollmannsberger, Christian K. verfasserin aut Yuasa, Takeshi verfasserin aut Srinivas, Sandy verfasserin aut Donskov, Frede verfasserin aut Bamias, Aristotelis verfasserin aut Wood, Lori A. verfasserin aut Ernst, D. Scott verfasserin aut Agarwal, Neeraj verfasserin aut Vaishampayan, Ulka N. verfasserin aut Rha, Sun Young verfasserin aut Kim, Jenny J. verfasserin aut Choueiri, Toni K. verfasserin aut Enthalten in European urology Amsterdam [u.a.] : Elsevier Science, 1976 66 Online-Ressource (DE-627)300191596 (DE-600)1482253-2 (DE-576)099718103 1873-7560 nnns volume:66 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.88 Urologie Nephrologie VZ AR 66 |
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10.1016/j.eururo.2014.05.034 doi (DE-627)ELV017488257 (ELSEVIER)S0302-2838(14)00494-1 DE-627 ger DE-627 rda eng 610 VZ 44.88 bkl Heng, Daniel Y.C. verfasserin aut Cytoreductive Nephrectomy in Patients with Synchronous Metastases from Renal Cell Carcinoma: Results from the International Metastatic Renal Cell Carcinoma Database Consortium 2014 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: The benefit of cytoreductive nephrectomy (CN) for overall survival (OS) is unclear in patients with synchronous metastatic renal cell carcinoma (mRCC) in the era of targeted therapy.Objective: To determine OS benefit of CN compared with no CN in mRCC patients treated with targeted therapies.Design, setting, and participants: Retrospective data from patients with synchronous mRCC (n =1658) from the International Metastatic Renal Cell Carcinoma Database Consortium (IMDC) were used to compare 982 mRCC patients who had a CN with 676 mRCC patients who did not.Outcome measurements and statistical analysis: OS was compared and hazard ratios (HRs) adjusted for IMDC poor prognostic criteria.Results and limitations: Patients who had CN had better IMDC prognostic profiles versus those without (favorable, intermediate, or poor in 9%, 63%, and 28% vs 1%, 45%, and 54%, respectively). The median OS of patients with CN versus without CN was 20.6 versus 9.5 mo (p <0.0001). When adjusted for IMDC criteria to correct for imbalances, the HR of death was 0.60 (95% confidence interval, 0.52–0.69; p <0.0001). Patients estimated to survive <12 mo may receive marginal benefit from CN. Patients who have four or more of the IMDC prognostic criteria did not benefit from CN. Data were collected retrospectively.Conclusions: CN is beneficial in synchronous mRCC patients treated with targeted therapy, even after adjusting for prognostic factors. Patients with estimated survival times <12 mo or four or more IMDC prognostic factors may not benefit from CN. This information may aid in patient selection as we await results from randomized controlled trials.Patient summary: We looked at the survival outcomes of metastatic renal cell carcinoma patients who did or did not have the primary tumor removed. We found that most patients benefited from tumor removal, except for those with four or more IMDC risk factors. Cytoreductive nephrectomy Metastatic renal cell carcinoma Targeted therapy Wells, J. Connor verfasserin aut Rini, Brian I. verfasserin aut Beuselinck, Benoit verfasserin aut Lee, Jae-Lyun verfasserin aut Knox, Jennifer J. verfasserin aut Bjarnason, Georg A. verfasserin aut Pal, Sumanta Kumar verfasserin aut Kollmannsberger, Christian K. verfasserin aut Yuasa, Takeshi verfasserin aut Srinivas, Sandy verfasserin aut Donskov, Frede verfasserin aut Bamias, Aristotelis verfasserin aut Wood, Lori A. verfasserin aut Ernst, D. Scott verfasserin aut Agarwal, Neeraj verfasserin aut Vaishampayan, Ulka N. verfasserin aut Rha, Sun Young verfasserin aut Kim, Jenny J. verfasserin aut Choueiri, Toni K. verfasserin aut Enthalten in European urology Amsterdam [u.a.] : Elsevier Science, 1976 66 Online-Ressource (DE-627)300191596 (DE-600)1482253-2 (DE-576)099718103 1873-7560 nnns volume:66 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.88 Urologie Nephrologie VZ AR 66 |
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10.1016/j.eururo.2014.05.034 doi (DE-627)ELV017488257 (ELSEVIER)S0302-2838(14)00494-1 DE-627 ger DE-627 rda eng 610 VZ 44.88 bkl Heng, Daniel Y.C. verfasserin aut Cytoreductive Nephrectomy in Patients with Synchronous Metastases from Renal Cell Carcinoma: Results from the International Metastatic Renal Cell Carcinoma Database Consortium 2014 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: The benefit of cytoreductive nephrectomy (CN) for overall survival (OS) is unclear in patients with synchronous metastatic renal cell carcinoma (mRCC) in the era of targeted therapy.Objective: To determine OS benefit of CN compared with no CN in mRCC patients treated with targeted therapies.Design, setting, and participants: Retrospective data from patients with synchronous mRCC (n =1658) from the International Metastatic Renal Cell Carcinoma Database Consortium (IMDC) were used to compare 982 mRCC patients who had a CN with 676 mRCC patients who did not.Outcome measurements and statistical analysis: OS was compared and hazard ratios (HRs) adjusted for IMDC poor prognostic criteria.Results and limitations: Patients who had CN had better IMDC prognostic profiles versus those without (favorable, intermediate, or poor in 9%, 63%, and 28% vs 1%, 45%, and 54%, respectively). The median OS of patients with CN versus without CN was 20.6 versus 9.5 mo (p <0.0001). When adjusted for IMDC criteria to correct for imbalances, the HR of death was 0.60 (95% confidence interval, 0.52–0.69; p <0.0001). Patients estimated to survive <12 mo may receive marginal benefit from CN. Patients who have four or more of the IMDC prognostic criteria did not benefit from CN. Data were collected retrospectively.Conclusions: CN is beneficial in synchronous mRCC patients treated with targeted therapy, even after adjusting for prognostic factors. Patients with estimated survival times <12 mo or four or more IMDC prognostic factors may not benefit from CN. This information may aid in patient selection as we await results from randomized controlled trials.Patient summary: We looked at the survival outcomes of metastatic renal cell carcinoma patients who did or did not have the primary tumor removed. We found that most patients benefited from tumor removal, except for those with four or more IMDC risk factors. Cytoreductive nephrectomy Metastatic renal cell carcinoma Targeted therapy Wells, J. Connor verfasserin aut Rini, Brian I. verfasserin aut Beuselinck, Benoit verfasserin aut Lee, Jae-Lyun verfasserin aut Knox, Jennifer J. verfasserin aut Bjarnason, Georg A. verfasserin aut Pal, Sumanta Kumar verfasserin aut Kollmannsberger, Christian K. verfasserin aut Yuasa, Takeshi verfasserin aut Srinivas, Sandy verfasserin aut Donskov, Frede verfasserin aut Bamias, Aristotelis verfasserin aut Wood, Lori A. verfasserin aut Ernst, D. Scott verfasserin aut Agarwal, Neeraj verfasserin aut Vaishampayan, Ulka N. verfasserin aut Rha, Sun Young verfasserin aut Kim, Jenny J. verfasserin aut Choueiri, Toni K. verfasserin aut Enthalten in European urology Amsterdam [u.a.] : Elsevier Science, 1976 66 Online-Ressource (DE-627)300191596 (DE-600)1482253-2 (DE-576)099718103 1873-7560 nnns volume:66 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.88 Urologie Nephrologie VZ AR 66 |
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Heng, Daniel Y.C. @@aut@@ Wells, J. Connor @@aut@@ Rini, Brian I. @@aut@@ Beuselinck, Benoit @@aut@@ Lee, Jae-Lyun @@aut@@ Knox, Jennifer J. @@aut@@ Bjarnason, Georg A. @@aut@@ Pal, Sumanta Kumar @@aut@@ Kollmannsberger, Christian K. @@aut@@ Yuasa, Takeshi @@aut@@ Srinivas, Sandy @@aut@@ Donskov, Frede @@aut@@ Bamias, Aristotelis @@aut@@ Wood, Lori A. @@aut@@ Ernst, D. Scott @@aut@@ Agarwal, Neeraj @@aut@@ Vaishampayan, Ulka N. @@aut@@ Rha, Sun Young @@aut@@ Kim, Jenny J. @@aut@@ Choueiri, Toni K. @@aut@@ |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">ELV017488257</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230926161909.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">180602s2014 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.eururo.2014.05.034</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)ELV017488257</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(ELSEVIER)S0302-2838(14)00494-1</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rda</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">44.88</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Heng, Daniel Y.C.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Cytoreductive Nephrectomy in Patients with Synchronous Metastases from Renal Cell Carcinoma: Results from the International Metastatic Renal Cell Carcinoma Database Consortium</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2014</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background: The benefit of cytoreductive nephrectomy (CN) for overall survival (OS) is unclear in patients with synchronous metastatic renal cell carcinoma (mRCC) in the era of targeted therapy.Objective: To determine OS benefit of CN compared with no CN in mRCC patients treated with targeted therapies.Design, setting, and participants: Retrospective data from patients with synchronous mRCC (n =1658) from the International Metastatic Renal Cell Carcinoma Database Consortium (IMDC) were used to compare 982 mRCC patients who had a CN with 676 mRCC patients who did not.Outcome measurements and statistical analysis: OS was compared and hazard ratios (HRs) adjusted for IMDC poor prognostic criteria.Results and limitations: Patients who had CN had better IMDC prognostic profiles versus those without (favorable, intermediate, or poor in 9%, 63%, and 28% vs 1%, 45%, and 54%, respectively). The median OS of patients with CN versus without CN was 20.6 versus 9.5 mo (p <0.0001). When adjusted for IMDC criteria to correct for imbalances, the HR of death was 0.60 (95% confidence interval, 0.52–0.69; p <0.0001). Patients estimated to survive <12 mo may receive marginal benefit from CN. Patients who have four or more of the IMDC prognostic criteria did not benefit from CN. Data were collected retrospectively.Conclusions: CN is beneficial in synchronous mRCC patients treated with targeted therapy, even after adjusting for prognostic factors. Patients with estimated survival times <12 mo or four or more IMDC prognostic factors may not benefit from CN. This information may aid in patient selection as we await results from randomized controlled trials.Patient summary: We looked at the survival outcomes of metastatic renal cell carcinoma patients who did or did not have the primary tumor removed. 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Heng, Daniel Y.C. |
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Heng, Daniel Y.C. ddc 610 bkl 44.88 misc Cytoreductive nephrectomy misc Metastatic renal cell carcinoma misc Targeted therapy Cytoreductive Nephrectomy in Patients with Synchronous Metastases from Renal Cell Carcinoma: Results from the International Metastatic Renal Cell Carcinoma Database Consortium |
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610 VZ 44.88 bkl Cytoreductive Nephrectomy in Patients with Synchronous Metastases from Renal Cell Carcinoma: Results from the International Metastatic Renal Cell Carcinoma Database Consortium Cytoreductive nephrectomy Metastatic renal cell carcinoma Targeted therapy |
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ddc 610 bkl 44.88 misc Cytoreductive nephrectomy misc Metastatic renal cell carcinoma misc Targeted therapy |
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Cytoreductive Nephrectomy in Patients with Synchronous Metastases from Renal Cell Carcinoma: Results from the International Metastatic Renal Cell Carcinoma Database Consortium |
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(DE-627)ELV017488257 (ELSEVIER)S0302-2838(14)00494-1 |
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Cytoreductive Nephrectomy in Patients with Synchronous Metastases from Renal Cell Carcinoma: Results from the International Metastatic Renal Cell Carcinoma Database Consortium |
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Heng, Daniel Y.C. |
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2014 |
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Heng, Daniel Y.C. Wells, J. Connor Rini, Brian I. Beuselinck, Benoit Lee, Jae-Lyun Knox, Jennifer J. Bjarnason, Georg A. Pal, Sumanta Kumar Kollmannsberger, Christian K. Yuasa, Takeshi Srinivas, Sandy Donskov, Frede Bamias, Aristotelis Wood, Lori A. Ernst, D. Scott Agarwal, Neeraj Vaishampayan, Ulka N. Rha, Sun Young Kim, Jenny J. Choueiri, Toni K. |
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10.1016/j.eururo.2014.05.034 |
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cytoreductive nephrectomy in patients with synchronous metastases from renal cell carcinoma: results from the international metastatic renal cell carcinoma database consortium |
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Cytoreductive Nephrectomy in Patients with Synchronous Metastases from Renal Cell Carcinoma: Results from the International Metastatic Renal Cell Carcinoma Database Consortium |
| abstract |
Background: The benefit of cytoreductive nephrectomy (CN) for overall survival (OS) is unclear in patients with synchronous metastatic renal cell carcinoma (mRCC) in the era of targeted therapy.Objective: To determine OS benefit of CN compared with no CN in mRCC patients treated with targeted therapies.Design, setting, and participants: Retrospective data from patients with synchronous mRCC (n =1658) from the International Metastatic Renal Cell Carcinoma Database Consortium (IMDC) were used to compare 982 mRCC patients who had a CN with 676 mRCC patients who did not.Outcome measurements and statistical analysis: OS was compared and hazard ratios (HRs) adjusted for IMDC poor prognostic criteria.Results and limitations: Patients who had CN had better IMDC prognostic profiles versus those without (favorable, intermediate, or poor in 9%, 63%, and 28% vs 1%, 45%, and 54%, respectively). The median OS of patients with CN versus without CN was 20.6 versus 9.5 mo (p <0.0001). When adjusted for IMDC criteria to correct for imbalances, the HR of death was 0.60 (95% confidence interval, 0.52–0.69; p <0.0001). Patients estimated to survive <12 mo may receive marginal benefit from CN. Patients who have four or more of the IMDC prognostic criteria did not benefit from CN. Data were collected retrospectively.Conclusions: CN is beneficial in synchronous mRCC patients treated with targeted therapy, even after adjusting for prognostic factors. Patients with estimated survival times <12 mo or four or more IMDC prognostic factors may not benefit from CN. This information may aid in patient selection as we await results from randomized controlled trials.Patient summary: We looked at the survival outcomes of metastatic renal cell carcinoma patients who did or did not have the primary tumor removed. We found that most patients benefited from tumor removal, except for those with four or more IMDC risk factors. |
| abstractGer |
Background: The benefit of cytoreductive nephrectomy (CN) for overall survival (OS) is unclear in patients with synchronous metastatic renal cell carcinoma (mRCC) in the era of targeted therapy.Objective: To determine OS benefit of CN compared with no CN in mRCC patients treated with targeted therapies.Design, setting, and participants: Retrospective data from patients with synchronous mRCC (n =1658) from the International Metastatic Renal Cell Carcinoma Database Consortium (IMDC) were used to compare 982 mRCC patients who had a CN with 676 mRCC patients who did not.Outcome measurements and statistical analysis: OS was compared and hazard ratios (HRs) adjusted for IMDC poor prognostic criteria.Results and limitations: Patients who had CN had better IMDC prognostic profiles versus those without (favorable, intermediate, or poor in 9%, 63%, and 28% vs 1%, 45%, and 54%, respectively). The median OS of patients with CN versus without CN was 20.6 versus 9.5 mo (p <0.0001). When adjusted for IMDC criteria to correct for imbalances, the HR of death was 0.60 (95% confidence interval, 0.52–0.69; p <0.0001). Patients estimated to survive <12 mo may receive marginal benefit from CN. Patients who have four or more of the IMDC prognostic criteria did not benefit from CN. Data were collected retrospectively.Conclusions: CN is beneficial in synchronous mRCC patients treated with targeted therapy, even after adjusting for prognostic factors. Patients with estimated survival times <12 mo or four or more IMDC prognostic factors may not benefit from CN. This information may aid in patient selection as we await results from randomized controlled trials.Patient summary: We looked at the survival outcomes of metastatic renal cell carcinoma patients who did or did not have the primary tumor removed. We found that most patients benefited from tumor removal, except for those with four or more IMDC risk factors. |
| abstract_unstemmed |
Background: The benefit of cytoreductive nephrectomy (CN) for overall survival (OS) is unclear in patients with synchronous metastatic renal cell carcinoma (mRCC) in the era of targeted therapy.Objective: To determine OS benefit of CN compared with no CN in mRCC patients treated with targeted therapies.Design, setting, and participants: Retrospective data from patients with synchronous mRCC (n =1658) from the International Metastatic Renal Cell Carcinoma Database Consortium (IMDC) were used to compare 982 mRCC patients who had a CN with 676 mRCC patients who did not.Outcome measurements and statistical analysis: OS was compared and hazard ratios (HRs) adjusted for IMDC poor prognostic criteria.Results and limitations: Patients who had CN had better IMDC prognostic profiles versus those without (favorable, intermediate, or poor in 9%, 63%, and 28% vs 1%, 45%, and 54%, respectively). The median OS of patients with CN versus without CN was 20.6 versus 9.5 mo (p <0.0001). When adjusted for IMDC criteria to correct for imbalances, the HR of death was 0.60 (95% confidence interval, 0.52–0.69; p <0.0001). Patients estimated to survive <12 mo may receive marginal benefit from CN. Patients who have four or more of the IMDC prognostic criteria did not benefit from CN. Data were collected retrospectively.Conclusions: CN is beneficial in synchronous mRCC patients treated with targeted therapy, even after adjusting for prognostic factors. Patients with estimated survival times <12 mo or four or more IMDC prognostic factors may not benefit from CN. This information may aid in patient selection as we await results from randomized controlled trials.Patient summary: We looked at the survival outcomes of metastatic renal cell carcinoma patients who did or did not have the primary tumor removed. We found that most patients benefited from tumor removal, except for those with four or more IMDC risk factors. |
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| title_short |
Cytoreductive Nephrectomy in Patients with Synchronous Metastases from Renal Cell Carcinoma: Results from the International Metastatic Renal Cell Carcinoma Database Consortium |
| remote_bool |
true |
| author2 |
Wells, J. Connor Rini, Brian I. Beuselinck, Benoit Lee, Jae-Lyun Knox, Jennifer J. Bjarnason, Georg A. Pal, Sumanta Kumar Kollmannsberger, Christian K. Yuasa, Takeshi Srinivas, Sandy Donskov, Frede Bamias, Aristotelis Wood, Lori A. Ernst, D. Scott Agarwal, Neeraj Vaishampayan, Ulka N. Rha, Sun Young Kim, Jenny J. Choueiri, Toni K. |
| author2Str |
Wells, J. Connor Rini, Brian I. Beuselinck, Benoit Lee, Jae-Lyun Knox, Jennifer J. Bjarnason, Georg A. Pal, Sumanta Kumar Kollmannsberger, Christian K. Yuasa, Takeshi Srinivas, Sandy Donskov, Frede Bamias, Aristotelis Wood, Lori A. Ernst, D. Scott Agarwal, Neeraj Vaishampayan, Ulka N. Rha, Sun Young Kim, Jenny J. Choueiri, Toni K. |
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300191596 |
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c |
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| doi_str |
10.1016/j.eururo.2014.05.034 |
| up_date |
2024-07-06T22:07:09.695Z |
| _version_ |
1803869098813161472 |
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|
| score |
7.400069 |