Dissecting the transcriptional phenotype of ribosomal protein deficiency: implications for Diamond-Blackfan Anemia
Defects in genes encoding ribosomal proteins cause Diamond Blackfan Anemia (DBA), a red cell aplasia often associated with physical abnormalities. Other bone marrow failure syndromes have been attributed to defects in ribosomal components but the link between erythropoiesis and the ribosome remains...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Aspesi, Anna [verfasserIn] |
|---|
| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2014 |
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| Umfang: |
8 |
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| Übergeordnetes Werk: |
Enthalten in: 26957 A study of dermoscopic features in relation to vitiligo activity - Lee, Jae-Ho ELSEVIER, 2021, an international journal on genes, genomes and evolution, Amsterdam |
|---|---|
| Übergeordnetes Werk: |
volume:545 ; year:2014 ; number:2 ; day:25 ; month:07 ; pages:282-289 ; extent:8 |
| Links: |
|---|
| DOI / URN: |
10.1016/j.gene.2014.04.077 |
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| 520 | |a Defects in genes encoding ribosomal proteins cause Diamond Blackfan Anemia (DBA), a red cell aplasia often associated with physical abnormalities. Other bone marrow failure syndromes have been attributed to defects in ribosomal components but the link between erythropoiesis and the ribosome remains to be fully defined. Several lines of evidence suggest that defects in ribosome synthesis lead to “ribosomal stress” with p53 activation and either cell cycle arrest or induction of apoptosis. Pathways independent of p53 have also been proposed to play a role in DBA pathogenesis. | ||
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10.1016/j.gene.2014.04.077 doi GBVA2014012000021.pica (DE-627)ELV017558867 (ELSEVIER)S0378-1119(14)00583-6 DE-627 ger DE-627 rakwb eng 570 570 DE-600 610 VZ 44.93 bkl Aspesi, Anna verfasserin aut Dissecting the transcriptional phenotype of ribosomal protein deficiency: implications for Diamond-Blackfan Anemia 2014 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Defects in genes encoding ribosomal proteins cause Diamond Blackfan Anemia (DBA), a red cell aplasia often associated with physical abnormalities. Other bone marrow failure syndromes have been attributed to defects in ribosomal components but the link between erythropoiesis and the ribosome remains to be fully defined. Several lines of evidence suggest that defects in ribosome synthesis lead to “ribosomal stress” with p53 activation and either cell cycle arrest or induction of apoptosis. Pathways independent of p53 have also been proposed to play a role in DBA pathogenesis. Pavesi, Elisa oth Robotti, Elisa oth Crescitelli, Rossella oth Boria, Ilenia oth Avondo, Federica oth Moniz, Hélène oth Da Costa, Lydie oth Mohandas, Narla oth Roncaglia, Paola oth Ramenghi, Ugo oth Ronchi, Antonella oth Gustincich, Stefano oth Merlin, Simone oth Marengo, Emilio oth Ellis, Steven R. oth Follenzi, Antonia oth Santoro, Claudio oth Dianzani, Irma oth Enthalten in Elsevier Lee, Jae-Ho ELSEVIER 26957 A study of dermoscopic features in relation to vitiligo activity 2021 an international journal on genes, genomes and evolution Amsterdam (DE-627)ELV006417590 volume:545 year:2014 number:2 day:25 month:07 pages:282-289 extent:8 https://doi.org/10.1016/j.gene.2014.04.077 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.93 Dermatologie VZ AR 545 2014 2 25 0725 282-289 8 045F 570 |
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10.1016/j.gene.2014.04.077 doi GBVA2014012000021.pica (DE-627)ELV017558867 (ELSEVIER)S0378-1119(14)00583-6 DE-627 ger DE-627 rakwb eng 570 570 DE-600 610 VZ 44.93 bkl Aspesi, Anna verfasserin aut Dissecting the transcriptional phenotype of ribosomal protein deficiency: implications for Diamond-Blackfan Anemia 2014 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Defects in genes encoding ribosomal proteins cause Diamond Blackfan Anemia (DBA), a red cell aplasia often associated with physical abnormalities. Other bone marrow failure syndromes have been attributed to defects in ribosomal components but the link between erythropoiesis and the ribosome remains to be fully defined. Several lines of evidence suggest that defects in ribosome synthesis lead to “ribosomal stress” with p53 activation and either cell cycle arrest or induction of apoptosis. Pathways independent of p53 have also been proposed to play a role in DBA pathogenesis. Pavesi, Elisa oth Robotti, Elisa oth Crescitelli, Rossella oth Boria, Ilenia oth Avondo, Federica oth Moniz, Hélène oth Da Costa, Lydie oth Mohandas, Narla oth Roncaglia, Paola oth Ramenghi, Ugo oth Ronchi, Antonella oth Gustincich, Stefano oth Merlin, Simone oth Marengo, Emilio oth Ellis, Steven R. oth Follenzi, Antonia oth Santoro, Claudio oth Dianzani, Irma oth Enthalten in Elsevier Lee, Jae-Ho ELSEVIER 26957 A study of dermoscopic features in relation to vitiligo activity 2021 an international journal on genes, genomes and evolution Amsterdam (DE-627)ELV006417590 volume:545 year:2014 number:2 day:25 month:07 pages:282-289 extent:8 https://doi.org/10.1016/j.gene.2014.04.077 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.93 Dermatologie VZ AR 545 2014 2 25 0725 282-289 8 045F 570 |
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10.1016/j.gene.2014.04.077 doi GBVA2014012000021.pica (DE-627)ELV017558867 (ELSEVIER)S0378-1119(14)00583-6 DE-627 ger DE-627 rakwb eng 570 570 DE-600 610 VZ 44.93 bkl Aspesi, Anna verfasserin aut Dissecting the transcriptional phenotype of ribosomal protein deficiency: implications for Diamond-Blackfan Anemia 2014 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Defects in genes encoding ribosomal proteins cause Diamond Blackfan Anemia (DBA), a red cell aplasia often associated with physical abnormalities. Other bone marrow failure syndromes have been attributed to defects in ribosomal components but the link between erythropoiesis and the ribosome remains to be fully defined. Several lines of evidence suggest that defects in ribosome synthesis lead to “ribosomal stress” with p53 activation and either cell cycle arrest or induction of apoptosis. Pathways independent of p53 have also been proposed to play a role in DBA pathogenesis. Pavesi, Elisa oth Robotti, Elisa oth Crescitelli, Rossella oth Boria, Ilenia oth Avondo, Federica oth Moniz, Hélène oth Da Costa, Lydie oth Mohandas, Narla oth Roncaglia, Paola oth Ramenghi, Ugo oth Ronchi, Antonella oth Gustincich, Stefano oth Merlin, Simone oth Marengo, Emilio oth Ellis, Steven R. oth Follenzi, Antonia oth Santoro, Claudio oth Dianzani, Irma oth Enthalten in Elsevier Lee, Jae-Ho ELSEVIER 26957 A study of dermoscopic features in relation to vitiligo activity 2021 an international journal on genes, genomes and evolution Amsterdam (DE-627)ELV006417590 volume:545 year:2014 number:2 day:25 month:07 pages:282-289 extent:8 https://doi.org/10.1016/j.gene.2014.04.077 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.93 Dermatologie VZ AR 545 2014 2 25 0725 282-289 8 045F 570 |
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10.1016/j.gene.2014.04.077 doi GBVA2014012000021.pica (DE-627)ELV017558867 (ELSEVIER)S0378-1119(14)00583-6 DE-627 ger DE-627 rakwb eng 570 570 DE-600 610 VZ 44.93 bkl Aspesi, Anna verfasserin aut Dissecting the transcriptional phenotype of ribosomal protein deficiency: implications for Diamond-Blackfan Anemia 2014 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Defects in genes encoding ribosomal proteins cause Diamond Blackfan Anemia (DBA), a red cell aplasia often associated with physical abnormalities. Other bone marrow failure syndromes have been attributed to defects in ribosomal components but the link between erythropoiesis and the ribosome remains to be fully defined. Several lines of evidence suggest that defects in ribosome synthesis lead to “ribosomal stress” with p53 activation and either cell cycle arrest or induction of apoptosis. Pathways independent of p53 have also been proposed to play a role in DBA pathogenesis. Pavesi, Elisa oth Robotti, Elisa oth Crescitelli, Rossella oth Boria, Ilenia oth Avondo, Federica oth Moniz, Hélène oth Da Costa, Lydie oth Mohandas, Narla oth Roncaglia, Paola oth Ramenghi, Ugo oth Ronchi, Antonella oth Gustincich, Stefano oth Merlin, Simone oth Marengo, Emilio oth Ellis, Steven R. oth Follenzi, Antonia oth Santoro, Claudio oth Dianzani, Irma oth Enthalten in Elsevier Lee, Jae-Ho ELSEVIER 26957 A study of dermoscopic features in relation to vitiligo activity 2021 an international journal on genes, genomes and evolution Amsterdam (DE-627)ELV006417590 volume:545 year:2014 number:2 day:25 month:07 pages:282-289 extent:8 https://doi.org/10.1016/j.gene.2014.04.077 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.93 Dermatologie VZ AR 545 2014 2 25 0725 282-289 8 045F 570 |
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10.1016/j.gene.2014.04.077 doi GBVA2014012000021.pica (DE-627)ELV017558867 (ELSEVIER)S0378-1119(14)00583-6 DE-627 ger DE-627 rakwb eng 570 570 DE-600 610 VZ 44.93 bkl Aspesi, Anna verfasserin aut Dissecting the transcriptional phenotype of ribosomal protein deficiency: implications for Diamond-Blackfan Anemia 2014 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Defects in genes encoding ribosomal proteins cause Diamond Blackfan Anemia (DBA), a red cell aplasia often associated with physical abnormalities. Other bone marrow failure syndromes have been attributed to defects in ribosomal components but the link between erythropoiesis and the ribosome remains to be fully defined. Several lines of evidence suggest that defects in ribosome synthesis lead to “ribosomal stress” with p53 activation and either cell cycle arrest or induction of apoptosis. Pathways independent of p53 have also been proposed to play a role in DBA pathogenesis. Pavesi, Elisa oth Robotti, Elisa oth Crescitelli, Rossella oth Boria, Ilenia oth Avondo, Federica oth Moniz, Hélène oth Da Costa, Lydie oth Mohandas, Narla oth Roncaglia, Paola oth Ramenghi, Ugo oth Ronchi, Antonella oth Gustincich, Stefano oth Merlin, Simone oth Marengo, Emilio oth Ellis, Steven R. oth Follenzi, Antonia oth Santoro, Claudio oth Dianzani, Irma oth Enthalten in Elsevier Lee, Jae-Ho ELSEVIER 26957 A study of dermoscopic features in relation to vitiligo activity 2021 an international journal on genes, genomes and evolution Amsterdam (DE-627)ELV006417590 volume:545 year:2014 number:2 day:25 month:07 pages:282-289 extent:8 https://doi.org/10.1016/j.gene.2014.04.077 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.93 Dermatologie VZ AR 545 2014 2 25 0725 282-289 8 045F 570 |
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Dissecting the transcriptional phenotype of ribosomal protein deficiency: implications for Diamond-Blackfan Anemia |
| author_sort |
Aspesi, Anna |
| journal |
26957 A study of dermoscopic features in relation to vitiligo activity |
| journalStr |
26957 A study of dermoscopic features in relation to vitiligo activity |
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eng |
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2014 |
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Aspesi, Anna |
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Elektronische Aufsätze |
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Aspesi, Anna |
| doi_str_mv |
10.1016/j.gene.2014.04.077 |
| dewey-full |
570 610 |
| title_sort |
dissecting the transcriptional phenotype of ribosomal protein deficiency: implications for diamond-blackfan anemia |
| title_auth |
Dissecting the transcriptional phenotype of ribosomal protein deficiency: implications for Diamond-Blackfan Anemia |
| abstract |
Defects in genes encoding ribosomal proteins cause Diamond Blackfan Anemia (DBA), a red cell aplasia often associated with physical abnormalities. Other bone marrow failure syndromes have been attributed to defects in ribosomal components but the link between erythropoiesis and the ribosome remains to be fully defined. Several lines of evidence suggest that defects in ribosome synthesis lead to “ribosomal stress” with p53 activation and either cell cycle arrest or induction of apoptosis. Pathways independent of p53 have also been proposed to play a role in DBA pathogenesis. |
| abstractGer |
Defects in genes encoding ribosomal proteins cause Diamond Blackfan Anemia (DBA), a red cell aplasia often associated with physical abnormalities. Other bone marrow failure syndromes have been attributed to defects in ribosomal components but the link between erythropoiesis and the ribosome remains to be fully defined. Several lines of evidence suggest that defects in ribosome synthesis lead to “ribosomal stress” with p53 activation and either cell cycle arrest or induction of apoptosis. Pathways independent of p53 have also been proposed to play a role in DBA pathogenesis. |
| abstract_unstemmed |
Defects in genes encoding ribosomal proteins cause Diamond Blackfan Anemia (DBA), a red cell aplasia often associated with physical abnormalities. Other bone marrow failure syndromes have been attributed to defects in ribosomal components but the link between erythropoiesis and the ribosome remains to be fully defined. Several lines of evidence suggest that defects in ribosome synthesis lead to “ribosomal stress” with p53 activation and either cell cycle arrest or induction of apoptosis. Pathways independent of p53 have also been proposed to play a role in DBA pathogenesis. |
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| title_short |
Dissecting the transcriptional phenotype of ribosomal protein deficiency: implications for Diamond-Blackfan Anemia |
| url |
https://doi.org/10.1016/j.gene.2014.04.077 |
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| author2 |
Pavesi, Elisa Robotti, Elisa Crescitelli, Rossella Boria, Ilenia Avondo, Federica Moniz, Hélène Da Costa, Lydie Mohandas, Narla Roncaglia, Paola Ramenghi, Ugo Ronchi, Antonella Gustincich, Stefano Merlin, Simone Marengo, Emilio Ellis, Steven R. Follenzi, Antonia Santoro, Claudio Dianzani, Irma |
| author2Str |
Pavesi, Elisa Robotti, Elisa Crescitelli, Rossella Boria, Ilenia Avondo, Federica Moniz, Hélène Da Costa, Lydie Mohandas, Narla Roncaglia, Paola Ramenghi, Ugo Ronchi, Antonella Gustincich, Stefano Merlin, Simone Marengo, Emilio Ellis, Steven R. Follenzi, Antonia Santoro, Claudio Dianzani, Irma |
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| doi_str |
10.1016/j.gene.2014.04.077 |
| up_date |
2024-07-06T16:37:52.729Z |
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