Long-Term Outcomes of Percutaneous Coronary Interventions or Coronary Artery Bypass Grafting for Left Main Coronary Artery Disease in Octogenarians (from a Drug-Eluting stent for LefT main Artery Registry Substudy)

Percutaneous coronary intervention (PCI) with drug-eluting stents is an accepted alternative to surgery for the treatment of unprotected left main coronary artery (ULMCA) disease, but the long-term outcome in elderly patients is unclear. Aim of our study was to compare the clinical outcomes of octog...
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Autor*in:	Conrotto, Federico [verfasserIn] Scacciatella, Paolo D'Ascenzo, Fabrizio Chieffo, Alaide Latib, Azeem Park, Seung Jung Kim, Young Hak Onuma, Yoshinobu Capranzano, Piera Jegere, Sanda Makkar, Raj Palacios, Igor Buszman, Pawel Chakravarty, Tarun Mehran, Roxana Naber, Christoph Margey, Ronan Leon, Martin Moses, Jeffrey Fajadet, Jean Lefèvre, Thierry Morice, Marie Claude Erglis, Andrejs Tamburino, Corrado Alfieri, Ottavio D'Amico, Maurizio Marra, Sebastiano Serruys, Patrick W. Colombo, Antonio Meliga, Emanuele

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2014transfer abstract

Umfang:	6

Übergeordnetes Werk:	Enthalten in: PI simultaneous stabilization and set-point output regulation of Port-Hamiltonian systems - Zhang, Meng ELSEVIER, 2017, official journal of the American College of Cardiology, Amsterdam [u.a.]
Übergeordnetes Werk:	volume:113 ; year:2014 ; number:12 ; day:15 ; month:06 ; pages:2007-2012 ; extent:6

Links:	Volltext

DOI / URN:	10.1016/j.amjcard.2014.03.044

Katalog-ID:	ELV01792071X

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520			\|a Percutaneous coronary intervention (PCI) with drug-eluting stents is an accepted alternative to surgery for the treatment of unprotected left main coronary artery (ULMCA) disease, but the long-term outcome in elderly patients is unclear. Aim of our study was to compare the clinical outcomes of octogenarians with ULMCA disease treated either with PCI with drug-eluting stents or coronary artery bypass grafting (CABG). The primary study end point was the composite of death, cerebrovascular accident, and myocardial infarction at follow-up. A total of 304 consecutive patients with ULMCA stenosis treated with PCI or CABG and aged ≥80 years were selected and analyzed in a large multinational registry. Two hundred eighteen were treated with PCI and 86 with CABG. During the hospitalization, a trend toward a higher mortality rate was reported in PCI-treated patients (3.5% vs 7.3%, p = 0.32). At a median follow-up of 1,088 days, the incidence of the primary end point was similar in the 2 groups (32.6% vs 30.2%, p = 0.69). Incidence of target vessel revascularization at follow-up was higher in PCI-treated patients (10% vs 4.2%, p = 0.05). At multivariate analysis, left ventricular ejection fraction was the only independent predictor of the primary end point (hazard ratio 0.95, 95% confidence interval 0.91 to 0.98, p = 0.001). After adjustment with propensity score, the revascularization strategy was not significantly correlated to the incidence of the primary end point (hazard ratio 0.98, 95% confidence interval 0.57 to 1.71, p = 0.95). In octogenarians, no difference was observed in the occurrence of the primary end point after PCI or CABG for the treatment of ULMCA disease. However, the rate of target vessel revascularization was higher in the PCI group.
520			\|a Percutaneous coronary intervention (PCI) with drug-eluting stents is an accepted alternative to surgery for the treatment of unprotected left main coronary artery (ULMCA) disease, but the long-term outcome in elderly patients is unclear. Aim of our study was to compare the clinical outcomes of octogenarians with ULMCA disease treated either with PCI with drug-eluting stents or coronary artery bypass grafting (CABG). The primary study end point was the composite of death, cerebrovascular accident, and myocardial infarction at follow-up. A total of 304 consecutive patients with ULMCA stenosis treated with PCI or CABG and aged ≥80 years were selected and analyzed in a large multinational registry. Two hundred eighteen were treated with PCI and 86 with CABG. During the hospitalization, a trend toward a higher mortality rate was reported in PCI-treated patients (3.5% vs 7.3%, p = 0.32). At a median follow-up of 1,088 days, the incidence of the primary end point was similar in the 2 groups (32.6% vs 30.2%, p = 0.69). Incidence of target vessel revascularization at follow-up was higher in PCI-treated patients (10% vs 4.2%, p = 0.05). At multivariate analysis, left ventricular ejection fraction was the only independent predictor of the primary end point (hazard ratio 0.95, 95% confidence interval 0.91 to 0.98, p = 0.001). After adjustment with propensity score, the revascularization strategy was not significantly correlated to the incidence of the primary end point (hazard ratio 0.98, 95% confidence interval 0.57 to 1.71, p = 0.95). In octogenarians, no difference was observed in the occurrence of the primary end point after PCI or CABG for the treatment of ULMCA disease. However, the rate of target vessel revascularization was higher in the PCI group.
700	1		\|a Scacciatella, Paolo \|4 oth
700	1		\|a D'Ascenzo, Fabrizio \|4 oth
700	1		\|a Chieffo, Alaide \|4 oth
700	1		\|a Latib, Azeem \|4 oth
700	1		\|a Park, Seung Jung \|4 oth
700	1		\|a Kim, Young Hak \|4 oth
700	1		\|a Onuma, Yoshinobu \|4 oth
700	1		\|a Capranzano, Piera \|4 oth
700	1		\|a Jegere, Sanda \|4 oth
700	1		\|a Makkar, Raj \|4 oth
700	1		\|a Palacios, Igor \|4 oth
700	1		\|a Buszman, Pawel \|4 oth
700	1		\|a Chakravarty, Tarun \|4 oth
700	1		\|a Mehran, Roxana \|4 oth
700	1		\|a Naber, Christoph \|4 oth
700	1		\|a Margey, Ronan \|4 oth
700	1		\|a Leon, Martin \|4 oth
700	1		\|a Moses, Jeffrey \|4 oth
700	1		\|a Fajadet, Jean \|4 oth
700	1		\|a Lefèvre, Thierry \|4 oth
700	1		\|a Morice, Marie Claude \|4 oth
700	1		\|a Erglis, Andrejs \|4 oth
700	1		\|a Tamburino, Corrado \|4 oth
700	1		\|a Alfieri, Ottavio \|4 oth
700	1		\|a D'Amico, Maurizio \|4 oth
700	1		\|a Marra, Sebastiano \|4 oth
700	1		\|a Serruys, Patrick W. \|4 oth
700	1		\|a Colombo, Antonio \|4 oth
700	1		\|a Meliga, Emanuele \|4 oth
773	0	8	\|i Enthalten in \|n Elsevier \|a Zhang, Meng ELSEVIER \|t PI simultaneous stabilization and set-point output regulation of Port-Hamiltonian systems \|d 2017 \|d official journal of the American College of Cardiology \|g Amsterdam [u.a.] \|w (DE-627)ELV000623679
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allfields	10.1016/j.amjcard.2014.03.044 doi GBVA2014019000017.pica (DE-627)ELV01792071X (ELSEVIER)S0002-9149(14)00887-X DE-627 ger DE-627 rakwb eng 610 610 DE-600 510 VZ 31.80 bkl Conrotto, Federico verfasserin aut Long-Term Outcomes of Percutaneous Coronary Interventions or Coronary Artery Bypass Grafting for Left Main Coronary Artery Disease in Octogenarians (from a Drug-Eluting stent for LefT main Artery Registry Substudy) 2014transfer abstract 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Percutaneous coronary intervention (PCI) with drug-eluting stents is an accepted alternative to surgery for the treatment of unprotected left main coronary artery (ULMCA) disease, but the long-term outcome in elderly patients is unclear. Aim of our study was to compare the clinical outcomes of octogenarians with ULMCA disease treated either with PCI with drug-eluting stents or coronary artery bypass grafting (CABG). The primary study end point was the composite of death, cerebrovascular accident, and myocardial infarction at follow-up. A total of 304 consecutive patients with ULMCA stenosis treated with PCI or CABG and aged ≥80 years were selected and analyzed in a large multinational registry. Two hundred eighteen were treated with PCI and 86 with CABG. During the hospitalization, a trend toward a higher mortality rate was reported in PCI-treated patients (3.5% vs 7.3%, p = 0.32). At a median follow-up of 1,088 days, the incidence of the primary end point was similar in the 2 groups (32.6% vs 30.2%, p = 0.69). Incidence of target vessel revascularization at follow-up was higher in PCI-treated patients (10% vs 4.2%, p = 0.05). At multivariate analysis, left ventricular ejection fraction was the only independent predictor of the primary end point (hazard ratio 0.95, 95% confidence interval 0.91 to 0.98, p = 0.001). After adjustment with propensity score, the revascularization strategy was not significantly correlated to the incidence of the primary end point (hazard ratio 0.98, 95% confidence interval 0.57 to 1.71, p = 0.95). In octogenarians, no difference was observed in the occurrence of the primary end point after PCI or CABG for the treatment of ULMCA disease. However, the rate of target vessel revascularization was higher in the PCI group. Percutaneous coronary intervention (PCI) with drug-eluting stents is an accepted alternative to surgery for the treatment of unprotected left main coronary artery (ULMCA) disease, but the long-term outcome in elderly patients is unclear. Aim of our study was to compare the clinical outcomes of octogenarians with ULMCA disease treated either with PCI with drug-eluting stents or coronary artery bypass grafting (CABG). The primary study end point was the composite of death, cerebrovascular accident, and myocardial infarction at follow-up. A total of 304 consecutive patients with ULMCA stenosis treated with PCI or CABG and aged ≥80 years were selected and analyzed in a large multinational registry. Two hundred eighteen were treated with PCI and 86 with CABG. During the hospitalization, a trend toward a higher mortality rate was reported in PCI-treated patients (3.5% vs 7.3%, p = 0.32). At a median follow-up of 1,088 days, the incidence of the primary end point was similar in the 2 groups (32.6% vs 30.2%, p = 0.69). Incidence of target vessel revascularization at follow-up was higher in PCI-treated patients (10% vs 4.2%, p = 0.05). At multivariate analysis, left ventricular ejection fraction was the only independent predictor of the primary end point (hazard ratio 0.95, 95% confidence interval 0.91 to 0.98, p = 0.001). After adjustment with propensity score, the revascularization strategy was not significantly correlated to the incidence of the primary end point (hazard ratio 0.98, 95% confidence interval 0.57 to 1.71, p = 0.95). In octogenarians, no difference was observed in the occurrence of the primary end point after PCI or CABG for the treatment of ULMCA disease. However, the rate of target vessel revascularization was higher in the PCI group. Scacciatella, Paolo oth D'Ascenzo, Fabrizio oth Chieffo, Alaide oth Latib, Azeem oth Park, Seung Jung oth Kim, Young Hak oth Onuma, Yoshinobu oth Capranzano, Piera oth Jegere, Sanda oth Makkar, Raj oth Palacios, Igor oth Buszman, Pawel oth Chakravarty, Tarun oth Mehran, Roxana oth Naber, Christoph oth Margey, Ronan oth Leon, Martin oth Moses, Jeffrey oth Fajadet, Jean oth Lefèvre, Thierry oth Morice, Marie Claude oth Erglis, Andrejs oth Tamburino, Corrado oth Alfieri, Ottavio oth D'Amico, Maurizio oth Marra, Sebastiano oth Serruys, Patrick W. oth Colombo, Antonio oth Meliga, Emanuele oth Enthalten in Elsevier Zhang, Meng ELSEVIER PI simultaneous stabilization and set-point output regulation of Port-Hamiltonian systems 2017 official journal of the American College of Cardiology Amsterdam [u.a.] (DE-627)ELV000623679 volume:113 year:2014 number:12 day:15 month:06 pages:2007-2012 extent:6 https://doi.org/10.1016/j.amjcard.2014.03.044 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-MAT 31.80 Angewandte Mathematik VZ AR 113 2014 12 15 0615 2007-2012 6 045F 610
spelling	10.1016/j.amjcard.2014.03.044 doi GBVA2014019000017.pica (DE-627)ELV01792071X (ELSEVIER)S0002-9149(14)00887-X DE-627 ger DE-627 rakwb eng 610 610 DE-600 510 VZ 31.80 bkl Conrotto, Federico verfasserin aut Long-Term Outcomes of Percutaneous Coronary Interventions or Coronary Artery Bypass Grafting for Left Main Coronary Artery Disease in Octogenarians (from a Drug-Eluting stent for LefT main Artery Registry Substudy) 2014transfer abstract 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Percutaneous coronary intervention (PCI) with drug-eluting stents is an accepted alternative to surgery for the treatment of unprotected left main coronary artery (ULMCA) disease, but the long-term outcome in elderly patients is unclear. Aim of our study was to compare the clinical outcomes of octogenarians with ULMCA disease treated either with PCI with drug-eluting stents or coronary artery bypass grafting (CABG). The primary study end point was the composite of death, cerebrovascular accident, and myocardial infarction at follow-up. A total of 304 consecutive patients with ULMCA stenosis treated with PCI or CABG and aged ≥80 years were selected and analyzed in a large multinational registry. Two hundred eighteen were treated with PCI and 86 with CABG. During the hospitalization, a trend toward a higher mortality rate was reported in PCI-treated patients (3.5% vs 7.3%, p = 0.32). At a median follow-up of 1,088 days, the incidence of the primary end point was similar in the 2 groups (32.6% vs 30.2%, p = 0.69). Incidence of target vessel revascularization at follow-up was higher in PCI-treated patients (10% vs 4.2%, p = 0.05). At multivariate analysis, left ventricular ejection fraction was the only independent predictor of the primary end point (hazard ratio 0.95, 95% confidence interval 0.91 to 0.98, p = 0.001). After adjustment with propensity score, the revascularization strategy was not significantly correlated to the incidence of the primary end point (hazard ratio 0.98, 95% confidence interval 0.57 to 1.71, p = 0.95). In octogenarians, no difference was observed in the occurrence of the primary end point after PCI or CABG for the treatment of ULMCA disease. However, the rate of target vessel revascularization was higher in the PCI group. Percutaneous coronary intervention (PCI) with drug-eluting stents is an accepted alternative to surgery for the treatment of unprotected left main coronary artery (ULMCA) disease, but the long-term outcome in elderly patients is unclear. Aim of our study was to compare the clinical outcomes of octogenarians with ULMCA disease treated either with PCI with drug-eluting stents or coronary artery bypass grafting (CABG). The primary study end point was the composite of death, cerebrovascular accident, and myocardial infarction at follow-up. A total of 304 consecutive patients with ULMCA stenosis treated with PCI or CABG and aged ≥80 years were selected and analyzed in a large multinational registry. Two hundred eighteen were treated with PCI and 86 with CABG. During the hospitalization, a trend toward a higher mortality rate was reported in PCI-treated patients (3.5% vs 7.3%, p = 0.32). At a median follow-up of 1,088 days, the incidence of the primary end point was similar in the 2 groups (32.6% vs 30.2%, p = 0.69). Incidence of target vessel revascularization at follow-up was higher in PCI-treated patients (10% vs 4.2%, p = 0.05). At multivariate analysis, left ventricular ejection fraction was the only independent predictor of the primary end point (hazard ratio 0.95, 95% confidence interval 0.91 to 0.98, p = 0.001). After adjustment with propensity score, the revascularization strategy was not significantly correlated to the incidence of the primary end point (hazard ratio 0.98, 95% confidence interval 0.57 to 1.71, p = 0.95). In octogenarians, no difference was observed in the occurrence of the primary end point after PCI or CABG for the treatment of ULMCA disease. However, the rate of target vessel revascularization was higher in the PCI group. Scacciatella, Paolo oth D'Ascenzo, Fabrizio oth Chieffo, Alaide oth Latib, Azeem oth Park, Seung Jung oth Kim, Young Hak oth Onuma, Yoshinobu oth Capranzano, Piera oth Jegere, Sanda oth Makkar, Raj oth Palacios, Igor oth Buszman, Pawel oth Chakravarty, Tarun oth Mehran, Roxana oth Naber, Christoph oth Margey, Ronan oth Leon, Martin oth Moses, Jeffrey oth Fajadet, Jean oth Lefèvre, Thierry oth Morice, Marie Claude oth Erglis, Andrejs oth Tamburino, Corrado oth Alfieri, Ottavio oth D'Amico, Maurizio oth Marra, Sebastiano oth Serruys, Patrick W. oth Colombo, Antonio oth Meliga, Emanuele oth Enthalten in Elsevier Zhang, Meng ELSEVIER PI simultaneous stabilization and set-point output regulation of Port-Hamiltonian systems 2017 official journal of the American College of Cardiology Amsterdam [u.a.] (DE-627)ELV000623679 volume:113 year:2014 number:12 day:15 month:06 pages:2007-2012 extent:6 https://doi.org/10.1016/j.amjcard.2014.03.044 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-MAT 31.80 Angewandte Mathematik VZ AR 113 2014 12 15 0615 2007-2012 6 045F 610
allfields_unstemmed	10.1016/j.amjcard.2014.03.044 doi GBVA2014019000017.pica (DE-627)ELV01792071X (ELSEVIER)S0002-9149(14)00887-X DE-627 ger DE-627 rakwb eng 610 610 DE-600 510 VZ 31.80 bkl Conrotto, Federico verfasserin aut Long-Term Outcomes of Percutaneous Coronary Interventions or Coronary Artery Bypass Grafting for Left Main Coronary Artery Disease in Octogenarians (from a Drug-Eluting stent for LefT main Artery Registry Substudy) 2014transfer abstract 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Percutaneous coronary intervention (PCI) with drug-eluting stents is an accepted alternative to surgery for the treatment of unprotected left main coronary artery (ULMCA) disease, but the long-term outcome in elderly patients is unclear. Aim of our study was to compare the clinical outcomes of octogenarians with ULMCA disease treated either with PCI with drug-eluting stents or coronary artery bypass grafting (CABG). The primary study end point was the composite of death, cerebrovascular accident, and myocardial infarction at follow-up. A total of 304 consecutive patients with ULMCA stenosis treated with PCI or CABG and aged ≥80 years were selected and analyzed in a large multinational registry. Two hundred eighteen were treated with PCI and 86 with CABG. During the hospitalization, a trend toward a higher mortality rate was reported in PCI-treated patients (3.5% vs 7.3%, p = 0.32). At a median follow-up of 1,088 days, the incidence of the primary end point was similar in the 2 groups (32.6% vs 30.2%, p = 0.69). Incidence of target vessel revascularization at follow-up was higher in PCI-treated patients (10% vs 4.2%, p = 0.05). At multivariate analysis, left ventricular ejection fraction was the only independent predictor of the primary end point (hazard ratio 0.95, 95% confidence interval 0.91 to 0.98, p = 0.001). After adjustment with propensity score, the revascularization strategy was not significantly correlated to the incidence of the primary end point (hazard ratio 0.98, 95% confidence interval 0.57 to 1.71, p = 0.95). In octogenarians, no difference was observed in the occurrence of the primary end point after PCI or CABG for the treatment of ULMCA disease. However, the rate of target vessel revascularization was higher in the PCI group. Percutaneous coronary intervention (PCI) with drug-eluting stents is an accepted alternative to surgery for the treatment of unprotected left main coronary artery (ULMCA) disease, but the long-term outcome in elderly patients is unclear. Aim of our study was to compare the clinical outcomes of octogenarians with ULMCA disease treated either with PCI with drug-eluting stents or coronary artery bypass grafting (CABG). The primary study end point was the composite of death, cerebrovascular accident, and myocardial infarction at follow-up. A total of 304 consecutive patients with ULMCA stenosis treated with PCI or CABG and aged ≥80 years were selected and analyzed in a large multinational registry. Two hundred eighteen were treated with PCI and 86 with CABG. During the hospitalization, a trend toward a higher mortality rate was reported in PCI-treated patients (3.5% vs 7.3%, p = 0.32). At a median follow-up of 1,088 days, the incidence of the primary end point was similar in the 2 groups (32.6% vs 30.2%, p = 0.69). Incidence of target vessel revascularization at follow-up was higher in PCI-treated patients (10% vs 4.2%, p = 0.05). At multivariate analysis, left ventricular ejection fraction was the only independent predictor of the primary end point (hazard ratio 0.95, 95% confidence interval 0.91 to 0.98, p = 0.001). After adjustment with propensity score, the revascularization strategy was not significantly correlated to the incidence of the primary end point (hazard ratio 0.98, 95% confidence interval 0.57 to 1.71, p = 0.95). In octogenarians, no difference was observed in the occurrence of the primary end point after PCI or CABG for the treatment of ULMCA disease. However, the rate of target vessel revascularization was higher in the PCI group. Scacciatella, Paolo oth D'Ascenzo, Fabrizio oth Chieffo, Alaide oth Latib, Azeem oth Park, Seung Jung oth Kim, Young Hak oth Onuma, Yoshinobu oth Capranzano, Piera oth Jegere, Sanda oth Makkar, Raj oth Palacios, Igor oth Buszman, Pawel oth Chakravarty, Tarun oth Mehran, Roxana oth Naber, Christoph oth Margey, Ronan oth Leon, Martin oth Moses, Jeffrey oth Fajadet, Jean oth Lefèvre, Thierry oth Morice, Marie Claude oth Erglis, Andrejs oth Tamburino, Corrado oth Alfieri, Ottavio oth D'Amico, Maurizio oth Marra, Sebastiano oth Serruys, Patrick W. oth Colombo, Antonio oth Meliga, Emanuele oth Enthalten in Elsevier Zhang, Meng ELSEVIER PI simultaneous stabilization and set-point output regulation of Port-Hamiltonian systems 2017 official journal of the American College of Cardiology Amsterdam [u.a.] (DE-627)ELV000623679 volume:113 year:2014 number:12 day:15 month:06 pages:2007-2012 extent:6 https://doi.org/10.1016/j.amjcard.2014.03.044 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-MAT 31.80 Angewandte Mathematik VZ AR 113 2014 12 15 0615 2007-2012 6 045F 610
allfieldsGer	10.1016/j.amjcard.2014.03.044 doi GBVA2014019000017.pica (DE-627)ELV01792071X (ELSEVIER)S0002-9149(14)00887-X DE-627 ger DE-627 rakwb eng 610 610 DE-600 510 VZ 31.80 bkl Conrotto, Federico verfasserin aut Long-Term Outcomes of Percutaneous Coronary Interventions or Coronary Artery Bypass Grafting for Left Main Coronary Artery Disease in Octogenarians (from a Drug-Eluting stent for LefT main Artery Registry Substudy) 2014transfer abstract 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Percutaneous coronary intervention (PCI) with drug-eluting stents is an accepted alternative to surgery for the treatment of unprotected left main coronary artery (ULMCA) disease, but the long-term outcome in elderly patients is unclear. Aim of our study was to compare the clinical outcomes of octogenarians with ULMCA disease treated either with PCI with drug-eluting stents or coronary artery bypass grafting (CABG). The primary study end point was the composite of death, cerebrovascular accident, and myocardial infarction at follow-up. A total of 304 consecutive patients with ULMCA stenosis treated with PCI or CABG and aged ≥80 years were selected and analyzed in a large multinational registry. Two hundred eighteen were treated with PCI and 86 with CABG. During the hospitalization, a trend toward a higher mortality rate was reported in PCI-treated patients (3.5% vs 7.3%, p = 0.32). At a median follow-up of 1,088 days, the incidence of the primary end point was similar in the 2 groups (32.6% vs 30.2%, p = 0.69). Incidence of target vessel revascularization at follow-up was higher in PCI-treated patients (10% vs 4.2%, p = 0.05). At multivariate analysis, left ventricular ejection fraction was the only independent predictor of the primary end point (hazard ratio 0.95, 95% confidence interval 0.91 to 0.98, p = 0.001). After adjustment with propensity score, the revascularization strategy was not significantly correlated to the incidence of the primary end point (hazard ratio 0.98, 95% confidence interval 0.57 to 1.71, p = 0.95). In octogenarians, no difference was observed in the occurrence of the primary end point after PCI or CABG for the treatment of ULMCA disease. However, the rate of target vessel revascularization was higher in the PCI group. Percutaneous coronary intervention (PCI) with drug-eluting stents is an accepted alternative to surgery for the treatment of unprotected left main coronary artery (ULMCA) disease, but the long-term outcome in elderly patients is unclear. Aim of our study was to compare the clinical outcomes of octogenarians with ULMCA disease treated either with PCI with drug-eluting stents or coronary artery bypass grafting (CABG). The primary study end point was the composite of death, cerebrovascular accident, and myocardial infarction at follow-up. A total of 304 consecutive patients with ULMCA stenosis treated with PCI or CABG and aged ≥80 years were selected and analyzed in a large multinational registry. Two hundred eighteen were treated with PCI and 86 with CABG. During the hospitalization, a trend toward a higher mortality rate was reported in PCI-treated patients (3.5% vs 7.3%, p = 0.32). At a median follow-up of 1,088 days, the incidence of the primary end point was similar in the 2 groups (32.6% vs 30.2%, p = 0.69). Incidence of target vessel revascularization at follow-up was higher in PCI-treated patients (10% vs 4.2%, p = 0.05). At multivariate analysis, left ventricular ejection fraction was the only independent predictor of the primary end point (hazard ratio 0.95, 95% confidence interval 0.91 to 0.98, p = 0.001). After adjustment with propensity score, the revascularization strategy was not significantly correlated to the incidence of the primary end point (hazard ratio 0.98, 95% confidence interval 0.57 to 1.71, p = 0.95). In octogenarians, no difference was observed in the occurrence of the primary end point after PCI or CABG for the treatment of ULMCA disease. However, the rate of target vessel revascularization was higher in the PCI group. Scacciatella, Paolo oth D'Ascenzo, Fabrizio oth Chieffo, Alaide oth Latib, Azeem oth Park, Seung Jung oth Kim, Young Hak oth Onuma, Yoshinobu oth Capranzano, Piera oth Jegere, Sanda oth Makkar, Raj oth Palacios, Igor oth Buszman, Pawel oth Chakravarty, Tarun oth Mehran, Roxana oth Naber, Christoph oth Margey, Ronan oth Leon, Martin oth Moses, Jeffrey oth Fajadet, Jean oth Lefèvre, Thierry oth Morice, Marie Claude oth Erglis, Andrejs oth Tamburino, Corrado oth Alfieri, Ottavio oth D'Amico, Maurizio oth Marra, Sebastiano oth Serruys, Patrick W. oth Colombo, Antonio oth Meliga, Emanuele oth Enthalten in Elsevier Zhang, Meng ELSEVIER PI simultaneous stabilization and set-point output regulation of Port-Hamiltonian systems 2017 official journal of the American College of Cardiology Amsterdam [u.a.] (DE-627)ELV000623679 volume:113 year:2014 number:12 day:15 month:06 pages:2007-2012 extent:6 https://doi.org/10.1016/j.amjcard.2014.03.044 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-MAT 31.80 Angewandte Mathematik VZ AR 113 2014 12 15 0615 2007-2012 6 045F 610
allfieldsSound	10.1016/j.amjcard.2014.03.044 doi GBVA2014019000017.pica (DE-627)ELV01792071X (ELSEVIER)S0002-9149(14)00887-X DE-627 ger DE-627 rakwb eng 610 610 DE-600 510 VZ 31.80 bkl Conrotto, Federico verfasserin aut Long-Term Outcomes of Percutaneous Coronary Interventions or Coronary Artery Bypass Grafting for Left Main Coronary Artery Disease in Octogenarians (from a Drug-Eluting stent for LefT main Artery Registry Substudy) 2014transfer abstract 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Percutaneous coronary intervention (PCI) with drug-eluting stents is an accepted alternative to surgery for the treatment of unprotected left main coronary artery (ULMCA) disease, but the long-term outcome in elderly patients is unclear. Aim of our study was to compare the clinical outcomes of octogenarians with ULMCA disease treated either with PCI with drug-eluting stents or coronary artery bypass grafting (CABG). The primary study end point was the composite of death, cerebrovascular accident, and myocardial infarction at follow-up. A total of 304 consecutive patients with ULMCA stenosis treated with PCI or CABG and aged ≥80 years were selected and analyzed in a large multinational registry. Two hundred eighteen were treated with PCI and 86 with CABG. During the hospitalization, a trend toward a higher mortality rate was reported in PCI-treated patients (3.5% vs 7.3%, p = 0.32). At a median follow-up of 1,088 days, the incidence of the primary end point was similar in the 2 groups (32.6% vs 30.2%, p = 0.69). Incidence of target vessel revascularization at follow-up was higher in PCI-treated patients (10% vs 4.2%, p = 0.05). At multivariate analysis, left ventricular ejection fraction was the only independent predictor of the primary end point (hazard ratio 0.95, 95% confidence interval 0.91 to 0.98, p = 0.001). After adjustment with propensity score, the revascularization strategy was not significantly correlated to the incidence of the primary end point (hazard ratio 0.98, 95% confidence interval 0.57 to 1.71, p = 0.95). In octogenarians, no difference was observed in the occurrence of the primary end point after PCI or CABG for the treatment of ULMCA disease. However, the rate of target vessel revascularization was higher in the PCI group. Percutaneous coronary intervention (PCI) with drug-eluting stents is an accepted alternative to surgery for the treatment of unprotected left main coronary artery (ULMCA) disease, but the long-term outcome in elderly patients is unclear. Aim of our study was to compare the clinical outcomes of octogenarians with ULMCA disease treated either with PCI with drug-eluting stents or coronary artery bypass grafting (CABG). The primary study end point was the composite of death, cerebrovascular accident, and myocardial infarction at follow-up. A total of 304 consecutive patients with ULMCA stenosis treated with PCI or CABG and aged ≥80 years were selected and analyzed in a large multinational registry. Two hundred eighteen were treated with PCI and 86 with CABG. During the hospitalization, a trend toward a higher mortality rate was reported in PCI-treated patients (3.5% vs 7.3%, p = 0.32). At a median follow-up of 1,088 days, the incidence of the primary end point was similar in the 2 groups (32.6% vs 30.2%, p = 0.69). Incidence of target vessel revascularization at follow-up was higher in PCI-treated patients (10% vs 4.2%, p = 0.05). At multivariate analysis, left ventricular ejection fraction was the only independent predictor of the primary end point (hazard ratio 0.95, 95% confidence interval 0.91 to 0.98, p = 0.001). After adjustment with propensity score, the revascularization strategy was not significantly correlated to the incidence of the primary end point (hazard ratio 0.98, 95% confidence interval 0.57 to 1.71, p = 0.95). In octogenarians, no difference was observed in the occurrence of the primary end point after PCI or CABG for the treatment of ULMCA disease. However, the rate of target vessel revascularization was higher in the PCI group. Scacciatella, Paolo oth D'Ascenzo, Fabrizio oth Chieffo, Alaide oth Latib, Azeem oth Park, Seung Jung oth Kim, Young Hak oth Onuma, Yoshinobu oth Capranzano, Piera oth Jegere, Sanda oth Makkar, Raj oth Palacios, Igor oth Buszman, Pawel oth Chakravarty, Tarun oth Mehran, Roxana oth Naber, Christoph oth Margey, Ronan oth Leon, Martin oth Moses, Jeffrey oth Fajadet, Jean oth Lefèvre, Thierry oth Morice, Marie Claude oth Erglis, Andrejs oth Tamburino, Corrado oth Alfieri, Ottavio oth D'Amico, Maurizio oth Marra, Sebastiano oth Serruys, Patrick W. oth Colombo, Antonio oth Meliga, Emanuele oth Enthalten in Elsevier Zhang, Meng ELSEVIER PI simultaneous stabilization and set-point output regulation of Port-Hamiltonian systems 2017 official journal of the American College of Cardiology Amsterdam [u.a.] (DE-627)ELV000623679 volume:113 year:2014 number:12 day:15 month:06 pages:2007-2012 extent:6 https://doi.org/10.1016/j.amjcard.2014.03.044 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-MAT 31.80 Angewandte Mathematik VZ AR 113 2014 12 15 0615 2007-2012 6 045F 610
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source	Enthalten in PI simultaneous stabilization and set-point output regulation of Port-Hamiltonian systems Amsterdam [u.a.] volume:113 year:2014 number:12 day:15 month:06 pages:2007-2012 extent:6
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authorswithroles_txt_mv	Conrotto, Federico @@aut@@ Scacciatella, Paolo @@oth@@ D'Ascenzo, Fabrizio @@oth@@ Chieffo, Alaide @@oth@@ Latib, Azeem @@oth@@ Park, Seung Jung @@oth@@ Kim, Young Hak @@oth@@ Onuma, Yoshinobu @@oth@@ Capranzano, Piera @@oth@@ Jegere, Sanda @@oth@@ Makkar, Raj @@oth@@ Palacios, Igor @@oth@@ Buszman, Pawel @@oth@@ Chakravarty, Tarun @@oth@@ Mehran, Roxana @@oth@@ Naber, Christoph @@oth@@ Margey, Ronan @@oth@@ Leon, Martin @@oth@@ Moses, Jeffrey @@oth@@ Fajadet, Jean @@oth@@ Lefèvre, Thierry @@oth@@ Morice, Marie Claude @@oth@@ Erglis, Andrejs @@oth@@ Tamburino, Corrado @@oth@@ Alfieri, Ottavio @@oth@@ D'Amico, Maurizio @@oth@@ Marra, Sebastiano @@oth@@ Serruys, Patrick W. @@oth@@ Colombo, Antonio @@oth@@ Meliga, Emanuele @@oth@@
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title_sort	long-term outcomes of percutaneous coronary interventions or coronary artery bypass grafting for left main coronary artery disease in octogenarians (from a drug-eluting stent for left main artery registry substudy)
title_auth	Long-Term Outcomes of Percutaneous Coronary Interventions or Coronary Artery Bypass Grafting for Left Main Coronary Artery Disease in Octogenarians (from a Drug-Eluting stent for LefT main Artery Registry Substudy)
abstract	Percutaneous coronary intervention (PCI) with drug-eluting stents is an accepted alternative to surgery for the treatment of unprotected left main coronary artery (ULMCA) disease, but the long-term outcome in elderly patients is unclear. Aim of our study was to compare the clinical outcomes of octogenarians with ULMCA disease treated either with PCI with drug-eluting stents or coronary artery bypass grafting (CABG). The primary study end point was the composite of death, cerebrovascular accident, and myocardial infarction at follow-up. A total of 304 consecutive patients with ULMCA stenosis treated with PCI or CABG and aged ≥80 years were selected and analyzed in a large multinational registry. Two hundred eighteen were treated with PCI and 86 with CABG. During the hospitalization, a trend toward a higher mortality rate was reported in PCI-treated patients (3.5% vs 7.3%, p = 0.32). At a median follow-up of 1,088 days, the incidence of the primary end point was similar in the 2 groups (32.6% vs 30.2%, p = 0.69). Incidence of target vessel revascularization at follow-up was higher in PCI-treated patients (10% vs 4.2%, p = 0.05). At multivariate analysis, left ventricular ejection fraction was the only independent predictor of the primary end point (hazard ratio 0.95, 95% confidence interval 0.91 to 0.98, p = 0.001). After adjustment with propensity score, the revascularization strategy was not significantly correlated to the incidence of the primary end point (hazard ratio 0.98, 95% confidence interval 0.57 to 1.71, p = 0.95). In octogenarians, no difference was observed in the occurrence of the primary end point after PCI or CABG for the treatment of ULMCA disease. However, the rate of target vessel revascularization was higher in the PCI group.
abstractGer	Percutaneous coronary intervention (PCI) with drug-eluting stents is an accepted alternative to surgery for the treatment of unprotected left main coronary artery (ULMCA) disease, but the long-term outcome in elderly patients is unclear. Aim of our study was to compare the clinical outcomes of octogenarians with ULMCA disease treated either with PCI with drug-eluting stents or coronary artery bypass grafting (CABG). The primary study end point was the composite of death, cerebrovascular accident, and myocardial infarction at follow-up. A total of 304 consecutive patients with ULMCA stenosis treated with PCI or CABG and aged ≥80 years were selected and analyzed in a large multinational registry. Two hundred eighteen were treated with PCI and 86 with CABG. During the hospitalization, a trend toward a higher mortality rate was reported in PCI-treated patients (3.5% vs 7.3%, p = 0.32). At a median follow-up of 1,088 days, the incidence of the primary end point was similar in the 2 groups (32.6% vs 30.2%, p = 0.69). Incidence of target vessel revascularization at follow-up was higher in PCI-treated patients (10% vs 4.2%, p = 0.05). At multivariate analysis, left ventricular ejection fraction was the only independent predictor of the primary end point (hazard ratio 0.95, 95% confidence interval 0.91 to 0.98, p = 0.001). After adjustment with propensity score, the revascularization strategy was not significantly correlated to the incidence of the primary end point (hazard ratio 0.98, 95% confidence interval 0.57 to 1.71, p = 0.95). In octogenarians, no difference was observed in the occurrence of the primary end point after PCI or CABG for the treatment of ULMCA disease. However, the rate of target vessel revascularization was higher in the PCI group.
abstract_unstemmed	Percutaneous coronary intervention (PCI) with drug-eluting stents is an accepted alternative to surgery for the treatment of unprotected left main coronary artery (ULMCA) disease, but the long-term outcome in elderly patients is unclear. Aim of our study was to compare the clinical outcomes of octogenarians with ULMCA disease treated either with PCI with drug-eluting stents or coronary artery bypass grafting (CABG). The primary study end point was the composite of death, cerebrovascular accident, and myocardial infarction at follow-up. A total of 304 consecutive patients with ULMCA stenosis treated with PCI or CABG and aged ≥80 years were selected and analyzed in a large multinational registry. Two hundred eighteen were treated with PCI and 86 with CABG. During the hospitalization, a trend toward a higher mortality rate was reported in PCI-treated patients (3.5% vs 7.3%, p = 0.32). At a median follow-up of 1,088 days, the incidence of the primary end point was similar in the 2 groups (32.6% vs 30.2%, p = 0.69). Incidence of target vessel revascularization at follow-up was higher in PCI-treated patients (10% vs 4.2%, p = 0.05). At multivariate analysis, left ventricular ejection fraction was the only independent predictor of the primary end point (hazard ratio 0.95, 95% confidence interval 0.91 to 0.98, p = 0.001). After adjustment with propensity score, the revascularization strategy was not significantly correlated to the incidence of the primary end point (hazard ratio 0.98, 95% confidence interval 0.57 to 1.71, p = 0.95). In octogenarians, no difference was observed in the occurrence of the primary end point after PCI or CABG for the treatment of ULMCA disease. However, the rate of target vessel revascularization was higher in the PCI group.
collection_details	GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-MAT
container_issue	12
title_short	Long-Term Outcomes of Percutaneous Coronary Interventions or Coronary Artery Bypass Grafting for Left Main Coronary Artery Disease in Octogenarians (from a Drug-Eluting stent for LefT main Artery Registry Substudy)
url	https://doi.org/10.1016/j.amjcard.2014.03.044
remote_bool	true
author2	Scacciatella, Paolo D'Ascenzo, Fabrizio Chieffo, Alaide Latib, Azeem Park, Seung Jung Kim, Young Hak Onuma, Yoshinobu Capranzano, Piera Jegere, Sanda Makkar, Raj Palacios, Igor Buszman, Pawel Chakravarty, Tarun Mehran, Roxana Naber, Christoph Margey, Ronan Leon, Martin Moses, Jeffrey Fajadet, Jean Lefèvre, Thierry Morice, Marie Claude Erglis, Andrejs Tamburino, Corrado Alfieri, Ottavio D'Amico, Maurizio Marra, Sebastiano Serruys, Patrick W. Colombo, Antonio Meliga, Emanuele
author2Str	Scacciatella, Paolo D'Ascenzo, Fabrizio Chieffo, Alaide Latib, Azeem Park, Seung Jung Kim, Young Hak Onuma, Yoshinobu Capranzano, Piera Jegere, Sanda Makkar, Raj Palacios, Igor Buszman, Pawel Chakravarty, Tarun Mehran, Roxana Naber, Christoph Margey, Ronan Leon, Martin Moses, Jeffrey Fajadet, Jean Lefèvre, Thierry Morice, Marie Claude Erglis, Andrejs Tamburino, Corrado Alfieri, Ottavio D'Amico, Maurizio Marra, Sebastiano Serruys, Patrick W. Colombo, Antonio Meliga, Emanuele
ppnlink	ELV000623679
mediatype_str_mv	z
isOA_txt	false
hochschulschrift_bool	false
author2_role	oth oth oth oth oth oth oth oth oth oth oth oth oth oth oth oth oth oth oth oth oth oth oth oth oth oth oth oth oth
doi_str	10.1016/j.amjcard.2014.03.044
up_date	2024-07-06T17:31:17.784Z
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Long-Term Outcomes of Percutaneous Coronary Interventions or Coronary Artery Bypass Grafting for Left Main Coronary Artery Disease in Octogenarians (from a Drug-Eluting stent for LefT main Artery Registry Substudy)

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