Unusual binding mode of scorpion toxin BmKTX onto potassium channels relies on its distribution of acidic residues
• The classical pore-blocking residue of potassium channel scorpion toxins is Lys26. • BmKTX exhibits a ‘non-classical’ channel pore-blocking residue Arg23 due to spatial vicinity between Lys26 and Asp33. • The unique mode is induced by electrostatic repulsion forces between toxin and potassium chan...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Chen, Zongyun [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2014 |
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| Schlagwörter: |
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| Umfang: |
7 |
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| Übergeordnetes Werk: |
Enthalten in: Preparation and characterization of glass-ceramics via co-sintering of coal fly ash and oil shale ash-derived amorphous slag - Zhang, Zhikun ELSEVIER, 2019, BBRC, Orlando, Fla |
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| Übergeordnetes Werk: |
volume:447 ; year:2014 ; number:1 ; day:25 ; month:04 ; pages:70-76 ; extent:7 |
| Links: |
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| DOI / URN: |
10.1016/j.bbrc.2014.03.101 |
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| 245 | 1 | 0 | |a Unusual binding mode of scorpion toxin BmKTX onto potassium channels relies on its distribution of acidic residues |
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| 520 | |a • The classical pore-blocking residue of potassium channel scorpion toxins is Lys26. • BmKTX exhibits a ‘non-classical’ channel pore-blocking residue Arg23 due to spatial vicinity between Lys26 and Asp33. • The unique mode is induced by electrostatic repulsion forces between toxin and potassium channel acidic residues. • These findings reveal a new functional role of toxin acidic residues in defining diverse binding modes. | ||
| 650 | 7 | |a Scorpion toxin BmKTX |2 Elsevier | |
| 650 | 7 | |a Binding mode |2 Elsevier | |
| 650 | 7 | |a BmKTX-D33H analog |2 Elsevier | |
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| 650 | 7 | |a Potassium channels |2 Elsevier | |
| 650 | 7 | |a Acidic residues |2 Elsevier | |
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10.1016/j.bbrc.2014.03.101 doi GBVA2014019000029.pica (DE-627)ELV017945704 (ELSEVIER)S0006-291X(14)00553-1 DE-627 ger DE-627 rakwb eng 570 570 DE-600 670 VZ 51.60 bkl 58.45 bkl Chen, Zongyun verfasserin aut Unusual binding mode of scorpion toxin BmKTX onto potassium channels relies on its distribution of acidic residues 2014 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • The classical pore-blocking residue of potassium channel scorpion toxins is Lys26. • BmKTX exhibits a ‘non-classical’ channel pore-blocking residue Arg23 due to spatial vicinity between Lys26 and Asp33. • The unique mode is induced by electrostatic repulsion forces between toxin and potassium channel acidic residues. • These findings reveal a new functional role of toxin acidic residues in defining diverse binding modes. Scorpion toxin BmKTX Elsevier Binding mode Elsevier BmKTX-D33H analog Elsevier Electrostatic repulsion Elsevier Potassium channels Elsevier Acidic residues Elsevier Hu, Youtian oth Hu, Jun oth Yang, Weishan oth Sabatier, Jean-Marc oth De Waard, Michel oth Cao, Zhijian oth Li, Wenxin oth Han, Song oth Wu, Yingliang oth Enthalten in Academic Press Zhang, Zhikun ELSEVIER Preparation and characterization of glass-ceramics via co-sintering of coal fly ash and oil shale ash-derived amorphous slag 2019 BBRC Orlando, Fla (DE-627)ELV002811154 volume:447 year:2014 number:1 day:25 month:04 pages:70-76 extent:7 https://doi.org/10.1016/j.bbrc.2014.03.101 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 51.60 Keramische Werkstoffe Hartstoffe Werkstoffkunde VZ 58.45 Gesteinshüttenkunde VZ AR 447 2014 1 25 0425 70-76 7 045F 570 |
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10.1016/j.bbrc.2014.03.101 doi GBVA2014019000029.pica (DE-627)ELV017945704 (ELSEVIER)S0006-291X(14)00553-1 DE-627 ger DE-627 rakwb eng 570 570 DE-600 670 VZ 51.60 bkl 58.45 bkl Chen, Zongyun verfasserin aut Unusual binding mode of scorpion toxin BmKTX onto potassium channels relies on its distribution of acidic residues 2014 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • The classical pore-blocking residue of potassium channel scorpion toxins is Lys26. • BmKTX exhibits a ‘non-classical’ channel pore-blocking residue Arg23 due to spatial vicinity between Lys26 and Asp33. • The unique mode is induced by electrostatic repulsion forces between toxin and potassium channel acidic residues. • These findings reveal a new functional role of toxin acidic residues in defining diverse binding modes. Scorpion toxin BmKTX Elsevier Binding mode Elsevier BmKTX-D33H analog Elsevier Electrostatic repulsion Elsevier Potassium channels Elsevier Acidic residues Elsevier Hu, Youtian oth Hu, Jun oth Yang, Weishan oth Sabatier, Jean-Marc oth De Waard, Michel oth Cao, Zhijian oth Li, Wenxin oth Han, Song oth Wu, Yingliang oth Enthalten in Academic Press Zhang, Zhikun ELSEVIER Preparation and characterization of glass-ceramics via co-sintering of coal fly ash and oil shale ash-derived amorphous slag 2019 BBRC Orlando, Fla (DE-627)ELV002811154 volume:447 year:2014 number:1 day:25 month:04 pages:70-76 extent:7 https://doi.org/10.1016/j.bbrc.2014.03.101 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 51.60 Keramische Werkstoffe Hartstoffe Werkstoffkunde VZ 58.45 Gesteinshüttenkunde VZ AR 447 2014 1 25 0425 70-76 7 045F 570 |
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10.1016/j.bbrc.2014.03.101 doi GBVA2014019000029.pica (DE-627)ELV017945704 (ELSEVIER)S0006-291X(14)00553-1 DE-627 ger DE-627 rakwb eng 570 570 DE-600 670 VZ 51.60 bkl 58.45 bkl Chen, Zongyun verfasserin aut Unusual binding mode of scorpion toxin BmKTX onto potassium channels relies on its distribution of acidic residues 2014 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • The classical pore-blocking residue of potassium channel scorpion toxins is Lys26. • BmKTX exhibits a ‘non-classical’ channel pore-blocking residue Arg23 due to spatial vicinity between Lys26 and Asp33. • The unique mode is induced by electrostatic repulsion forces between toxin and potassium channel acidic residues. • These findings reveal a new functional role of toxin acidic residues in defining diverse binding modes. Scorpion toxin BmKTX Elsevier Binding mode Elsevier BmKTX-D33H analog Elsevier Electrostatic repulsion Elsevier Potassium channels Elsevier Acidic residues Elsevier Hu, Youtian oth Hu, Jun oth Yang, Weishan oth Sabatier, Jean-Marc oth De Waard, Michel oth Cao, Zhijian oth Li, Wenxin oth Han, Song oth Wu, Yingliang oth Enthalten in Academic Press Zhang, Zhikun ELSEVIER Preparation and characterization of glass-ceramics via co-sintering of coal fly ash and oil shale ash-derived amorphous slag 2019 BBRC Orlando, Fla (DE-627)ELV002811154 volume:447 year:2014 number:1 day:25 month:04 pages:70-76 extent:7 https://doi.org/10.1016/j.bbrc.2014.03.101 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 51.60 Keramische Werkstoffe Hartstoffe Werkstoffkunde VZ 58.45 Gesteinshüttenkunde VZ AR 447 2014 1 25 0425 70-76 7 045F 570 |
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10.1016/j.bbrc.2014.03.101 doi GBVA2014019000029.pica (DE-627)ELV017945704 (ELSEVIER)S0006-291X(14)00553-1 DE-627 ger DE-627 rakwb eng 570 570 DE-600 670 VZ 51.60 bkl 58.45 bkl Chen, Zongyun verfasserin aut Unusual binding mode of scorpion toxin BmKTX onto potassium channels relies on its distribution of acidic residues 2014 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • The classical pore-blocking residue of potassium channel scorpion toxins is Lys26. • BmKTX exhibits a ‘non-classical’ channel pore-blocking residue Arg23 due to spatial vicinity between Lys26 and Asp33. • The unique mode is induced by electrostatic repulsion forces between toxin and potassium channel acidic residues. • These findings reveal a new functional role of toxin acidic residues in defining diverse binding modes. Scorpion toxin BmKTX Elsevier Binding mode Elsevier BmKTX-D33H analog Elsevier Electrostatic repulsion Elsevier Potassium channels Elsevier Acidic residues Elsevier Hu, Youtian oth Hu, Jun oth Yang, Weishan oth Sabatier, Jean-Marc oth De Waard, Michel oth Cao, Zhijian oth Li, Wenxin oth Han, Song oth Wu, Yingliang oth Enthalten in Academic Press Zhang, Zhikun ELSEVIER Preparation and characterization of glass-ceramics via co-sintering of coal fly ash and oil shale ash-derived amorphous slag 2019 BBRC Orlando, Fla (DE-627)ELV002811154 volume:447 year:2014 number:1 day:25 month:04 pages:70-76 extent:7 https://doi.org/10.1016/j.bbrc.2014.03.101 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 51.60 Keramische Werkstoffe Hartstoffe Werkstoffkunde VZ 58.45 Gesteinshüttenkunde VZ AR 447 2014 1 25 0425 70-76 7 045F 570 |
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Unusual binding mode of scorpion toxin BmKTX onto potassium channels relies on its distribution of acidic residues |
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Unusual binding mode of scorpion toxin BmKTX onto potassium channels relies on its distribution of acidic residues |
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Chen, Zongyun |
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Preparation and characterization of glass-ceramics via co-sintering of coal fly ash and oil shale ash-derived amorphous slag |
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Preparation and characterization of glass-ceramics via co-sintering of coal fly ash and oil shale ash-derived amorphous slag |
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2014 |
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Chen, Zongyun |
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Chen, Zongyun |
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10.1016/j.bbrc.2014.03.101 |
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570 670 |
| title_sort |
unusual binding mode of scorpion toxin bmktx onto potassium channels relies on its distribution of acidic residues |
| title_auth |
Unusual binding mode of scorpion toxin BmKTX onto potassium channels relies on its distribution of acidic residues |
| abstract |
• The classical pore-blocking residue of potassium channel scorpion toxins is Lys26. • BmKTX exhibits a ‘non-classical’ channel pore-blocking residue Arg23 due to spatial vicinity between Lys26 and Asp33. • The unique mode is induced by electrostatic repulsion forces between toxin and potassium channel acidic residues. • These findings reveal a new functional role of toxin acidic residues in defining diverse binding modes. |
| abstractGer |
• The classical pore-blocking residue of potassium channel scorpion toxins is Lys26. • BmKTX exhibits a ‘non-classical’ channel pore-blocking residue Arg23 due to spatial vicinity between Lys26 and Asp33. • The unique mode is induced by electrostatic repulsion forces between toxin and potassium channel acidic residues. • These findings reveal a new functional role of toxin acidic residues in defining diverse binding modes. |
| abstract_unstemmed |
• The classical pore-blocking residue of potassium channel scorpion toxins is Lys26. • BmKTX exhibits a ‘non-classical’ channel pore-blocking residue Arg23 due to spatial vicinity between Lys26 and Asp33. • The unique mode is induced by electrostatic repulsion forces between toxin and potassium channel acidic residues. • These findings reveal a new functional role of toxin acidic residues in defining diverse binding modes. |
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| title_short |
Unusual binding mode of scorpion toxin BmKTX onto potassium channels relies on its distribution of acidic residues |
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https://doi.org/10.1016/j.bbrc.2014.03.101 |
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Hu, Youtian Hu, Jun Yang, Weishan Sabatier, Jean-Marc De Waard, Michel Cao, Zhijian Li, Wenxin Han, Song Wu, Yingliang |
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Hu, Youtian Hu, Jun Yang, Weishan Sabatier, Jean-Marc De Waard, Michel Cao, Zhijian Li, Wenxin Han, Song Wu, Yingliang |
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