Self-assembled macromolecular nanocoatings to stabilize and control drug release from nanoparticles
A layer-by-layer (LbL) nanocoat (<25nm thick) of two polyelectrolytes, chitosan and chondroitin sulfate was self-assembled step-wise onto drug nanoparticles that were prepared by a solvent-evaporation emulsification method using eucalyptol as the oil phase. Four poorly water-soluble model drugs,...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Strydom, Schalk J. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2014transfer abstract |
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| Umfang: |
7 |
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| Übergeordnetes Werk: |
Enthalten in: Role of sulfur in combating arsenic stress through upregulation of important proteins, and - Amna, Syeda ELSEVIER, 2020, an international journal on the science and technology of wet and dry particulate systems, Amsterdam [u.a.] |
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| Übergeordnetes Werk: |
volume:256 ; year:2014 ; pages:470-476 ; extent:7 |
| Links: |
|---|
| DOI / URN: |
10.1016/j.powtec.2014.01.088 |
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| 520 | |a A layer-by-layer (LbL) nanocoat (<25nm thick) of two polyelectrolytes, chitosan and chondroitin sulfate was self-assembled step-wise onto drug nanoparticles that were prepared by a solvent-evaporation emulsification method using eucalyptol as the oil phase. Four poorly water-soluble model drugs, furosemide, isoxyl, rifampin and paclitaxel were chosen to prepare these particles. Zeta potential, particle size measurements, and microscopic inspection of the coated particles were used to confirm the successful addition of each polyelectrolyte layer and the stability of the nanoparticles. This manufacturing process produced stable drug nanoparticles with volume mean diameters below 250nm. Dissolution tests confirmed that although the nanocoat reduced the dissolution of nanoparticles proportional to the coat thickness; they still dissolved much faster than commercially available micronized powders of the drugs. In addition, increasing the layer thickness (still less than 50nm thick) by adding more LbL bilayers produced sustained release nanoparticles. Ultimately, the LbL nanocoating stabilized these small particles against crystal growth and aggregation in suspension and resulted in nearly perfect controlled drug release. | ||
| 520 | |a A layer-by-layer (LbL) nanocoat (<25nm thick) of two polyelectrolytes, chitosan and chondroitin sulfate was self-assembled step-wise onto drug nanoparticles that were prepared by a solvent-evaporation emulsification method using eucalyptol as the oil phase. Four poorly water-soluble model drugs, furosemide, isoxyl, rifampin and paclitaxel were chosen to prepare these particles. Zeta potential, particle size measurements, and microscopic inspection of the coated particles were used to confirm the successful addition of each polyelectrolyte layer and the stability of the nanoparticles. This manufacturing process produced stable drug nanoparticles with volume mean diameters below 250nm. Dissolution tests confirmed that although the nanocoat reduced the dissolution of nanoparticles proportional to the coat thickness; they still dissolved much faster than commercially available micronized powders of the drugs. In addition, increasing the layer thickness (still less than 50nm thick) by adding more LbL bilayers produced sustained release nanoparticles. Ultimately, the LbL nanocoating stabilized these small particles against crystal growth and aggregation in suspension and resulted in nearly perfect controlled drug release. | ||
| 700 | 1 | |a Otto, Daniel P. |4 oth | |
| 700 | 1 | |a Stieger, Nicole |4 oth | |
| 700 | 1 | |a Aucamp, Marique E. |4 oth | |
| 700 | 1 | |a Liebenberg, Wilna |4 oth | |
| 700 | 1 | |a de Villiers, Melgardt M. |4 oth | |
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10.1016/j.powtec.2014.01.088 doi GBVA2014023000011.pica (DE-627)ELV018111254 (ELSEVIER)S0032-5910(14)00107-7 DE-627 ger DE-627 rakwb eng 660 660 DE-600 630 640 580 VZ BIODIV DE-30 fid 42.00 bkl Strydom, Schalk J. verfasserin aut Self-assembled macromolecular nanocoatings to stabilize and control drug release from nanoparticles 2014transfer abstract 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier A layer-by-layer (LbL) nanocoat (<25nm thick) of two polyelectrolytes, chitosan and chondroitin sulfate was self-assembled step-wise onto drug nanoparticles that were prepared by a solvent-evaporation emulsification method using eucalyptol as the oil phase. Four poorly water-soluble model drugs, furosemide, isoxyl, rifampin and paclitaxel were chosen to prepare these particles. Zeta potential, particle size measurements, and microscopic inspection of the coated particles were used to confirm the successful addition of each polyelectrolyte layer and the stability of the nanoparticles. This manufacturing process produced stable drug nanoparticles with volume mean diameters below 250nm. Dissolution tests confirmed that although the nanocoat reduced the dissolution of nanoparticles proportional to the coat thickness; they still dissolved much faster than commercially available micronized powders of the drugs. In addition, increasing the layer thickness (still less than 50nm thick) by adding more LbL bilayers produced sustained release nanoparticles. Ultimately, the LbL nanocoating stabilized these small particles against crystal growth and aggregation in suspension and resulted in nearly perfect controlled drug release. A layer-by-layer (LbL) nanocoat (<25nm thick) of two polyelectrolytes, chitosan and chondroitin sulfate was self-assembled step-wise onto drug nanoparticles that were prepared by a solvent-evaporation emulsification method using eucalyptol as the oil phase. Four poorly water-soluble model drugs, furosemide, isoxyl, rifampin and paclitaxel were chosen to prepare these particles. Zeta potential, particle size measurements, and microscopic inspection of the coated particles were used to confirm the successful addition of each polyelectrolyte layer and the stability of the nanoparticles. This manufacturing process produced stable drug nanoparticles with volume mean diameters below 250nm. Dissolution tests confirmed that although the nanocoat reduced the dissolution of nanoparticles proportional to the coat thickness; they still dissolved much faster than commercially available micronized powders of the drugs. In addition, increasing the layer thickness (still less than 50nm thick) by adding more LbL bilayers produced sustained release nanoparticles. Ultimately, the LbL nanocoating stabilized these small particles against crystal growth and aggregation in suspension and resulted in nearly perfect controlled drug release. Otto, Daniel P. oth Stieger, Nicole oth Aucamp, Marique E. oth Liebenberg, Wilna oth de Villiers, Melgardt M. oth Enthalten in Elsevier Science Amna, Syeda ELSEVIER Role of sulfur in combating arsenic stress through upregulation of important proteins, and 2020 an international journal on the science and technology of wet and dry particulate systems Amsterdam [u.a.] (DE-627)ELV005093252 volume:256 year:2014 pages:470-476 extent:7 https://doi.org/10.1016/j.powtec.2014.01.088 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV 42.00 Biologie: Allgemeines VZ AR 256 2014 470-476 7 045F 660 |
| spelling |
10.1016/j.powtec.2014.01.088 doi GBVA2014023000011.pica (DE-627)ELV018111254 (ELSEVIER)S0032-5910(14)00107-7 DE-627 ger DE-627 rakwb eng 660 660 DE-600 630 640 580 VZ BIODIV DE-30 fid 42.00 bkl Strydom, Schalk J. verfasserin aut Self-assembled macromolecular nanocoatings to stabilize and control drug release from nanoparticles 2014transfer abstract 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier A layer-by-layer (LbL) nanocoat (<25nm thick) of two polyelectrolytes, chitosan and chondroitin sulfate was self-assembled step-wise onto drug nanoparticles that were prepared by a solvent-evaporation emulsification method using eucalyptol as the oil phase. Four poorly water-soluble model drugs, furosemide, isoxyl, rifampin and paclitaxel were chosen to prepare these particles. Zeta potential, particle size measurements, and microscopic inspection of the coated particles were used to confirm the successful addition of each polyelectrolyte layer and the stability of the nanoparticles. This manufacturing process produced stable drug nanoparticles with volume mean diameters below 250nm. Dissolution tests confirmed that although the nanocoat reduced the dissolution of nanoparticles proportional to the coat thickness; they still dissolved much faster than commercially available micronized powders of the drugs. In addition, increasing the layer thickness (still less than 50nm thick) by adding more LbL bilayers produced sustained release nanoparticles. Ultimately, the LbL nanocoating stabilized these small particles against crystal growth and aggregation in suspension and resulted in nearly perfect controlled drug release. A layer-by-layer (LbL) nanocoat (<25nm thick) of two polyelectrolytes, chitosan and chondroitin sulfate was self-assembled step-wise onto drug nanoparticles that were prepared by a solvent-evaporation emulsification method using eucalyptol as the oil phase. Four poorly water-soluble model drugs, furosemide, isoxyl, rifampin and paclitaxel were chosen to prepare these particles. Zeta potential, particle size measurements, and microscopic inspection of the coated particles were used to confirm the successful addition of each polyelectrolyte layer and the stability of the nanoparticles. This manufacturing process produced stable drug nanoparticles with volume mean diameters below 250nm. Dissolution tests confirmed that although the nanocoat reduced the dissolution of nanoparticles proportional to the coat thickness; they still dissolved much faster than commercially available micronized powders of the drugs. In addition, increasing the layer thickness (still less than 50nm thick) by adding more LbL bilayers produced sustained release nanoparticles. Ultimately, the LbL nanocoating stabilized these small particles against crystal growth and aggregation in suspension and resulted in nearly perfect controlled drug release. Otto, Daniel P. oth Stieger, Nicole oth Aucamp, Marique E. oth Liebenberg, Wilna oth de Villiers, Melgardt M. oth Enthalten in Elsevier Science Amna, Syeda ELSEVIER Role of sulfur in combating arsenic stress through upregulation of important proteins, and 2020 an international journal on the science and technology of wet and dry particulate systems Amsterdam [u.a.] (DE-627)ELV005093252 volume:256 year:2014 pages:470-476 extent:7 https://doi.org/10.1016/j.powtec.2014.01.088 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV 42.00 Biologie: Allgemeines VZ AR 256 2014 470-476 7 045F 660 |
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10.1016/j.powtec.2014.01.088 doi GBVA2014023000011.pica (DE-627)ELV018111254 (ELSEVIER)S0032-5910(14)00107-7 DE-627 ger DE-627 rakwb eng 660 660 DE-600 630 640 580 VZ BIODIV DE-30 fid 42.00 bkl Strydom, Schalk J. verfasserin aut Self-assembled macromolecular nanocoatings to stabilize and control drug release from nanoparticles 2014transfer abstract 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier A layer-by-layer (LbL) nanocoat (<25nm thick) of two polyelectrolytes, chitosan and chondroitin sulfate was self-assembled step-wise onto drug nanoparticles that were prepared by a solvent-evaporation emulsification method using eucalyptol as the oil phase. Four poorly water-soluble model drugs, furosemide, isoxyl, rifampin and paclitaxel were chosen to prepare these particles. Zeta potential, particle size measurements, and microscopic inspection of the coated particles were used to confirm the successful addition of each polyelectrolyte layer and the stability of the nanoparticles. This manufacturing process produced stable drug nanoparticles with volume mean diameters below 250nm. Dissolution tests confirmed that although the nanocoat reduced the dissolution of nanoparticles proportional to the coat thickness; they still dissolved much faster than commercially available micronized powders of the drugs. In addition, increasing the layer thickness (still less than 50nm thick) by adding more LbL bilayers produced sustained release nanoparticles. Ultimately, the LbL nanocoating stabilized these small particles against crystal growth and aggregation in suspension and resulted in nearly perfect controlled drug release. A layer-by-layer (LbL) nanocoat (<25nm thick) of two polyelectrolytes, chitosan and chondroitin sulfate was self-assembled step-wise onto drug nanoparticles that were prepared by a solvent-evaporation emulsification method using eucalyptol as the oil phase. Four poorly water-soluble model drugs, furosemide, isoxyl, rifampin and paclitaxel were chosen to prepare these particles. Zeta potential, particle size measurements, and microscopic inspection of the coated particles were used to confirm the successful addition of each polyelectrolyte layer and the stability of the nanoparticles. This manufacturing process produced stable drug nanoparticles with volume mean diameters below 250nm. Dissolution tests confirmed that although the nanocoat reduced the dissolution of nanoparticles proportional to the coat thickness; they still dissolved much faster than commercially available micronized powders of the drugs. In addition, increasing the layer thickness (still less than 50nm thick) by adding more LbL bilayers produced sustained release nanoparticles. Ultimately, the LbL nanocoating stabilized these small particles against crystal growth and aggregation in suspension and resulted in nearly perfect controlled drug release. Otto, Daniel P. oth Stieger, Nicole oth Aucamp, Marique E. oth Liebenberg, Wilna oth de Villiers, Melgardt M. oth Enthalten in Elsevier Science Amna, Syeda ELSEVIER Role of sulfur in combating arsenic stress through upregulation of important proteins, and 2020 an international journal on the science and technology of wet and dry particulate systems Amsterdam [u.a.] (DE-627)ELV005093252 volume:256 year:2014 pages:470-476 extent:7 https://doi.org/10.1016/j.powtec.2014.01.088 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV 42.00 Biologie: Allgemeines VZ AR 256 2014 470-476 7 045F 660 |
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10.1016/j.powtec.2014.01.088 doi GBVA2014023000011.pica (DE-627)ELV018111254 (ELSEVIER)S0032-5910(14)00107-7 DE-627 ger DE-627 rakwb eng 660 660 DE-600 630 640 580 VZ BIODIV DE-30 fid 42.00 bkl Strydom, Schalk J. verfasserin aut Self-assembled macromolecular nanocoatings to stabilize and control drug release from nanoparticles 2014transfer abstract 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier A layer-by-layer (LbL) nanocoat (<25nm thick) of two polyelectrolytes, chitosan and chondroitin sulfate was self-assembled step-wise onto drug nanoparticles that were prepared by a solvent-evaporation emulsification method using eucalyptol as the oil phase. Four poorly water-soluble model drugs, furosemide, isoxyl, rifampin and paclitaxel were chosen to prepare these particles. Zeta potential, particle size measurements, and microscopic inspection of the coated particles were used to confirm the successful addition of each polyelectrolyte layer and the stability of the nanoparticles. This manufacturing process produced stable drug nanoparticles with volume mean diameters below 250nm. Dissolution tests confirmed that although the nanocoat reduced the dissolution of nanoparticles proportional to the coat thickness; they still dissolved much faster than commercially available micronized powders of the drugs. In addition, increasing the layer thickness (still less than 50nm thick) by adding more LbL bilayers produced sustained release nanoparticles. Ultimately, the LbL nanocoating stabilized these small particles against crystal growth and aggregation in suspension and resulted in nearly perfect controlled drug release. A layer-by-layer (LbL) nanocoat (<25nm thick) of two polyelectrolytes, chitosan and chondroitin sulfate was self-assembled step-wise onto drug nanoparticles that were prepared by a solvent-evaporation emulsification method using eucalyptol as the oil phase. Four poorly water-soluble model drugs, furosemide, isoxyl, rifampin and paclitaxel were chosen to prepare these particles. Zeta potential, particle size measurements, and microscopic inspection of the coated particles were used to confirm the successful addition of each polyelectrolyte layer and the stability of the nanoparticles. This manufacturing process produced stable drug nanoparticles with volume mean diameters below 250nm. Dissolution tests confirmed that although the nanocoat reduced the dissolution of nanoparticles proportional to the coat thickness; they still dissolved much faster than commercially available micronized powders of the drugs. In addition, increasing the layer thickness (still less than 50nm thick) by adding more LbL bilayers produced sustained release nanoparticles. Ultimately, the LbL nanocoating stabilized these small particles against crystal growth and aggregation in suspension and resulted in nearly perfect controlled drug release. Otto, Daniel P. oth Stieger, Nicole oth Aucamp, Marique E. oth Liebenberg, Wilna oth de Villiers, Melgardt M. oth Enthalten in Elsevier Science Amna, Syeda ELSEVIER Role of sulfur in combating arsenic stress through upregulation of important proteins, and 2020 an international journal on the science and technology of wet and dry particulate systems Amsterdam [u.a.] (DE-627)ELV005093252 volume:256 year:2014 pages:470-476 extent:7 https://doi.org/10.1016/j.powtec.2014.01.088 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV 42.00 Biologie: Allgemeines VZ AR 256 2014 470-476 7 045F 660 |
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10.1016/j.powtec.2014.01.088 doi GBVA2014023000011.pica (DE-627)ELV018111254 (ELSEVIER)S0032-5910(14)00107-7 DE-627 ger DE-627 rakwb eng 660 660 DE-600 630 640 580 VZ BIODIV DE-30 fid 42.00 bkl Strydom, Schalk J. verfasserin aut Self-assembled macromolecular nanocoatings to stabilize and control drug release from nanoparticles 2014transfer abstract 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier A layer-by-layer (LbL) nanocoat (<25nm thick) of two polyelectrolytes, chitosan and chondroitin sulfate was self-assembled step-wise onto drug nanoparticles that were prepared by a solvent-evaporation emulsification method using eucalyptol as the oil phase. Four poorly water-soluble model drugs, furosemide, isoxyl, rifampin and paclitaxel were chosen to prepare these particles. Zeta potential, particle size measurements, and microscopic inspection of the coated particles were used to confirm the successful addition of each polyelectrolyte layer and the stability of the nanoparticles. This manufacturing process produced stable drug nanoparticles with volume mean diameters below 250nm. Dissolution tests confirmed that although the nanocoat reduced the dissolution of nanoparticles proportional to the coat thickness; they still dissolved much faster than commercially available micronized powders of the drugs. In addition, increasing the layer thickness (still less than 50nm thick) by adding more LbL bilayers produced sustained release nanoparticles. Ultimately, the LbL nanocoating stabilized these small particles against crystal growth and aggregation in suspension and resulted in nearly perfect controlled drug release. A layer-by-layer (LbL) nanocoat (<25nm thick) of two polyelectrolytes, chitosan and chondroitin sulfate was self-assembled step-wise onto drug nanoparticles that were prepared by a solvent-evaporation emulsification method using eucalyptol as the oil phase. Four poorly water-soluble model drugs, furosemide, isoxyl, rifampin and paclitaxel were chosen to prepare these particles. Zeta potential, particle size measurements, and microscopic inspection of the coated particles were used to confirm the successful addition of each polyelectrolyte layer and the stability of the nanoparticles. This manufacturing process produced stable drug nanoparticles with volume mean diameters below 250nm. Dissolution tests confirmed that although the nanocoat reduced the dissolution of nanoparticles proportional to the coat thickness; they still dissolved much faster than commercially available micronized powders of the drugs. In addition, increasing the layer thickness (still less than 50nm thick) by adding more LbL bilayers produced sustained release nanoparticles. Ultimately, the LbL nanocoating stabilized these small particles against crystal growth and aggregation in suspension and resulted in nearly perfect controlled drug release. Otto, Daniel P. oth Stieger, Nicole oth Aucamp, Marique E. oth Liebenberg, Wilna oth de Villiers, Melgardt M. oth Enthalten in Elsevier Science Amna, Syeda ELSEVIER Role of sulfur in combating arsenic stress through upregulation of important proteins, and 2020 an international journal on the science and technology of wet and dry particulate systems Amsterdam [u.a.] (DE-627)ELV005093252 volume:256 year:2014 pages:470-476 extent:7 https://doi.org/10.1016/j.powtec.2014.01.088 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV 42.00 Biologie: Allgemeines VZ AR 256 2014 470-476 7 045F 660 |
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self-assembled macromolecular nanocoatings to stabilize and control drug release from nanoparticles |
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Self-assembled macromolecular nanocoatings to stabilize and control drug release from nanoparticles |
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A layer-by-layer (LbL) nanocoat (<25nm thick) of two polyelectrolytes, chitosan and chondroitin sulfate was self-assembled step-wise onto drug nanoparticles that were prepared by a solvent-evaporation emulsification method using eucalyptol as the oil phase. Four poorly water-soluble model drugs, furosemide, isoxyl, rifampin and paclitaxel were chosen to prepare these particles. Zeta potential, particle size measurements, and microscopic inspection of the coated particles were used to confirm the successful addition of each polyelectrolyte layer and the stability of the nanoparticles. This manufacturing process produced stable drug nanoparticles with volume mean diameters below 250nm. Dissolution tests confirmed that although the nanocoat reduced the dissolution of nanoparticles proportional to the coat thickness; they still dissolved much faster than commercially available micronized powders of the drugs. In addition, increasing the layer thickness (still less than 50nm thick) by adding more LbL bilayers produced sustained release nanoparticles. Ultimately, the LbL nanocoating stabilized these small particles against crystal growth and aggregation in suspension and resulted in nearly perfect controlled drug release. |
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A layer-by-layer (LbL) nanocoat (<25nm thick) of two polyelectrolytes, chitosan and chondroitin sulfate was self-assembled step-wise onto drug nanoparticles that were prepared by a solvent-evaporation emulsification method using eucalyptol as the oil phase. Four poorly water-soluble model drugs, furosemide, isoxyl, rifampin and paclitaxel were chosen to prepare these particles. Zeta potential, particle size measurements, and microscopic inspection of the coated particles were used to confirm the successful addition of each polyelectrolyte layer and the stability of the nanoparticles. This manufacturing process produced stable drug nanoparticles with volume mean diameters below 250nm. Dissolution tests confirmed that although the nanocoat reduced the dissolution of nanoparticles proportional to the coat thickness; they still dissolved much faster than commercially available micronized powders of the drugs. In addition, increasing the layer thickness (still less than 50nm thick) by adding more LbL bilayers produced sustained release nanoparticles. Ultimately, the LbL nanocoating stabilized these small particles against crystal growth and aggregation in suspension and resulted in nearly perfect controlled drug release. |
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A layer-by-layer (LbL) nanocoat (<25nm thick) of two polyelectrolytes, chitosan and chondroitin sulfate was self-assembled step-wise onto drug nanoparticles that were prepared by a solvent-evaporation emulsification method using eucalyptol as the oil phase. Four poorly water-soluble model drugs, furosemide, isoxyl, rifampin and paclitaxel were chosen to prepare these particles. Zeta potential, particle size measurements, and microscopic inspection of the coated particles were used to confirm the successful addition of each polyelectrolyte layer and the stability of the nanoparticles. This manufacturing process produced stable drug nanoparticles with volume mean diameters below 250nm. Dissolution tests confirmed that although the nanocoat reduced the dissolution of nanoparticles proportional to the coat thickness; they still dissolved much faster than commercially available micronized powders of the drugs. In addition, increasing the layer thickness (still less than 50nm thick) by adding more LbL bilayers produced sustained release nanoparticles. Ultimately, the LbL nanocoating stabilized these small particles against crystal growth and aggregation in suspension and resulted in nearly perfect controlled drug release. |
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Self-assembled macromolecular nanocoatings to stabilize and control drug release from nanoparticles |
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