V16. MRI abnormalities of the cerebellar cortex and nuclei in SCA3, SCA6, and Friedreich’s ataxia
In the present study, susceptibility weighted imaging (SWI) was used to show atrophy of cerebellar nuclei in spinocerebellar ataxia type 6 (SCA6), Friedreich ataxia (FRDA), and spinocerebellar ataxia type 3 (SCA3). We tested the hypothesis that cerebellar nuclei are smaller in FRDA and SCA3 compared...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Stefanescu, M.R. [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
2015transfer abstract |
|---|
| Übergeordnetes Werk: |
Enthalten in: Medical students' biomedical and clinical knowledge: Combining longitudinal design, eye tracking and comparison with residents' performance - Södervik, Ilona ELSEVIER, 2017, Amsterdam [u.a.] |
|---|---|
| Übergeordnetes Werk: |
volume:126 ; year:2015 ; number:8 ; pages:73 |
| Links: |
|---|
| DOI / URN: |
10.1016/j.clinph.2015.04.094 |
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| 245 | 1 | 0 | |a V16. MRI abnormalities of the cerebellar cortex and nuclei in SCA3, SCA6, and Friedreich’s ataxia |
| 264 | 1 | |c 2015transfer abstract | |
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| 520 | |a In the present study, susceptibility weighted imaging (SWI) was used to show atrophy of cerebellar nuclei in spinocerebellar ataxia type 6 (SCA6), Friedreich ataxia (FRDA), and spinocerebellar ataxia type 3 (SCA3). We tested the hypothesis that cerebellar nuclei are smaller in FRDA and SCA3 compared to healthy controls, but relatively preserved in SCA6. In addition, 7T fMRI was performed with optimized normalization methods to assess function of the cerebellar cortex and nuclei during simple hand movements. Twelve SCA6 patients (age range 41–76years, five female), twelve FRDA patients (age range 21–55years, seven female), and ten SCA3 patients (age range 34–67years, three female), and age- and gender-matched control groups (total n =23, age range 22–75years, ten female) were included. As expected, volume of the cerebellum was most markedly reduced in SCA6, with no significant reduction in FRDA and a slight decrease in SCA3. Atrophy of the cerebellar nuclei was not only present in FRDA and SCA3, but also in SCA6. In fact, volume reduction of the nuclei was most marked in SCA6. On a functional level, fMRI signal was altered both within the cerebellar cortex and the nuclei in the three disorders. In the nuclei, the reduction was most prominent in FRDA. Different from initial expectations, the decrease of fMRI signal in the cerebellar cortex appeared more prominent in SCA3 and FRDA than in SCA6. These findings will be discussed in further detail in the light of the known pathohistology of the diseases. | ||
| 520 | |a In the present study, susceptibility weighted imaging (SWI) was used to show atrophy of cerebellar nuclei in spinocerebellar ataxia type 6 (SCA6), Friedreich ataxia (FRDA), and spinocerebellar ataxia type 3 (SCA3). We tested the hypothesis that cerebellar nuclei are smaller in FRDA and SCA3 compared to healthy controls, but relatively preserved in SCA6. In addition, 7T fMRI was performed with optimized normalization methods to assess function of the cerebellar cortex and nuclei during simple hand movements. Twelve SCA6 patients (age range 41–76years, five female), twelve FRDA patients (age range 21–55years, seven female), and ten SCA3 patients (age range 34–67years, three female), and age- and gender-matched control groups (total n =23, age range 22–75years, ten female) were included. As expected, volume of the cerebellum was most markedly reduced in SCA6, with no significant reduction in FRDA and a slight decrease in SCA3. Atrophy of the cerebellar nuclei was not only present in FRDA and SCA3, but also in SCA6. In fact, volume reduction of the nuclei was most marked in SCA6. On a functional level, fMRI signal was altered both within the cerebellar cortex and the nuclei in the three disorders. In the nuclei, the reduction was most prominent in FRDA. Different from initial expectations, the decrease of fMRI signal in the cerebellar cortex appeared more prominent in SCA3 and FRDA than in SCA6. These findings will be discussed in further detail in the light of the known pathohistology of the diseases. | ||
| 700 | 1 | |a Dohnalek, M. |4 oth | |
| 700 | 1 | |a Maderwald, S. |4 oth | |
| 700 | 1 | |a Thürling, M. |4 oth | |
| 700 | 1 | |a Minnerop, M. |4 oth | |
| 700 | 1 | |a Beck, A. |4 oth | |
| 700 | 1 | |a Schlamann, M. |4 oth | |
| 700 | 1 | |a Diedrichsen, J. |4 oth | |
| 700 | 1 | |a Ladd, M.E. |4 oth | |
| 700 | 1 | |a Timmann, D. |4 oth | |
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10.1016/j.clinph.2015.04.094 doi GBVA2015003000012.pica (DE-627)ELV018225500 (ELSEVIER)S1388-2457(15)00341-7 DE-627 ger DE-627 rakwb eng 610 610 DE-600 370 VZ 5,3 ssgn 80.00 bkl Stefanescu, M.R. verfasserin aut V16. MRI abnormalities of the cerebellar cortex and nuclei in SCA3, SCA6, and Friedreich’s ataxia 2015transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier In the present study, susceptibility weighted imaging (SWI) was used to show atrophy of cerebellar nuclei in spinocerebellar ataxia type 6 (SCA6), Friedreich ataxia (FRDA), and spinocerebellar ataxia type 3 (SCA3). We tested the hypothesis that cerebellar nuclei are smaller in FRDA and SCA3 compared to healthy controls, but relatively preserved in SCA6. In addition, 7T fMRI was performed with optimized normalization methods to assess function of the cerebellar cortex and nuclei during simple hand movements. Twelve SCA6 patients (age range 41–76years, five female), twelve FRDA patients (age range 21–55years, seven female), and ten SCA3 patients (age range 34–67years, three female), and age- and gender-matched control groups (total n =23, age range 22–75years, ten female) were included. As expected, volume of the cerebellum was most markedly reduced in SCA6, with no significant reduction in FRDA and a slight decrease in SCA3. Atrophy of the cerebellar nuclei was not only present in FRDA and SCA3, but also in SCA6. In fact, volume reduction of the nuclei was most marked in SCA6. On a functional level, fMRI signal was altered both within the cerebellar cortex and the nuclei in the three disorders. In the nuclei, the reduction was most prominent in FRDA. Different from initial expectations, the decrease of fMRI signal in the cerebellar cortex appeared more prominent in SCA3 and FRDA than in SCA6. These findings will be discussed in further detail in the light of the known pathohistology of the diseases. In the present study, susceptibility weighted imaging (SWI) was used to show atrophy of cerebellar nuclei in spinocerebellar ataxia type 6 (SCA6), Friedreich ataxia (FRDA), and spinocerebellar ataxia type 3 (SCA3). We tested the hypothesis that cerebellar nuclei are smaller in FRDA and SCA3 compared to healthy controls, but relatively preserved in SCA6. In addition, 7T fMRI was performed with optimized normalization methods to assess function of the cerebellar cortex and nuclei during simple hand movements. Twelve SCA6 patients (age range 41–76years, five female), twelve FRDA patients (age range 21–55years, seven female), and ten SCA3 patients (age range 34–67years, three female), and age- and gender-matched control groups (total n =23, age range 22–75years, ten female) were included. As expected, volume of the cerebellum was most markedly reduced in SCA6, with no significant reduction in FRDA and a slight decrease in SCA3. Atrophy of the cerebellar nuclei was not only present in FRDA and SCA3, but also in SCA6. In fact, volume reduction of the nuclei was most marked in SCA6. On a functional level, fMRI signal was altered both within the cerebellar cortex and the nuclei in the three disorders. In the nuclei, the reduction was most prominent in FRDA. Different from initial expectations, the decrease of fMRI signal in the cerebellar cortex appeared more prominent in SCA3 and FRDA than in SCA6. These findings will be discussed in further detail in the light of the known pathohistology of the diseases. Dohnalek, M. oth Maderwald, S. oth Thürling, M. oth Minnerop, M. oth Beck, A. oth Schlamann, M. oth Diedrichsen, J. oth Ladd, M.E. oth Timmann, D. oth Enthalten in Elsevier Science Södervik, Ilona ELSEVIER Medical students' biomedical and clinical knowledge: Combining longitudinal design, eye tracking and comparison with residents' performance 2017 Amsterdam [u.a.] (DE-627)ELV000764582 volume:126 year:2015 number:8 pages:73 https://doi.org/10.1016/j.clinph.2015.04.094 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 80.00 Pädagogik: Allgemeines VZ AR 126 2015 8 73 126.2015, 8, e73- 045F 610 |
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10.1016/j.clinph.2015.04.094 doi GBVA2015003000012.pica (DE-627)ELV018225500 (ELSEVIER)S1388-2457(15)00341-7 DE-627 ger DE-627 rakwb eng 610 610 DE-600 370 VZ 5,3 ssgn 80.00 bkl Stefanescu, M.R. verfasserin aut V16. MRI abnormalities of the cerebellar cortex and nuclei in SCA3, SCA6, and Friedreich’s ataxia 2015transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier In the present study, susceptibility weighted imaging (SWI) was used to show atrophy of cerebellar nuclei in spinocerebellar ataxia type 6 (SCA6), Friedreich ataxia (FRDA), and spinocerebellar ataxia type 3 (SCA3). We tested the hypothesis that cerebellar nuclei are smaller in FRDA and SCA3 compared to healthy controls, but relatively preserved in SCA6. In addition, 7T fMRI was performed with optimized normalization methods to assess function of the cerebellar cortex and nuclei during simple hand movements. Twelve SCA6 patients (age range 41–76years, five female), twelve FRDA patients (age range 21–55years, seven female), and ten SCA3 patients (age range 34–67years, three female), and age- and gender-matched control groups (total n =23, age range 22–75years, ten female) were included. As expected, volume of the cerebellum was most markedly reduced in SCA6, with no significant reduction in FRDA and a slight decrease in SCA3. Atrophy of the cerebellar nuclei was not only present in FRDA and SCA3, but also in SCA6. In fact, volume reduction of the nuclei was most marked in SCA6. On a functional level, fMRI signal was altered both within the cerebellar cortex and the nuclei in the three disorders. In the nuclei, the reduction was most prominent in FRDA. Different from initial expectations, the decrease of fMRI signal in the cerebellar cortex appeared more prominent in SCA3 and FRDA than in SCA6. These findings will be discussed in further detail in the light of the known pathohistology of the diseases. In the present study, susceptibility weighted imaging (SWI) was used to show atrophy of cerebellar nuclei in spinocerebellar ataxia type 6 (SCA6), Friedreich ataxia (FRDA), and spinocerebellar ataxia type 3 (SCA3). We tested the hypothesis that cerebellar nuclei are smaller in FRDA and SCA3 compared to healthy controls, but relatively preserved in SCA6. In addition, 7T fMRI was performed with optimized normalization methods to assess function of the cerebellar cortex and nuclei during simple hand movements. Twelve SCA6 patients (age range 41–76years, five female), twelve FRDA patients (age range 21–55years, seven female), and ten SCA3 patients (age range 34–67years, three female), and age- and gender-matched control groups (total n =23, age range 22–75years, ten female) were included. As expected, volume of the cerebellum was most markedly reduced in SCA6, with no significant reduction in FRDA and a slight decrease in SCA3. Atrophy of the cerebellar nuclei was not only present in FRDA and SCA3, but also in SCA6. In fact, volume reduction of the nuclei was most marked in SCA6. On a functional level, fMRI signal was altered both within the cerebellar cortex and the nuclei in the three disorders. In the nuclei, the reduction was most prominent in FRDA. Different from initial expectations, the decrease of fMRI signal in the cerebellar cortex appeared more prominent in SCA3 and FRDA than in SCA6. These findings will be discussed in further detail in the light of the known pathohistology of the diseases. Dohnalek, M. oth Maderwald, S. oth Thürling, M. oth Minnerop, M. oth Beck, A. oth Schlamann, M. oth Diedrichsen, J. oth Ladd, M.E. oth Timmann, D. oth Enthalten in Elsevier Science Södervik, Ilona ELSEVIER Medical students' biomedical and clinical knowledge: Combining longitudinal design, eye tracking and comparison with residents' performance 2017 Amsterdam [u.a.] (DE-627)ELV000764582 volume:126 year:2015 number:8 pages:73 https://doi.org/10.1016/j.clinph.2015.04.094 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 80.00 Pädagogik: Allgemeines VZ AR 126 2015 8 73 126.2015, 8, e73- 045F 610 |
| allfields_unstemmed |
10.1016/j.clinph.2015.04.094 doi GBVA2015003000012.pica (DE-627)ELV018225500 (ELSEVIER)S1388-2457(15)00341-7 DE-627 ger DE-627 rakwb eng 610 610 DE-600 370 VZ 5,3 ssgn 80.00 bkl Stefanescu, M.R. verfasserin aut V16. MRI abnormalities of the cerebellar cortex and nuclei in SCA3, SCA6, and Friedreich’s ataxia 2015transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier In the present study, susceptibility weighted imaging (SWI) was used to show atrophy of cerebellar nuclei in spinocerebellar ataxia type 6 (SCA6), Friedreich ataxia (FRDA), and spinocerebellar ataxia type 3 (SCA3). We tested the hypothesis that cerebellar nuclei are smaller in FRDA and SCA3 compared to healthy controls, but relatively preserved in SCA6. In addition, 7T fMRI was performed with optimized normalization methods to assess function of the cerebellar cortex and nuclei during simple hand movements. Twelve SCA6 patients (age range 41–76years, five female), twelve FRDA patients (age range 21–55years, seven female), and ten SCA3 patients (age range 34–67years, three female), and age- and gender-matched control groups (total n =23, age range 22–75years, ten female) were included. As expected, volume of the cerebellum was most markedly reduced in SCA6, with no significant reduction in FRDA and a slight decrease in SCA3. Atrophy of the cerebellar nuclei was not only present in FRDA and SCA3, but also in SCA6. In fact, volume reduction of the nuclei was most marked in SCA6. On a functional level, fMRI signal was altered both within the cerebellar cortex and the nuclei in the three disorders. In the nuclei, the reduction was most prominent in FRDA. Different from initial expectations, the decrease of fMRI signal in the cerebellar cortex appeared more prominent in SCA3 and FRDA than in SCA6. These findings will be discussed in further detail in the light of the known pathohistology of the diseases. In the present study, susceptibility weighted imaging (SWI) was used to show atrophy of cerebellar nuclei in spinocerebellar ataxia type 6 (SCA6), Friedreich ataxia (FRDA), and spinocerebellar ataxia type 3 (SCA3). We tested the hypothesis that cerebellar nuclei are smaller in FRDA and SCA3 compared to healthy controls, but relatively preserved in SCA6. In addition, 7T fMRI was performed with optimized normalization methods to assess function of the cerebellar cortex and nuclei during simple hand movements. Twelve SCA6 patients (age range 41–76years, five female), twelve FRDA patients (age range 21–55years, seven female), and ten SCA3 patients (age range 34–67years, three female), and age- and gender-matched control groups (total n =23, age range 22–75years, ten female) were included. As expected, volume of the cerebellum was most markedly reduced in SCA6, with no significant reduction in FRDA and a slight decrease in SCA3. Atrophy of the cerebellar nuclei was not only present in FRDA and SCA3, but also in SCA6. In fact, volume reduction of the nuclei was most marked in SCA6. On a functional level, fMRI signal was altered both within the cerebellar cortex and the nuclei in the three disorders. In the nuclei, the reduction was most prominent in FRDA. Different from initial expectations, the decrease of fMRI signal in the cerebellar cortex appeared more prominent in SCA3 and FRDA than in SCA6. These findings will be discussed in further detail in the light of the known pathohistology of the diseases. Dohnalek, M. oth Maderwald, S. oth Thürling, M. oth Minnerop, M. oth Beck, A. oth Schlamann, M. oth Diedrichsen, J. oth Ladd, M.E. oth Timmann, D. oth Enthalten in Elsevier Science Södervik, Ilona ELSEVIER Medical students' biomedical and clinical knowledge: Combining longitudinal design, eye tracking and comparison with residents' performance 2017 Amsterdam [u.a.] (DE-627)ELV000764582 volume:126 year:2015 number:8 pages:73 https://doi.org/10.1016/j.clinph.2015.04.094 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 80.00 Pädagogik: Allgemeines VZ AR 126 2015 8 73 126.2015, 8, e73- 045F 610 |
| allfieldsGer |
10.1016/j.clinph.2015.04.094 doi GBVA2015003000012.pica (DE-627)ELV018225500 (ELSEVIER)S1388-2457(15)00341-7 DE-627 ger DE-627 rakwb eng 610 610 DE-600 370 VZ 5,3 ssgn 80.00 bkl Stefanescu, M.R. verfasserin aut V16. MRI abnormalities of the cerebellar cortex and nuclei in SCA3, SCA6, and Friedreich’s ataxia 2015transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier In the present study, susceptibility weighted imaging (SWI) was used to show atrophy of cerebellar nuclei in spinocerebellar ataxia type 6 (SCA6), Friedreich ataxia (FRDA), and spinocerebellar ataxia type 3 (SCA3). We tested the hypothesis that cerebellar nuclei are smaller in FRDA and SCA3 compared to healthy controls, but relatively preserved in SCA6. In addition, 7T fMRI was performed with optimized normalization methods to assess function of the cerebellar cortex and nuclei during simple hand movements. Twelve SCA6 patients (age range 41–76years, five female), twelve FRDA patients (age range 21–55years, seven female), and ten SCA3 patients (age range 34–67years, three female), and age- and gender-matched control groups (total n =23, age range 22–75years, ten female) were included. As expected, volume of the cerebellum was most markedly reduced in SCA6, with no significant reduction in FRDA and a slight decrease in SCA3. Atrophy of the cerebellar nuclei was not only present in FRDA and SCA3, but also in SCA6. In fact, volume reduction of the nuclei was most marked in SCA6. On a functional level, fMRI signal was altered both within the cerebellar cortex and the nuclei in the three disorders. In the nuclei, the reduction was most prominent in FRDA. Different from initial expectations, the decrease of fMRI signal in the cerebellar cortex appeared more prominent in SCA3 and FRDA than in SCA6. These findings will be discussed in further detail in the light of the known pathohistology of the diseases. In the present study, susceptibility weighted imaging (SWI) was used to show atrophy of cerebellar nuclei in spinocerebellar ataxia type 6 (SCA6), Friedreich ataxia (FRDA), and spinocerebellar ataxia type 3 (SCA3). We tested the hypothesis that cerebellar nuclei are smaller in FRDA and SCA3 compared to healthy controls, but relatively preserved in SCA6. In addition, 7T fMRI was performed with optimized normalization methods to assess function of the cerebellar cortex and nuclei during simple hand movements. Twelve SCA6 patients (age range 41–76years, five female), twelve FRDA patients (age range 21–55years, seven female), and ten SCA3 patients (age range 34–67years, three female), and age- and gender-matched control groups (total n =23, age range 22–75years, ten female) were included. As expected, volume of the cerebellum was most markedly reduced in SCA6, with no significant reduction in FRDA and a slight decrease in SCA3. Atrophy of the cerebellar nuclei was not only present in FRDA and SCA3, but also in SCA6. In fact, volume reduction of the nuclei was most marked in SCA6. On a functional level, fMRI signal was altered both within the cerebellar cortex and the nuclei in the three disorders. In the nuclei, the reduction was most prominent in FRDA. Different from initial expectations, the decrease of fMRI signal in the cerebellar cortex appeared more prominent in SCA3 and FRDA than in SCA6. These findings will be discussed in further detail in the light of the known pathohistology of the diseases. Dohnalek, M. oth Maderwald, S. oth Thürling, M. oth Minnerop, M. oth Beck, A. oth Schlamann, M. oth Diedrichsen, J. oth Ladd, M.E. oth Timmann, D. oth Enthalten in Elsevier Science Södervik, Ilona ELSEVIER Medical students' biomedical and clinical knowledge: Combining longitudinal design, eye tracking and comparison with residents' performance 2017 Amsterdam [u.a.] (DE-627)ELV000764582 volume:126 year:2015 number:8 pages:73 https://doi.org/10.1016/j.clinph.2015.04.094 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 80.00 Pädagogik: Allgemeines VZ AR 126 2015 8 73 126.2015, 8, e73- 045F 610 |
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10.1016/j.clinph.2015.04.094 doi GBVA2015003000012.pica (DE-627)ELV018225500 (ELSEVIER)S1388-2457(15)00341-7 DE-627 ger DE-627 rakwb eng 610 610 DE-600 370 VZ 5,3 ssgn 80.00 bkl Stefanescu, M.R. verfasserin aut V16. MRI abnormalities of the cerebellar cortex and nuclei in SCA3, SCA6, and Friedreich’s ataxia 2015transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier In the present study, susceptibility weighted imaging (SWI) was used to show atrophy of cerebellar nuclei in spinocerebellar ataxia type 6 (SCA6), Friedreich ataxia (FRDA), and spinocerebellar ataxia type 3 (SCA3). We tested the hypothesis that cerebellar nuclei are smaller in FRDA and SCA3 compared to healthy controls, but relatively preserved in SCA6. In addition, 7T fMRI was performed with optimized normalization methods to assess function of the cerebellar cortex and nuclei during simple hand movements. Twelve SCA6 patients (age range 41–76years, five female), twelve FRDA patients (age range 21–55years, seven female), and ten SCA3 patients (age range 34–67years, three female), and age- and gender-matched control groups (total n =23, age range 22–75years, ten female) were included. As expected, volume of the cerebellum was most markedly reduced in SCA6, with no significant reduction in FRDA and a slight decrease in SCA3. Atrophy of the cerebellar nuclei was not only present in FRDA and SCA3, but also in SCA6. In fact, volume reduction of the nuclei was most marked in SCA6. On a functional level, fMRI signal was altered both within the cerebellar cortex and the nuclei in the three disorders. In the nuclei, the reduction was most prominent in FRDA. Different from initial expectations, the decrease of fMRI signal in the cerebellar cortex appeared more prominent in SCA3 and FRDA than in SCA6. These findings will be discussed in further detail in the light of the known pathohistology of the diseases. In the present study, susceptibility weighted imaging (SWI) was used to show atrophy of cerebellar nuclei in spinocerebellar ataxia type 6 (SCA6), Friedreich ataxia (FRDA), and spinocerebellar ataxia type 3 (SCA3). We tested the hypothesis that cerebellar nuclei are smaller in FRDA and SCA3 compared to healthy controls, but relatively preserved in SCA6. In addition, 7T fMRI was performed with optimized normalization methods to assess function of the cerebellar cortex and nuclei during simple hand movements. Twelve SCA6 patients (age range 41–76years, five female), twelve FRDA patients (age range 21–55years, seven female), and ten SCA3 patients (age range 34–67years, three female), and age- and gender-matched control groups (total n =23, age range 22–75years, ten female) were included. As expected, volume of the cerebellum was most markedly reduced in SCA6, with no significant reduction in FRDA and a slight decrease in SCA3. Atrophy of the cerebellar nuclei was not only present in FRDA and SCA3, but also in SCA6. In fact, volume reduction of the nuclei was most marked in SCA6. On a functional level, fMRI signal was altered both within the cerebellar cortex and the nuclei in the three disorders. In the nuclei, the reduction was most prominent in FRDA. Different from initial expectations, the decrease of fMRI signal in the cerebellar cortex appeared more prominent in SCA3 and FRDA than in SCA6. These findings will be discussed in further detail in the light of the known pathohistology of the diseases. Dohnalek, M. oth Maderwald, S. oth Thürling, M. oth Minnerop, M. oth Beck, A. oth Schlamann, M. oth Diedrichsen, J. oth Ladd, M.E. oth Timmann, D. oth Enthalten in Elsevier Science Södervik, Ilona ELSEVIER Medical students' biomedical and clinical knowledge: Combining longitudinal design, eye tracking and comparison with residents' performance 2017 Amsterdam [u.a.] (DE-627)ELV000764582 volume:126 year:2015 number:8 pages:73 https://doi.org/10.1016/j.clinph.2015.04.094 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 80.00 Pädagogik: Allgemeines VZ AR 126 2015 8 73 126.2015, 8, e73- 045F 610 |
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v16. mri abnormalities of the cerebellar cortex and nuclei in sca3, sca6, and friedreich’s ataxia |
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V16. MRI abnormalities of the cerebellar cortex and nuclei in SCA3, SCA6, and Friedreich’s ataxia |
| abstract |
In the present study, susceptibility weighted imaging (SWI) was used to show atrophy of cerebellar nuclei in spinocerebellar ataxia type 6 (SCA6), Friedreich ataxia (FRDA), and spinocerebellar ataxia type 3 (SCA3). We tested the hypothesis that cerebellar nuclei are smaller in FRDA and SCA3 compared to healthy controls, but relatively preserved in SCA6. In addition, 7T fMRI was performed with optimized normalization methods to assess function of the cerebellar cortex and nuclei during simple hand movements. Twelve SCA6 patients (age range 41–76years, five female), twelve FRDA patients (age range 21–55years, seven female), and ten SCA3 patients (age range 34–67years, three female), and age- and gender-matched control groups (total n =23, age range 22–75years, ten female) were included. As expected, volume of the cerebellum was most markedly reduced in SCA6, with no significant reduction in FRDA and a slight decrease in SCA3. Atrophy of the cerebellar nuclei was not only present in FRDA and SCA3, but also in SCA6. In fact, volume reduction of the nuclei was most marked in SCA6. On a functional level, fMRI signal was altered both within the cerebellar cortex and the nuclei in the three disorders. In the nuclei, the reduction was most prominent in FRDA. Different from initial expectations, the decrease of fMRI signal in the cerebellar cortex appeared more prominent in SCA3 and FRDA than in SCA6. These findings will be discussed in further detail in the light of the known pathohistology of the diseases. |
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In the present study, susceptibility weighted imaging (SWI) was used to show atrophy of cerebellar nuclei in spinocerebellar ataxia type 6 (SCA6), Friedreich ataxia (FRDA), and spinocerebellar ataxia type 3 (SCA3). We tested the hypothesis that cerebellar nuclei are smaller in FRDA and SCA3 compared to healthy controls, but relatively preserved in SCA6. In addition, 7T fMRI was performed with optimized normalization methods to assess function of the cerebellar cortex and nuclei during simple hand movements. Twelve SCA6 patients (age range 41–76years, five female), twelve FRDA patients (age range 21–55years, seven female), and ten SCA3 patients (age range 34–67years, three female), and age- and gender-matched control groups (total n =23, age range 22–75years, ten female) were included. As expected, volume of the cerebellum was most markedly reduced in SCA6, with no significant reduction in FRDA and a slight decrease in SCA3. Atrophy of the cerebellar nuclei was not only present in FRDA and SCA3, but also in SCA6. In fact, volume reduction of the nuclei was most marked in SCA6. On a functional level, fMRI signal was altered both within the cerebellar cortex and the nuclei in the three disorders. In the nuclei, the reduction was most prominent in FRDA. Different from initial expectations, the decrease of fMRI signal in the cerebellar cortex appeared more prominent in SCA3 and FRDA than in SCA6. These findings will be discussed in further detail in the light of the known pathohistology of the diseases. |
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In the present study, susceptibility weighted imaging (SWI) was used to show atrophy of cerebellar nuclei in spinocerebellar ataxia type 6 (SCA6), Friedreich ataxia (FRDA), and spinocerebellar ataxia type 3 (SCA3). We tested the hypothesis that cerebellar nuclei are smaller in FRDA and SCA3 compared to healthy controls, but relatively preserved in SCA6. In addition, 7T fMRI was performed with optimized normalization methods to assess function of the cerebellar cortex and nuclei during simple hand movements. Twelve SCA6 patients (age range 41–76years, five female), twelve FRDA patients (age range 21–55years, seven female), and ten SCA3 patients (age range 34–67years, three female), and age- and gender-matched control groups (total n =23, age range 22–75years, ten female) were included. As expected, volume of the cerebellum was most markedly reduced in SCA6, with no significant reduction in FRDA and a slight decrease in SCA3. Atrophy of the cerebellar nuclei was not only present in FRDA and SCA3, but also in SCA6. In fact, volume reduction of the nuclei was most marked in SCA6. On a functional level, fMRI signal was altered both within the cerebellar cortex and the nuclei in the three disorders. In the nuclei, the reduction was most prominent in FRDA. Different from initial expectations, the decrease of fMRI signal in the cerebellar cortex appeared more prominent in SCA3 and FRDA than in SCA6. These findings will be discussed in further detail in the light of the known pathohistology of the diseases. |
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