Electroconvulsive therapy improves clinical manifestations of treatment-resistant depression without changing serum BDNF levels
Electroconvulsive therapy (ECT) is effective in treatment-resistant depression (TRD). It may act through intracellular process modulation, but its exact mechanism is still unknown. Animal research supports a neurotrophic effect for ECT. We aimed to investigate the association between changes in seru...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Rapinesi, Chiara [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2015transfer abstract |
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| Schlagwörter: |
Brain-derived neurotrophic factor (BDNF), serum levels Electroconvulsive therapy (ECT) |
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| Umfang: |
8 |
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| Übergeordnetes Werk: |
Enthalten in: No title available - 227(2015), 2 vom: 30., Seite 171-178 |
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| Übergeordnetes Werk: |
volume:227 ; year:2015 ; number:2 ; day:30 ; month:06 ; pages:171-178 ; extent:8 |
| Links: |
|---|
| DOI / URN: |
10.1016/j.psychres.2015.04.009 |
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ELV018237770 |
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| 245 | 1 | 0 | |a Electroconvulsive therapy improves clinical manifestations of treatment-resistant depression without changing serum BDNF levels |
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| 520 | |a Electroconvulsive therapy (ECT) is effective in treatment-resistant depression (TRD). It may act through intracellular process modulation, but its exact mechanism is still unknown. Animal research supports a neurotrophic effect for ECT. We aimed to investigate the association between changes in serum brain-derived neurotrophic factor (sBDNF) levels and clinical improvement following ECT in patients with TRD. Twenty-one patients with TRD (2 men, 19 women; mean age, 63.5 years; S.D., 11.9) were assessed through the Hamilton Depression Rating Scale (HDRS), the Brief Psychiatric Rating Scale (BPRS), and the Clinical Global Impressions scale, Severity (CGIs) before and after a complete ECT cycle. At the same time-points, patients underwent blood withdrawal for measuring sBDNF levels. ECT significantly reduced HDRS, BPRS, and CGIS scores, but not sBDNF levels. No significant correlation was found between sBDNF changes, and each of HDRS, BPRS, and CGIs score changes. sBDNF levels in TRD patients were low both at baseline and post-ECT. Our results do not support that improvements in TRD following ECT are mediated through increases in sBDNF levels. | ||
| 520 | |a Electroconvulsive therapy (ECT) is effective in treatment-resistant depression (TRD). It may act through intracellular process modulation, but its exact mechanism is still unknown. Animal research supports a neurotrophic effect for ECT. We aimed to investigate the association between changes in serum brain-derived neurotrophic factor (sBDNF) levels and clinical improvement following ECT in patients with TRD. Twenty-one patients with TRD (2 men, 19 women; mean age, 63.5 years; S.D., 11.9) were assessed through the Hamilton Depression Rating Scale (HDRS), the Brief Psychiatric Rating Scale (BPRS), and the Clinical Global Impressions scale, Severity (CGIs) before and after a complete ECT cycle. At the same time-points, patients underwent blood withdrawal for measuring sBDNF levels. ECT significantly reduced HDRS, BPRS, and CGIS scores, but not sBDNF levels. No significant correlation was found between sBDNF changes, and each of HDRS, BPRS, and CGIs score changes. sBDNF levels in TRD patients were low both at baseline and post-ECT. Our results do not support that improvements in TRD following ECT are mediated through increases in sBDNF levels. | ||
| 650 | 7 | |a Brain-derived neurotrophic factor (BDNF), serum levels |2 Elsevier | |
| 650 | 7 | |a Major depression |2 Elsevier | |
| 650 | 7 | |a Electroconvulsive therapy (ECT) |2 Elsevier | |
| 650 | 7 | |a Treatment-resistant depression |2 Elsevier | |
| 650 | 7 | |a Bipolar depression |2 Elsevier | |
| 700 | 1 | |a Kotzalidis, Georgios D. |4 oth | |
| 700 | 1 | |a Curto, Martina |4 oth | |
| 700 | 1 | |a Serata, Daniele |4 oth | |
| 700 | 1 | |a Ferri, Vittoria R. |4 oth | |
| 700 | 1 | |a Scatena, Paola |4 oth | |
| 700 | 1 | |a Carbonetti, Paolo |4 oth | |
| 700 | 1 | |a Napoletano, Flavia |4 oth | |
| 700 | 1 | |a Miele, Jessica |4 oth | |
| 700 | 1 | |a Scaccianoce, Sergio |4 oth | |
| 700 | 1 | |a Del Casale, Antonio |4 oth | |
| 700 | 1 | |a Nicoletti, Ferdinando |4 oth | |
| 700 | 1 | |a Angeletti, Gloria |4 oth | |
| 700 | 1 | |a Girardi, Paolo |4 oth | |
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10.1016/j.psychres.2015.04.009 doi /export/home/cbs_olc/import_discovery/elsevier/convert/GBV-Archive_01_06_pica_neu/GBVA2015004000010.pica (DE-627)ELV018237770 (ELSEVIER)S0165-1781(15)00194-8 DE-627 ger DE-627 rakwb eng Rapinesi, Chiara verfasserin aut Electroconvulsive therapy improves clinical manifestations of treatment-resistant depression without changing serum BDNF levels 2015transfer abstract 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Electroconvulsive therapy (ECT) is effective in treatment-resistant depression (TRD). It may act through intracellular process modulation, but its exact mechanism is still unknown. Animal research supports a neurotrophic effect for ECT. We aimed to investigate the association between changes in serum brain-derived neurotrophic factor (sBDNF) levels and clinical improvement following ECT in patients with TRD. Twenty-one patients with TRD (2 men, 19 women; mean age, 63.5 years; S.D., 11.9) were assessed through the Hamilton Depression Rating Scale (HDRS), the Brief Psychiatric Rating Scale (BPRS), and the Clinical Global Impressions scale, Severity (CGIs) before and after a complete ECT cycle. At the same time-points, patients underwent blood withdrawal for measuring sBDNF levels. ECT significantly reduced HDRS, BPRS, and CGIS scores, but not sBDNF levels. No significant correlation was found between sBDNF changes, and each of HDRS, BPRS, and CGIs score changes. sBDNF levels in TRD patients were low both at baseline and post-ECT. Our results do not support that improvements in TRD following ECT are mediated through increases in sBDNF levels. Electroconvulsive therapy (ECT) is effective in treatment-resistant depression (TRD). It may act through intracellular process modulation, but its exact mechanism is still unknown. Animal research supports a neurotrophic effect for ECT. We aimed to investigate the association between changes in serum brain-derived neurotrophic factor (sBDNF) levels and clinical improvement following ECT in patients with TRD. Twenty-one patients with TRD (2 men, 19 women; mean age, 63.5 years; S.D., 11.9) were assessed through the Hamilton Depression Rating Scale (HDRS), the Brief Psychiatric Rating Scale (BPRS), and the Clinical Global Impressions scale, Severity (CGIs) before and after a complete ECT cycle. At the same time-points, patients underwent blood withdrawal for measuring sBDNF levels. ECT significantly reduced HDRS, BPRS, and CGIS scores, but not sBDNF levels. No significant correlation was found between sBDNF changes, and each of HDRS, BPRS, and CGIs score changes. sBDNF levels in TRD patients were low both at baseline and post-ECT. Our results do not support that improvements in TRD following ECT are mediated through increases in sBDNF levels. Brain-derived neurotrophic factor (BDNF), serum levels Elsevier Major depression Elsevier Electroconvulsive therapy (ECT) Elsevier Treatment-resistant depression Elsevier Bipolar depression Elsevier Kotzalidis, Georgios D. oth Curto, Martina oth Serata, Daniele oth Ferri, Vittoria R. oth Scatena, Paola oth Carbonetti, Paolo oth Napoletano, Flavia oth Miele, Jessica oth Scaccianoce, Sergio oth Del Casale, Antonio oth Nicoletti, Ferdinando oth Angeletti, Gloria oth Girardi, Paolo oth Enthalten in No title available 227(2015), 2 vom: 30., Seite 171-178 (DE-627)ELV013759760 (DE-600)5-1781 nnns volume:227 year:2015 number:2 day:30 month:06 pages:171-178 extent:8 https://doi.org/10.1016/j.psychres.2015.04.009 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U AR 227 2015 2 30 0630 171-178 8 |
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10.1016/j.psychres.2015.04.009 doi /export/home/cbs_olc/import_discovery/elsevier/convert/GBV-Archive_01_06_pica_neu/GBVA2015004000010.pica (DE-627)ELV018237770 (ELSEVIER)S0165-1781(15)00194-8 DE-627 ger DE-627 rakwb eng Rapinesi, Chiara verfasserin aut Electroconvulsive therapy improves clinical manifestations of treatment-resistant depression without changing serum BDNF levels 2015transfer abstract 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Electroconvulsive therapy (ECT) is effective in treatment-resistant depression (TRD). It may act through intracellular process modulation, but its exact mechanism is still unknown. Animal research supports a neurotrophic effect for ECT. We aimed to investigate the association between changes in serum brain-derived neurotrophic factor (sBDNF) levels and clinical improvement following ECT in patients with TRD. Twenty-one patients with TRD (2 men, 19 women; mean age, 63.5 years; S.D., 11.9) were assessed through the Hamilton Depression Rating Scale (HDRS), the Brief Psychiatric Rating Scale (BPRS), and the Clinical Global Impressions scale, Severity (CGIs) before and after a complete ECT cycle. At the same time-points, patients underwent blood withdrawal for measuring sBDNF levels. ECT significantly reduced HDRS, BPRS, and CGIS scores, but not sBDNF levels. No significant correlation was found between sBDNF changes, and each of HDRS, BPRS, and CGIs score changes. sBDNF levels in TRD patients were low both at baseline and post-ECT. Our results do not support that improvements in TRD following ECT are mediated through increases in sBDNF levels. Electroconvulsive therapy (ECT) is effective in treatment-resistant depression (TRD). It may act through intracellular process modulation, but its exact mechanism is still unknown. Animal research supports a neurotrophic effect for ECT. We aimed to investigate the association between changes in serum brain-derived neurotrophic factor (sBDNF) levels and clinical improvement following ECT in patients with TRD. Twenty-one patients with TRD (2 men, 19 women; mean age, 63.5 years; S.D., 11.9) were assessed through the Hamilton Depression Rating Scale (HDRS), the Brief Psychiatric Rating Scale (BPRS), and the Clinical Global Impressions scale, Severity (CGIs) before and after a complete ECT cycle. At the same time-points, patients underwent blood withdrawal for measuring sBDNF levels. ECT significantly reduced HDRS, BPRS, and CGIS scores, but not sBDNF levels. No significant correlation was found between sBDNF changes, and each of HDRS, BPRS, and CGIs score changes. sBDNF levels in TRD patients were low both at baseline and post-ECT. Our results do not support that improvements in TRD following ECT are mediated through increases in sBDNF levels. Brain-derived neurotrophic factor (BDNF), serum levels Elsevier Major depression Elsevier Electroconvulsive therapy (ECT) Elsevier Treatment-resistant depression Elsevier Bipolar depression Elsevier Kotzalidis, Georgios D. oth Curto, Martina oth Serata, Daniele oth Ferri, Vittoria R. oth Scatena, Paola oth Carbonetti, Paolo oth Napoletano, Flavia oth Miele, Jessica oth Scaccianoce, Sergio oth Del Casale, Antonio oth Nicoletti, Ferdinando oth Angeletti, Gloria oth Girardi, Paolo oth Enthalten in No title available 227(2015), 2 vom: 30., Seite 171-178 (DE-627)ELV013759760 (DE-600)5-1781 nnns volume:227 year:2015 number:2 day:30 month:06 pages:171-178 extent:8 https://doi.org/10.1016/j.psychres.2015.04.009 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U AR 227 2015 2 30 0630 171-178 8 |
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10.1016/j.psychres.2015.04.009 doi /export/home/cbs_olc/import_discovery/elsevier/convert/GBV-Archive_01_06_pica_neu/GBVA2015004000010.pica (DE-627)ELV018237770 (ELSEVIER)S0165-1781(15)00194-8 DE-627 ger DE-627 rakwb eng Rapinesi, Chiara verfasserin aut Electroconvulsive therapy improves clinical manifestations of treatment-resistant depression without changing serum BDNF levels 2015transfer abstract 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Electroconvulsive therapy (ECT) is effective in treatment-resistant depression (TRD). It may act through intracellular process modulation, but its exact mechanism is still unknown. Animal research supports a neurotrophic effect for ECT. We aimed to investigate the association between changes in serum brain-derived neurotrophic factor (sBDNF) levels and clinical improvement following ECT in patients with TRD. Twenty-one patients with TRD (2 men, 19 women; mean age, 63.5 years; S.D., 11.9) were assessed through the Hamilton Depression Rating Scale (HDRS), the Brief Psychiatric Rating Scale (BPRS), and the Clinical Global Impressions scale, Severity (CGIs) before and after a complete ECT cycle. At the same time-points, patients underwent blood withdrawal for measuring sBDNF levels. ECT significantly reduced HDRS, BPRS, and CGIS scores, but not sBDNF levels. No significant correlation was found between sBDNF changes, and each of HDRS, BPRS, and CGIs score changes. sBDNF levels in TRD patients were low both at baseline and post-ECT. Our results do not support that improvements in TRD following ECT are mediated through increases in sBDNF levels. Electroconvulsive therapy (ECT) is effective in treatment-resistant depression (TRD). It may act through intracellular process modulation, but its exact mechanism is still unknown. Animal research supports a neurotrophic effect for ECT. We aimed to investigate the association between changes in serum brain-derived neurotrophic factor (sBDNF) levels and clinical improvement following ECT in patients with TRD. Twenty-one patients with TRD (2 men, 19 women; mean age, 63.5 years; S.D., 11.9) were assessed through the Hamilton Depression Rating Scale (HDRS), the Brief Psychiatric Rating Scale (BPRS), and the Clinical Global Impressions scale, Severity (CGIs) before and after a complete ECT cycle. At the same time-points, patients underwent blood withdrawal for measuring sBDNF levels. ECT significantly reduced HDRS, BPRS, and CGIS scores, but not sBDNF levels. No significant correlation was found between sBDNF changes, and each of HDRS, BPRS, and CGIs score changes. sBDNF levels in TRD patients were low both at baseline and post-ECT. Our results do not support that improvements in TRD following ECT are mediated through increases in sBDNF levels. Brain-derived neurotrophic factor (BDNF), serum levels Elsevier Major depression Elsevier Electroconvulsive therapy (ECT) Elsevier Treatment-resistant depression Elsevier Bipolar depression Elsevier Kotzalidis, Georgios D. oth Curto, Martina oth Serata, Daniele oth Ferri, Vittoria R. oth Scatena, Paola oth Carbonetti, Paolo oth Napoletano, Flavia oth Miele, Jessica oth Scaccianoce, Sergio oth Del Casale, Antonio oth Nicoletti, Ferdinando oth Angeletti, Gloria oth Girardi, Paolo oth Enthalten in No title available 227(2015), 2 vom: 30., Seite 171-178 (DE-627)ELV013759760 (DE-600)5-1781 nnns volume:227 year:2015 number:2 day:30 month:06 pages:171-178 extent:8 https://doi.org/10.1016/j.psychres.2015.04.009 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U AR 227 2015 2 30 0630 171-178 8 |
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10.1016/j.psychres.2015.04.009 doi /export/home/cbs_olc/import_discovery/elsevier/convert/GBV-Archive_01_06_pica_neu/GBVA2015004000010.pica (DE-627)ELV018237770 (ELSEVIER)S0165-1781(15)00194-8 DE-627 ger DE-627 rakwb eng Rapinesi, Chiara verfasserin aut Electroconvulsive therapy improves clinical manifestations of treatment-resistant depression without changing serum BDNF levels 2015transfer abstract 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Electroconvulsive therapy (ECT) is effective in treatment-resistant depression (TRD). It may act through intracellular process modulation, but its exact mechanism is still unknown. Animal research supports a neurotrophic effect for ECT. We aimed to investigate the association between changes in serum brain-derived neurotrophic factor (sBDNF) levels and clinical improvement following ECT in patients with TRD. Twenty-one patients with TRD (2 men, 19 women; mean age, 63.5 years; S.D., 11.9) were assessed through the Hamilton Depression Rating Scale (HDRS), the Brief Psychiatric Rating Scale (BPRS), and the Clinical Global Impressions scale, Severity (CGIs) before and after a complete ECT cycle. At the same time-points, patients underwent blood withdrawal for measuring sBDNF levels. ECT significantly reduced HDRS, BPRS, and CGIS scores, but not sBDNF levels. No significant correlation was found between sBDNF changes, and each of HDRS, BPRS, and CGIs score changes. sBDNF levels in TRD patients were low both at baseline and post-ECT. Our results do not support that improvements in TRD following ECT are mediated through increases in sBDNF levels. Electroconvulsive therapy (ECT) is effective in treatment-resistant depression (TRD). It may act through intracellular process modulation, but its exact mechanism is still unknown. Animal research supports a neurotrophic effect for ECT. We aimed to investigate the association between changes in serum brain-derived neurotrophic factor (sBDNF) levels and clinical improvement following ECT in patients with TRD. Twenty-one patients with TRD (2 men, 19 women; mean age, 63.5 years; S.D., 11.9) were assessed through the Hamilton Depression Rating Scale (HDRS), the Brief Psychiatric Rating Scale (BPRS), and the Clinical Global Impressions scale, Severity (CGIs) before and after a complete ECT cycle. At the same time-points, patients underwent blood withdrawal for measuring sBDNF levels. ECT significantly reduced HDRS, BPRS, and CGIS scores, but not sBDNF levels. No significant correlation was found between sBDNF changes, and each of HDRS, BPRS, and CGIs score changes. sBDNF levels in TRD patients were low both at baseline and post-ECT. Our results do not support that improvements in TRD following ECT are mediated through increases in sBDNF levels. Brain-derived neurotrophic factor (BDNF), serum levels Elsevier Major depression Elsevier Electroconvulsive therapy (ECT) Elsevier Treatment-resistant depression Elsevier Bipolar depression Elsevier Kotzalidis, Georgios D. oth Curto, Martina oth Serata, Daniele oth Ferri, Vittoria R. oth Scatena, Paola oth Carbonetti, Paolo oth Napoletano, Flavia oth Miele, Jessica oth Scaccianoce, Sergio oth Del Casale, Antonio oth Nicoletti, Ferdinando oth Angeletti, Gloria oth Girardi, Paolo oth Enthalten in No title available 227(2015), 2 vom: 30., Seite 171-178 (DE-627)ELV013759760 (DE-600)5-1781 nnns volume:227 year:2015 number:2 day:30 month:06 pages:171-178 extent:8 https://doi.org/10.1016/j.psychres.2015.04.009 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U AR 227 2015 2 30 0630 171-178 8 |
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10.1016/j.psychres.2015.04.009 doi /export/home/cbs_olc/import_discovery/elsevier/convert/GBV-Archive_01_06_pica_neu/GBVA2015004000010.pica (DE-627)ELV018237770 (ELSEVIER)S0165-1781(15)00194-8 DE-627 ger DE-627 rakwb eng Rapinesi, Chiara verfasserin aut Electroconvulsive therapy improves clinical manifestations of treatment-resistant depression without changing serum BDNF levels 2015transfer abstract 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Electroconvulsive therapy (ECT) is effective in treatment-resistant depression (TRD). It may act through intracellular process modulation, but its exact mechanism is still unknown. Animal research supports a neurotrophic effect for ECT. We aimed to investigate the association between changes in serum brain-derived neurotrophic factor (sBDNF) levels and clinical improvement following ECT in patients with TRD. Twenty-one patients with TRD (2 men, 19 women; mean age, 63.5 years; S.D., 11.9) were assessed through the Hamilton Depression Rating Scale (HDRS), the Brief Psychiatric Rating Scale (BPRS), and the Clinical Global Impressions scale, Severity (CGIs) before and after a complete ECT cycle. At the same time-points, patients underwent blood withdrawal for measuring sBDNF levels. ECT significantly reduced HDRS, BPRS, and CGIS scores, but not sBDNF levels. No significant correlation was found between sBDNF changes, and each of HDRS, BPRS, and CGIs score changes. sBDNF levels in TRD patients were low both at baseline and post-ECT. Our results do not support that improvements in TRD following ECT are mediated through increases in sBDNF levels. Electroconvulsive therapy (ECT) is effective in treatment-resistant depression (TRD). It may act through intracellular process modulation, but its exact mechanism is still unknown. Animal research supports a neurotrophic effect for ECT. We aimed to investigate the association between changes in serum brain-derived neurotrophic factor (sBDNF) levels and clinical improvement following ECT in patients with TRD. Twenty-one patients with TRD (2 men, 19 women; mean age, 63.5 years; S.D., 11.9) were assessed through the Hamilton Depression Rating Scale (HDRS), the Brief Psychiatric Rating Scale (BPRS), and the Clinical Global Impressions scale, Severity (CGIs) before and after a complete ECT cycle. At the same time-points, patients underwent blood withdrawal for measuring sBDNF levels. ECT significantly reduced HDRS, BPRS, and CGIS scores, but not sBDNF levels. No significant correlation was found between sBDNF changes, and each of HDRS, BPRS, and CGIs score changes. sBDNF levels in TRD patients were low both at baseline and post-ECT. Our results do not support that improvements in TRD following ECT are mediated through increases in sBDNF levels. Brain-derived neurotrophic factor (BDNF), serum levels Elsevier Major depression Elsevier Electroconvulsive therapy (ECT) Elsevier Treatment-resistant depression Elsevier Bipolar depression Elsevier Kotzalidis, Georgios D. oth Curto, Martina oth Serata, Daniele oth Ferri, Vittoria R. oth Scatena, Paola oth Carbonetti, Paolo oth Napoletano, Flavia oth Miele, Jessica oth Scaccianoce, Sergio oth Del Casale, Antonio oth Nicoletti, Ferdinando oth Angeletti, Gloria oth Girardi, Paolo oth Enthalten in No title available 227(2015), 2 vom: 30., Seite 171-178 (DE-627)ELV013759760 (DE-600)5-1781 nnns volume:227 year:2015 number:2 day:30 month:06 pages:171-178 extent:8 https://doi.org/10.1016/j.psychres.2015.04.009 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U AR 227 2015 2 30 0630 171-178 8 |
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electroconvulsive therapy improves clinical manifestations of treatment-resistant depression without changing serum bdnf levels |
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Electroconvulsive therapy improves clinical manifestations of treatment-resistant depression without changing serum BDNF levels |
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Electroconvulsive therapy (ECT) is effective in treatment-resistant depression (TRD). It may act through intracellular process modulation, but its exact mechanism is still unknown. Animal research supports a neurotrophic effect for ECT. We aimed to investigate the association between changes in serum brain-derived neurotrophic factor (sBDNF) levels and clinical improvement following ECT in patients with TRD. Twenty-one patients with TRD (2 men, 19 women; mean age, 63.5 years; S.D., 11.9) were assessed through the Hamilton Depression Rating Scale (HDRS), the Brief Psychiatric Rating Scale (BPRS), and the Clinical Global Impressions scale, Severity (CGIs) before and after a complete ECT cycle. At the same time-points, patients underwent blood withdrawal for measuring sBDNF levels. ECT significantly reduced HDRS, BPRS, and CGIS scores, but not sBDNF levels. No significant correlation was found between sBDNF changes, and each of HDRS, BPRS, and CGIs score changes. sBDNF levels in TRD patients were low both at baseline and post-ECT. Our results do not support that improvements in TRD following ECT are mediated through increases in sBDNF levels. |
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Electroconvulsive therapy (ECT) is effective in treatment-resistant depression (TRD). It may act through intracellular process modulation, but its exact mechanism is still unknown. Animal research supports a neurotrophic effect for ECT. We aimed to investigate the association between changes in serum brain-derived neurotrophic factor (sBDNF) levels and clinical improvement following ECT in patients with TRD. Twenty-one patients with TRD (2 men, 19 women; mean age, 63.5 years; S.D., 11.9) were assessed through the Hamilton Depression Rating Scale (HDRS), the Brief Psychiatric Rating Scale (BPRS), and the Clinical Global Impressions scale, Severity (CGIs) before and after a complete ECT cycle. At the same time-points, patients underwent blood withdrawal for measuring sBDNF levels. ECT significantly reduced HDRS, BPRS, and CGIS scores, but not sBDNF levels. No significant correlation was found between sBDNF changes, and each of HDRS, BPRS, and CGIs score changes. sBDNF levels in TRD patients were low both at baseline and post-ECT. Our results do not support that improvements in TRD following ECT are mediated through increases in sBDNF levels. |
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Electroconvulsive therapy (ECT) is effective in treatment-resistant depression (TRD). It may act through intracellular process modulation, but its exact mechanism is still unknown. Animal research supports a neurotrophic effect for ECT. We aimed to investigate the association between changes in serum brain-derived neurotrophic factor (sBDNF) levels and clinical improvement following ECT in patients with TRD. Twenty-one patients with TRD (2 men, 19 women; mean age, 63.5 years; S.D., 11.9) were assessed through the Hamilton Depression Rating Scale (HDRS), the Brief Psychiatric Rating Scale (BPRS), and the Clinical Global Impressions scale, Severity (CGIs) before and after a complete ECT cycle. At the same time-points, patients underwent blood withdrawal for measuring sBDNF levels. ECT significantly reduced HDRS, BPRS, and CGIS scores, but not sBDNF levels. No significant correlation was found between sBDNF changes, and each of HDRS, BPRS, and CGIs score changes. sBDNF levels in TRD patients were low both at baseline and post-ECT. Our results do not support that improvements in TRD following ECT are mediated through increases in sBDNF levels. |
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