Poly(ADP-ribosylation) and neurodegenerative disorders
Impaired mitochondrial structure and function are common features of neurodegenerative disorders, ultimately characterized by the death of neural cells promoted by still unknown signals. Among the possible modulators of neurodegeneration, the activation of poly(ADP-ribosylation), a post-translationa...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Basello, Davide Alessandro [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2015transfer abstract |
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| Umfang: |
8 |
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| Übergeordnetes Werk: |
Enthalten in: Efficient generation of anisotropic N-field microstructures from 2-point statistics using multi-output Gaussian random fields - Robertson, Andreas E. ELSEVIER, 2022, official journal of the Mitochondria Research Society, Amsterdam [u.a.] |
|---|---|
| Übergeordnetes Werk: |
volume:24 ; year:2015 ; pages:56-63 ; extent:8 |
| Links: |
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| DOI / URN: |
10.1016/j.mito.2015.07.005 |
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| 520 | |a Impaired mitochondrial structure and function are common features of neurodegenerative disorders, ultimately characterized by the death of neural cells promoted by still unknown signals. Among the possible modulators of neurodegeneration, the activation of poly(ADP-ribosylation), a post-translational modification of proteins, has been considered, being the product of the reaction, poly(ADP-ribose), a signaling molecule for different cell death paradigms. The basic properties of poly(ADP-ribosylation) are here described, focusing on the mitochondrial events; cell death paradigms such as apoptosis, parthanatos, necroptosis and mitophagy are illustrated. Finally, the promising use of poly(ADP-ribosylation) inhibitors to rescue neurodegeneration is addressed. | ||
| 520 | |a Impaired mitochondrial structure and function are common features of neurodegenerative disorders, ultimately characterized by the death of neural cells promoted by still unknown signals. Among the possible modulators of neurodegeneration, the activation of poly(ADP-ribosylation), a post-translational modification of proteins, has been considered, being the product of the reaction, poly(ADP-ribose), a signaling molecule for different cell death paradigms. The basic properties of poly(ADP-ribosylation) are here described, focusing on the mitochondrial events; cell death paradigms such as apoptosis, parthanatos, necroptosis and mitophagy are illustrated. Finally, the promising use of poly(ADP-ribosylation) inhibitors to rescue neurodegeneration is addressed. | ||
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10.1016/j.mito.2015.07.005 doi GBVA2015007000003.pica (DE-627)ELV018350720 (ELSEVIER)S1567-7249(15)30012-X DE-627 ger DE-627 rakwb eng 540 540 DE-600 670 VZ 51.00 bkl Basello, Davide Alessandro verfasserin aut Poly(ADP-ribosylation) and neurodegenerative disorders 2015transfer abstract 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Impaired mitochondrial structure and function are common features of neurodegenerative disorders, ultimately characterized by the death of neural cells promoted by still unknown signals. Among the possible modulators of neurodegeneration, the activation of poly(ADP-ribosylation), a post-translational modification of proteins, has been considered, being the product of the reaction, poly(ADP-ribose), a signaling molecule for different cell death paradigms. The basic properties of poly(ADP-ribosylation) are here described, focusing on the mitochondrial events; cell death paradigms such as apoptosis, parthanatos, necroptosis and mitophagy are illustrated. Finally, the promising use of poly(ADP-ribosylation) inhibitors to rescue neurodegeneration is addressed. Impaired mitochondrial structure and function are common features of neurodegenerative disorders, ultimately characterized by the death of neural cells promoted by still unknown signals. Among the possible modulators of neurodegeneration, the activation of poly(ADP-ribosylation), a post-translational modification of proteins, has been considered, being the product of the reaction, poly(ADP-ribose), a signaling molecule for different cell death paradigms. The basic properties of poly(ADP-ribosylation) are here described, focusing on the mitochondrial events; cell death paradigms such as apoptosis, parthanatos, necroptosis and mitophagy are illustrated. Finally, the promising use of poly(ADP-ribosylation) inhibitors to rescue neurodegeneration is addressed. Scovassi, Anna Ivana oth Enthalten in Elsevier Science Robertson, Andreas E. ELSEVIER Efficient generation of anisotropic N-field microstructures from 2-point statistics using multi-output Gaussian random fields 2022 official journal of the Mitochondria Research Society Amsterdam [u.a.] (DE-627)ELV007863942 volume:24 year:2015 pages:56-63 extent:8 https://doi.org/10.1016/j.mito.2015.07.005 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 51.00 Werkstoffkunde: Allgemeines VZ AR 24 2015 56-63 8 045F 540 |
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10.1016/j.mito.2015.07.005 doi GBVA2015007000003.pica (DE-627)ELV018350720 (ELSEVIER)S1567-7249(15)30012-X DE-627 ger DE-627 rakwb eng 540 540 DE-600 670 VZ 51.00 bkl Basello, Davide Alessandro verfasserin aut Poly(ADP-ribosylation) and neurodegenerative disorders 2015transfer abstract 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Impaired mitochondrial structure and function are common features of neurodegenerative disorders, ultimately characterized by the death of neural cells promoted by still unknown signals. Among the possible modulators of neurodegeneration, the activation of poly(ADP-ribosylation), a post-translational modification of proteins, has been considered, being the product of the reaction, poly(ADP-ribose), a signaling molecule for different cell death paradigms. The basic properties of poly(ADP-ribosylation) are here described, focusing on the mitochondrial events; cell death paradigms such as apoptosis, parthanatos, necroptosis and mitophagy are illustrated. Finally, the promising use of poly(ADP-ribosylation) inhibitors to rescue neurodegeneration is addressed. Impaired mitochondrial structure and function are common features of neurodegenerative disorders, ultimately characterized by the death of neural cells promoted by still unknown signals. Among the possible modulators of neurodegeneration, the activation of poly(ADP-ribosylation), a post-translational modification of proteins, has been considered, being the product of the reaction, poly(ADP-ribose), a signaling molecule for different cell death paradigms. The basic properties of poly(ADP-ribosylation) are here described, focusing on the mitochondrial events; cell death paradigms such as apoptosis, parthanatos, necroptosis and mitophagy are illustrated. Finally, the promising use of poly(ADP-ribosylation) inhibitors to rescue neurodegeneration is addressed. Scovassi, Anna Ivana oth Enthalten in Elsevier Science Robertson, Andreas E. ELSEVIER Efficient generation of anisotropic N-field microstructures from 2-point statistics using multi-output Gaussian random fields 2022 official journal of the Mitochondria Research Society Amsterdam [u.a.] (DE-627)ELV007863942 volume:24 year:2015 pages:56-63 extent:8 https://doi.org/10.1016/j.mito.2015.07.005 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 51.00 Werkstoffkunde: Allgemeines VZ AR 24 2015 56-63 8 045F 540 |
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10.1016/j.mito.2015.07.005 doi GBVA2015007000003.pica (DE-627)ELV018350720 (ELSEVIER)S1567-7249(15)30012-X DE-627 ger DE-627 rakwb eng 540 540 DE-600 670 VZ 51.00 bkl Basello, Davide Alessandro verfasserin aut Poly(ADP-ribosylation) and neurodegenerative disorders 2015transfer abstract 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Impaired mitochondrial structure and function are common features of neurodegenerative disorders, ultimately characterized by the death of neural cells promoted by still unknown signals. Among the possible modulators of neurodegeneration, the activation of poly(ADP-ribosylation), a post-translational modification of proteins, has been considered, being the product of the reaction, poly(ADP-ribose), a signaling molecule for different cell death paradigms. The basic properties of poly(ADP-ribosylation) are here described, focusing on the mitochondrial events; cell death paradigms such as apoptosis, parthanatos, necroptosis and mitophagy are illustrated. Finally, the promising use of poly(ADP-ribosylation) inhibitors to rescue neurodegeneration is addressed. Impaired mitochondrial structure and function are common features of neurodegenerative disorders, ultimately characterized by the death of neural cells promoted by still unknown signals. Among the possible modulators of neurodegeneration, the activation of poly(ADP-ribosylation), a post-translational modification of proteins, has been considered, being the product of the reaction, poly(ADP-ribose), a signaling molecule for different cell death paradigms. The basic properties of poly(ADP-ribosylation) are here described, focusing on the mitochondrial events; cell death paradigms such as apoptosis, parthanatos, necroptosis and mitophagy are illustrated. Finally, the promising use of poly(ADP-ribosylation) inhibitors to rescue neurodegeneration is addressed. Scovassi, Anna Ivana oth Enthalten in Elsevier Science Robertson, Andreas E. ELSEVIER Efficient generation of anisotropic N-field microstructures from 2-point statistics using multi-output Gaussian random fields 2022 official journal of the Mitochondria Research Society Amsterdam [u.a.] (DE-627)ELV007863942 volume:24 year:2015 pages:56-63 extent:8 https://doi.org/10.1016/j.mito.2015.07.005 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 51.00 Werkstoffkunde: Allgemeines VZ AR 24 2015 56-63 8 045F 540 |
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10.1016/j.mito.2015.07.005 doi GBVA2015007000003.pica (DE-627)ELV018350720 (ELSEVIER)S1567-7249(15)30012-X DE-627 ger DE-627 rakwb eng 540 540 DE-600 670 VZ 51.00 bkl Basello, Davide Alessandro verfasserin aut Poly(ADP-ribosylation) and neurodegenerative disorders 2015transfer abstract 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Impaired mitochondrial structure and function are common features of neurodegenerative disorders, ultimately characterized by the death of neural cells promoted by still unknown signals. Among the possible modulators of neurodegeneration, the activation of poly(ADP-ribosylation), a post-translational modification of proteins, has been considered, being the product of the reaction, poly(ADP-ribose), a signaling molecule for different cell death paradigms. The basic properties of poly(ADP-ribosylation) are here described, focusing on the mitochondrial events; cell death paradigms such as apoptosis, parthanatos, necroptosis and mitophagy are illustrated. Finally, the promising use of poly(ADP-ribosylation) inhibitors to rescue neurodegeneration is addressed. Impaired mitochondrial structure and function are common features of neurodegenerative disorders, ultimately characterized by the death of neural cells promoted by still unknown signals. Among the possible modulators of neurodegeneration, the activation of poly(ADP-ribosylation), a post-translational modification of proteins, has been considered, being the product of the reaction, poly(ADP-ribose), a signaling molecule for different cell death paradigms. The basic properties of poly(ADP-ribosylation) are here described, focusing on the mitochondrial events; cell death paradigms such as apoptosis, parthanatos, necroptosis and mitophagy are illustrated. Finally, the promising use of poly(ADP-ribosylation) inhibitors to rescue neurodegeneration is addressed. Scovassi, Anna Ivana oth Enthalten in Elsevier Science Robertson, Andreas E. ELSEVIER Efficient generation of anisotropic N-field microstructures from 2-point statistics using multi-output Gaussian random fields 2022 official journal of the Mitochondria Research Society Amsterdam [u.a.] (DE-627)ELV007863942 volume:24 year:2015 pages:56-63 extent:8 https://doi.org/10.1016/j.mito.2015.07.005 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 51.00 Werkstoffkunde: Allgemeines VZ AR 24 2015 56-63 8 045F 540 |
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Poly(ADP-ribosylation) and neurodegenerative disorders |
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Impaired mitochondrial structure and function are common features of neurodegenerative disorders, ultimately characterized by the death of neural cells promoted by still unknown signals. Among the possible modulators of neurodegeneration, the activation of poly(ADP-ribosylation), a post-translational modification of proteins, has been considered, being the product of the reaction, poly(ADP-ribose), a signaling molecule for different cell death paradigms. The basic properties of poly(ADP-ribosylation) are here described, focusing on the mitochondrial events; cell death paradigms such as apoptosis, parthanatos, necroptosis and mitophagy are illustrated. Finally, the promising use of poly(ADP-ribosylation) inhibitors to rescue neurodegeneration is addressed. |
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Impaired mitochondrial structure and function are common features of neurodegenerative disorders, ultimately characterized by the death of neural cells promoted by still unknown signals. Among the possible modulators of neurodegeneration, the activation of poly(ADP-ribosylation), a post-translational modification of proteins, has been considered, being the product of the reaction, poly(ADP-ribose), a signaling molecule for different cell death paradigms. The basic properties of poly(ADP-ribosylation) are here described, focusing on the mitochondrial events; cell death paradigms such as apoptosis, parthanatos, necroptosis and mitophagy are illustrated. Finally, the promising use of poly(ADP-ribosylation) inhibitors to rescue neurodegeneration is addressed. |
| abstract_unstemmed |
Impaired mitochondrial structure and function are common features of neurodegenerative disorders, ultimately characterized by the death of neural cells promoted by still unknown signals. Among the possible modulators of neurodegeneration, the activation of poly(ADP-ribosylation), a post-translational modification of proteins, has been considered, being the product of the reaction, poly(ADP-ribose), a signaling molecule for different cell death paradigms. The basic properties of poly(ADP-ribosylation) are here described, focusing on the mitochondrial events; cell death paradigms such as apoptosis, parthanatos, necroptosis and mitophagy are illustrated. Finally, the promising use of poly(ADP-ribosylation) inhibitors to rescue neurodegeneration is addressed. |
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Scovassi, Anna Ivana |
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2024-07-06T18:36:37.668Z |
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