NGF but not BDNF overexpression protects hippocampal LTP from beta-amyloid-induced impairment
• A twofold increase of NGF and BDNF concentrations was obtained in the hippocampus using lentiviral gene transfer. • 50nM Aβ (25–35) was chosen for modeling of pathological conditions and hippocampal LTP impairment. • NGF overexpression protects hippocampal LTP from Aβ-induced impairment, while BDN...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Ivanov, A.D. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2015 |
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| Schlagwörter: |
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| Umfang: |
9 |
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| Übergeordnetes Werk: |
Enthalten in: Status of beetroot processing and processed products: Thermal and emerging technologies intervention - Dhiman, Atul ELSEVIER, 2021, an international journal under the editorial direction of IBRO, Amsterdam [u.a.] |
|---|---|
| Übergeordnetes Werk: |
volume:289 ; year:2015 ; day:19 ; month:03 ; pages:114-122 ; extent:9 |
| Links: |
|---|
| DOI / URN: |
10.1016/j.neuroscience.2014.12.063 |
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10.1016/j.neuroscience.2014.12.063 doi GBVA2015008000021.pica (DE-627)ELV018407625 (ELSEVIER)S0306-4522(15)00037-8 DE-627 ger DE-627 rakwb eng 610 610 DE-600 630 640 VZ 58.34 bkl Ivanov, A.D. verfasserin aut NGF but not BDNF overexpression protects hippocampal LTP from beta-amyloid-induced impairment 2015 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • A twofold increase of NGF and BDNF concentrations was obtained in the hippocampus using lentiviral gene transfer. • 50nM Aβ (25–35) was chosen for modeling of pathological conditions and hippocampal LTP impairment. • NGF overexpression protects hippocampal LTP from Aβ-induced impairment, while BDNF overexpression does not. • Blockade of PI3K signaling cascade by LY294002 inhibitor abolishes the neuroprotective effect of NGF. DG Elsevier BDNF Elsevier DMSO Elsevier fEPSPs Elsevier HRP Elsevier NT-3 Elsevier LTP Elsevier NT-4 Elsevier SDS-PAAG Elsevier ACSF Elsevier EGFP Elsevier MPP Elsevier NGF Elsevier CMV Elsevier PVDF Elsevier Aβ Elsevier TBS-T Elsevier HFS Elsevier ANOVA Elsevier hNGF Elsevier IRES Elsevier hBDNF Elsevier ELISA Elsevier Tukhbatova, G.R. oth Salozhin, S.V. oth Markevich, V.A. oth Enthalten in Elsevier Science Dhiman, Atul ELSEVIER Status of beetroot processing and processed products: Thermal and emerging technologies intervention 2021 an international journal under the editorial direction of IBRO Amsterdam [u.a.] (DE-627)ELV006262988 volume:289 year:2015 day:19 month:03 pages:114-122 extent:9 https://doi.org/10.1016/j.neuroscience.2014.12.063 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 58.34 Lebensmitteltechnologie VZ AR 289 2015 19 0319 114-122 9 045F 610 |
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NGF but not BDNF overexpression protects hippocampal LTP from beta-amyloid-induced impairment |
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ngf but not bdnf overexpression protects hippocampal ltp from beta-amyloid-induced impairment |
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NGF but not BDNF overexpression protects hippocampal LTP from beta-amyloid-induced impairment |
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• A twofold increase of NGF and BDNF concentrations was obtained in the hippocampus using lentiviral gene transfer. • 50nM Aβ (25–35) was chosen for modeling of pathological conditions and hippocampal LTP impairment. • NGF overexpression protects hippocampal LTP from Aβ-induced impairment, while BDNF overexpression does not. • Blockade of PI3K signaling cascade by LY294002 inhibitor abolishes the neuroprotective effect of NGF. |
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• A twofold increase of NGF and BDNF concentrations was obtained in the hippocampus using lentiviral gene transfer. • 50nM Aβ (25–35) was chosen for modeling of pathological conditions and hippocampal LTP impairment. • NGF overexpression protects hippocampal LTP from Aβ-induced impairment, while BDNF overexpression does not. • Blockade of PI3K signaling cascade by LY294002 inhibitor abolishes the neuroprotective effect of NGF. |
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• A twofold increase of NGF and BDNF concentrations was obtained in the hippocampus using lentiviral gene transfer. • 50nM Aβ (25–35) was chosen for modeling of pathological conditions and hippocampal LTP impairment. • NGF overexpression protects hippocampal LTP from Aβ-induced impairment, while BDNF overexpression does not. • Blockade of PI3K signaling cascade by LY294002 inhibitor abolishes the neuroprotective effect of NGF. |
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NGF but not BDNF overexpression protects hippocampal LTP from beta-amyloid-induced impairment |
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