Anterior and posterior MTL networks in aging and MCI
Two neuroanatomically dissociable, large-scale cortical memory networks, referred to as the anterior and posterior medial temporal lobe (MTL) networks have recently been described in young adults using resting-state blood oxygen level–dependent (BOLD) functional magnetic resonance imaging (fMRI)–bas...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Das, Sandhitsu R. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2015transfer abstract |
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| Schlagwörter: |
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| Umfang: |
1361 |
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| Übergeordnetes Werk: |
Enthalten in: Corrigendum to “Electrical and thermal transport properties of Fe–Ni based ternary alloys in the earth's inner core: An ab initio study” [Physics of the Earth and Planetary Interiors - Zidane, Mustapha ELSEVIER, 2021, Amsterdam [u.a.] |
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| Übergeordnetes Werk: |
volume:36 ; year:2015 ; pages:141-1501 ; extent:1361 |
| Links: |
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| DOI / URN: |
10.1016/j.neurobiolaging.2014.03.041 |
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| 520 | |a Two neuroanatomically dissociable, large-scale cortical memory networks, referred to as the anterior and posterior medial temporal lobe (MTL) networks have recently been described in young adults using resting-state blood oxygen level–dependent (BOLD) functional magnetic resonance imaging (fMRI)–based functional connectivity (fc-BOLD). They have been hypothesized to subserve distinct mnemonic and non-memory cognitive functions and are thought to be associated with differential vulnerability in neurological disorders. In this article, we demonstrate the existence of these functional networks in an older adult population and in a cohort of patients diagnosed with amnestic mild cognitive impairment (aMCI). Anatomic subregions of interest in the MTL were defined using high-resolution T2-weighted MRI and used as seeds for defining the putative networks using fc-BOLD. Although the literature has suggested that the posterior MTL network is particularly vulnerable to early Alzheimer's disease, we show that both the networks are affected in MCI, to varying degrees, compared with the control group. Furthermore, cortical thickness in the brain regions defined by these networks was reduced in MCI. | ||
| 520 | |a Two neuroanatomically dissociable, large-scale cortical memory networks, referred to as the anterior and posterior medial temporal lobe (MTL) networks have recently been described in young adults using resting-state blood oxygen level–dependent (BOLD) functional magnetic resonance imaging (fMRI)–based functional connectivity (fc-BOLD). They have been hypothesized to subserve distinct mnemonic and non-memory cognitive functions and are thought to be associated with differential vulnerability in neurological disorders. In this article, we demonstrate the existence of these functional networks in an older adult population and in a cohort of patients diagnosed with amnestic mild cognitive impairment (aMCI). Anatomic subregions of interest in the MTL were defined using high-resolution T2-weighted MRI and used as seeds for defining the putative networks using fc-BOLD. Although the literature has suggested that the posterior MTL network is particularly vulnerable to early Alzheimer's disease, we show that both the networks are affected in MCI, to varying degrees, compared with the control group. Furthermore, cortical thickness in the brain regions defined by these networks was reduced in MCI. | ||
| 650 | 7 | |a Older healthy control |2 Elsevier | |
| 650 | 7 | |a Functional connectivity |2 Elsevier | |
| 650 | 7 | |a MCI |2 Elsevier | |
| 650 | 7 | |a MTL |2 Elsevier | |
| 650 | 7 | |a Posterior MTL network |2 Elsevier | |
| 650 | 7 | |a Amnesic |2 Elsevier | |
| 650 | 7 | |a Anterior MTL network |2 Elsevier | |
| 650 | 7 | |a BOLD fMRI |2 Elsevier | |
| 700 | 1 | |a Pluta, John |4 oth | |
| 700 | 1 | |a Mancuso, Lauren |4 oth | |
| 700 | 1 | |a Kliot, Daria |4 oth | |
| 700 | 1 | |a Yushkevich, Paul A. |4 oth | |
| 700 | 1 | |a Wolk, David A. |4 oth | |
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10.1016/j.neurobiolaging.2014.03.041 doi GBVA2015008000022.pica (DE-627)ELV018413048 (ELSEVIER)S0197-4580(14)00547-8 DE-627 ger DE-627 rakwb eng 610 610 DE-600 550 520 VZ 38.70 bkl 39.53 bkl Das, Sandhitsu R. verfasserin aut Anterior and posterior MTL networks in aging and MCI 2015transfer abstract 1361 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Two neuroanatomically dissociable, large-scale cortical memory networks, referred to as the anterior and posterior medial temporal lobe (MTL) networks have recently been described in young adults using resting-state blood oxygen level–dependent (BOLD) functional magnetic resonance imaging (fMRI)–based functional connectivity (fc-BOLD). They have been hypothesized to subserve distinct mnemonic and non-memory cognitive functions and are thought to be associated with differential vulnerability in neurological disorders. In this article, we demonstrate the existence of these functional networks in an older adult population and in a cohort of patients diagnosed with amnestic mild cognitive impairment (aMCI). Anatomic subregions of interest in the MTL were defined using high-resolution T2-weighted MRI and used as seeds for defining the putative networks using fc-BOLD. Although the literature has suggested that the posterior MTL network is particularly vulnerable to early Alzheimer's disease, we show that both the networks are affected in MCI, to varying degrees, compared with the control group. Furthermore, cortical thickness in the brain regions defined by these networks was reduced in MCI. Two neuroanatomically dissociable, large-scale cortical memory networks, referred to as the anterior and posterior medial temporal lobe (MTL) networks have recently been described in young adults using resting-state blood oxygen level–dependent (BOLD) functional magnetic resonance imaging (fMRI)–based functional connectivity (fc-BOLD). They have been hypothesized to subserve distinct mnemonic and non-memory cognitive functions and are thought to be associated with differential vulnerability in neurological disorders. In this article, we demonstrate the existence of these functional networks in an older adult population and in a cohort of patients diagnosed with amnestic mild cognitive impairment (aMCI). Anatomic subregions of interest in the MTL were defined using high-resolution T2-weighted MRI and used as seeds for defining the putative networks using fc-BOLD. Although the literature has suggested that the posterior MTL network is particularly vulnerable to early Alzheimer's disease, we show that both the networks are affected in MCI, to varying degrees, compared with the control group. Furthermore, cortical thickness in the brain regions defined by these networks was reduced in MCI. Older healthy control Elsevier Functional connectivity Elsevier MCI Elsevier MTL Elsevier Posterior MTL network Elsevier Amnesic Elsevier Anterior MTL network Elsevier BOLD fMRI Elsevier Pluta, John oth Mancuso, Lauren oth Kliot, Daria oth Yushkevich, Paul A. oth Wolk, David A. oth Enthalten in Elsevier Science Zidane, Mustapha ELSEVIER Corrigendum to “Electrical and thermal transport properties of Fe–Ni based ternary alloys in the earth's inner core: An ab initio study” [Physics of the Earth and Planetary Interiors 2021 Amsterdam [u.a.] (DE-627)ELV005660645 volume:36 year:2015 pages:141-1501 extent:1361 https://doi.org/10.1016/j.neurobiolaging.2014.03.041 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-GGO SSG-OPC-GEO SSG-OPC-AST 38.70 Geophysik: Allgemeines VZ 39.53 Planeten VZ AR 36 2015 141-1501 1361 36.2015, S141-, (1361 S.) 045F 610 |
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10.1016/j.neurobiolaging.2014.03.041 doi GBVA2015008000022.pica (DE-627)ELV018413048 (ELSEVIER)S0197-4580(14)00547-8 DE-627 ger DE-627 rakwb eng 610 610 DE-600 550 520 VZ 38.70 bkl 39.53 bkl Das, Sandhitsu R. verfasserin aut Anterior and posterior MTL networks in aging and MCI 2015transfer abstract 1361 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Two neuroanatomically dissociable, large-scale cortical memory networks, referred to as the anterior and posterior medial temporal lobe (MTL) networks have recently been described in young adults using resting-state blood oxygen level–dependent (BOLD) functional magnetic resonance imaging (fMRI)–based functional connectivity (fc-BOLD). They have been hypothesized to subserve distinct mnemonic and non-memory cognitive functions and are thought to be associated with differential vulnerability in neurological disorders. In this article, we demonstrate the existence of these functional networks in an older adult population and in a cohort of patients diagnosed with amnestic mild cognitive impairment (aMCI). Anatomic subregions of interest in the MTL were defined using high-resolution T2-weighted MRI and used as seeds for defining the putative networks using fc-BOLD. Although the literature has suggested that the posterior MTL network is particularly vulnerable to early Alzheimer's disease, we show that both the networks are affected in MCI, to varying degrees, compared with the control group. Furthermore, cortical thickness in the brain regions defined by these networks was reduced in MCI. Two neuroanatomically dissociable, large-scale cortical memory networks, referred to as the anterior and posterior medial temporal lobe (MTL) networks have recently been described in young adults using resting-state blood oxygen level–dependent (BOLD) functional magnetic resonance imaging (fMRI)–based functional connectivity (fc-BOLD). They have been hypothesized to subserve distinct mnemonic and non-memory cognitive functions and are thought to be associated with differential vulnerability in neurological disorders. In this article, we demonstrate the existence of these functional networks in an older adult population and in a cohort of patients diagnosed with amnestic mild cognitive impairment (aMCI). Anatomic subregions of interest in the MTL were defined using high-resolution T2-weighted MRI and used as seeds for defining the putative networks using fc-BOLD. Although the literature has suggested that the posterior MTL network is particularly vulnerable to early Alzheimer's disease, we show that both the networks are affected in MCI, to varying degrees, compared with the control group. Furthermore, cortical thickness in the brain regions defined by these networks was reduced in MCI. Older healthy control Elsevier Functional connectivity Elsevier MCI Elsevier MTL Elsevier Posterior MTL network Elsevier Amnesic Elsevier Anterior MTL network Elsevier BOLD fMRI Elsevier Pluta, John oth Mancuso, Lauren oth Kliot, Daria oth Yushkevich, Paul A. oth Wolk, David A. oth Enthalten in Elsevier Science Zidane, Mustapha ELSEVIER Corrigendum to “Electrical and thermal transport properties of Fe–Ni based ternary alloys in the earth's inner core: An ab initio study” [Physics of the Earth and Planetary Interiors 2021 Amsterdam [u.a.] (DE-627)ELV005660645 volume:36 year:2015 pages:141-1501 extent:1361 https://doi.org/10.1016/j.neurobiolaging.2014.03.041 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-GGO SSG-OPC-GEO SSG-OPC-AST 38.70 Geophysik: Allgemeines VZ 39.53 Planeten VZ AR 36 2015 141-1501 1361 36.2015, S141-, (1361 S.) 045F 610 |
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10.1016/j.neurobiolaging.2014.03.041 doi GBVA2015008000022.pica (DE-627)ELV018413048 (ELSEVIER)S0197-4580(14)00547-8 DE-627 ger DE-627 rakwb eng 610 610 DE-600 550 520 VZ 38.70 bkl 39.53 bkl Das, Sandhitsu R. verfasserin aut Anterior and posterior MTL networks in aging and MCI 2015transfer abstract 1361 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Two neuroanatomically dissociable, large-scale cortical memory networks, referred to as the anterior and posterior medial temporal lobe (MTL) networks have recently been described in young adults using resting-state blood oxygen level–dependent (BOLD) functional magnetic resonance imaging (fMRI)–based functional connectivity (fc-BOLD). They have been hypothesized to subserve distinct mnemonic and non-memory cognitive functions and are thought to be associated with differential vulnerability in neurological disorders. In this article, we demonstrate the existence of these functional networks in an older adult population and in a cohort of patients diagnosed with amnestic mild cognitive impairment (aMCI). Anatomic subregions of interest in the MTL were defined using high-resolution T2-weighted MRI and used as seeds for defining the putative networks using fc-BOLD. Although the literature has suggested that the posterior MTL network is particularly vulnerable to early Alzheimer's disease, we show that both the networks are affected in MCI, to varying degrees, compared with the control group. Furthermore, cortical thickness in the brain regions defined by these networks was reduced in MCI. Two neuroanatomically dissociable, large-scale cortical memory networks, referred to as the anterior and posterior medial temporal lobe (MTL) networks have recently been described in young adults using resting-state blood oxygen level–dependent (BOLD) functional magnetic resonance imaging (fMRI)–based functional connectivity (fc-BOLD). They have been hypothesized to subserve distinct mnemonic and non-memory cognitive functions and are thought to be associated with differential vulnerability in neurological disorders. In this article, we demonstrate the existence of these functional networks in an older adult population and in a cohort of patients diagnosed with amnestic mild cognitive impairment (aMCI). Anatomic subregions of interest in the MTL were defined using high-resolution T2-weighted MRI and used as seeds for defining the putative networks using fc-BOLD. Although the literature has suggested that the posterior MTL network is particularly vulnerable to early Alzheimer's disease, we show that both the networks are affected in MCI, to varying degrees, compared with the control group. Furthermore, cortical thickness in the brain regions defined by these networks was reduced in MCI. Older healthy control Elsevier Functional connectivity Elsevier MCI Elsevier MTL Elsevier Posterior MTL network Elsevier Amnesic Elsevier Anterior MTL network Elsevier BOLD fMRI Elsevier Pluta, John oth Mancuso, Lauren oth Kliot, Daria oth Yushkevich, Paul A. oth Wolk, David A. oth Enthalten in Elsevier Science Zidane, Mustapha ELSEVIER Corrigendum to “Electrical and thermal transport properties of Fe–Ni based ternary alloys in the earth's inner core: An ab initio study” [Physics of the Earth and Planetary Interiors 2021 Amsterdam [u.a.] (DE-627)ELV005660645 volume:36 year:2015 pages:141-1501 extent:1361 https://doi.org/10.1016/j.neurobiolaging.2014.03.041 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-GGO SSG-OPC-GEO SSG-OPC-AST 38.70 Geophysik: Allgemeines VZ 39.53 Planeten VZ AR 36 2015 141-1501 1361 36.2015, S141-, (1361 S.) 045F 610 |
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10.1016/j.neurobiolaging.2014.03.041 doi GBVA2015008000022.pica (DE-627)ELV018413048 (ELSEVIER)S0197-4580(14)00547-8 DE-627 ger DE-627 rakwb eng 610 610 DE-600 550 520 VZ 38.70 bkl 39.53 bkl Das, Sandhitsu R. verfasserin aut Anterior and posterior MTL networks in aging and MCI 2015transfer abstract 1361 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Two neuroanatomically dissociable, large-scale cortical memory networks, referred to as the anterior and posterior medial temporal lobe (MTL) networks have recently been described in young adults using resting-state blood oxygen level–dependent (BOLD) functional magnetic resonance imaging (fMRI)–based functional connectivity (fc-BOLD). They have been hypothesized to subserve distinct mnemonic and non-memory cognitive functions and are thought to be associated with differential vulnerability in neurological disorders. In this article, we demonstrate the existence of these functional networks in an older adult population and in a cohort of patients diagnosed with amnestic mild cognitive impairment (aMCI). Anatomic subregions of interest in the MTL were defined using high-resolution T2-weighted MRI and used as seeds for defining the putative networks using fc-BOLD. Although the literature has suggested that the posterior MTL network is particularly vulnerable to early Alzheimer's disease, we show that both the networks are affected in MCI, to varying degrees, compared with the control group. Furthermore, cortical thickness in the brain regions defined by these networks was reduced in MCI. Two neuroanatomically dissociable, large-scale cortical memory networks, referred to as the anterior and posterior medial temporal lobe (MTL) networks have recently been described in young adults using resting-state blood oxygen level–dependent (BOLD) functional magnetic resonance imaging (fMRI)–based functional connectivity (fc-BOLD). They have been hypothesized to subserve distinct mnemonic and non-memory cognitive functions and are thought to be associated with differential vulnerability in neurological disorders. In this article, we demonstrate the existence of these functional networks in an older adult population and in a cohort of patients diagnosed with amnestic mild cognitive impairment (aMCI). Anatomic subregions of interest in the MTL were defined using high-resolution T2-weighted MRI and used as seeds for defining the putative networks using fc-BOLD. Although the literature has suggested that the posterior MTL network is particularly vulnerable to early Alzheimer's disease, we show that both the networks are affected in MCI, to varying degrees, compared with the control group. Furthermore, cortical thickness in the brain regions defined by these networks was reduced in MCI. Older healthy control Elsevier Functional connectivity Elsevier MCI Elsevier MTL Elsevier Posterior MTL network Elsevier Amnesic Elsevier Anterior MTL network Elsevier BOLD fMRI Elsevier Pluta, John oth Mancuso, Lauren oth Kliot, Daria oth Yushkevich, Paul A. oth Wolk, David A. oth Enthalten in Elsevier Science Zidane, Mustapha ELSEVIER Corrigendum to “Electrical and thermal transport properties of Fe–Ni based ternary alloys in the earth's inner core: An ab initio study” [Physics of the Earth and Planetary Interiors 2021 Amsterdam [u.a.] (DE-627)ELV005660645 volume:36 year:2015 pages:141-1501 extent:1361 https://doi.org/10.1016/j.neurobiolaging.2014.03.041 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-GGO SSG-OPC-GEO SSG-OPC-AST 38.70 Geophysik: Allgemeines VZ 39.53 Planeten VZ AR 36 2015 141-1501 1361 36.2015, S141-, (1361 S.) 045F 610 |
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10.1016/j.neurobiolaging.2014.03.041 doi GBVA2015008000022.pica (DE-627)ELV018413048 (ELSEVIER)S0197-4580(14)00547-8 DE-627 ger DE-627 rakwb eng 610 610 DE-600 550 520 VZ 38.70 bkl 39.53 bkl Das, Sandhitsu R. verfasserin aut Anterior and posterior MTL networks in aging and MCI 2015transfer abstract 1361 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Two neuroanatomically dissociable, large-scale cortical memory networks, referred to as the anterior and posterior medial temporal lobe (MTL) networks have recently been described in young adults using resting-state blood oxygen level–dependent (BOLD) functional magnetic resonance imaging (fMRI)–based functional connectivity (fc-BOLD). They have been hypothesized to subserve distinct mnemonic and non-memory cognitive functions and are thought to be associated with differential vulnerability in neurological disorders. In this article, we demonstrate the existence of these functional networks in an older adult population and in a cohort of patients diagnosed with amnestic mild cognitive impairment (aMCI). Anatomic subregions of interest in the MTL were defined using high-resolution T2-weighted MRI and used as seeds for defining the putative networks using fc-BOLD. Although the literature has suggested that the posterior MTL network is particularly vulnerable to early Alzheimer's disease, we show that both the networks are affected in MCI, to varying degrees, compared with the control group. Furthermore, cortical thickness in the brain regions defined by these networks was reduced in MCI. Two neuroanatomically dissociable, large-scale cortical memory networks, referred to as the anterior and posterior medial temporal lobe (MTL) networks have recently been described in young adults using resting-state blood oxygen level–dependent (BOLD) functional magnetic resonance imaging (fMRI)–based functional connectivity (fc-BOLD). They have been hypothesized to subserve distinct mnemonic and non-memory cognitive functions and are thought to be associated with differential vulnerability in neurological disorders. In this article, we demonstrate the existence of these functional networks in an older adult population and in a cohort of patients diagnosed with amnestic mild cognitive impairment (aMCI). Anatomic subregions of interest in the MTL were defined using high-resolution T2-weighted MRI and used as seeds for defining the putative networks using fc-BOLD. Although the literature has suggested that the posterior MTL network is particularly vulnerable to early Alzheimer's disease, we show that both the networks are affected in MCI, to varying degrees, compared with the control group. Furthermore, cortical thickness in the brain regions defined by these networks was reduced in MCI. Older healthy control Elsevier Functional connectivity Elsevier MCI Elsevier MTL Elsevier Posterior MTL network Elsevier Amnesic Elsevier Anterior MTL network Elsevier BOLD fMRI Elsevier Pluta, John oth Mancuso, Lauren oth Kliot, Daria oth Yushkevich, Paul A. oth Wolk, David A. oth Enthalten in Elsevier Science Zidane, Mustapha ELSEVIER Corrigendum to “Electrical and thermal transport properties of Fe–Ni based ternary alloys in the earth's inner core: An ab initio study” [Physics of the Earth and Planetary Interiors 2021 Amsterdam [u.a.] (DE-627)ELV005660645 volume:36 year:2015 pages:141-1501 extent:1361 https://doi.org/10.1016/j.neurobiolaging.2014.03.041 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-GGO SSG-OPC-GEO SSG-OPC-AST 38.70 Geophysik: Allgemeines VZ 39.53 Planeten VZ AR 36 2015 141-1501 1361 36.2015, S141-, (1361 S.) 045F 610 |
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Enthalten in Corrigendum to “Electrical and thermal transport properties of Fe–Ni based ternary alloys in the earth's inner core: An ab initio study” [Physics of the Earth and Planetary Interiors Amsterdam [u.a.] volume:36 year:2015 pages:141-1501 extent:1361 |
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Enthalten in Corrigendum to “Electrical and thermal transport properties of Fe–Ni based ternary alloys in the earth's inner core: An ab initio study” [Physics of the Earth and Planetary Interiors Amsterdam [u.a.] volume:36 year:2015 pages:141-1501 extent:1361 |
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Das, Sandhitsu R. @@aut@@ Pluta, John @@oth@@ Mancuso, Lauren @@oth@@ Kliot, Daria @@oth@@ Yushkevich, Paul A. @@oth@@ Wolk, David A. @@oth@@ |
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Anterior and posterior MTL networks in aging and MCI |
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Two neuroanatomically dissociable, large-scale cortical memory networks, referred to as the anterior and posterior medial temporal lobe (MTL) networks have recently been described in young adults using resting-state blood oxygen level–dependent (BOLD) functional magnetic resonance imaging (fMRI)–based functional connectivity (fc-BOLD). They have been hypothesized to subserve distinct mnemonic and non-memory cognitive functions and are thought to be associated with differential vulnerability in neurological disorders. In this article, we demonstrate the existence of these functional networks in an older adult population and in a cohort of patients diagnosed with amnestic mild cognitive impairment (aMCI). Anatomic subregions of interest in the MTL were defined using high-resolution T2-weighted MRI and used as seeds for defining the putative networks using fc-BOLD. Although the literature has suggested that the posterior MTL network is particularly vulnerable to early Alzheimer's disease, we show that both the networks are affected in MCI, to varying degrees, compared with the control group. Furthermore, cortical thickness in the brain regions defined by these networks was reduced in MCI. |
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Two neuroanatomically dissociable, large-scale cortical memory networks, referred to as the anterior and posterior medial temporal lobe (MTL) networks have recently been described in young adults using resting-state blood oxygen level–dependent (BOLD) functional magnetic resonance imaging (fMRI)–based functional connectivity (fc-BOLD). They have been hypothesized to subserve distinct mnemonic and non-memory cognitive functions and are thought to be associated with differential vulnerability in neurological disorders. In this article, we demonstrate the existence of these functional networks in an older adult population and in a cohort of patients diagnosed with amnestic mild cognitive impairment (aMCI). Anatomic subregions of interest in the MTL were defined using high-resolution T2-weighted MRI and used as seeds for defining the putative networks using fc-BOLD. Although the literature has suggested that the posterior MTL network is particularly vulnerable to early Alzheimer's disease, we show that both the networks are affected in MCI, to varying degrees, compared with the control group. Furthermore, cortical thickness in the brain regions defined by these networks was reduced in MCI. |
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Two neuroanatomically dissociable, large-scale cortical memory networks, referred to as the anterior and posterior medial temporal lobe (MTL) networks have recently been described in young adults using resting-state blood oxygen level–dependent (BOLD) functional magnetic resonance imaging (fMRI)–based functional connectivity (fc-BOLD). They have been hypothesized to subserve distinct mnemonic and non-memory cognitive functions and are thought to be associated with differential vulnerability in neurological disorders. In this article, we demonstrate the existence of these functional networks in an older adult population and in a cohort of patients diagnosed with amnestic mild cognitive impairment (aMCI). Anatomic subregions of interest in the MTL were defined using high-resolution T2-weighted MRI and used as seeds for defining the putative networks using fc-BOLD. Although the literature has suggested that the posterior MTL network is particularly vulnerable to early Alzheimer's disease, we show that both the networks are affected in MCI, to varying degrees, compared with the control group. Furthermore, cortical thickness in the brain regions defined by these networks was reduced in MCI. |
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