Application of lipid peroxidation products as biomarkers for flutamide-induced oxidative stress in vitro
• This paper describes the increase of isoprostanes and hydroxynonenal (HNE) derivatives as early safety biomarkers of hepatotoxicity caused by oxidative stress. • The hepatotoxic drug flutamide provoked oxidative stress in primary hepatocytes resulting in a time and dose dependent increase of 15R-p...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Teppner, Marieke [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2015transfer abstract |
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| Schlagwörter: |
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| Umfang: |
7 |
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| Übergeordnetes Werk: |
Enthalten in: Toxicology letters - Chen, Yun-Ru ELSEVIER, 2019, an international journal for the rapid publication of short reports on all aspects of toxicology especially mechanisms of toxicity, Amsterdam [u.a.] |
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| Übergeordnetes Werk: |
volume:238 ; year:2015 ; number:3 ; day:4 ; month:11 ; pages:53-59 ; extent:7 |
| Links: |
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| DOI / URN: |
10.1016/j.toxlet.2015.08.005 |
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ELV018559824 |
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| 520 | |a • This paper describes the increase of isoprostanes and hydroxynonenal (HNE) derivatives as early safety biomarkers of hepatotoxicity caused by oxidative stress. • The hepatotoxic drug flutamide provoked oxidative stress in primary hepatocytes resulting in a time and dose dependent increase of 15R-prostaglandin D2, prostaglandin E2, 13,14-dihydro-15-keto prostaglandin E2 and 5-iso prostaglandin F2α VI. • HNE-mercapturic acid and its metabolite dihydroxynonene-mercapturic acid were also time and concentration dependently increased. • Lipid peroxidation products as markers of reactive oxygen species were demonstrated to be more sensitive than conventional cytotoxicity markers for an early detection of drug-induced liver injury. | ||
| 520 | |a • This paper describes the increase of isoprostanes and hydroxynonenal (HNE) derivatives as early safety biomarkers of hepatotoxicity caused by oxidative stress. • The hepatotoxic drug flutamide provoked oxidative stress in primary hepatocytes resulting in a time and dose dependent increase of 15R-prostaglandin D2, prostaglandin E2, 13,14-dihydro-15-keto prostaglandin E2 and 5-iso prostaglandin F2α VI. • HNE-mercapturic acid and its metabolite dihydroxynonene-mercapturic acid were also time and concentration dependently increased. • Lipid peroxidation products as markers of reactive oxygen species were demonstrated to be more sensitive than conventional cytotoxicity markers for an early detection of drug-induced liver injury. | ||
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10.1016/j.toxlet.2015.08.005 doi GBVA2015012000030.pica (DE-627)ELV018559824 (ELSEVIER)S0378-4274(15)30026-6 DE-627 ger DE-627 rakwb eng 570 540 610 570 DE-600 540 DE-600 610 DE-600 610 VZ 42.13 bkl 44.33 bkl Teppner, Marieke verfasserin aut Application of lipid peroxidation products as biomarkers for flutamide-induced oxidative stress in vitro 2015transfer abstract 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • This paper describes the increase of isoprostanes and hydroxynonenal (HNE) derivatives as early safety biomarkers of hepatotoxicity caused by oxidative stress. • The hepatotoxic drug flutamide provoked oxidative stress in primary hepatocytes resulting in a time and dose dependent increase of 15R-prostaglandin D2, prostaglandin E2, 13,14-dihydro-15-keto prostaglandin E2 and 5-iso prostaglandin F2α VI. • HNE-mercapturic acid and its metabolite dihydroxynonene-mercapturic acid were also time and concentration dependently increased. • Lipid peroxidation products as markers of reactive oxygen species were demonstrated to be more sensitive than conventional cytotoxicity markers for an early detection of drug-induced liver injury. • This paper describes the increase of isoprostanes and hydroxynonenal (HNE) derivatives as early safety biomarkers of hepatotoxicity caused by oxidative stress. • The hepatotoxic drug flutamide provoked oxidative stress in primary hepatocytes resulting in a time and dose dependent increase of 15R-prostaglandin D2, prostaglandin E2, 13,14-dihydro-15-keto prostaglandin E2 and 5-iso prostaglandin F2α VI. • HNE-mercapturic acid and its metabolite dihydroxynonene-mercapturic acid were also time and concentration dependently increased. • Lipid peroxidation products as markers of reactive oxygen species were demonstrated to be more sensitive than conventional cytotoxicity markers for an early detection of drug-induced liver injury. iPF2α-VI Elsevier LDH Elsevier DILI Elsevier DHN-MA Elsevier 15R-PD2 Elsevier Dihydro-keto PE2 Elsevier HRP Elsevier ROS Elsevier HNE-MA Elsevier HNE Elsevier PE2 Elsevier Böss, Franziska oth Ernst, Beat oth Pähler, Axel oth Enthalten in Elsevier Science Chen, Yun-Ru ELSEVIER Toxicology letters 2019 an international journal for the rapid publication of short reports on all aspects of toxicology especially mechanisms of toxicity Amsterdam [u.a.] (DE-627)ELV003574431 volume:238 year:2015 number:3 day:4 month:11 pages:53-59 extent:7 https://doi.org/10.1016/j.toxlet.2015.08.005 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 42.13 Molekularbiologie VZ 44.33 Physiologische Chemie VZ AR 238 2015 3 4 1104 53-59 7 045F 570 |
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10.1016/j.toxlet.2015.08.005 doi GBVA2015012000030.pica (DE-627)ELV018559824 (ELSEVIER)S0378-4274(15)30026-6 DE-627 ger DE-627 rakwb eng 570 540 610 570 DE-600 540 DE-600 610 DE-600 610 VZ 42.13 bkl 44.33 bkl Teppner, Marieke verfasserin aut Application of lipid peroxidation products as biomarkers for flutamide-induced oxidative stress in vitro 2015transfer abstract 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • This paper describes the increase of isoprostanes and hydroxynonenal (HNE) derivatives as early safety biomarkers of hepatotoxicity caused by oxidative stress. • The hepatotoxic drug flutamide provoked oxidative stress in primary hepatocytes resulting in a time and dose dependent increase of 15R-prostaglandin D2, prostaglandin E2, 13,14-dihydro-15-keto prostaglandin E2 and 5-iso prostaglandin F2α VI. • HNE-mercapturic acid and its metabolite dihydroxynonene-mercapturic acid were also time and concentration dependently increased. • Lipid peroxidation products as markers of reactive oxygen species were demonstrated to be more sensitive than conventional cytotoxicity markers for an early detection of drug-induced liver injury. • This paper describes the increase of isoprostanes and hydroxynonenal (HNE) derivatives as early safety biomarkers of hepatotoxicity caused by oxidative stress. • The hepatotoxic drug flutamide provoked oxidative stress in primary hepatocytes resulting in a time and dose dependent increase of 15R-prostaglandin D2, prostaglandin E2, 13,14-dihydro-15-keto prostaglandin E2 and 5-iso prostaglandin F2α VI. • HNE-mercapturic acid and its metabolite dihydroxynonene-mercapturic acid were also time and concentration dependently increased. • Lipid peroxidation products as markers of reactive oxygen species were demonstrated to be more sensitive than conventional cytotoxicity markers for an early detection of drug-induced liver injury. iPF2α-VI Elsevier LDH Elsevier DILI Elsevier DHN-MA Elsevier 15R-PD2 Elsevier Dihydro-keto PE2 Elsevier HRP Elsevier ROS Elsevier HNE-MA Elsevier HNE Elsevier PE2 Elsevier Böss, Franziska oth Ernst, Beat oth Pähler, Axel oth Enthalten in Elsevier Science Chen, Yun-Ru ELSEVIER Toxicology letters 2019 an international journal for the rapid publication of short reports on all aspects of toxicology especially mechanisms of toxicity Amsterdam [u.a.] (DE-627)ELV003574431 volume:238 year:2015 number:3 day:4 month:11 pages:53-59 extent:7 https://doi.org/10.1016/j.toxlet.2015.08.005 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 42.13 Molekularbiologie VZ 44.33 Physiologische Chemie VZ AR 238 2015 3 4 1104 53-59 7 045F 570 |
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10.1016/j.toxlet.2015.08.005 doi GBVA2015012000030.pica (DE-627)ELV018559824 (ELSEVIER)S0378-4274(15)30026-6 DE-627 ger DE-627 rakwb eng 570 540 610 570 DE-600 540 DE-600 610 DE-600 610 VZ 42.13 bkl 44.33 bkl Teppner, Marieke verfasserin aut Application of lipid peroxidation products as biomarkers for flutamide-induced oxidative stress in vitro 2015transfer abstract 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • This paper describes the increase of isoprostanes and hydroxynonenal (HNE) derivatives as early safety biomarkers of hepatotoxicity caused by oxidative stress. • The hepatotoxic drug flutamide provoked oxidative stress in primary hepatocytes resulting in a time and dose dependent increase of 15R-prostaglandin D2, prostaglandin E2, 13,14-dihydro-15-keto prostaglandin E2 and 5-iso prostaglandin F2α VI. • HNE-mercapturic acid and its metabolite dihydroxynonene-mercapturic acid were also time and concentration dependently increased. • Lipid peroxidation products as markers of reactive oxygen species were demonstrated to be more sensitive than conventional cytotoxicity markers for an early detection of drug-induced liver injury. • This paper describes the increase of isoprostanes and hydroxynonenal (HNE) derivatives as early safety biomarkers of hepatotoxicity caused by oxidative stress. • The hepatotoxic drug flutamide provoked oxidative stress in primary hepatocytes resulting in a time and dose dependent increase of 15R-prostaglandin D2, prostaglandin E2, 13,14-dihydro-15-keto prostaglandin E2 and 5-iso prostaglandin F2α VI. • HNE-mercapturic acid and its metabolite dihydroxynonene-mercapturic acid were also time and concentration dependently increased. • Lipid peroxidation products as markers of reactive oxygen species were demonstrated to be more sensitive than conventional cytotoxicity markers for an early detection of drug-induced liver injury. iPF2α-VI Elsevier LDH Elsevier DILI Elsevier DHN-MA Elsevier 15R-PD2 Elsevier Dihydro-keto PE2 Elsevier HRP Elsevier ROS Elsevier HNE-MA Elsevier HNE Elsevier PE2 Elsevier Böss, Franziska oth Ernst, Beat oth Pähler, Axel oth Enthalten in Elsevier Science Chen, Yun-Ru ELSEVIER Toxicology letters 2019 an international journal for the rapid publication of short reports on all aspects of toxicology especially mechanisms of toxicity Amsterdam [u.a.] (DE-627)ELV003574431 volume:238 year:2015 number:3 day:4 month:11 pages:53-59 extent:7 https://doi.org/10.1016/j.toxlet.2015.08.005 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 42.13 Molekularbiologie VZ 44.33 Physiologische Chemie VZ AR 238 2015 3 4 1104 53-59 7 045F 570 |
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10.1016/j.toxlet.2015.08.005 doi GBVA2015012000030.pica (DE-627)ELV018559824 (ELSEVIER)S0378-4274(15)30026-6 DE-627 ger DE-627 rakwb eng 570 540 610 570 DE-600 540 DE-600 610 DE-600 610 VZ 42.13 bkl 44.33 bkl Teppner, Marieke verfasserin aut Application of lipid peroxidation products as biomarkers for flutamide-induced oxidative stress in vitro 2015transfer abstract 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • This paper describes the increase of isoprostanes and hydroxynonenal (HNE) derivatives as early safety biomarkers of hepatotoxicity caused by oxidative stress. • The hepatotoxic drug flutamide provoked oxidative stress in primary hepatocytes resulting in a time and dose dependent increase of 15R-prostaglandin D2, prostaglandin E2, 13,14-dihydro-15-keto prostaglandin E2 and 5-iso prostaglandin F2α VI. • HNE-mercapturic acid and its metabolite dihydroxynonene-mercapturic acid were also time and concentration dependently increased. • Lipid peroxidation products as markers of reactive oxygen species were demonstrated to be more sensitive than conventional cytotoxicity markers for an early detection of drug-induced liver injury. • This paper describes the increase of isoprostanes and hydroxynonenal (HNE) derivatives as early safety biomarkers of hepatotoxicity caused by oxidative stress. • The hepatotoxic drug flutamide provoked oxidative stress in primary hepatocytes resulting in a time and dose dependent increase of 15R-prostaglandin D2, prostaglandin E2, 13,14-dihydro-15-keto prostaglandin E2 and 5-iso prostaglandin F2α VI. • HNE-mercapturic acid and its metabolite dihydroxynonene-mercapturic acid were also time and concentration dependently increased. • Lipid peroxidation products as markers of reactive oxygen species were demonstrated to be more sensitive than conventional cytotoxicity markers for an early detection of drug-induced liver injury. iPF2α-VI Elsevier LDH Elsevier DILI Elsevier DHN-MA Elsevier 15R-PD2 Elsevier Dihydro-keto PE2 Elsevier HRP Elsevier ROS Elsevier HNE-MA Elsevier HNE Elsevier PE2 Elsevier Böss, Franziska oth Ernst, Beat oth Pähler, Axel oth Enthalten in Elsevier Science Chen, Yun-Ru ELSEVIER Toxicology letters 2019 an international journal for the rapid publication of short reports on all aspects of toxicology especially mechanisms of toxicity Amsterdam [u.a.] (DE-627)ELV003574431 volume:238 year:2015 number:3 day:4 month:11 pages:53-59 extent:7 https://doi.org/10.1016/j.toxlet.2015.08.005 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 42.13 Molekularbiologie VZ 44.33 Physiologische Chemie VZ AR 238 2015 3 4 1104 53-59 7 045F 570 |
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10.1016/j.toxlet.2015.08.005 doi GBVA2015012000030.pica (DE-627)ELV018559824 (ELSEVIER)S0378-4274(15)30026-6 DE-627 ger DE-627 rakwb eng 570 540 610 570 DE-600 540 DE-600 610 DE-600 610 VZ 42.13 bkl 44.33 bkl Teppner, Marieke verfasserin aut Application of lipid peroxidation products as biomarkers for flutamide-induced oxidative stress in vitro 2015transfer abstract 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • This paper describes the increase of isoprostanes and hydroxynonenal (HNE) derivatives as early safety biomarkers of hepatotoxicity caused by oxidative stress. • The hepatotoxic drug flutamide provoked oxidative stress in primary hepatocytes resulting in a time and dose dependent increase of 15R-prostaglandin D2, prostaglandin E2, 13,14-dihydro-15-keto prostaglandin E2 and 5-iso prostaglandin F2α VI. • HNE-mercapturic acid and its metabolite dihydroxynonene-mercapturic acid were also time and concentration dependently increased. • Lipid peroxidation products as markers of reactive oxygen species were demonstrated to be more sensitive than conventional cytotoxicity markers for an early detection of drug-induced liver injury. • This paper describes the increase of isoprostanes and hydroxynonenal (HNE) derivatives as early safety biomarkers of hepatotoxicity caused by oxidative stress. • The hepatotoxic drug flutamide provoked oxidative stress in primary hepatocytes resulting in a time and dose dependent increase of 15R-prostaglandin D2, prostaglandin E2, 13,14-dihydro-15-keto prostaglandin E2 and 5-iso prostaglandin F2α VI. • HNE-mercapturic acid and its metabolite dihydroxynonene-mercapturic acid were also time and concentration dependently increased. • Lipid peroxidation products as markers of reactive oxygen species were demonstrated to be more sensitive than conventional cytotoxicity markers for an early detection of drug-induced liver injury. iPF2α-VI Elsevier LDH Elsevier DILI Elsevier DHN-MA Elsevier 15R-PD2 Elsevier Dihydro-keto PE2 Elsevier HRP Elsevier ROS Elsevier HNE-MA Elsevier HNE Elsevier PE2 Elsevier Böss, Franziska oth Ernst, Beat oth Pähler, Axel oth Enthalten in Elsevier Science Chen, Yun-Ru ELSEVIER Toxicology letters 2019 an international journal for the rapid publication of short reports on all aspects of toxicology especially mechanisms of toxicity Amsterdam [u.a.] (DE-627)ELV003574431 volume:238 year:2015 number:3 day:4 month:11 pages:53-59 extent:7 https://doi.org/10.1016/j.toxlet.2015.08.005 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 42.13 Molekularbiologie VZ 44.33 Physiologische Chemie VZ AR 238 2015 3 4 1104 53-59 7 045F 570 |
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Application of lipid peroxidation products as biomarkers for flutamide-induced oxidative stress in vitro |
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• This paper describes the increase of isoprostanes and hydroxynonenal (HNE) derivatives as early safety biomarkers of hepatotoxicity caused by oxidative stress. • The hepatotoxic drug flutamide provoked oxidative stress in primary hepatocytes resulting in a time and dose dependent increase of 15R-prostaglandin D2, prostaglandin E2, 13,14-dihydro-15-keto prostaglandin E2 and 5-iso prostaglandin F2α VI. • HNE-mercapturic acid and its metabolite dihydroxynonene-mercapturic acid were also time and concentration dependently increased. • Lipid peroxidation products as markers of reactive oxygen species were demonstrated to be more sensitive than conventional cytotoxicity markers for an early detection of drug-induced liver injury. |
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• This paper describes the increase of isoprostanes and hydroxynonenal (HNE) derivatives as early safety biomarkers of hepatotoxicity caused by oxidative stress. • The hepatotoxic drug flutamide provoked oxidative stress in primary hepatocytes resulting in a time and dose dependent increase of 15R-prostaglandin D2, prostaglandin E2, 13,14-dihydro-15-keto prostaglandin E2 and 5-iso prostaglandin F2α VI. • HNE-mercapturic acid and its metabolite dihydroxynonene-mercapturic acid were also time and concentration dependently increased. • Lipid peroxidation products as markers of reactive oxygen species were demonstrated to be more sensitive than conventional cytotoxicity markers for an early detection of drug-induced liver injury. |
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• This paper describes the increase of isoprostanes and hydroxynonenal (HNE) derivatives as early safety biomarkers of hepatotoxicity caused by oxidative stress. • The hepatotoxic drug flutamide provoked oxidative stress in primary hepatocytes resulting in a time and dose dependent increase of 15R-prostaglandin D2, prostaglandin E2, 13,14-dihydro-15-keto prostaglandin E2 and 5-iso prostaglandin F2α VI. • HNE-mercapturic acid and its metabolite dihydroxynonene-mercapturic acid were also time and concentration dependently increased. • Lipid peroxidation products as markers of reactive oxygen species were demonstrated to be more sensitive than conventional cytotoxicity markers for an early detection of drug-induced liver injury. |
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