Statins enhance cognitive performance in object location test in albino Swiss mice: Involvement of beta-adrenoceptors
Statins are inhibitors of the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, thereby inhibiting cell synthesis of cholesterol and isoprenoids. Moreover, several studies have been evaluating pleiotropic effects of statins, mainly because they present neuroprotective effects in various pat...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Vandresen-Filho, Samuel [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2015transfer abstract |
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| Umfang: |
8 |
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| Übergeordnetes Werk: |
Enthalten in: Étale triviality of finite vector bundles over compact complex manifolds - Biswas, Indranil ELSEVIER, 2020, official journal of the International Behavioral Neuroscience Society, Amsterdam [u.a.] |
|---|---|
| Übergeordnetes Werk: |
volume:143 ; year:2015 ; day:1 ; month:05 ; pages:27-34 ; extent:8 |
| Links: |
|---|
| DOI / URN: |
10.1016/j.physbeh.2015.02.024 |
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| 245 | 1 | 0 | |a Statins enhance cognitive performance in object location test in albino Swiss mice: Involvement of beta-adrenoceptors |
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| 520 | |a Statins are inhibitors of the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, thereby inhibiting cell synthesis of cholesterol and isoprenoids. Moreover, several studies have been evaluating pleiotropic effects of statins, mainly because they present neuroprotective effects in various pathological conditions. However, knowledge about behavioral effects of statins per se is relatively scarce. Considering these facts, we aimed to analyze behavioral responses of atorvastatin or simvastatin-treated mice in the open field test, elevated plus maze and object location test. Atorvastatin treatment for 7 consecutive days at 1mg/kg or 10mg/kg (v.o.) or simvastatin 10mg/kg or 20mg/kg enhanced cognitive performance in object location test when compared to control group (saline-treated mice). Simvastatin effects on mice performance in the object location test was abolished by post-training infusion of the beta-adrenoceptor antagonist propranolol. Atorvastatin and simvastatin did not change the behavioral response in open field and elevated plus-maze (EPM) tests in any of the used doses. These data demonstrate the positive effects of both statins in cognitive processes in mice, without any alteration in locomotor parameters in the open field test or anxiolytic-like behavior in EPM. In conclusion, we demonstrate that atorvastatin and simvastatin per se improve the cognitive performance in a rodent model of spatial memory and this effect is related to beta-adrenergic receptors modulation. | ||
| 520 | |a Statins are inhibitors of the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, thereby inhibiting cell synthesis of cholesterol and isoprenoids. Moreover, several studies have been evaluating pleiotropic effects of statins, mainly because they present neuroprotective effects in various pathological conditions. However, knowledge about behavioral effects of statins per se is relatively scarce. Considering these facts, we aimed to analyze behavioral responses of atorvastatin or simvastatin-treated mice in the open field test, elevated plus maze and object location test. Atorvastatin treatment for 7 consecutive days at 1mg/kg or 10mg/kg (v.o.) or simvastatin 10mg/kg or 20mg/kg enhanced cognitive performance in object location test when compared to control group (saline-treated mice). Simvastatin effects on mice performance in the object location test was abolished by post-training infusion of the beta-adrenoceptor antagonist propranolol. Atorvastatin and simvastatin did not change the behavioral response in open field and elevated plus-maze (EPM) tests in any of the used doses. These data demonstrate the positive effects of both statins in cognitive processes in mice, without any alteration in locomotor parameters in the open field test or anxiolytic-like behavior in EPM. In conclusion, we demonstrate that atorvastatin and simvastatin per se improve the cognitive performance in a rodent model of spatial memory and this effect is related to beta-adrenergic receptors modulation. | ||
| 700 | 1 | |a França, Lucas Moreira |4 oth | |
| 700 | 1 | |a Alcantara-Junior, José |4 oth | |
| 700 | 1 | |a Nogueira, Lucas Caixeta |4 oth | |
| 700 | 1 | |a de Brito, Thiago Marques |4 oth | |
| 700 | 1 | |a Lopes, Lousã |4 oth | |
| 700 | 1 | |a Junior, Fernando Mesquita |4 oth | |
| 700 | 1 | |a Vanzeler, Maria Luzinete |4 oth | |
| 700 | 1 | |a Bertoldo, Daniela Bohn |4 oth | |
| 700 | 1 | |a Dias, Paula Gomes |4 oth | |
| 700 | 1 | |a Colla, André R.S. |4 oth | |
| 700 | 1 | |a Hoeller, Alexandre |4 oth | |
| 700 | 1 | |a Duzzioni, Marcelo |4 oth | |
| 700 | 1 | |a Rodrigues, Ana Lúcia S. |4 oth | |
| 700 | 1 | |a de Lima, Thereza C.M. |4 oth | |
| 700 | 1 | |a Tasca, Carla Inês |4 oth | |
| 700 | 1 | |a Viola, Giordano Gubert |4 oth | |
| 773 | 0 | 8 | |i Enthalten in |n Elsevier Science |a Biswas, Indranil ELSEVIER |t Étale triviality of finite vector bundles over compact complex manifolds |d 2020 |d official journal of the International Behavioral Neuroscience Society |g Amsterdam [u.a.] |w (DE-627)ELV004116763 |
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10.1016/j.physbeh.2015.02.024 doi GBVA2015023000019.pica (DE-627)ELV018999611 (ELSEVIER)S0031-9384(15)00088-8 DE-627 ger DE-627 rakwb eng 570 570 DE-600 510 VZ 31.00 bkl Vandresen-Filho, Samuel verfasserin aut Statins enhance cognitive performance in object location test in albino Swiss mice: Involvement of beta-adrenoceptors 2015transfer abstract 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Statins are inhibitors of the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, thereby inhibiting cell synthesis of cholesterol and isoprenoids. Moreover, several studies have been evaluating pleiotropic effects of statins, mainly because they present neuroprotective effects in various pathological conditions. However, knowledge about behavioral effects of statins per se is relatively scarce. Considering these facts, we aimed to analyze behavioral responses of atorvastatin or simvastatin-treated mice in the open field test, elevated plus maze and object location test. Atorvastatin treatment for 7 consecutive days at 1mg/kg or 10mg/kg (v.o.) or simvastatin 10mg/kg or 20mg/kg enhanced cognitive performance in object location test when compared to control group (saline-treated mice). Simvastatin effects on mice performance in the object location test was abolished by post-training infusion of the beta-adrenoceptor antagonist propranolol. Atorvastatin and simvastatin did not change the behavioral response in open field and elevated plus-maze (EPM) tests in any of the used doses. These data demonstrate the positive effects of both statins in cognitive processes in mice, without any alteration in locomotor parameters in the open field test or anxiolytic-like behavior in EPM. In conclusion, we demonstrate that atorvastatin and simvastatin per se improve the cognitive performance in a rodent model of spatial memory and this effect is related to beta-adrenergic receptors modulation. Statins are inhibitors of the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, thereby inhibiting cell synthesis of cholesterol and isoprenoids. Moreover, several studies have been evaluating pleiotropic effects of statins, mainly because they present neuroprotective effects in various pathological conditions. However, knowledge about behavioral effects of statins per se is relatively scarce. Considering these facts, we aimed to analyze behavioral responses of atorvastatin or simvastatin-treated mice in the open field test, elevated plus maze and object location test. Atorvastatin treatment for 7 consecutive days at 1mg/kg or 10mg/kg (v.o.) or simvastatin 10mg/kg or 20mg/kg enhanced cognitive performance in object location test when compared to control group (saline-treated mice). Simvastatin effects on mice performance in the object location test was abolished by post-training infusion of the beta-adrenoceptor antagonist propranolol. Atorvastatin and simvastatin did not change the behavioral response in open field and elevated plus-maze (EPM) tests in any of the used doses. These data demonstrate the positive effects of both statins in cognitive processes in mice, without any alteration in locomotor parameters in the open field test or anxiolytic-like behavior in EPM. In conclusion, we demonstrate that atorvastatin and simvastatin per se improve the cognitive performance in a rodent model of spatial memory and this effect is related to beta-adrenergic receptors modulation. França, Lucas Moreira oth Alcantara-Junior, José oth Nogueira, Lucas Caixeta oth de Brito, Thiago Marques oth Lopes, Lousã oth Junior, Fernando Mesquita oth Vanzeler, Maria Luzinete oth Bertoldo, Daniela Bohn oth Dias, Paula Gomes oth Colla, André R.S. oth Hoeller, Alexandre oth Duzzioni, Marcelo oth Rodrigues, Ana Lúcia S. oth de Lima, Thereza C.M. oth Tasca, Carla Inês oth Viola, Giordano Gubert oth Enthalten in Elsevier Science Biswas, Indranil ELSEVIER Étale triviality of finite vector bundles over compact complex manifolds 2020 official journal of the International Behavioral Neuroscience Society Amsterdam [u.a.] (DE-627)ELV004116763 volume:143 year:2015 day:1 month:05 pages:27-34 extent:8 https://doi.org/10.1016/j.physbeh.2015.02.024 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-MAT 31.00 Mathematik: Allgemeines VZ AR 143 2015 1 0501 27-34 8 045F 570 |
| spelling |
10.1016/j.physbeh.2015.02.024 doi GBVA2015023000019.pica (DE-627)ELV018999611 (ELSEVIER)S0031-9384(15)00088-8 DE-627 ger DE-627 rakwb eng 570 570 DE-600 510 VZ 31.00 bkl Vandresen-Filho, Samuel verfasserin aut Statins enhance cognitive performance in object location test in albino Swiss mice: Involvement of beta-adrenoceptors 2015transfer abstract 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Statins are inhibitors of the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, thereby inhibiting cell synthesis of cholesterol and isoprenoids. Moreover, several studies have been evaluating pleiotropic effects of statins, mainly because they present neuroprotective effects in various pathological conditions. However, knowledge about behavioral effects of statins per se is relatively scarce. Considering these facts, we aimed to analyze behavioral responses of atorvastatin or simvastatin-treated mice in the open field test, elevated plus maze and object location test. Atorvastatin treatment for 7 consecutive days at 1mg/kg or 10mg/kg (v.o.) or simvastatin 10mg/kg or 20mg/kg enhanced cognitive performance in object location test when compared to control group (saline-treated mice). Simvastatin effects on mice performance in the object location test was abolished by post-training infusion of the beta-adrenoceptor antagonist propranolol. Atorvastatin and simvastatin did not change the behavioral response in open field and elevated plus-maze (EPM) tests in any of the used doses. These data demonstrate the positive effects of both statins in cognitive processes in mice, without any alteration in locomotor parameters in the open field test or anxiolytic-like behavior in EPM. In conclusion, we demonstrate that atorvastatin and simvastatin per se improve the cognitive performance in a rodent model of spatial memory and this effect is related to beta-adrenergic receptors modulation. Statins are inhibitors of the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, thereby inhibiting cell synthesis of cholesterol and isoprenoids. Moreover, several studies have been evaluating pleiotropic effects of statins, mainly because they present neuroprotective effects in various pathological conditions. However, knowledge about behavioral effects of statins per se is relatively scarce. Considering these facts, we aimed to analyze behavioral responses of atorvastatin or simvastatin-treated mice in the open field test, elevated plus maze and object location test. Atorvastatin treatment for 7 consecutive days at 1mg/kg or 10mg/kg (v.o.) or simvastatin 10mg/kg or 20mg/kg enhanced cognitive performance in object location test when compared to control group (saline-treated mice). Simvastatin effects on mice performance in the object location test was abolished by post-training infusion of the beta-adrenoceptor antagonist propranolol. Atorvastatin and simvastatin did not change the behavioral response in open field and elevated plus-maze (EPM) tests in any of the used doses. These data demonstrate the positive effects of both statins in cognitive processes in mice, without any alteration in locomotor parameters in the open field test or anxiolytic-like behavior in EPM. In conclusion, we demonstrate that atorvastatin and simvastatin per se improve the cognitive performance in a rodent model of spatial memory and this effect is related to beta-adrenergic receptors modulation. França, Lucas Moreira oth Alcantara-Junior, José oth Nogueira, Lucas Caixeta oth de Brito, Thiago Marques oth Lopes, Lousã oth Junior, Fernando Mesquita oth Vanzeler, Maria Luzinete oth Bertoldo, Daniela Bohn oth Dias, Paula Gomes oth Colla, André R.S. oth Hoeller, Alexandre oth Duzzioni, Marcelo oth Rodrigues, Ana Lúcia S. oth de Lima, Thereza C.M. oth Tasca, Carla Inês oth Viola, Giordano Gubert oth Enthalten in Elsevier Science Biswas, Indranil ELSEVIER Étale triviality of finite vector bundles over compact complex manifolds 2020 official journal of the International Behavioral Neuroscience Society Amsterdam [u.a.] (DE-627)ELV004116763 volume:143 year:2015 day:1 month:05 pages:27-34 extent:8 https://doi.org/10.1016/j.physbeh.2015.02.024 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-MAT 31.00 Mathematik: Allgemeines VZ AR 143 2015 1 0501 27-34 8 045F 570 |
| allfields_unstemmed |
10.1016/j.physbeh.2015.02.024 doi GBVA2015023000019.pica (DE-627)ELV018999611 (ELSEVIER)S0031-9384(15)00088-8 DE-627 ger DE-627 rakwb eng 570 570 DE-600 510 VZ 31.00 bkl Vandresen-Filho, Samuel verfasserin aut Statins enhance cognitive performance in object location test in albino Swiss mice: Involvement of beta-adrenoceptors 2015transfer abstract 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Statins are inhibitors of the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, thereby inhibiting cell synthesis of cholesterol and isoprenoids. Moreover, several studies have been evaluating pleiotropic effects of statins, mainly because they present neuroprotective effects in various pathological conditions. However, knowledge about behavioral effects of statins per se is relatively scarce. Considering these facts, we aimed to analyze behavioral responses of atorvastatin or simvastatin-treated mice in the open field test, elevated plus maze and object location test. Atorvastatin treatment for 7 consecutive days at 1mg/kg or 10mg/kg (v.o.) or simvastatin 10mg/kg or 20mg/kg enhanced cognitive performance in object location test when compared to control group (saline-treated mice). Simvastatin effects on mice performance in the object location test was abolished by post-training infusion of the beta-adrenoceptor antagonist propranolol. Atorvastatin and simvastatin did not change the behavioral response in open field and elevated plus-maze (EPM) tests in any of the used doses. These data demonstrate the positive effects of both statins in cognitive processes in mice, without any alteration in locomotor parameters in the open field test or anxiolytic-like behavior in EPM. In conclusion, we demonstrate that atorvastatin and simvastatin per se improve the cognitive performance in a rodent model of spatial memory and this effect is related to beta-adrenergic receptors modulation. Statins are inhibitors of the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, thereby inhibiting cell synthesis of cholesterol and isoprenoids. Moreover, several studies have been evaluating pleiotropic effects of statins, mainly because they present neuroprotective effects in various pathological conditions. However, knowledge about behavioral effects of statins per se is relatively scarce. Considering these facts, we aimed to analyze behavioral responses of atorvastatin or simvastatin-treated mice in the open field test, elevated plus maze and object location test. Atorvastatin treatment for 7 consecutive days at 1mg/kg or 10mg/kg (v.o.) or simvastatin 10mg/kg or 20mg/kg enhanced cognitive performance in object location test when compared to control group (saline-treated mice). Simvastatin effects on mice performance in the object location test was abolished by post-training infusion of the beta-adrenoceptor antagonist propranolol. Atorvastatin and simvastatin did not change the behavioral response in open field and elevated plus-maze (EPM) tests in any of the used doses. These data demonstrate the positive effects of both statins in cognitive processes in mice, without any alteration in locomotor parameters in the open field test or anxiolytic-like behavior in EPM. In conclusion, we demonstrate that atorvastatin and simvastatin per se improve the cognitive performance in a rodent model of spatial memory and this effect is related to beta-adrenergic receptors modulation. França, Lucas Moreira oth Alcantara-Junior, José oth Nogueira, Lucas Caixeta oth de Brito, Thiago Marques oth Lopes, Lousã oth Junior, Fernando Mesquita oth Vanzeler, Maria Luzinete oth Bertoldo, Daniela Bohn oth Dias, Paula Gomes oth Colla, André R.S. oth Hoeller, Alexandre oth Duzzioni, Marcelo oth Rodrigues, Ana Lúcia S. oth de Lima, Thereza C.M. oth Tasca, Carla Inês oth Viola, Giordano Gubert oth Enthalten in Elsevier Science Biswas, Indranil ELSEVIER Étale triviality of finite vector bundles over compact complex manifolds 2020 official journal of the International Behavioral Neuroscience Society Amsterdam [u.a.] (DE-627)ELV004116763 volume:143 year:2015 day:1 month:05 pages:27-34 extent:8 https://doi.org/10.1016/j.physbeh.2015.02.024 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-MAT 31.00 Mathematik: Allgemeines VZ AR 143 2015 1 0501 27-34 8 045F 570 |
| allfieldsGer |
10.1016/j.physbeh.2015.02.024 doi GBVA2015023000019.pica (DE-627)ELV018999611 (ELSEVIER)S0031-9384(15)00088-8 DE-627 ger DE-627 rakwb eng 570 570 DE-600 510 VZ 31.00 bkl Vandresen-Filho, Samuel verfasserin aut Statins enhance cognitive performance in object location test in albino Swiss mice: Involvement of beta-adrenoceptors 2015transfer abstract 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Statins are inhibitors of the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, thereby inhibiting cell synthesis of cholesterol and isoprenoids. Moreover, several studies have been evaluating pleiotropic effects of statins, mainly because they present neuroprotective effects in various pathological conditions. However, knowledge about behavioral effects of statins per se is relatively scarce. Considering these facts, we aimed to analyze behavioral responses of atorvastatin or simvastatin-treated mice in the open field test, elevated plus maze and object location test. Atorvastatin treatment for 7 consecutive days at 1mg/kg or 10mg/kg (v.o.) or simvastatin 10mg/kg or 20mg/kg enhanced cognitive performance in object location test when compared to control group (saline-treated mice). Simvastatin effects on mice performance in the object location test was abolished by post-training infusion of the beta-adrenoceptor antagonist propranolol. Atorvastatin and simvastatin did not change the behavioral response in open field and elevated plus-maze (EPM) tests in any of the used doses. These data demonstrate the positive effects of both statins in cognitive processes in mice, without any alteration in locomotor parameters in the open field test or anxiolytic-like behavior in EPM. In conclusion, we demonstrate that atorvastatin and simvastatin per se improve the cognitive performance in a rodent model of spatial memory and this effect is related to beta-adrenergic receptors modulation. Statins are inhibitors of the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, thereby inhibiting cell synthesis of cholesterol and isoprenoids. Moreover, several studies have been evaluating pleiotropic effects of statins, mainly because they present neuroprotective effects in various pathological conditions. However, knowledge about behavioral effects of statins per se is relatively scarce. Considering these facts, we aimed to analyze behavioral responses of atorvastatin or simvastatin-treated mice in the open field test, elevated plus maze and object location test. Atorvastatin treatment for 7 consecutive days at 1mg/kg or 10mg/kg (v.o.) or simvastatin 10mg/kg or 20mg/kg enhanced cognitive performance in object location test when compared to control group (saline-treated mice). Simvastatin effects on mice performance in the object location test was abolished by post-training infusion of the beta-adrenoceptor antagonist propranolol. Atorvastatin and simvastatin did not change the behavioral response in open field and elevated plus-maze (EPM) tests in any of the used doses. These data demonstrate the positive effects of both statins in cognitive processes in mice, without any alteration in locomotor parameters in the open field test or anxiolytic-like behavior in EPM. In conclusion, we demonstrate that atorvastatin and simvastatin per se improve the cognitive performance in a rodent model of spatial memory and this effect is related to beta-adrenergic receptors modulation. França, Lucas Moreira oth Alcantara-Junior, José oth Nogueira, Lucas Caixeta oth de Brito, Thiago Marques oth Lopes, Lousã oth Junior, Fernando Mesquita oth Vanzeler, Maria Luzinete oth Bertoldo, Daniela Bohn oth Dias, Paula Gomes oth Colla, André R.S. oth Hoeller, Alexandre oth Duzzioni, Marcelo oth Rodrigues, Ana Lúcia S. oth de Lima, Thereza C.M. oth Tasca, Carla Inês oth Viola, Giordano Gubert oth Enthalten in Elsevier Science Biswas, Indranil ELSEVIER Étale triviality of finite vector bundles over compact complex manifolds 2020 official journal of the International Behavioral Neuroscience Society Amsterdam [u.a.] (DE-627)ELV004116763 volume:143 year:2015 day:1 month:05 pages:27-34 extent:8 https://doi.org/10.1016/j.physbeh.2015.02.024 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-MAT 31.00 Mathematik: Allgemeines VZ AR 143 2015 1 0501 27-34 8 045F 570 |
| allfieldsSound |
10.1016/j.physbeh.2015.02.024 doi GBVA2015023000019.pica (DE-627)ELV018999611 (ELSEVIER)S0031-9384(15)00088-8 DE-627 ger DE-627 rakwb eng 570 570 DE-600 510 VZ 31.00 bkl Vandresen-Filho, Samuel verfasserin aut Statins enhance cognitive performance in object location test in albino Swiss mice: Involvement of beta-adrenoceptors 2015transfer abstract 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Statins are inhibitors of the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, thereby inhibiting cell synthesis of cholesterol and isoprenoids. Moreover, several studies have been evaluating pleiotropic effects of statins, mainly because they present neuroprotective effects in various pathological conditions. However, knowledge about behavioral effects of statins per se is relatively scarce. Considering these facts, we aimed to analyze behavioral responses of atorvastatin or simvastatin-treated mice in the open field test, elevated plus maze and object location test. Atorvastatin treatment for 7 consecutive days at 1mg/kg or 10mg/kg (v.o.) or simvastatin 10mg/kg or 20mg/kg enhanced cognitive performance in object location test when compared to control group (saline-treated mice). Simvastatin effects on mice performance in the object location test was abolished by post-training infusion of the beta-adrenoceptor antagonist propranolol. Atorvastatin and simvastatin did not change the behavioral response in open field and elevated plus-maze (EPM) tests in any of the used doses. These data demonstrate the positive effects of both statins in cognitive processes in mice, without any alteration in locomotor parameters in the open field test or anxiolytic-like behavior in EPM. In conclusion, we demonstrate that atorvastatin and simvastatin per se improve the cognitive performance in a rodent model of spatial memory and this effect is related to beta-adrenergic receptors modulation. Statins are inhibitors of the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, thereby inhibiting cell synthesis of cholesterol and isoprenoids. Moreover, several studies have been evaluating pleiotropic effects of statins, mainly because they present neuroprotective effects in various pathological conditions. However, knowledge about behavioral effects of statins per se is relatively scarce. Considering these facts, we aimed to analyze behavioral responses of atorvastatin or simvastatin-treated mice in the open field test, elevated plus maze and object location test. Atorvastatin treatment for 7 consecutive days at 1mg/kg or 10mg/kg (v.o.) or simvastatin 10mg/kg or 20mg/kg enhanced cognitive performance in object location test when compared to control group (saline-treated mice). Simvastatin effects on mice performance in the object location test was abolished by post-training infusion of the beta-adrenoceptor antagonist propranolol. Atorvastatin and simvastatin did not change the behavioral response in open field and elevated plus-maze (EPM) tests in any of the used doses. These data demonstrate the positive effects of both statins in cognitive processes in mice, without any alteration in locomotor parameters in the open field test or anxiolytic-like behavior in EPM. In conclusion, we demonstrate that atorvastatin and simvastatin per se improve the cognitive performance in a rodent model of spatial memory and this effect is related to beta-adrenergic receptors modulation. França, Lucas Moreira oth Alcantara-Junior, José oth Nogueira, Lucas Caixeta oth de Brito, Thiago Marques oth Lopes, Lousã oth Junior, Fernando Mesquita oth Vanzeler, Maria Luzinete oth Bertoldo, Daniela Bohn oth Dias, Paula Gomes oth Colla, André R.S. oth Hoeller, Alexandre oth Duzzioni, Marcelo oth Rodrigues, Ana Lúcia S. oth de Lima, Thereza C.M. oth Tasca, Carla Inês oth Viola, Giordano Gubert oth Enthalten in Elsevier Science Biswas, Indranil ELSEVIER Étale triviality of finite vector bundles over compact complex manifolds 2020 official journal of the International Behavioral Neuroscience Society Amsterdam [u.a.] (DE-627)ELV004116763 volume:143 year:2015 day:1 month:05 pages:27-34 extent:8 https://doi.org/10.1016/j.physbeh.2015.02.024 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-MAT 31.00 Mathematik: Allgemeines VZ AR 143 2015 1 0501 27-34 8 045F 570 |
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Vandresen-Filho, Samuel @@aut@@ França, Lucas Moreira @@oth@@ Alcantara-Junior, José @@oth@@ Nogueira, Lucas Caixeta @@oth@@ de Brito, Thiago Marques @@oth@@ Lopes, Lousã @@oth@@ Junior, Fernando Mesquita @@oth@@ Vanzeler, Maria Luzinete @@oth@@ Bertoldo, Daniela Bohn @@oth@@ Dias, Paula Gomes @@oth@@ Colla, André R.S. @@oth@@ Hoeller, Alexandre @@oth@@ Duzzioni, Marcelo @@oth@@ Rodrigues, Ana Lúcia S. @@oth@@ de Lima, Thereza C.M. @@oth@@ Tasca, Carla Inês @@oth@@ Viola, Giordano Gubert @@oth@@ |
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statins enhance cognitive performance in object location test in albino swiss mice: involvement of beta-adrenoceptors |
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Statins enhance cognitive performance in object location test in albino Swiss mice: Involvement of beta-adrenoceptors |
| abstract |
Statins are inhibitors of the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, thereby inhibiting cell synthesis of cholesterol and isoprenoids. Moreover, several studies have been evaluating pleiotropic effects of statins, mainly because they present neuroprotective effects in various pathological conditions. However, knowledge about behavioral effects of statins per se is relatively scarce. Considering these facts, we aimed to analyze behavioral responses of atorvastatin or simvastatin-treated mice in the open field test, elevated plus maze and object location test. Atorvastatin treatment for 7 consecutive days at 1mg/kg or 10mg/kg (v.o.) or simvastatin 10mg/kg or 20mg/kg enhanced cognitive performance in object location test when compared to control group (saline-treated mice). Simvastatin effects on mice performance in the object location test was abolished by post-training infusion of the beta-adrenoceptor antagonist propranolol. Atorvastatin and simvastatin did not change the behavioral response in open field and elevated plus-maze (EPM) tests in any of the used doses. These data demonstrate the positive effects of both statins in cognitive processes in mice, without any alteration in locomotor parameters in the open field test or anxiolytic-like behavior in EPM. In conclusion, we demonstrate that atorvastatin and simvastatin per se improve the cognitive performance in a rodent model of spatial memory and this effect is related to beta-adrenergic receptors modulation. |
| abstractGer |
Statins are inhibitors of the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, thereby inhibiting cell synthesis of cholesterol and isoprenoids. Moreover, several studies have been evaluating pleiotropic effects of statins, mainly because they present neuroprotective effects in various pathological conditions. However, knowledge about behavioral effects of statins per se is relatively scarce. Considering these facts, we aimed to analyze behavioral responses of atorvastatin or simvastatin-treated mice in the open field test, elevated plus maze and object location test. Atorvastatin treatment for 7 consecutive days at 1mg/kg or 10mg/kg (v.o.) or simvastatin 10mg/kg or 20mg/kg enhanced cognitive performance in object location test when compared to control group (saline-treated mice). Simvastatin effects on mice performance in the object location test was abolished by post-training infusion of the beta-adrenoceptor antagonist propranolol. Atorvastatin and simvastatin did not change the behavioral response in open field and elevated plus-maze (EPM) tests in any of the used doses. These data demonstrate the positive effects of both statins in cognitive processes in mice, without any alteration in locomotor parameters in the open field test or anxiolytic-like behavior in EPM. In conclusion, we demonstrate that atorvastatin and simvastatin per se improve the cognitive performance in a rodent model of spatial memory and this effect is related to beta-adrenergic receptors modulation. |
| abstract_unstemmed |
Statins are inhibitors of the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, thereby inhibiting cell synthesis of cholesterol and isoprenoids. Moreover, several studies have been evaluating pleiotropic effects of statins, mainly because they present neuroprotective effects in various pathological conditions. However, knowledge about behavioral effects of statins per se is relatively scarce. Considering these facts, we aimed to analyze behavioral responses of atorvastatin or simvastatin-treated mice in the open field test, elevated plus maze and object location test. Atorvastatin treatment for 7 consecutive days at 1mg/kg or 10mg/kg (v.o.) or simvastatin 10mg/kg or 20mg/kg enhanced cognitive performance in object location test when compared to control group (saline-treated mice). Simvastatin effects on mice performance in the object location test was abolished by post-training infusion of the beta-adrenoceptor antagonist propranolol. Atorvastatin and simvastatin did not change the behavioral response in open field and elevated plus-maze (EPM) tests in any of the used doses. These data demonstrate the positive effects of both statins in cognitive processes in mice, without any alteration in locomotor parameters in the open field test or anxiolytic-like behavior in EPM. In conclusion, we demonstrate that atorvastatin and simvastatin per se improve the cognitive performance in a rodent model of spatial memory and this effect is related to beta-adrenergic receptors modulation. |
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These data demonstrate the positive effects of both statins in cognitive processes in mice, without any alteration in locomotor parameters in the open field test or anxiolytic-like behavior in EPM. In conclusion, we demonstrate that atorvastatin and simvastatin per se improve the cognitive performance in a rodent model of spatial memory and this effect is related to beta-adrenergic receptors modulation.</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Statins are inhibitors of the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, thereby inhibiting cell synthesis of cholesterol and isoprenoids. Moreover, several studies have been evaluating pleiotropic effects of statins, mainly because they present neuroprotective effects in various pathological conditions. However, knowledge about behavioral effects of statins per se is relatively scarce. Considering these facts, we aimed to analyze behavioral responses of atorvastatin or simvastatin-treated mice in the open field test, elevated plus maze and object location test. Atorvastatin treatment for 7 consecutive days at 1mg/kg or 10mg/kg (v.o.) or simvastatin 10mg/kg or 20mg/kg enhanced cognitive performance in object location test when compared to control group (saline-treated mice). Simvastatin effects on mice performance in the object location test was abolished by post-training infusion of the beta-adrenoceptor antagonist propranolol. Atorvastatin and simvastatin did not change the behavioral response in open field and elevated plus-maze (EPM) tests in any of the used doses. These data demonstrate the positive effects of both statins in cognitive processes in mice, without any alteration in locomotor parameters in the open field test or anxiolytic-like behavior in EPM. In conclusion, we demonstrate that atorvastatin and simvastatin per se improve the cognitive performance in a rodent model of spatial memory and this effect is related to beta-adrenergic receptors modulation.</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">França, Lucas Moreira</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Alcantara-Junior, José</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Nogueira, Lucas Caixeta</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">de Brito, Thiago Marques</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Lopes, Lousã</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Junior, Fernando Mesquita</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Vanzeler, Maria Luzinete</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Bertoldo, Daniela Bohn</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Dias, Paula Gomes</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Colla, André R.S.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Hoeller, Alexandre</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Duzzioni, Marcelo</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Rodrigues, Ana Lúcia S.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">de Lima, Thereza C.M.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Tasca, Carla Inês</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Viola, Giordano Gubert</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="n">Elsevier Science</subfield><subfield code="a">Biswas, Indranil ELSEVIER</subfield><subfield code="t">Étale triviality of finite vector bundles over compact complex manifolds</subfield><subfield code="d">2020</subfield><subfield code="d">official journal of the International Behavioral Neuroscience Society</subfield><subfield code="g">Amsterdam [u.a.]</subfield><subfield code="w">(DE-627)ELV004116763</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:143</subfield><subfield code="g">year:2015</subfield><subfield code="g">day:1</subfield><subfield code="g">month:05</subfield><subfield code="g">pages:27-34</subfield><subfield code="g">extent:8</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1016/j.physbeh.2015.02.024</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ELV</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OPC-MAT</subfield></datafield><datafield tag="936" ind1="b" ind2="k"><subfield code="a">31.00</subfield><subfield code="j">Mathematik: Allgemeines</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">143</subfield><subfield code="j">2015</subfield><subfield code="b">1</subfield><subfield code="c">0501</subfield><subfield code="h">27-34</subfield><subfield code="g">8</subfield></datafield><datafield tag="953" ind1=" " ind2=" "><subfield code="2">045F</subfield><subfield code="a">570</subfield></datafield></record></collection>
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