A potential role for the acid-sensing T cell death associated gene-8 (TDAG8) receptor in depression-like behavior
Inflammation has been suggested to contribute to the pathophysiology of depression. The T cell death associated gene-8 (TDAG8) receptor is a proton-sensing G-protein-coupled receptor (GPCR) expressed on immune cells in both the CNS and periphery. Previous work has shown modulation of inflammation by...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Vollmer, Lauren Larke [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2015transfer abstract |
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| Umfang: |
5 |
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| Übergeordnetes Werk: |
Enthalten in: Étale triviality of finite vector bundles over compact complex manifolds - Biswas, Indranil ELSEVIER, 2020, official journal of the International Behavioral Neuroscience Society, Amsterdam [u.a.] |
|---|---|
| Übergeordnetes Werk: |
volume:150 ; year:2015 ; day:15 ; month:10 ; pages:78-82 ; extent:5 |
| Links: |
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| DOI / URN: |
10.1016/j.physbeh.2015.03.012 |
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| 245 | 1 | 0 | |a A potential role for the acid-sensing T cell death associated gene-8 (TDAG8) receptor in depression-like behavior |
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| 520 | |a Inflammation has been suggested to contribute to the pathophysiology of depression. The T cell death associated gene-8 (TDAG8) receptor is a proton-sensing G-protein-coupled receptor (GPCR) expressed on immune cells in both the CNS and periphery. Previous work has shown modulation of inflammation by the TDAG8 receptor, with pro-inflammatory responses reported in the central nervous system (CNS). Given the link between depression and inflammation, the aim of the present study was to investigate the role of TDAG8 in depression relevant behaviors. Mice deficient in TDAG8 (TDAG8−/−) were tested in the forced swim test (FST) and sucrose preference paradigm. TDAG8 deficiency resulted in significant attenuation of immobility in the FST as compared to wild type TDAG8 (TDAG8+/+) mice. These differences were not due to alterations in motor activity evoked by TDAG8 deficiency as TDAG8+/+ and TDAG8−/− mice displayed similar activity in the home cage or in a novel context. TDAG8−/− mice showed significantly higher consumption of sucrose compared to wild type mice although sucrose preference was not significantly different between genotypes. Collectively, our results support the involvement of the TDAG8 receptor in behavioral response relevant to depression. Further investigation is required to validate TDAG8 as a novel target linking inflammation and depression. | ||
| 520 | |a Inflammation has been suggested to contribute to the pathophysiology of depression. The T cell death associated gene-8 (TDAG8) receptor is a proton-sensing G-protein-coupled receptor (GPCR) expressed on immune cells in both the CNS and periphery. Previous work has shown modulation of inflammation by the TDAG8 receptor, with pro-inflammatory responses reported in the central nervous system (CNS). Given the link between depression and inflammation, the aim of the present study was to investigate the role of TDAG8 in depression relevant behaviors. Mice deficient in TDAG8 (TDAG8−/−) were tested in the forced swim test (FST) and sucrose preference paradigm. TDAG8 deficiency resulted in significant attenuation of immobility in the FST as compared to wild type TDAG8 (TDAG8+/+) mice. These differences were not due to alterations in motor activity evoked by TDAG8 deficiency as TDAG8+/+ and TDAG8−/− mice displayed similar activity in the home cage or in a novel context. TDAG8−/− mice showed significantly higher consumption of sucrose compared to wild type mice although sucrose preference was not significantly different between genotypes. Collectively, our results support the involvement of the TDAG8 receptor in behavioral response relevant to depression. Further investigation is required to validate TDAG8 as a novel target linking inflammation and depression. | ||
| 700 | 1 | |a Schmeltzer, Sarah N. |4 oth | |
| 700 | 1 | |a Ahlbrand, Rebecca |4 oth | |
| 700 | 1 | |a Sah, Renu |4 oth | |
| 773 | 0 | 8 | |i Enthalten in |n Elsevier Science |a Biswas, Indranil ELSEVIER |t Étale triviality of finite vector bundles over compact complex manifolds |d 2020 |d official journal of the International Behavioral Neuroscience Society |g Amsterdam [u.a.] |w (DE-627)ELV004116763 |
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10.1016/j.physbeh.2015.03.012 doi GBVA2015023000019.pica (DE-627)ELV019001983 (ELSEVIER)S0031-9384(15)00150-X DE-627 ger DE-627 rakwb eng 570 570 DE-600 510 VZ 31.00 bkl Vollmer, Lauren Larke verfasserin aut A potential role for the acid-sensing T cell death associated gene-8 (TDAG8) receptor in depression-like behavior 2015transfer abstract 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Inflammation has been suggested to contribute to the pathophysiology of depression. The T cell death associated gene-8 (TDAG8) receptor is a proton-sensing G-protein-coupled receptor (GPCR) expressed on immune cells in both the CNS and periphery. Previous work has shown modulation of inflammation by the TDAG8 receptor, with pro-inflammatory responses reported in the central nervous system (CNS). Given the link between depression and inflammation, the aim of the present study was to investigate the role of TDAG8 in depression relevant behaviors. Mice deficient in TDAG8 (TDAG8−/−) were tested in the forced swim test (FST) and sucrose preference paradigm. TDAG8 deficiency resulted in significant attenuation of immobility in the FST as compared to wild type TDAG8 (TDAG8+/+) mice. These differences were not due to alterations in motor activity evoked by TDAG8 deficiency as TDAG8+/+ and TDAG8−/− mice displayed similar activity in the home cage or in a novel context. TDAG8−/− mice showed significantly higher consumption of sucrose compared to wild type mice although sucrose preference was not significantly different between genotypes. Collectively, our results support the involvement of the TDAG8 receptor in behavioral response relevant to depression. Further investigation is required to validate TDAG8 as a novel target linking inflammation and depression. Inflammation has been suggested to contribute to the pathophysiology of depression. The T cell death associated gene-8 (TDAG8) receptor is a proton-sensing G-protein-coupled receptor (GPCR) expressed on immune cells in both the CNS and periphery. Previous work has shown modulation of inflammation by the TDAG8 receptor, with pro-inflammatory responses reported in the central nervous system (CNS). Given the link between depression and inflammation, the aim of the present study was to investigate the role of TDAG8 in depression relevant behaviors. Mice deficient in TDAG8 (TDAG8−/−) were tested in the forced swim test (FST) and sucrose preference paradigm. TDAG8 deficiency resulted in significant attenuation of immobility in the FST as compared to wild type TDAG8 (TDAG8+/+) mice. These differences were not due to alterations in motor activity evoked by TDAG8 deficiency as TDAG8+/+ and TDAG8−/− mice displayed similar activity in the home cage or in a novel context. TDAG8−/− mice showed significantly higher consumption of sucrose compared to wild type mice although sucrose preference was not significantly different between genotypes. Collectively, our results support the involvement of the TDAG8 receptor in behavioral response relevant to depression. Further investigation is required to validate TDAG8 as a novel target linking inflammation and depression. Schmeltzer, Sarah N. oth Ahlbrand, Rebecca oth Sah, Renu oth Enthalten in Elsevier Science Biswas, Indranil ELSEVIER Étale triviality of finite vector bundles over compact complex manifolds 2020 official journal of the International Behavioral Neuroscience Society Amsterdam [u.a.] (DE-627)ELV004116763 volume:150 year:2015 day:15 month:10 pages:78-82 extent:5 https://doi.org/10.1016/j.physbeh.2015.03.012 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-MAT 31.00 Mathematik: Allgemeines VZ AR 150 2015 15 1015 78-82 5 045F 570 |
| spelling |
10.1016/j.physbeh.2015.03.012 doi GBVA2015023000019.pica (DE-627)ELV019001983 (ELSEVIER)S0031-9384(15)00150-X DE-627 ger DE-627 rakwb eng 570 570 DE-600 510 VZ 31.00 bkl Vollmer, Lauren Larke verfasserin aut A potential role for the acid-sensing T cell death associated gene-8 (TDAG8) receptor in depression-like behavior 2015transfer abstract 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Inflammation has been suggested to contribute to the pathophysiology of depression. The T cell death associated gene-8 (TDAG8) receptor is a proton-sensing G-protein-coupled receptor (GPCR) expressed on immune cells in both the CNS and periphery. Previous work has shown modulation of inflammation by the TDAG8 receptor, with pro-inflammatory responses reported in the central nervous system (CNS). Given the link between depression and inflammation, the aim of the present study was to investigate the role of TDAG8 in depression relevant behaviors. Mice deficient in TDAG8 (TDAG8−/−) were tested in the forced swim test (FST) and sucrose preference paradigm. TDAG8 deficiency resulted in significant attenuation of immobility in the FST as compared to wild type TDAG8 (TDAG8+/+) mice. These differences were not due to alterations in motor activity evoked by TDAG8 deficiency as TDAG8+/+ and TDAG8−/− mice displayed similar activity in the home cage or in a novel context. TDAG8−/− mice showed significantly higher consumption of sucrose compared to wild type mice although sucrose preference was not significantly different between genotypes. Collectively, our results support the involvement of the TDAG8 receptor in behavioral response relevant to depression. Further investigation is required to validate TDAG8 as a novel target linking inflammation and depression. Inflammation has been suggested to contribute to the pathophysiology of depression. The T cell death associated gene-8 (TDAG8) receptor is a proton-sensing G-protein-coupled receptor (GPCR) expressed on immune cells in both the CNS and periphery. Previous work has shown modulation of inflammation by the TDAG8 receptor, with pro-inflammatory responses reported in the central nervous system (CNS). Given the link between depression and inflammation, the aim of the present study was to investigate the role of TDAG8 in depression relevant behaviors. Mice deficient in TDAG8 (TDAG8−/−) were tested in the forced swim test (FST) and sucrose preference paradigm. TDAG8 deficiency resulted in significant attenuation of immobility in the FST as compared to wild type TDAG8 (TDAG8+/+) mice. These differences were not due to alterations in motor activity evoked by TDAG8 deficiency as TDAG8+/+ and TDAG8−/− mice displayed similar activity in the home cage or in a novel context. TDAG8−/− mice showed significantly higher consumption of sucrose compared to wild type mice although sucrose preference was not significantly different between genotypes. Collectively, our results support the involvement of the TDAG8 receptor in behavioral response relevant to depression. Further investigation is required to validate TDAG8 as a novel target linking inflammation and depression. Schmeltzer, Sarah N. oth Ahlbrand, Rebecca oth Sah, Renu oth Enthalten in Elsevier Science Biswas, Indranil ELSEVIER Étale triviality of finite vector bundles over compact complex manifolds 2020 official journal of the International Behavioral Neuroscience Society Amsterdam [u.a.] (DE-627)ELV004116763 volume:150 year:2015 day:15 month:10 pages:78-82 extent:5 https://doi.org/10.1016/j.physbeh.2015.03.012 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-MAT 31.00 Mathematik: Allgemeines VZ AR 150 2015 15 1015 78-82 5 045F 570 |
| allfields_unstemmed |
10.1016/j.physbeh.2015.03.012 doi GBVA2015023000019.pica (DE-627)ELV019001983 (ELSEVIER)S0031-9384(15)00150-X DE-627 ger DE-627 rakwb eng 570 570 DE-600 510 VZ 31.00 bkl Vollmer, Lauren Larke verfasserin aut A potential role for the acid-sensing T cell death associated gene-8 (TDAG8) receptor in depression-like behavior 2015transfer abstract 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Inflammation has been suggested to contribute to the pathophysiology of depression. The T cell death associated gene-8 (TDAG8) receptor is a proton-sensing G-protein-coupled receptor (GPCR) expressed on immune cells in both the CNS and periphery. Previous work has shown modulation of inflammation by the TDAG8 receptor, with pro-inflammatory responses reported in the central nervous system (CNS). Given the link between depression and inflammation, the aim of the present study was to investigate the role of TDAG8 in depression relevant behaviors. Mice deficient in TDAG8 (TDAG8−/−) were tested in the forced swim test (FST) and sucrose preference paradigm. TDAG8 deficiency resulted in significant attenuation of immobility in the FST as compared to wild type TDAG8 (TDAG8+/+) mice. These differences were not due to alterations in motor activity evoked by TDAG8 deficiency as TDAG8+/+ and TDAG8−/− mice displayed similar activity in the home cage or in a novel context. TDAG8−/− mice showed significantly higher consumption of sucrose compared to wild type mice although sucrose preference was not significantly different between genotypes. Collectively, our results support the involvement of the TDAG8 receptor in behavioral response relevant to depression. Further investigation is required to validate TDAG8 as a novel target linking inflammation and depression. Inflammation has been suggested to contribute to the pathophysiology of depression. The T cell death associated gene-8 (TDAG8) receptor is a proton-sensing G-protein-coupled receptor (GPCR) expressed on immune cells in both the CNS and periphery. Previous work has shown modulation of inflammation by the TDAG8 receptor, with pro-inflammatory responses reported in the central nervous system (CNS). Given the link between depression and inflammation, the aim of the present study was to investigate the role of TDAG8 in depression relevant behaviors. Mice deficient in TDAG8 (TDAG8−/−) were tested in the forced swim test (FST) and sucrose preference paradigm. TDAG8 deficiency resulted in significant attenuation of immobility in the FST as compared to wild type TDAG8 (TDAG8+/+) mice. These differences were not due to alterations in motor activity evoked by TDAG8 deficiency as TDAG8+/+ and TDAG8−/− mice displayed similar activity in the home cage or in a novel context. TDAG8−/− mice showed significantly higher consumption of sucrose compared to wild type mice although sucrose preference was not significantly different between genotypes. Collectively, our results support the involvement of the TDAG8 receptor in behavioral response relevant to depression. Further investigation is required to validate TDAG8 as a novel target linking inflammation and depression. Schmeltzer, Sarah N. oth Ahlbrand, Rebecca oth Sah, Renu oth Enthalten in Elsevier Science Biswas, Indranil ELSEVIER Étale triviality of finite vector bundles over compact complex manifolds 2020 official journal of the International Behavioral Neuroscience Society Amsterdam [u.a.] (DE-627)ELV004116763 volume:150 year:2015 day:15 month:10 pages:78-82 extent:5 https://doi.org/10.1016/j.physbeh.2015.03.012 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-MAT 31.00 Mathematik: Allgemeines VZ AR 150 2015 15 1015 78-82 5 045F 570 |
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10.1016/j.physbeh.2015.03.012 doi GBVA2015023000019.pica (DE-627)ELV019001983 (ELSEVIER)S0031-9384(15)00150-X DE-627 ger DE-627 rakwb eng 570 570 DE-600 510 VZ 31.00 bkl Vollmer, Lauren Larke verfasserin aut A potential role for the acid-sensing T cell death associated gene-8 (TDAG8) receptor in depression-like behavior 2015transfer abstract 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Inflammation has been suggested to contribute to the pathophysiology of depression. The T cell death associated gene-8 (TDAG8) receptor is a proton-sensing G-protein-coupled receptor (GPCR) expressed on immune cells in both the CNS and periphery. Previous work has shown modulation of inflammation by the TDAG8 receptor, with pro-inflammatory responses reported in the central nervous system (CNS). Given the link between depression and inflammation, the aim of the present study was to investigate the role of TDAG8 in depression relevant behaviors. Mice deficient in TDAG8 (TDAG8−/−) were tested in the forced swim test (FST) and sucrose preference paradigm. TDAG8 deficiency resulted in significant attenuation of immobility in the FST as compared to wild type TDAG8 (TDAG8+/+) mice. These differences were not due to alterations in motor activity evoked by TDAG8 deficiency as TDAG8+/+ and TDAG8−/− mice displayed similar activity in the home cage or in a novel context. TDAG8−/− mice showed significantly higher consumption of sucrose compared to wild type mice although sucrose preference was not significantly different between genotypes. Collectively, our results support the involvement of the TDAG8 receptor in behavioral response relevant to depression. Further investigation is required to validate TDAG8 as a novel target linking inflammation and depression. Inflammation has been suggested to contribute to the pathophysiology of depression. The T cell death associated gene-8 (TDAG8) receptor is a proton-sensing G-protein-coupled receptor (GPCR) expressed on immune cells in both the CNS and periphery. Previous work has shown modulation of inflammation by the TDAG8 receptor, with pro-inflammatory responses reported in the central nervous system (CNS). Given the link between depression and inflammation, the aim of the present study was to investigate the role of TDAG8 in depression relevant behaviors. Mice deficient in TDAG8 (TDAG8−/−) were tested in the forced swim test (FST) and sucrose preference paradigm. TDAG8 deficiency resulted in significant attenuation of immobility in the FST as compared to wild type TDAG8 (TDAG8+/+) mice. These differences were not due to alterations in motor activity evoked by TDAG8 deficiency as TDAG8+/+ and TDAG8−/− mice displayed similar activity in the home cage or in a novel context. TDAG8−/− mice showed significantly higher consumption of sucrose compared to wild type mice although sucrose preference was not significantly different between genotypes. Collectively, our results support the involvement of the TDAG8 receptor in behavioral response relevant to depression. Further investigation is required to validate TDAG8 as a novel target linking inflammation and depression. Schmeltzer, Sarah N. oth Ahlbrand, Rebecca oth Sah, Renu oth Enthalten in Elsevier Science Biswas, Indranil ELSEVIER Étale triviality of finite vector bundles over compact complex manifolds 2020 official journal of the International Behavioral Neuroscience Society Amsterdam [u.a.] (DE-627)ELV004116763 volume:150 year:2015 day:15 month:10 pages:78-82 extent:5 https://doi.org/10.1016/j.physbeh.2015.03.012 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-MAT 31.00 Mathematik: Allgemeines VZ AR 150 2015 15 1015 78-82 5 045F 570 |
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10.1016/j.physbeh.2015.03.012 doi GBVA2015023000019.pica (DE-627)ELV019001983 (ELSEVIER)S0031-9384(15)00150-X DE-627 ger DE-627 rakwb eng 570 570 DE-600 510 VZ 31.00 bkl Vollmer, Lauren Larke verfasserin aut A potential role for the acid-sensing T cell death associated gene-8 (TDAG8) receptor in depression-like behavior 2015transfer abstract 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Inflammation has been suggested to contribute to the pathophysiology of depression. The T cell death associated gene-8 (TDAG8) receptor is a proton-sensing G-protein-coupled receptor (GPCR) expressed on immune cells in both the CNS and periphery. Previous work has shown modulation of inflammation by the TDAG8 receptor, with pro-inflammatory responses reported in the central nervous system (CNS). Given the link between depression and inflammation, the aim of the present study was to investigate the role of TDAG8 in depression relevant behaviors. Mice deficient in TDAG8 (TDAG8−/−) were tested in the forced swim test (FST) and sucrose preference paradigm. TDAG8 deficiency resulted in significant attenuation of immobility in the FST as compared to wild type TDAG8 (TDAG8+/+) mice. These differences were not due to alterations in motor activity evoked by TDAG8 deficiency as TDAG8+/+ and TDAG8−/− mice displayed similar activity in the home cage or in a novel context. TDAG8−/− mice showed significantly higher consumption of sucrose compared to wild type mice although sucrose preference was not significantly different between genotypes. Collectively, our results support the involvement of the TDAG8 receptor in behavioral response relevant to depression. Further investigation is required to validate TDAG8 as a novel target linking inflammation and depression. Inflammation has been suggested to contribute to the pathophysiology of depression. The T cell death associated gene-8 (TDAG8) receptor is a proton-sensing G-protein-coupled receptor (GPCR) expressed on immune cells in both the CNS and periphery. Previous work has shown modulation of inflammation by the TDAG8 receptor, with pro-inflammatory responses reported in the central nervous system (CNS). Given the link between depression and inflammation, the aim of the present study was to investigate the role of TDAG8 in depression relevant behaviors. Mice deficient in TDAG8 (TDAG8−/−) were tested in the forced swim test (FST) and sucrose preference paradigm. TDAG8 deficiency resulted in significant attenuation of immobility in the FST as compared to wild type TDAG8 (TDAG8+/+) mice. These differences were not due to alterations in motor activity evoked by TDAG8 deficiency as TDAG8+/+ and TDAG8−/− mice displayed similar activity in the home cage or in a novel context. TDAG8−/− mice showed significantly higher consumption of sucrose compared to wild type mice although sucrose preference was not significantly different between genotypes. Collectively, our results support the involvement of the TDAG8 receptor in behavioral response relevant to depression. Further investigation is required to validate TDAG8 as a novel target linking inflammation and depression. Schmeltzer, Sarah N. oth Ahlbrand, Rebecca oth Sah, Renu oth Enthalten in Elsevier Science Biswas, Indranil ELSEVIER Étale triviality of finite vector bundles over compact complex manifolds 2020 official journal of the International Behavioral Neuroscience Society Amsterdam [u.a.] (DE-627)ELV004116763 volume:150 year:2015 day:15 month:10 pages:78-82 extent:5 https://doi.org/10.1016/j.physbeh.2015.03.012 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-MAT 31.00 Mathematik: Allgemeines VZ AR 150 2015 15 1015 78-82 5 045F 570 |
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Enthalten in Étale triviality of finite vector bundles over compact complex manifolds Amsterdam [u.a.] volume:150 year:2015 day:15 month:10 pages:78-82 extent:5 |
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Étale triviality of finite vector bundles over compact complex manifolds |
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Vollmer, Lauren Larke @@aut@@ Schmeltzer, Sarah N. @@oth@@ Ahlbrand, Rebecca @@oth@@ Sah, Renu @@oth@@ |
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TDAG8−/− mice showed significantly higher consumption of sucrose compared to wild type mice although sucrose preference was not significantly different between genotypes. Collectively, our results support the involvement of the TDAG8 receptor in behavioral response relevant to depression. Further investigation is required to validate TDAG8 as a novel target linking inflammation and depression.</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Inflammation has been suggested to contribute to the pathophysiology of depression. The T cell death associated gene-8 (TDAG8) receptor is a proton-sensing G-protein-coupled receptor (GPCR) expressed on immune cells in both the CNS and periphery. Previous work has shown modulation of inflammation by the TDAG8 receptor, with pro-inflammatory responses reported in the central nervous system (CNS). Given the link between depression and inflammation, the aim of the present study was to investigate the role of TDAG8 in depression relevant behaviors. Mice deficient in TDAG8 (TDAG8−/−) were tested in the forced swim test (FST) and sucrose preference paradigm. TDAG8 deficiency resulted in significant attenuation of immobility in the FST as compared to wild type TDAG8 (TDAG8+/+) mice. These differences were not due to alterations in motor activity evoked by TDAG8 deficiency as TDAG8+/+ and TDAG8−/− mice displayed similar activity in the home cage or in a novel context. TDAG8−/− mice showed significantly higher consumption of sucrose compared to wild type mice although sucrose preference was not significantly different between genotypes. Collectively, our results support the involvement of the TDAG8 receptor in behavioral response relevant to depression. 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a potential role for the acid-sensing t cell death associated gene-8 (tdag8) receptor in depression-like behavior |
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A potential role for the acid-sensing T cell death associated gene-8 (TDAG8) receptor in depression-like behavior |
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Inflammation has been suggested to contribute to the pathophysiology of depression. The T cell death associated gene-8 (TDAG8) receptor is a proton-sensing G-protein-coupled receptor (GPCR) expressed on immune cells in both the CNS and periphery. Previous work has shown modulation of inflammation by the TDAG8 receptor, with pro-inflammatory responses reported in the central nervous system (CNS). Given the link between depression and inflammation, the aim of the present study was to investigate the role of TDAG8 in depression relevant behaviors. Mice deficient in TDAG8 (TDAG8−/−) were tested in the forced swim test (FST) and sucrose preference paradigm. TDAG8 deficiency resulted in significant attenuation of immobility in the FST as compared to wild type TDAG8 (TDAG8+/+) mice. These differences were not due to alterations in motor activity evoked by TDAG8 deficiency as TDAG8+/+ and TDAG8−/− mice displayed similar activity in the home cage or in a novel context. TDAG8−/− mice showed significantly higher consumption of sucrose compared to wild type mice although sucrose preference was not significantly different between genotypes. Collectively, our results support the involvement of the TDAG8 receptor in behavioral response relevant to depression. Further investigation is required to validate TDAG8 as a novel target linking inflammation and depression. |
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Inflammation has been suggested to contribute to the pathophysiology of depression. The T cell death associated gene-8 (TDAG8) receptor is a proton-sensing G-protein-coupled receptor (GPCR) expressed on immune cells in both the CNS and periphery. Previous work has shown modulation of inflammation by the TDAG8 receptor, with pro-inflammatory responses reported in the central nervous system (CNS). Given the link between depression and inflammation, the aim of the present study was to investigate the role of TDAG8 in depression relevant behaviors. Mice deficient in TDAG8 (TDAG8−/−) were tested in the forced swim test (FST) and sucrose preference paradigm. TDAG8 deficiency resulted in significant attenuation of immobility in the FST as compared to wild type TDAG8 (TDAG8+/+) mice. These differences were not due to alterations in motor activity evoked by TDAG8 deficiency as TDAG8+/+ and TDAG8−/− mice displayed similar activity in the home cage or in a novel context. TDAG8−/− mice showed significantly higher consumption of sucrose compared to wild type mice although sucrose preference was not significantly different between genotypes. Collectively, our results support the involvement of the TDAG8 receptor in behavioral response relevant to depression. Further investigation is required to validate TDAG8 as a novel target linking inflammation and depression. |
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Inflammation has been suggested to contribute to the pathophysiology of depression. The T cell death associated gene-8 (TDAG8) receptor is a proton-sensing G-protein-coupled receptor (GPCR) expressed on immune cells in both the CNS and periphery. Previous work has shown modulation of inflammation by the TDAG8 receptor, with pro-inflammatory responses reported in the central nervous system (CNS). Given the link between depression and inflammation, the aim of the present study was to investigate the role of TDAG8 in depression relevant behaviors. Mice deficient in TDAG8 (TDAG8−/−) were tested in the forced swim test (FST) and sucrose preference paradigm. TDAG8 deficiency resulted in significant attenuation of immobility in the FST as compared to wild type TDAG8 (TDAG8+/+) mice. These differences were not due to alterations in motor activity evoked by TDAG8 deficiency as TDAG8+/+ and TDAG8−/− mice displayed similar activity in the home cage or in a novel context. TDAG8−/− mice showed significantly higher consumption of sucrose compared to wild type mice although sucrose preference was not significantly different between genotypes. Collectively, our results support the involvement of the TDAG8 receptor in behavioral response relevant to depression. Further investigation is required to validate TDAG8 as a novel target linking inflammation and depression. |
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