Sodium alginate as a potential carrier in solid dispersion formulations to enhance dissolution rate and apparent water solubility of BCS II drugs
• Sodium alginate was used as a potential carrier in solid dispersions. • The solid dispersions were characterized by DSC, XRPD, FTIR, Raman and SEM. • The solid dispersions successfully improved the drug aqueous solubility up to 16.7-fold. • The solid dispersions achieved promising dissolution rate...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Borba, Paola Aline Amarante [verfasserIn] |
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E-Artikel |
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Englisch |
| Erschienen: |
2016 |
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| Schlagwörter: |
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| Umfang: |
10 |
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| Übergeordnetes Werk: |
Enthalten in: Residue co-evolution helps predict interaction sites in α-helical membrane proteins - Zeng, Bo ELSEVIER, 2019, an international journal devoted to scientific and technological aspects of industrially important polysaccharides, Amsterdam [u.a.] |
|---|---|
| Übergeordnetes Werk: |
volume:137 ; year:2016 ; day:10 ; month:02 ; pages:350-359 ; extent:10 |
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| DOI / URN: |
10.1016/j.carbpol.2015.10.070 |
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Sodium alginate as a potential carrier in solid dispersion formulations to enhance dissolution rate and apparent water solubility of BCS II drugs |
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• Sodium alginate was used as a potential carrier in solid dispersions. • The solid dispersions were characterized by DSC, XRPD, FTIR, Raman and SEM. • The solid dispersions successfully improved the drug aqueous solubility up to 16.7-fold. • The solid dispersions achieved promising dissolution rates releasing more than 80% of drug in the SD. • SA acted as good anti plasticizer agent preventing the drug crystallization for 90 days. |
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• Sodium alginate was used as a potential carrier in solid dispersions. • The solid dispersions were characterized by DSC, XRPD, FTIR, Raman and SEM. • The solid dispersions successfully improved the drug aqueous solubility up to 16.7-fold. • The solid dispersions achieved promising dissolution rates releasing more than 80% of drug in the SD. • SA acted as good anti plasticizer agent preventing the drug crystallization for 90 days. |
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• Sodium alginate was used as a potential carrier in solid dispersions. • The solid dispersions were characterized by DSC, XRPD, FTIR, Raman and SEM. • The solid dispersions successfully improved the drug aqueous solubility up to 16.7-fold. • The solid dispersions achieved promising dissolution rates releasing more than 80% of drug in the SD. • SA acted as good anti plasticizer agent preventing the drug crystallization for 90 days. |
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Sodium alginate as a potential carrier in solid dispersion formulations to enhance dissolution rate and apparent water solubility of BCS II drugs |
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https://doi.org/10.1016/j.carbpol.2015.10.070 |
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Pinotti, Marihá de Campos, Carlos Eduardo Maduro Pezzini, Bianca Ramos Stulzer, Hellen Karine |
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10.1016/j.carbpol.2015.10.070 |
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2024-07-06T20:28:00.842Z |
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