Synthesis and evaluation of gallocyanine dyes as potential agents for the treatment of Alzheimer's disease and related neurodegenerative tauopathies
In search of safe and effective anti-Alzheimer disease agents a series of gallocyanine dyes have been synthesized and evaluated for their ability to inhibit LRPs/DKK1 interactions. Modulation of the interactions between LRPS and DKK1, regulate Wnt signaling pathway and affect Tau phosphorylation. Th...
Ausführliche Beschreibung
Gespeichert in:
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Mpousis, Spyros [verfasserIn] |
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E-Artikel |
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Englisch |
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2016 |
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| Schlagwörter: |
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11 |
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| Übergeordnetes Werk: |
Enthalten in: Electrochemical synthesis, photodegradation and antibacterial properties of PEG capped zinc oxide nanoparticles - Jose, Ajay ELSEVIER, 2018, Amsterdam [u.a.] |
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| Übergeordnetes Werk: |
volume:108 ; year:2016 ; day:27 ; month:01 ; pages:28-38 ; extent:11 |
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10.1016/j.ejmech.2015.11.024 |
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| 520 | |a In search of safe and effective anti-Alzheimer disease agents a series of gallocyanine dyes have been synthesized and evaluated for their ability to inhibit LRPs/DKK1 interactions. Modulation of the interactions between LRPS and DKK1, regulate Wnt signaling pathway and affect Tau phosphorylation. The current efforts resulted in the identification of potent DKK1 inhibitors which are able to inhibit prostaglandin J2-induced tau phosphorylation at serine 396. | ||
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synthesis and evaluation of gallocyanine dyes as potential agents for the treatment of alzheimer's disease and related neurodegenerative tauopathies |
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Synthesis and evaluation of gallocyanine dyes as potential agents for the treatment of Alzheimer's disease and related neurodegenerative tauopathies |
| abstract |
In search of safe and effective anti-Alzheimer disease agents a series of gallocyanine dyes have been synthesized and evaluated for their ability to inhibit LRPs/DKK1 interactions. Modulation of the interactions between LRPS and DKK1, regulate Wnt signaling pathway and affect Tau phosphorylation. The current efforts resulted in the identification of potent DKK1 inhibitors which are able to inhibit prostaglandin J2-induced tau phosphorylation at serine 396. |
| abstractGer |
In search of safe and effective anti-Alzheimer disease agents a series of gallocyanine dyes have been synthesized and evaluated for their ability to inhibit LRPs/DKK1 interactions. Modulation of the interactions between LRPS and DKK1, regulate Wnt signaling pathway and affect Tau phosphorylation. The current efforts resulted in the identification of potent DKK1 inhibitors which are able to inhibit prostaglandin J2-induced tau phosphorylation at serine 396. |
| abstract_unstemmed |
In search of safe and effective anti-Alzheimer disease agents a series of gallocyanine dyes have been synthesized and evaluated for their ability to inhibit LRPs/DKK1 interactions. Modulation of the interactions between LRPS and DKK1, regulate Wnt signaling pathway and affect Tau phosphorylation. The current efforts resulted in the identification of potent DKK1 inhibitors which are able to inhibit prostaglandin J2-induced tau phosphorylation at serine 396. |
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| title_short |
Synthesis and evaluation of gallocyanine dyes as potential agents for the treatment of Alzheimer's disease and related neurodegenerative tauopathies |
| url |
https://doi.org/10.1016/j.ejmech.2015.11.024 |
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| author2 |
Thysiadis, Savvas Avramidis, Nicolaos Katsamakas, Sotirios Efthimiopoulos, Spiros Sarli, Vasiliki |
| author2Str |
Thysiadis, Savvas Avramidis, Nicolaos Katsamakas, Sotirios Efthimiopoulos, Spiros Sarli, Vasiliki |
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| doi_str |
10.1016/j.ejmech.2015.11.024 |
| up_date |
2024-07-06T21:05:01.121Z |
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1803865189118902272 |
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