Astrogliosis: An integral player in the pathogenesis of Alzheimer's disease

• Astrogliosis is a characteristic feature of Alzheimer's disease (AD). • Astrocytes undergo pertinent molecular changes in AD, switching genetic profiles. • Functional changes in astrocytes in AD perturb the micromilieu surrounding neurons. • Astrocyte dysfunction compromises local and network...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Osborn, Lana M. [verfasserIn] Kamphuis, Willem Wadman, Wytse J. Hol, Elly M.

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2016

Schlagwörter:	APP TNFα SR-BI BBB LRP1 CEBPD HSPB8-BAG3 ACh ApoE4 EAAT1,EAAT2 ALS α7nAChRs MHC TREM2 PEA-15 CLU NFAT JAK/STAT3 Aβ GLAST Nrf2 SAP-C1q AICD ApoE IF LDLR GSH EC ABCA1 BCHE CAA AD AMPAR ECM PrPc GFAP BACE1 CaMKII GABA TGFβ VIM mGluR5 ATP GLT-1 PICALM

Umfang:	21

Übergeordnetes Werk:	Enthalten in: Influences of mine water on the properties of construction and demolition waste-based cemented paste backfill - Zhou, Nan ELSEVIER, 2021, an international review journal, Amsterdam [u.a.]
Übergeordnetes Werk:	volume:144 ; year:2016 ; pages:121-141 ; extent:21

Links:	Volltext

DOI / URN:	10.1016/j.pneurobio.2016.01.001

Katalog-ID:	ELV019362374

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allfields	10.1016/j.pneurobio.2016.01.001 doi GBVA2016010000026.pica (DE-627)ELV019362374 (ELSEVIER)S0301-0082(15)30021-6 DE-627 ger DE-627 rakwb eng 610 610 DE-600 690 VZ 56.45 bkl Osborn, Lana M. verfasserin aut Astrogliosis: An integral player in the pathogenesis of Alzheimer's disease 2016 21 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • Astrogliosis is a characteristic feature of Alzheimer's disease (AD). • Astrocytes undergo pertinent molecular changes in AD, switching genetic profiles. • Functional changes in astrocytes in AD perturb the micromilieu surrounding neurons. • Astrocyte dysfunction compromises local and network level neuronal communication. • Research focused on astrocytes as therapeutic targets in AD is imperative. APP Elsevier TNFα Elsevier SR-BI Elsevier BBB Elsevier LRP1 Elsevier CEBPD Elsevier HSPB8-BAG3 Elsevier ACh Elsevier ApoE4 Elsevier EAAT1,EAAT2 Elsevier ALS Elsevier α7nAChRs Elsevier MHC Elsevier TREM2 Elsevier PEA-15 Elsevier CLU Elsevier NFAT Elsevier JAK/STAT3 Elsevier Aβ Elsevier GLAST Elsevier Nrf2 Elsevier SAP-C1q Elsevier AICD Elsevier ApoE Elsevier IF Elsevier LDLR Elsevier GSH Elsevier EC Elsevier ABCA1 Elsevier BCHE Elsevier CAA Elsevier AD Elsevier AMPAR Elsevier ECM Elsevier PrPc Elsevier GFAP Elsevier BACE1 Elsevier CaMKII Elsevier GABA Elsevier TGFβ Elsevier VIM Elsevier mGluR5 Elsevier ATP Elsevier GLT-1 Elsevier PICALM Elsevier Kamphuis, Willem oth Wadman, Wytse J. oth Hol, Elly M. oth Enthalten in Elsevier Zhou, Nan ELSEVIER Influences of mine water on the properties of construction and demolition waste-based cemented paste backfill 2021 an international review journal Amsterdam [u.a.] (DE-627)ELV006964737 volume:144 year:2016 pages:121-141 extent:21 https://doi.org/10.1016/j.pneurobio.2016.01.001 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 56.45 Baustoffkunde VZ AR 144 2016 121-141 21 045F 610
spelling	10.1016/j.pneurobio.2016.01.001 doi GBVA2016010000026.pica (DE-627)ELV019362374 (ELSEVIER)S0301-0082(15)30021-6 DE-627 ger DE-627 rakwb eng 610 610 DE-600 690 VZ 56.45 bkl Osborn, Lana M. verfasserin aut Astrogliosis: An integral player in the pathogenesis of Alzheimer's disease 2016 21 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • Astrogliosis is a characteristic feature of Alzheimer's disease (AD). • Astrocytes undergo pertinent molecular changes in AD, switching genetic profiles. • Functional changes in astrocytes in AD perturb the micromilieu surrounding neurons. • Astrocyte dysfunction compromises local and network level neuronal communication. • Research focused on astrocytes as therapeutic targets in AD is imperative. APP Elsevier TNFα Elsevier SR-BI Elsevier BBB Elsevier LRP1 Elsevier CEBPD Elsevier HSPB8-BAG3 Elsevier ACh Elsevier ApoE4 Elsevier EAAT1,EAAT2 Elsevier ALS Elsevier α7nAChRs Elsevier MHC Elsevier TREM2 Elsevier PEA-15 Elsevier CLU Elsevier NFAT Elsevier JAK/STAT3 Elsevier Aβ Elsevier GLAST Elsevier Nrf2 Elsevier SAP-C1q Elsevier AICD Elsevier ApoE Elsevier IF Elsevier LDLR Elsevier GSH Elsevier EC Elsevier ABCA1 Elsevier BCHE Elsevier CAA Elsevier AD Elsevier AMPAR Elsevier ECM Elsevier PrPc Elsevier GFAP Elsevier BACE1 Elsevier CaMKII Elsevier GABA Elsevier TGFβ Elsevier VIM Elsevier mGluR5 Elsevier ATP Elsevier GLT-1 Elsevier PICALM Elsevier Kamphuis, Willem oth Wadman, Wytse J. oth Hol, Elly M. oth Enthalten in Elsevier Zhou, Nan ELSEVIER Influences of mine water on the properties of construction and demolition waste-based cemented paste backfill 2021 an international review journal Amsterdam [u.a.] (DE-627)ELV006964737 volume:144 year:2016 pages:121-141 extent:21 https://doi.org/10.1016/j.pneurobio.2016.01.001 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 56.45 Baustoffkunde VZ AR 144 2016 121-141 21 045F 610
allfields_unstemmed	10.1016/j.pneurobio.2016.01.001 doi GBVA2016010000026.pica (DE-627)ELV019362374 (ELSEVIER)S0301-0082(15)30021-6 DE-627 ger DE-627 rakwb eng 610 610 DE-600 690 VZ 56.45 bkl Osborn, Lana M. verfasserin aut Astrogliosis: An integral player in the pathogenesis of Alzheimer's disease 2016 21 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • Astrogliosis is a characteristic feature of Alzheimer's disease (AD). • Astrocytes undergo pertinent molecular changes in AD, switching genetic profiles. • Functional changes in astrocytes in AD perturb the micromilieu surrounding neurons. • Astrocyte dysfunction compromises local and network level neuronal communication. • Research focused on astrocytes as therapeutic targets in AD is imperative. APP Elsevier TNFα Elsevier SR-BI Elsevier BBB Elsevier LRP1 Elsevier CEBPD Elsevier HSPB8-BAG3 Elsevier ACh Elsevier ApoE4 Elsevier EAAT1,EAAT2 Elsevier ALS Elsevier α7nAChRs Elsevier MHC Elsevier TREM2 Elsevier PEA-15 Elsevier CLU Elsevier NFAT Elsevier JAK/STAT3 Elsevier Aβ Elsevier GLAST Elsevier Nrf2 Elsevier SAP-C1q Elsevier AICD Elsevier ApoE Elsevier IF Elsevier LDLR Elsevier GSH Elsevier EC Elsevier ABCA1 Elsevier BCHE Elsevier CAA Elsevier AD Elsevier AMPAR Elsevier ECM Elsevier PrPc Elsevier GFAP Elsevier BACE1 Elsevier CaMKII Elsevier GABA Elsevier TGFβ Elsevier VIM Elsevier mGluR5 Elsevier ATP Elsevier GLT-1 Elsevier PICALM Elsevier Kamphuis, Willem oth Wadman, Wytse J. oth Hol, Elly M. oth Enthalten in Elsevier Zhou, Nan ELSEVIER Influences of mine water on the properties of construction and demolition waste-based cemented paste backfill 2021 an international review journal Amsterdam [u.a.] (DE-627)ELV006964737 volume:144 year:2016 pages:121-141 extent:21 https://doi.org/10.1016/j.pneurobio.2016.01.001 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 56.45 Baustoffkunde VZ AR 144 2016 121-141 21 045F 610
allfieldsGer	10.1016/j.pneurobio.2016.01.001 doi GBVA2016010000026.pica (DE-627)ELV019362374 (ELSEVIER)S0301-0082(15)30021-6 DE-627 ger DE-627 rakwb eng 610 610 DE-600 690 VZ 56.45 bkl Osborn, Lana M. verfasserin aut Astrogliosis: An integral player in the pathogenesis of Alzheimer's disease 2016 21 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • Astrogliosis is a characteristic feature of Alzheimer's disease (AD). • Astrocytes undergo pertinent molecular changes in AD, switching genetic profiles. • Functional changes in astrocytes in AD perturb the micromilieu surrounding neurons. • Astrocyte dysfunction compromises local and network level neuronal communication. • Research focused on astrocytes as therapeutic targets in AD is imperative. APP Elsevier TNFα Elsevier SR-BI Elsevier BBB Elsevier LRP1 Elsevier CEBPD Elsevier HSPB8-BAG3 Elsevier ACh Elsevier ApoE4 Elsevier EAAT1,EAAT2 Elsevier ALS Elsevier α7nAChRs Elsevier MHC Elsevier TREM2 Elsevier PEA-15 Elsevier CLU Elsevier NFAT Elsevier JAK/STAT3 Elsevier Aβ Elsevier GLAST Elsevier Nrf2 Elsevier SAP-C1q Elsevier AICD Elsevier ApoE Elsevier IF Elsevier LDLR Elsevier GSH Elsevier EC Elsevier ABCA1 Elsevier BCHE Elsevier CAA Elsevier AD Elsevier AMPAR Elsevier ECM Elsevier PrPc Elsevier GFAP Elsevier BACE1 Elsevier CaMKII Elsevier GABA Elsevier TGFβ Elsevier VIM Elsevier mGluR5 Elsevier ATP Elsevier GLT-1 Elsevier PICALM Elsevier Kamphuis, Willem oth Wadman, Wytse J. oth Hol, Elly M. oth Enthalten in Elsevier Zhou, Nan ELSEVIER Influences of mine water on the properties of construction and demolition waste-based cemented paste backfill 2021 an international review journal Amsterdam [u.a.] (DE-627)ELV006964737 volume:144 year:2016 pages:121-141 extent:21 https://doi.org/10.1016/j.pneurobio.2016.01.001 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 56.45 Baustoffkunde VZ AR 144 2016 121-141 21 045F 610
allfieldsSound	10.1016/j.pneurobio.2016.01.001 doi GBVA2016010000026.pica (DE-627)ELV019362374 (ELSEVIER)S0301-0082(15)30021-6 DE-627 ger DE-627 rakwb eng 610 610 DE-600 690 VZ 56.45 bkl Osborn, Lana M. verfasserin aut Astrogliosis: An integral player in the pathogenesis of Alzheimer's disease 2016 21 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • Astrogliosis is a characteristic feature of Alzheimer's disease (AD). • Astrocytes undergo pertinent molecular changes in AD, switching genetic profiles. • Functional changes in astrocytes in AD perturb the micromilieu surrounding neurons. • Astrocyte dysfunction compromises local and network level neuronal communication. • Research focused on astrocytes as therapeutic targets in AD is imperative. APP Elsevier TNFα Elsevier SR-BI Elsevier BBB Elsevier LRP1 Elsevier CEBPD Elsevier HSPB8-BAG3 Elsevier ACh Elsevier ApoE4 Elsevier EAAT1,EAAT2 Elsevier ALS Elsevier α7nAChRs Elsevier MHC Elsevier TREM2 Elsevier PEA-15 Elsevier CLU Elsevier NFAT Elsevier JAK/STAT3 Elsevier Aβ Elsevier GLAST Elsevier Nrf2 Elsevier SAP-C1q Elsevier AICD Elsevier ApoE Elsevier IF Elsevier LDLR Elsevier GSH Elsevier EC Elsevier ABCA1 Elsevier BCHE Elsevier CAA Elsevier AD Elsevier AMPAR Elsevier ECM Elsevier PrPc Elsevier GFAP Elsevier BACE1 Elsevier CaMKII Elsevier GABA Elsevier TGFβ Elsevier VIM Elsevier mGluR5 Elsevier ATP Elsevier GLT-1 Elsevier PICALM Elsevier Kamphuis, Willem oth Wadman, Wytse J. oth Hol, Elly M. oth Enthalten in Elsevier Zhou, Nan ELSEVIER Influences of mine water on the properties of construction and demolition waste-based cemented paste backfill 2021 an international review journal Amsterdam [u.a.] (DE-627)ELV006964737 volume:144 year:2016 pages:121-141 extent:21 https://doi.org/10.1016/j.pneurobio.2016.01.001 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 56.45 Baustoffkunde VZ AR 144 2016 121-141 21 045F 610
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source	Enthalten in Influences of mine water on the properties of construction and demolition waste-based cemented paste backfill Amsterdam [u.a.] volume:144 year:2016 pages:121-141 extent:21
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container_title	Influences of mine water on the properties of construction and demolition waste-based cemented paste backfill
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title	Astrogliosis: An integral player in the pathogenesis of Alzheimer's disease
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title_full	Astrogliosis: An integral player in the pathogenesis of Alzheimer's disease
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title_sort	astrogliosis: an integral player in the pathogenesis of alzheimer's disease
title_auth	Astrogliosis: An integral player in the pathogenesis of Alzheimer's disease
abstract	• Astrogliosis is a characteristic feature of Alzheimer's disease (AD). • Astrocytes undergo pertinent molecular changes in AD, switching genetic profiles. • Functional changes in astrocytes in AD perturb the micromilieu surrounding neurons. • Astrocyte dysfunction compromises local and network level neuronal communication. • Research focused on astrocytes as therapeutic targets in AD is imperative.
abstractGer	• Astrogliosis is a characteristic feature of Alzheimer's disease (AD). • Astrocytes undergo pertinent molecular changes in AD, switching genetic profiles. • Functional changes in astrocytes in AD perturb the micromilieu surrounding neurons. • Astrocyte dysfunction compromises local and network level neuronal communication. • Research focused on astrocytes as therapeutic targets in AD is imperative.
abstract_unstemmed	• Astrogliosis is a characteristic feature of Alzheimer's disease (AD). • Astrocytes undergo pertinent molecular changes in AD, switching genetic profiles. • Functional changes in astrocytes in AD perturb the micromilieu surrounding neurons. • Astrocyte dysfunction compromises local and network level neuronal communication. • Research focused on astrocytes as therapeutic targets in AD is imperative.
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title_short	Astrogliosis: An integral player in the pathogenesis of Alzheimer's disease
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author2	Kamphuis, Willem Wadman, Wytse J. Hol, Elly M.
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