The type I interferons: Basic concepts and clinical relevance in immune-mediated inflammatory diseases
There is increasing scientific and clinical interest in elucidating the biology of type I Interferons, which began approximately 60years ago with the concept of “viral interference”, a property that reduces the ability of a virus to infect cells. Although our understanding of the multiple cellular a...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
López de Padilla, Consuelo M. [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
2016transfer abstract |
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| Umfang: |
8 |
|---|
| Übergeordnetes Werk: |
Enthalten in: 26957 A study of dermoscopic features in relation to vitiligo activity - Lee, Jae-Ho ELSEVIER, 2021, an international journal on genes, genomes and evolution, Amsterdam |
|---|---|
| Übergeordnetes Werk: |
volume:576 ; year:2016 ; number:1 ; day:15 ; month:01 ; pages:14-21 ; extent:8 |
| Links: |
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| DOI / URN: |
10.1016/j.gene.2015.09.058 |
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| 520 | |a There is increasing scientific and clinical interest in elucidating the biology of type I Interferons, which began approximately 60years ago with the concept of “viral interference”, a property that reduces the ability of a virus to infect cells. Although our understanding of the multiple cellular and molecular functions of interferons has advanced significantly, much remains to be learned and type I Interferons remain an active and fascinating area of inquiry. In this review, we cover some general aspects of type I interferon genes, with emphasis on interferon-alpha, and various aspects of molecular mechanisms triggered by type I interferons and toll-like receptor signaling by the Janus activated kinase/signal transducer activation of transcription (JAK–STAT) pathway and interferon regulatory factor pathway. We will also describe the role of type I interferons in autoimmune and inflammatory diseases, and its potential use as therapeutic agent. | ||
| 520 | |a There is increasing scientific and clinical interest in elucidating the biology of type I Interferons, which began approximately 60years ago with the concept of “viral interference”, a property that reduces the ability of a virus to infect cells. Although our understanding of the multiple cellular and molecular functions of interferons has advanced significantly, much remains to be learned and type I Interferons remain an active and fascinating area of inquiry. In this review, we cover some general aspects of type I interferon genes, with emphasis on interferon-alpha, and various aspects of molecular mechanisms triggered by type I interferons and toll-like receptor signaling by the Janus activated kinase/signal transducer activation of transcription (JAK–STAT) pathway and interferon regulatory factor pathway. We will also describe the role of type I interferons in autoimmune and inflammatory diseases, and its potential use as therapeutic agent. | ||
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10.1016/j.gene.2015.09.058 doi GBVA2016012000014.pica (DE-627)ELV019400888 (ELSEVIER)S0378-1119(15)01167-1 DE-627 ger DE-627 rakwb eng 570 570 DE-600 610 VZ 44.93 bkl López de Padilla, Consuelo M. verfasserin aut The type I interferons: Basic concepts and clinical relevance in immune-mediated inflammatory diseases 2016transfer abstract 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier There is increasing scientific and clinical interest in elucidating the biology of type I Interferons, which began approximately 60years ago with the concept of “viral interference”, a property that reduces the ability of a virus to infect cells. Although our understanding of the multiple cellular and molecular functions of interferons has advanced significantly, much remains to be learned and type I Interferons remain an active and fascinating area of inquiry. In this review, we cover some general aspects of type I interferon genes, with emphasis on interferon-alpha, and various aspects of molecular mechanisms triggered by type I interferons and toll-like receptor signaling by the Janus activated kinase/signal transducer activation of transcription (JAK–STAT) pathway and interferon regulatory factor pathway. We will also describe the role of type I interferons in autoimmune and inflammatory diseases, and its potential use as therapeutic agent. There is increasing scientific and clinical interest in elucidating the biology of type I Interferons, which began approximately 60years ago with the concept of “viral interference”, a property that reduces the ability of a virus to infect cells. Although our understanding of the multiple cellular and molecular functions of interferons has advanced significantly, much remains to be learned and type I Interferons remain an active and fascinating area of inquiry. In this review, we cover some general aspects of type I interferon genes, with emphasis on interferon-alpha, and various aspects of molecular mechanisms triggered by type I interferons and toll-like receptor signaling by the Janus activated kinase/signal transducer activation of transcription (JAK–STAT) pathway and interferon regulatory factor pathway. We will also describe the role of type I interferons in autoimmune and inflammatory diseases, and its potential use as therapeutic agent. Niewold, Timothy B. oth Enthalten in Elsevier Lee, Jae-Ho ELSEVIER 26957 A study of dermoscopic features in relation to vitiligo activity 2021 an international journal on genes, genomes and evolution Amsterdam (DE-627)ELV006417590 volume:576 year:2016 number:1 day:15 month:01 pages:14-21 extent:8 https://doi.org/10.1016/j.gene.2015.09.058 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.93 Dermatologie VZ AR 576 2016 1 15 0115 14-21 8 045F 570 |
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10.1016/j.gene.2015.09.058 doi GBVA2016012000014.pica (DE-627)ELV019400888 (ELSEVIER)S0378-1119(15)01167-1 DE-627 ger DE-627 rakwb eng 570 570 DE-600 610 VZ 44.93 bkl López de Padilla, Consuelo M. verfasserin aut The type I interferons: Basic concepts and clinical relevance in immune-mediated inflammatory diseases 2016transfer abstract 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier There is increasing scientific and clinical interest in elucidating the biology of type I Interferons, which began approximately 60years ago with the concept of “viral interference”, a property that reduces the ability of a virus to infect cells. Although our understanding of the multiple cellular and molecular functions of interferons has advanced significantly, much remains to be learned and type I Interferons remain an active and fascinating area of inquiry. In this review, we cover some general aspects of type I interferon genes, with emphasis on interferon-alpha, and various aspects of molecular mechanisms triggered by type I interferons and toll-like receptor signaling by the Janus activated kinase/signal transducer activation of transcription (JAK–STAT) pathway and interferon regulatory factor pathway. We will also describe the role of type I interferons in autoimmune and inflammatory diseases, and its potential use as therapeutic agent. There is increasing scientific and clinical interest in elucidating the biology of type I Interferons, which began approximately 60years ago with the concept of “viral interference”, a property that reduces the ability of a virus to infect cells. Although our understanding of the multiple cellular and molecular functions of interferons has advanced significantly, much remains to be learned and type I Interferons remain an active and fascinating area of inquiry. In this review, we cover some general aspects of type I interferon genes, with emphasis on interferon-alpha, and various aspects of molecular mechanisms triggered by type I interferons and toll-like receptor signaling by the Janus activated kinase/signal transducer activation of transcription (JAK–STAT) pathway and interferon regulatory factor pathway. We will also describe the role of type I interferons in autoimmune and inflammatory diseases, and its potential use as therapeutic agent. Niewold, Timothy B. oth Enthalten in Elsevier Lee, Jae-Ho ELSEVIER 26957 A study of dermoscopic features in relation to vitiligo activity 2021 an international journal on genes, genomes and evolution Amsterdam (DE-627)ELV006417590 volume:576 year:2016 number:1 day:15 month:01 pages:14-21 extent:8 https://doi.org/10.1016/j.gene.2015.09.058 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.93 Dermatologie VZ AR 576 2016 1 15 0115 14-21 8 045F 570 |
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10.1016/j.gene.2015.09.058 doi GBVA2016012000014.pica (DE-627)ELV019400888 (ELSEVIER)S0378-1119(15)01167-1 DE-627 ger DE-627 rakwb eng 570 570 DE-600 610 VZ 44.93 bkl López de Padilla, Consuelo M. verfasserin aut The type I interferons: Basic concepts and clinical relevance in immune-mediated inflammatory diseases 2016transfer abstract 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier There is increasing scientific and clinical interest in elucidating the biology of type I Interferons, which began approximately 60years ago with the concept of “viral interference”, a property that reduces the ability of a virus to infect cells. Although our understanding of the multiple cellular and molecular functions of interferons has advanced significantly, much remains to be learned and type I Interferons remain an active and fascinating area of inquiry. In this review, we cover some general aspects of type I interferon genes, with emphasis on interferon-alpha, and various aspects of molecular mechanisms triggered by type I interferons and toll-like receptor signaling by the Janus activated kinase/signal transducer activation of transcription (JAK–STAT) pathway and interferon regulatory factor pathway. We will also describe the role of type I interferons in autoimmune and inflammatory diseases, and its potential use as therapeutic agent. There is increasing scientific and clinical interest in elucidating the biology of type I Interferons, which began approximately 60years ago with the concept of “viral interference”, a property that reduces the ability of a virus to infect cells. Although our understanding of the multiple cellular and molecular functions of interferons has advanced significantly, much remains to be learned and type I Interferons remain an active and fascinating area of inquiry. In this review, we cover some general aspects of type I interferon genes, with emphasis on interferon-alpha, and various aspects of molecular mechanisms triggered by type I interferons and toll-like receptor signaling by the Janus activated kinase/signal transducer activation of transcription (JAK–STAT) pathway and interferon regulatory factor pathway. We will also describe the role of type I interferons in autoimmune and inflammatory diseases, and its potential use as therapeutic agent. Niewold, Timothy B. oth Enthalten in Elsevier Lee, Jae-Ho ELSEVIER 26957 A study of dermoscopic features in relation to vitiligo activity 2021 an international journal on genes, genomes and evolution Amsterdam (DE-627)ELV006417590 volume:576 year:2016 number:1 day:15 month:01 pages:14-21 extent:8 https://doi.org/10.1016/j.gene.2015.09.058 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.93 Dermatologie VZ AR 576 2016 1 15 0115 14-21 8 045F 570 |
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10.1016/j.gene.2015.09.058 doi GBVA2016012000014.pica (DE-627)ELV019400888 (ELSEVIER)S0378-1119(15)01167-1 DE-627 ger DE-627 rakwb eng 570 570 DE-600 610 VZ 44.93 bkl López de Padilla, Consuelo M. verfasserin aut The type I interferons: Basic concepts and clinical relevance in immune-mediated inflammatory diseases 2016transfer abstract 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier There is increasing scientific and clinical interest in elucidating the biology of type I Interferons, which began approximately 60years ago with the concept of “viral interference”, a property that reduces the ability of a virus to infect cells. Although our understanding of the multiple cellular and molecular functions of interferons has advanced significantly, much remains to be learned and type I Interferons remain an active and fascinating area of inquiry. In this review, we cover some general aspects of type I interferon genes, with emphasis on interferon-alpha, and various aspects of molecular mechanisms triggered by type I interferons and toll-like receptor signaling by the Janus activated kinase/signal transducer activation of transcription (JAK–STAT) pathway and interferon regulatory factor pathway. We will also describe the role of type I interferons in autoimmune and inflammatory diseases, and its potential use as therapeutic agent. There is increasing scientific and clinical interest in elucidating the biology of type I Interferons, which began approximately 60years ago with the concept of “viral interference”, a property that reduces the ability of a virus to infect cells. Although our understanding of the multiple cellular and molecular functions of interferons has advanced significantly, much remains to be learned and type I Interferons remain an active and fascinating area of inquiry. In this review, we cover some general aspects of type I interferon genes, with emphasis on interferon-alpha, and various aspects of molecular mechanisms triggered by type I interferons and toll-like receptor signaling by the Janus activated kinase/signal transducer activation of transcription (JAK–STAT) pathway and interferon regulatory factor pathway. We will also describe the role of type I interferons in autoimmune and inflammatory diseases, and its potential use as therapeutic agent. Niewold, Timothy B. oth Enthalten in Elsevier Lee, Jae-Ho ELSEVIER 26957 A study of dermoscopic features in relation to vitiligo activity 2021 an international journal on genes, genomes and evolution Amsterdam (DE-627)ELV006417590 volume:576 year:2016 number:1 day:15 month:01 pages:14-21 extent:8 https://doi.org/10.1016/j.gene.2015.09.058 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.93 Dermatologie VZ AR 576 2016 1 15 0115 14-21 8 045F 570 |
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López de Padilla, Consuelo M. |
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type i interferons: basic concepts and clinical relevance in immune-mediated inflammatory diseases |
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The type I interferons: Basic concepts and clinical relevance in immune-mediated inflammatory diseases |
| abstract |
There is increasing scientific and clinical interest in elucidating the biology of type I Interferons, which began approximately 60years ago with the concept of “viral interference”, a property that reduces the ability of a virus to infect cells. Although our understanding of the multiple cellular and molecular functions of interferons has advanced significantly, much remains to be learned and type I Interferons remain an active and fascinating area of inquiry. In this review, we cover some general aspects of type I interferon genes, with emphasis on interferon-alpha, and various aspects of molecular mechanisms triggered by type I interferons and toll-like receptor signaling by the Janus activated kinase/signal transducer activation of transcription (JAK–STAT) pathway and interferon regulatory factor pathway. We will also describe the role of type I interferons in autoimmune and inflammatory diseases, and its potential use as therapeutic agent. |
| abstractGer |
There is increasing scientific and clinical interest in elucidating the biology of type I Interferons, which began approximately 60years ago with the concept of “viral interference”, a property that reduces the ability of a virus to infect cells. Although our understanding of the multiple cellular and molecular functions of interferons has advanced significantly, much remains to be learned and type I Interferons remain an active and fascinating area of inquiry. In this review, we cover some general aspects of type I interferon genes, with emphasis on interferon-alpha, and various aspects of molecular mechanisms triggered by type I interferons and toll-like receptor signaling by the Janus activated kinase/signal transducer activation of transcription (JAK–STAT) pathway and interferon regulatory factor pathway. We will also describe the role of type I interferons in autoimmune and inflammatory diseases, and its potential use as therapeutic agent. |
| abstract_unstemmed |
There is increasing scientific and clinical interest in elucidating the biology of type I Interferons, which began approximately 60years ago with the concept of “viral interference”, a property that reduces the ability of a virus to infect cells. Although our understanding of the multiple cellular and molecular functions of interferons has advanced significantly, much remains to be learned and type I Interferons remain an active and fascinating area of inquiry. In this review, we cover some general aspects of type I interferon genes, with emphasis on interferon-alpha, and various aspects of molecular mechanisms triggered by type I interferons and toll-like receptor signaling by the Janus activated kinase/signal transducer activation of transcription (JAK–STAT) pathway and interferon regulatory factor pathway. We will also describe the role of type I interferons in autoimmune and inflammatory diseases, and its potential use as therapeutic agent. |
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| title_short |
The type I interferons: Basic concepts and clinical relevance in immune-mediated inflammatory diseases |
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https://doi.org/10.1016/j.gene.2015.09.058 |
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| author2 |
Niewold, Timothy B. |
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2024-07-06T21:21:20.723Z |
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