Identifying Patient-Specific Pathology in Osteoarthritis Development Based on MicroCT Analysis of Subchondral Trabecular Bone
The goal of this study was to identify alternative mechanisms of osteoarthritis pathology by analyzing subchondral bone. Femoral condyle samples were collected from post-menopausal female patients with knee osteoarthritis undegoing total knee arthroplasty. In the majority of patients, subchondral tr...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Steinbeck, Marla J. [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
2016transfer abstract |
|---|
| Umfang: |
9 |
|---|
| Übergeordnetes Werk: |
Enthalten in: Spatially varying crustal stress along the Zagros seismic belt inferred from earthquake focal mechanisms - Nouri, Ahad ELSEVIER, 2022, official journal of the American Association of Hip and Knee Surgeons, Orlando, Fla |
|---|---|
| Übergeordnetes Werk: |
volume:31 ; year:2016 ; number:1 ; pages:269-277 ; extent:9 |
| Links: |
|---|
| DOI / URN: |
10.1016/j.arth.2015.08.021 |
|---|
| Katalog-ID: |
ELV019497717 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | ELV019497717 | ||
| 003 | DE-627 | ||
| 005 | 20230625130051.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 180603s2016 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.arth.2015.08.021 |2 doi | |
| 028 | 5 | 2 | |a GBVA2016014000012.pica |
| 035 | |a (DE-627)ELV019497717 | ||
| 035 | |a (ELSEVIER)S0883-5403(15)00775-5 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 082 | 0 | |a 610 | |
| 082 | 0 | 4 | |a 610 |q DE-600 |
| 082 | 0 | 4 | |a 550 |q VZ |
| 084 | |a 38.36 |2 bkl | ||
| 084 | |a 38.58 |2 bkl | ||
| 100 | 1 | |a Steinbeck, Marla J. |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Identifying Patient-Specific Pathology in Osteoarthritis Development Based on MicroCT Analysis of Subchondral Trabecular Bone |
| 264 | 1 | |c 2016transfer abstract | |
| 300 | |a 9 | ||
| 336 | |a nicht spezifiziert |b zzz |2 rdacontent | ||
| 337 | |a nicht spezifiziert |b z |2 rdamedia | ||
| 338 | |a nicht spezifiziert |b zu |2 rdacarrier | ||
| 520 | |a The goal of this study was to identify alternative mechanisms of osteoarthritis pathology by analyzing subchondral bone. Femoral condyle samples were collected from post-menopausal female patients with knee osteoarthritis undegoing total knee arthroplasty. In the majority of patients, subchondral trabecular bone volume doubled under a region of the medial femoral condyle with full-thickness cartilage deterioration. However, in a subset of patients the bone volume in this region remained constant. This subset also had larger areas of vascular penetration in the calcified cartilage of the lateral condyle concurrent with increased vascular endothelial growth factor expression. Subtyping by subchondral bone characteristics identified a unique population, which lacked the sclerotic bone characteristic of late-stage osteoarthritis. Identification of subtypes within the osteoarthritis population allows investigation of alternate disease pathologies. | ||
| 520 | |a The goal of this study was to identify alternative mechanisms of osteoarthritis pathology by analyzing subchondral bone. Femoral condyle samples were collected from post-menopausal female patients with knee osteoarthritis undegoing total knee arthroplasty. In the majority of patients, subchondral trabecular bone volume doubled under a region of the medial femoral condyle with full-thickness cartilage deterioration. However, in a subset of patients the bone volume in this region remained constant. This subset also had larger areas of vascular penetration in the calcified cartilage of the lateral condyle concurrent with increased vascular endothelial growth factor expression. Subtyping by subchondral bone characteristics identified a unique population, which lacked the sclerotic bone characteristic of late-stage osteoarthritis. Identification of subtypes within the osteoarthritis population allows investigation of alternate disease pathologies. | ||
| 700 | 1 | |a Eisenhauer, Peter T. |4 oth | |
| 700 | 1 | |a Maltenfort, Mitchell G. |4 oth | |
| 700 | 1 | |a Parvizi, Javad |4 oth | |
| 700 | 1 | |a Freeman, Theresa A. |4 oth | |
| 773 | 0 | 8 | |i Enthalten in |n Churchill Livingstone |a Nouri, Ahad ELSEVIER |t Spatially varying crustal stress along the Zagros seismic belt inferred from earthquake focal mechanisms |d 2022 |d official journal of the American Association of Hip and Knee Surgeons |g Orlando, Fla |w (DE-627)ELV009019677 |
| 773 | 1 | 8 | |g volume:31 |g year:2016 |g number:1 |g pages:269-277 |g extent:9 |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.arth.2015.08.021 |3 Volltext |
| 912 | |a GBV_USEFLAG_U | ||
| 912 | |a GBV_ELV | ||
| 912 | |a SYSFLAG_U | ||
| 912 | |a SSG-OPC-GGO | ||
| 912 | |a SSG-OPC-GEO | ||
| 936 | b | k | |a 38.36 |j Tektonik |q VZ |
| 936 | b | k | |a 38.58 |j Geomechanik |q VZ |
| 951 | |a AR | ||
| 952 | |d 31 |j 2016 |e 1 |h 269-277 |g 9 | ||
| 953 | |2 045F |a 610 | ||
| author_variant |
m j s mj mjs |
|---|---|
| matchkey_str |
steinbeckmarlajeisenhauerpetertmaltenfor:2016----:dniynptetpcfcahlgiotorhiidvlpetaeomcotnl |
| hierarchy_sort_str |
2016transfer abstract |
| bklnumber |
38.36 38.58 |
| publishDate |
2016 |
| allfields |
10.1016/j.arth.2015.08.021 doi GBVA2016014000012.pica (DE-627)ELV019497717 (ELSEVIER)S0883-5403(15)00775-5 DE-627 ger DE-627 rakwb eng 610 610 DE-600 550 VZ 38.36 bkl 38.58 bkl Steinbeck, Marla J. verfasserin aut Identifying Patient-Specific Pathology in Osteoarthritis Development Based on MicroCT Analysis of Subchondral Trabecular Bone 2016transfer abstract 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The goal of this study was to identify alternative mechanisms of osteoarthritis pathology by analyzing subchondral bone. Femoral condyle samples were collected from post-menopausal female patients with knee osteoarthritis undegoing total knee arthroplasty. In the majority of patients, subchondral trabecular bone volume doubled under a region of the medial femoral condyle with full-thickness cartilage deterioration. However, in a subset of patients the bone volume in this region remained constant. This subset also had larger areas of vascular penetration in the calcified cartilage of the lateral condyle concurrent with increased vascular endothelial growth factor expression. Subtyping by subchondral bone characteristics identified a unique population, which lacked the sclerotic bone characteristic of late-stage osteoarthritis. Identification of subtypes within the osteoarthritis population allows investigation of alternate disease pathologies. The goal of this study was to identify alternative mechanisms of osteoarthritis pathology by analyzing subchondral bone. Femoral condyle samples were collected from post-menopausal female patients with knee osteoarthritis undegoing total knee arthroplasty. In the majority of patients, subchondral trabecular bone volume doubled under a region of the medial femoral condyle with full-thickness cartilage deterioration. However, in a subset of patients the bone volume in this region remained constant. This subset also had larger areas of vascular penetration in the calcified cartilage of the lateral condyle concurrent with increased vascular endothelial growth factor expression. Subtyping by subchondral bone characteristics identified a unique population, which lacked the sclerotic bone characteristic of late-stage osteoarthritis. Identification of subtypes within the osteoarthritis population allows investigation of alternate disease pathologies. Eisenhauer, Peter T. oth Maltenfort, Mitchell G. oth Parvizi, Javad oth Freeman, Theresa A. oth Enthalten in Churchill Livingstone Nouri, Ahad ELSEVIER Spatially varying crustal stress along the Zagros seismic belt inferred from earthquake focal mechanisms 2022 official journal of the American Association of Hip and Knee Surgeons Orlando, Fla (DE-627)ELV009019677 volume:31 year:2016 number:1 pages:269-277 extent:9 https://doi.org/10.1016/j.arth.2015.08.021 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-GGO SSG-OPC-GEO 38.36 Tektonik VZ 38.58 Geomechanik VZ AR 31 2016 1 269-277 9 045F 610 |
| spelling |
10.1016/j.arth.2015.08.021 doi GBVA2016014000012.pica (DE-627)ELV019497717 (ELSEVIER)S0883-5403(15)00775-5 DE-627 ger DE-627 rakwb eng 610 610 DE-600 550 VZ 38.36 bkl 38.58 bkl Steinbeck, Marla J. verfasserin aut Identifying Patient-Specific Pathology in Osteoarthritis Development Based on MicroCT Analysis of Subchondral Trabecular Bone 2016transfer abstract 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The goal of this study was to identify alternative mechanisms of osteoarthritis pathology by analyzing subchondral bone. Femoral condyle samples were collected from post-menopausal female patients with knee osteoarthritis undegoing total knee arthroplasty. In the majority of patients, subchondral trabecular bone volume doubled under a region of the medial femoral condyle with full-thickness cartilage deterioration. However, in a subset of patients the bone volume in this region remained constant. This subset also had larger areas of vascular penetration in the calcified cartilage of the lateral condyle concurrent with increased vascular endothelial growth factor expression. Subtyping by subchondral bone characteristics identified a unique population, which lacked the sclerotic bone characteristic of late-stage osteoarthritis. Identification of subtypes within the osteoarthritis population allows investigation of alternate disease pathologies. The goal of this study was to identify alternative mechanisms of osteoarthritis pathology by analyzing subchondral bone. Femoral condyle samples were collected from post-menopausal female patients with knee osteoarthritis undegoing total knee arthroplasty. In the majority of patients, subchondral trabecular bone volume doubled under a region of the medial femoral condyle with full-thickness cartilage deterioration. However, in a subset of patients the bone volume in this region remained constant. This subset also had larger areas of vascular penetration in the calcified cartilage of the lateral condyle concurrent with increased vascular endothelial growth factor expression. Subtyping by subchondral bone characteristics identified a unique population, which lacked the sclerotic bone characteristic of late-stage osteoarthritis. Identification of subtypes within the osteoarthritis population allows investigation of alternate disease pathologies. Eisenhauer, Peter T. oth Maltenfort, Mitchell G. oth Parvizi, Javad oth Freeman, Theresa A. oth Enthalten in Churchill Livingstone Nouri, Ahad ELSEVIER Spatially varying crustal stress along the Zagros seismic belt inferred from earthquake focal mechanisms 2022 official journal of the American Association of Hip and Knee Surgeons Orlando, Fla (DE-627)ELV009019677 volume:31 year:2016 number:1 pages:269-277 extent:9 https://doi.org/10.1016/j.arth.2015.08.021 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-GGO SSG-OPC-GEO 38.36 Tektonik VZ 38.58 Geomechanik VZ AR 31 2016 1 269-277 9 045F 610 |
| allfields_unstemmed |
10.1016/j.arth.2015.08.021 doi GBVA2016014000012.pica (DE-627)ELV019497717 (ELSEVIER)S0883-5403(15)00775-5 DE-627 ger DE-627 rakwb eng 610 610 DE-600 550 VZ 38.36 bkl 38.58 bkl Steinbeck, Marla J. verfasserin aut Identifying Patient-Specific Pathology in Osteoarthritis Development Based on MicroCT Analysis of Subchondral Trabecular Bone 2016transfer abstract 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The goal of this study was to identify alternative mechanisms of osteoarthritis pathology by analyzing subchondral bone. Femoral condyle samples were collected from post-menopausal female patients with knee osteoarthritis undegoing total knee arthroplasty. In the majority of patients, subchondral trabecular bone volume doubled under a region of the medial femoral condyle with full-thickness cartilage deterioration. However, in a subset of patients the bone volume in this region remained constant. This subset also had larger areas of vascular penetration in the calcified cartilage of the lateral condyle concurrent with increased vascular endothelial growth factor expression. Subtyping by subchondral bone characteristics identified a unique population, which lacked the sclerotic bone characteristic of late-stage osteoarthritis. Identification of subtypes within the osteoarthritis population allows investigation of alternate disease pathologies. The goal of this study was to identify alternative mechanisms of osteoarthritis pathology by analyzing subchondral bone. Femoral condyle samples were collected from post-menopausal female patients with knee osteoarthritis undegoing total knee arthroplasty. In the majority of patients, subchondral trabecular bone volume doubled under a region of the medial femoral condyle with full-thickness cartilage deterioration. However, in a subset of patients the bone volume in this region remained constant. This subset also had larger areas of vascular penetration in the calcified cartilage of the lateral condyle concurrent with increased vascular endothelial growth factor expression. Subtyping by subchondral bone characteristics identified a unique population, which lacked the sclerotic bone characteristic of late-stage osteoarthritis. Identification of subtypes within the osteoarthritis population allows investigation of alternate disease pathologies. Eisenhauer, Peter T. oth Maltenfort, Mitchell G. oth Parvizi, Javad oth Freeman, Theresa A. oth Enthalten in Churchill Livingstone Nouri, Ahad ELSEVIER Spatially varying crustal stress along the Zagros seismic belt inferred from earthquake focal mechanisms 2022 official journal of the American Association of Hip and Knee Surgeons Orlando, Fla (DE-627)ELV009019677 volume:31 year:2016 number:1 pages:269-277 extent:9 https://doi.org/10.1016/j.arth.2015.08.021 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-GGO SSG-OPC-GEO 38.36 Tektonik VZ 38.58 Geomechanik VZ AR 31 2016 1 269-277 9 045F 610 |
| allfieldsGer |
10.1016/j.arth.2015.08.021 doi GBVA2016014000012.pica (DE-627)ELV019497717 (ELSEVIER)S0883-5403(15)00775-5 DE-627 ger DE-627 rakwb eng 610 610 DE-600 550 VZ 38.36 bkl 38.58 bkl Steinbeck, Marla J. verfasserin aut Identifying Patient-Specific Pathology in Osteoarthritis Development Based on MicroCT Analysis of Subchondral Trabecular Bone 2016transfer abstract 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The goal of this study was to identify alternative mechanisms of osteoarthritis pathology by analyzing subchondral bone. Femoral condyle samples were collected from post-menopausal female patients with knee osteoarthritis undegoing total knee arthroplasty. In the majority of patients, subchondral trabecular bone volume doubled under a region of the medial femoral condyle with full-thickness cartilage deterioration. However, in a subset of patients the bone volume in this region remained constant. This subset also had larger areas of vascular penetration in the calcified cartilage of the lateral condyle concurrent with increased vascular endothelial growth factor expression. Subtyping by subchondral bone characteristics identified a unique population, which lacked the sclerotic bone characteristic of late-stage osteoarthritis. Identification of subtypes within the osteoarthritis population allows investigation of alternate disease pathologies. The goal of this study was to identify alternative mechanisms of osteoarthritis pathology by analyzing subchondral bone. Femoral condyle samples were collected from post-menopausal female patients with knee osteoarthritis undegoing total knee arthroplasty. In the majority of patients, subchondral trabecular bone volume doubled under a region of the medial femoral condyle with full-thickness cartilage deterioration. However, in a subset of patients the bone volume in this region remained constant. This subset also had larger areas of vascular penetration in the calcified cartilage of the lateral condyle concurrent with increased vascular endothelial growth factor expression. Subtyping by subchondral bone characteristics identified a unique population, which lacked the sclerotic bone characteristic of late-stage osteoarthritis. Identification of subtypes within the osteoarthritis population allows investigation of alternate disease pathologies. Eisenhauer, Peter T. oth Maltenfort, Mitchell G. oth Parvizi, Javad oth Freeman, Theresa A. oth Enthalten in Churchill Livingstone Nouri, Ahad ELSEVIER Spatially varying crustal stress along the Zagros seismic belt inferred from earthquake focal mechanisms 2022 official journal of the American Association of Hip and Knee Surgeons Orlando, Fla (DE-627)ELV009019677 volume:31 year:2016 number:1 pages:269-277 extent:9 https://doi.org/10.1016/j.arth.2015.08.021 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-GGO SSG-OPC-GEO 38.36 Tektonik VZ 38.58 Geomechanik VZ AR 31 2016 1 269-277 9 045F 610 |
| allfieldsSound |
10.1016/j.arth.2015.08.021 doi GBVA2016014000012.pica (DE-627)ELV019497717 (ELSEVIER)S0883-5403(15)00775-5 DE-627 ger DE-627 rakwb eng 610 610 DE-600 550 VZ 38.36 bkl 38.58 bkl Steinbeck, Marla J. verfasserin aut Identifying Patient-Specific Pathology in Osteoarthritis Development Based on MicroCT Analysis of Subchondral Trabecular Bone 2016transfer abstract 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The goal of this study was to identify alternative mechanisms of osteoarthritis pathology by analyzing subchondral bone. Femoral condyle samples were collected from post-menopausal female patients with knee osteoarthritis undegoing total knee arthroplasty. In the majority of patients, subchondral trabecular bone volume doubled under a region of the medial femoral condyle with full-thickness cartilage deterioration. However, in a subset of patients the bone volume in this region remained constant. This subset also had larger areas of vascular penetration in the calcified cartilage of the lateral condyle concurrent with increased vascular endothelial growth factor expression. Subtyping by subchondral bone characteristics identified a unique population, which lacked the sclerotic bone characteristic of late-stage osteoarthritis. Identification of subtypes within the osteoarthritis population allows investigation of alternate disease pathologies. The goal of this study was to identify alternative mechanisms of osteoarthritis pathology by analyzing subchondral bone. Femoral condyle samples were collected from post-menopausal female patients with knee osteoarthritis undegoing total knee arthroplasty. In the majority of patients, subchondral trabecular bone volume doubled under a region of the medial femoral condyle with full-thickness cartilage deterioration. However, in a subset of patients the bone volume in this region remained constant. This subset also had larger areas of vascular penetration in the calcified cartilage of the lateral condyle concurrent with increased vascular endothelial growth factor expression. Subtyping by subchondral bone characteristics identified a unique population, which lacked the sclerotic bone characteristic of late-stage osteoarthritis. Identification of subtypes within the osteoarthritis population allows investigation of alternate disease pathologies. Eisenhauer, Peter T. oth Maltenfort, Mitchell G. oth Parvizi, Javad oth Freeman, Theresa A. oth Enthalten in Churchill Livingstone Nouri, Ahad ELSEVIER Spatially varying crustal stress along the Zagros seismic belt inferred from earthquake focal mechanisms 2022 official journal of the American Association of Hip and Knee Surgeons Orlando, Fla (DE-627)ELV009019677 volume:31 year:2016 number:1 pages:269-277 extent:9 https://doi.org/10.1016/j.arth.2015.08.021 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-GGO SSG-OPC-GEO 38.36 Tektonik VZ 38.58 Geomechanik VZ AR 31 2016 1 269-277 9 045F 610 |
| language |
English |
| source |
Enthalten in Spatially varying crustal stress along the Zagros seismic belt inferred from earthquake focal mechanisms Orlando, Fla volume:31 year:2016 number:1 pages:269-277 extent:9 |
| sourceStr |
Enthalten in Spatially varying crustal stress along the Zagros seismic belt inferred from earthquake focal mechanisms Orlando, Fla volume:31 year:2016 number:1 pages:269-277 extent:9 |
| format_phy_str_mv |
Article |
| bklname |
Tektonik Geomechanik |
| institution |
findex.gbv.de |
| dewey-raw |
610 |
| isfreeaccess_bool |
false |
| container_title |
Spatially varying crustal stress along the Zagros seismic belt inferred from earthquake focal mechanisms |
| authorswithroles_txt_mv |
Steinbeck, Marla J. @@aut@@ Eisenhauer, Peter T. @@oth@@ Maltenfort, Mitchell G. @@oth@@ Parvizi, Javad @@oth@@ Freeman, Theresa A. @@oth@@ |
| publishDateDaySort_date |
2016-01-01T00:00:00Z |
| hierarchy_top_id |
ELV009019677 |
| dewey-sort |
3610 |
| id |
ELV019497717 |
| language_de |
englisch |
| fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">ELV019497717</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230625130051.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">180603s2016 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.arth.2015.08.021</subfield><subfield code="2">doi</subfield></datafield><datafield tag="028" ind1="5" ind2="2"><subfield code="a">GBVA2016014000012.pica</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)ELV019497717</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(ELSEVIER)S0883-5403(15)00775-5</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">610</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">DE-600</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">550</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">38.36</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">38.58</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Steinbeck, Marla J.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Identifying Patient-Specific Pathology in Osteoarthritis Development Based on MicroCT Analysis of Subchondral Trabecular Bone</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2016transfer abstract</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">9</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">The goal of this study was to identify alternative mechanisms of osteoarthritis pathology by analyzing subchondral bone. Femoral condyle samples were collected from post-menopausal female patients with knee osteoarthritis undegoing total knee arthroplasty. In the majority of patients, subchondral trabecular bone volume doubled under a region of the medial femoral condyle with full-thickness cartilage deterioration. However, in a subset of patients the bone volume in this region remained constant. This subset also had larger areas of vascular penetration in the calcified cartilage of the lateral condyle concurrent with increased vascular endothelial growth factor expression. Subtyping by subchondral bone characteristics identified a unique population, which lacked the sclerotic bone characteristic of late-stage osteoarthritis. Identification of subtypes within the osteoarthritis population allows investigation of alternate disease pathologies.</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">The goal of this study was to identify alternative mechanisms of osteoarthritis pathology by analyzing subchondral bone. Femoral condyle samples were collected from post-menopausal female patients with knee osteoarthritis undegoing total knee arthroplasty. In the majority of patients, subchondral trabecular bone volume doubled under a region of the medial femoral condyle with full-thickness cartilage deterioration. However, in a subset of patients the bone volume in this region remained constant. This subset also had larger areas of vascular penetration in the calcified cartilage of the lateral condyle concurrent with increased vascular endothelial growth factor expression. Subtyping by subchondral bone characteristics identified a unique population, which lacked the sclerotic bone characteristic of late-stage osteoarthritis. Identification of subtypes within the osteoarthritis population allows investigation of alternate disease pathologies.</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Eisenhauer, Peter T.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Maltenfort, Mitchell G.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Parvizi, Javad</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Freeman, Theresa A.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="n">Churchill Livingstone</subfield><subfield code="a">Nouri, Ahad ELSEVIER</subfield><subfield code="t">Spatially varying crustal stress along the Zagros seismic belt inferred from earthquake focal mechanisms</subfield><subfield code="d">2022</subfield><subfield code="d">official journal of the American Association of Hip and Knee Surgeons</subfield><subfield code="g">Orlando, Fla</subfield><subfield code="w">(DE-627)ELV009019677</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:31</subfield><subfield code="g">year:2016</subfield><subfield code="g">number:1</subfield><subfield code="g">pages:269-277</subfield><subfield code="g">extent:9</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1016/j.arth.2015.08.021</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ELV</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OPC-GGO</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OPC-GEO</subfield></datafield><datafield tag="936" ind1="b" ind2="k"><subfield code="a">38.36</subfield><subfield code="j">Tektonik</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="936" ind1="b" ind2="k"><subfield code="a">38.58</subfield><subfield code="j">Geomechanik</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">31</subfield><subfield code="j">2016</subfield><subfield code="e">1</subfield><subfield code="h">269-277</subfield><subfield code="g">9</subfield></datafield><datafield tag="953" ind1=" " ind2=" "><subfield code="2">045F</subfield><subfield code="a">610</subfield></datafield></record></collection>
|
| author |
Steinbeck, Marla J. |
| spellingShingle |
Steinbeck, Marla J. ddc 610 ddc 550 bkl 38.36 bkl 38.58 Identifying Patient-Specific Pathology in Osteoarthritis Development Based on MicroCT Analysis of Subchondral Trabecular Bone |
| authorStr |
Steinbeck, Marla J. |
| ppnlink_with_tag_str_mv |
@@773@@(DE-627)ELV009019677 |
| format |
electronic Article |
| dewey-ones |
610 - Medicine & health 550 - Earth sciences |
| delete_txt_mv |
keep |
| author_role |
aut |
| collection |
elsevier |
| remote_str |
true |
| illustrated |
Not Illustrated |
| topic_title |
610 610 DE-600 550 VZ 38.36 bkl 38.58 bkl Identifying Patient-Specific Pathology in Osteoarthritis Development Based on MicroCT Analysis of Subchondral Trabecular Bone |
| topic |
ddc 610 ddc 550 bkl 38.36 bkl 38.58 |
| topic_unstemmed |
ddc 610 ddc 550 bkl 38.36 bkl 38.58 |
| topic_browse |
ddc 610 ddc 550 bkl 38.36 bkl 38.58 |
| format_facet |
Elektronische Aufsätze Aufsätze Elektronische Ressource |
| format_main_str_mv |
Text Zeitschrift/Artikel |
| carriertype_str_mv |
zu |
| author2_variant |
p t e pt pte m g m mg mgm j p jp t a f ta taf |
| hierarchy_parent_title |
Spatially varying crustal stress along the Zagros seismic belt inferred from earthquake focal mechanisms |
| hierarchy_parent_id |
ELV009019677 |
| dewey-tens |
610 - Medicine & health 550 - Earth sciences & geology |
| hierarchy_top_title |
Spatially varying crustal stress along the Zagros seismic belt inferred from earthquake focal mechanisms |
| isfreeaccess_txt |
false |
| familylinks_str_mv |
(DE-627)ELV009019677 |
| title |
Identifying Patient-Specific Pathology in Osteoarthritis Development Based on MicroCT Analysis of Subchondral Trabecular Bone |
| ctrlnum |
(DE-627)ELV019497717 (ELSEVIER)S0883-5403(15)00775-5 |
| title_full |
Identifying Patient-Specific Pathology in Osteoarthritis Development Based on MicroCT Analysis of Subchondral Trabecular Bone |
| author_sort |
Steinbeck, Marla J. |
| journal |
Spatially varying crustal stress along the Zagros seismic belt inferred from earthquake focal mechanisms |
| journalStr |
Spatially varying crustal stress along the Zagros seismic belt inferred from earthquake focal mechanisms |
| lang_code |
eng |
| isOA_bool |
false |
| dewey-hundreds |
600 - Technology 500 - Science |
| recordtype |
marc |
| publishDateSort |
2016 |
| contenttype_str_mv |
zzz |
| container_start_page |
269 |
| author_browse |
Steinbeck, Marla J. |
| container_volume |
31 |
| physical |
9 |
| class |
610 610 DE-600 550 VZ 38.36 bkl 38.58 bkl |
| format_se |
Elektronische Aufsätze |
| author-letter |
Steinbeck, Marla J. |
| doi_str_mv |
10.1016/j.arth.2015.08.021 |
| dewey-full |
610 550 |
| title_sort |
identifying patient-specific pathology in osteoarthritis development based on microct analysis of subchondral trabecular bone |
| title_auth |
Identifying Patient-Specific Pathology in Osteoarthritis Development Based on MicroCT Analysis of Subchondral Trabecular Bone |
| abstract |
The goal of this study was to identify alternative mechanisms of osteoarthritis pathology by analyzing subchondral bone. Femoral condyle samples were collected from post-menopausal female patients with knee osteoarthritis undegoing total knee arthroplasty. In the majority of patients, subchondral trabecular bone volume doubled under a region of the medial femoral condyle with full-thickness cartilage deterioration. However, in a subset of patients the bone volume in this region remained constant. This subset also had larger areas of vascular penetration in the calcified cartilage of the lateral condyle concurrent with increased vascular endothelial growth factor expression. Subtyping by subchondral bone characteristics identified a unique population, which lacked the sclerotic bone characteristic of late-stage osteoarthritis. Identification of subtypes within the osteoarthritis population allows investigation of alternate disease pathologies. |
| abstractGer |
The goal of this study was to identify alternative mechanisms of osteoarthritis pathology by analyzing subchondral bone. Femoral condyle samples were collected from post-menopausal female patients with knee osteoarthritis undegoing total knee arthroplasty. In the majority of patients, subchondral trabecular bone volume doubled under a region of the medial femoral condyle with full-thickness cartilage deterioration. However, in a subset of patients the bone volume in this region remained constant. This subset also had larger areas of vascular penetration in the calcified cartilage of the lateral condyle concurrent with increased vascular endothelial growth factor expression. Subtyping by subchondral bone characteristics identified a unique population, which lacked the sclerotic bone characteristic of late-stage osteoarthritis. Identification of subtypes within the osteoarthritis population allows investigation of alternate disease pathologies. |
| abstract_unstemmed |
The goal of this study was to identify alternative mechanisms of osteoarthritis pathology by analyzing subchondral bone. Femoral condyle samples were collected from post-menopausal female patients with knee osteoarthritis undegoing total knee arthroplasty. In the majority of patients, subchondral trabecular bone volume doubled under a region of the medial femoral condyle with full-thickness cartilage deterioration. However, in a subset of patients the bone volume in this region remained constant. This subset also had larger areas of vascular penetration in the calcified cartilage of the lateral condyle concurrent with increased vascular endothelial growth factor expression. Subtyping by subchondral bone characteristics identified a unique population, which lacked the sclerotic bone characteristic of late-stage osteoarthritis. Identification of subtypes within the osteoarthritis population allows investigation of alternate disease pathologies. |
| collection_details |
GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-GGO SSG-OPC-GEO |
| container_issue |
1 |
| title_short |
Identifying Patient-Specific Pathology in Osteoarthritis Development Based on MicroCT Analysis of Subchondral Trabecular Bone |
| url |
https://doi.org/10.1016/j.arth.2015.08.021 |
| remote_bool |
true |
| author2 |
Eisenhauer, Peter T. Maltenfort, Mitchell G. Parvizi, Javad Freeman, Theresa A. |
| author2Str |
Eisenhauer, Peter T. Maltenfort, Mitchell G. Parvizi, Javad Freeman, Theresa A. |
| ppnlink |
ELV009019677 |
| mediatype_str_mv |
z |
| isOA_txt |
false |
| hochschulschrift_bool |
false |
| author2_role |
oth oth oth oth |
| doi_str |
10.1016/j.arth.2015.08.021 |
| up_date |
2024-07-06T21:35:27.679Z |
| _version_ |
1803867104404832256 |
| fullrecord_marcxml |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">ELV019497717</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230625130051.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">180603s2016 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.arth.2015.08.021</subfield><subfield code="2">doi</subfield></datafield><datafield tag="028" ind1="5" ind2="2"><subfield code="a">GBVA2016014000012.pica</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)ELV019497717</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(ELSEVIER)S0883-5403(15)00775-5</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">610</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">DE-600</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">550</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">38.36</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">38.58</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Steinbeck, Marla J.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Identifying Patient-Specific Pathology in Osteoarthritis Development Based on MicroCT Analysis of Subchondral Trabecular Bone</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2016transfer abstract</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">9</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">The goal of this study was to identify alternative mechanisms of osteoarthritis pathology by analyzing subchondral bone. Femoral condyle samples were collected from post-menopausal female patients with knee osteoarthritis undegoing total knee arthroplasty. In the majority of patients, subchondral trabecular bone volume doubled under a region of the medial femoral condyle with full-thickness cartilage deterioration. However, in a subset of patients the bone volume in this region remained constant. This subset also had larger areas of vascular penetration in the calcified cartilage of the lateral condyle concurrent with increased vascular endothelial growth factor expression. Subtyping by subchondral bone characteristics identified a unique population, which lacked the sclerotic bone characteristic of late-stage osteoarthritis. Identification of subtypes within the osteoarthritis population allows investigation of alternate disease pathologies.</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">The goal of this study was to identify alternative mechanisms of osteoarthritis pathology by analyzing subchondral bone. Femoral condyle samples were collected from post-menopausal female patients with knee osteoarthritis undegoing total knee arthroplasty. In the majority of patients, subchondral trabecular bone volume doubled under a region of the medial femoral condyle with full-thickness cartilage deterioration. However, in a subset of patients the bone volume in this region remained constant. This subset also had larger areas of vascular penetration in the calcified cartilage of the lateral condyle concurrent with increased vascular endothelial growth factor expression. Subtyping by subchondral bone characteristics identified a unique population, which lacked the sclerotic bone characteristic of late-stage osteoarthritis. Identification of subtypes within the osteoarthritis population allows investigation of alternate disease pathologies.</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Eisenhauer, Peter T.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Maltenfort, Mitchell G.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Parvizi, Javad</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Freeman, Theresa A.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="n">Churchill Livingstone</subfield><subfield code="a">Nouri, Ahad ELSEVIER</subfield><subfield code="t">Spatially varying crustal stress along the Zagros seismic belt inferred from earthquake focal mechanisms</subfield><subfield code="d">2022</subfield><subfield code="d">official journal of the American Association of Hip and Knee Surgeons</subfield><subfield code="g">Orlando, Fla</subfield><subfield code="w">(DE-627)ELV009019677</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:31</subfield><subfield code="g">year:2016</subfield><subfield code="g">number:1</subfield><subfield code="g">pages:269-277</subfield><subfield code="g">extent:9</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1016/j.arth.2015.08.021</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ELV</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OPC-GGO</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OPC-GEO</subfield></datafield><datafield tag="936" ind1="b" ind2="k"><subfield code="a">38.36</subfield><subfield code="j">Tektonik</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="936" ind1="b" ind2="k"><subfield code="a">38.58</subfield><subfield code="j">Geomechanik</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">31</subfield><subfield code="j">2016</subfield><subfield code="e">1</subfield><subfield code="h">269-277</subfield><subfield code="g">9</subfield></datafield><datafield tag="953" ind1=" " ind2=" "><subfield code="2">045F</subfield><subfield code="a">610</subfield></datafield></record></collection>
|
| score |
7.398855 |