Lack of association between polymorphisms in the SIRT6 gene and longevity in a Chinese population
Sirtuin 6 (SIRT6) has recently been demonstrated to play an important role in the regulation of longevity in mammals. We therefore aimed to determine whether common variations in the SIRT6 gene are associated with human longevity. Five tag single nucleotide polymorphisms (SNPs) across the SIRT6 gene...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Lin, Rong [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2016transfer abstract |
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| Schlagwörter: |
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| Umfang: |
4 |
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| Übergeordnetes Werk: |
Enthalten in: Metamorphic - Xu, Nanqing ELSEVIER, 2022, London |
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| Übergeordnetes Werk: |
volume:30 ; year:2016 ; number:2 ; pages:79-82 ; extent:4 |
| Links: |
|---|
| DOI / URN: |
10.1016/j.mcp.2016.01.005 |
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| 520 | |a Sirtuin 6 (SIRT6) has recently been demonstrated to play an important role in the regulation of longevity in mammals. We therefore aimed to determine whether common variations in the SIRT6 gene are associated with human longevity. Five tag single nucleotide polymorphisms (SNPs) across the SIRT6 gene and its 5 kb up-/downstream region, including rs350852, rs350844, rs352493, rs4807546 and rs3760905, have been successfully determined in 616 unrelated Chinese long-lived individuals (LLIs) (mean age: 102.4 ± 2.3 years) and 846 younger controls (mean age: 48.9 ± 10.6 years) from Hainan Island, China. The allele and genotype frequencies of the five SNPs showed no statistically significant difference between the LLIs and controls (all P > 0.05). The five SNPs were in strong linkage disequilibrium and defined seven common haplotypes. Likewise, no association between these haplotypes and longevity was observed (all P > 0.05). The present study reveals that common genetic variations in the SIRT6 gene are not associated with human longevity. | ||
| 520 | |a Sirtuin 6 (SIRT6) has recently been demonstrated to play an important role in the regulation of longevity in mammals. We therefore aimed to determine whether common variations in the SIRT6 gene are associated with human longevity. Five tag single nucleotide polymorphisms (SNPs) across the SIRT6 gene and its 5 kb up-/downstream region, including rs350852, rs350844, rs352493, rs4807546 and rs3760905, have been successfully determined in 616 unrelated Chinese long-lived individuals (LLIs) (mean age: 102.4 ± 2.3 years) and 846 younger controls (mean age: 48.9 ± 10.6 years) from Hainan Island, China. The allele and genotype frequencies of the five SNPs showed no statistically significant difference between the LLIs and controls (all P > 0.05). The five SNPs were in strong linkage disequilibrium and defined seven common haplotypes. Likewise, no association between these haplotypes and longevity was observed (all P > 0.05). The present study reveals that common genetic variations in the SIRT6 gene are not associated with human longevity. | ||
| 650 | 7 | |a Association study |2 Elsevier | |
| 650 | 7 | |a SIRT6 |2 Elsevier | |
| 650 | 7 | |a Longevity |2 Elsevier | |
| 650 | 7 | |a Polymorphism |2 Elsevier | |
| 700 | 1 | |a Zhang, Yunxia |4 oth | |
| 700 | 1 | |a Yan, Dongjing |4 oth | |
| 700 | 1 | |a Liao, Xiaoping |4 oth | |
| 700 | 1 | |a Gong, Gu |4 oth | |
| 700 | 1 | |a Hu, Junjie |4 oth | |
| 700 | 1 | |a Fu, Yunxin |4 oth | |
| 700 | 1 | |a Cai, Wangwei |4 oth | |
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10.1016/j.mcp.2016.01.005 doi GBVA2016015000005.pica (DE-627)ELV01953986X (ELSEVIER)S0890-8508(16)30005-6 DE-627 ger DE-627 rakwb eng 570 610 570 DE-600 610 DE-600 550 VZ 38.25 bkl 38.30 bkl 38.32 bkl Lin, Rong verfasserin aut Lack of association between polymorphisms in the SIRT6 gene and longevity in a Chinese population 2016transfer abstract 4 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Sirtuin 6 (SIRT6) has recently been demonstrated to play an important role in the regulation of longevity in mammals. We therefore aimed to determine whether common variations in the SIRT6 gene are associated with human longevity. Five tag single nucleotide polymorphisms (SNPs) across the SIRT6 gene and its 5 kb up-/downstream region, including rs350852, rs350844, rs352493, rs4807546 and rs3760905, have been successfully determined in 616 unrelated Chinese long-lived individuals (LLIs) (mean age: 102.4 ± 2.3 years) and 846 younger controls (mean age: 48.9 ± 10.6 years) from Hainan Island, China. The allele and genotype frequencies of the five SNPs showed no statistically significant difference between the LLIs and controls (all P > 0.05). The five SNPs were in strong linkage disequilibrium and defined seven common haplotypes. Likewise, no association between these haplotypes and longevity was observed (all P > 0.05). The present study reveals that common genetic variations in the SIRT6 gene are not associated with human longevity. Sirtuin 6 (SIRT6) has recently been demonstrated to play an important role in the regulation of longevity in mammals. We therefore aimed to determine whether common variations in the SIRT6 gene are associated with human longevity. Five tag single nucleotide polymorphisms (SNPs) across the SIRT6 gene and its 5 kb up-/downstream region, including rs350852, rs350844, rs352493, rs4807546 and rs3760905, have been successfully determined in 616 unrelated Chinese long-lived individuals (LLIs) (mean age: 102.4 ± 2.3 years) and 846 younger controls (mean age: 48.9 ± 10.6 years) from Hainan Island, China. The allele and genotype frequencies of the five SNPs showed no statistically significant difference between the LLIs and controls (all P > 0.05). The five SNPs were in strong linkage disequilibrium and defined seven common haplotypes. Likewise, no association between these haplotypes and longevity was observed (all P > 0.05). The present study reveals that common genetic variations in the SIRT6 gene are not associated with human longevity. Association study Elsevier SIRT6 Elsevier Longevity Elsevier Polymorphism Elsevier Zhang, Yunxia oth Yan, Dongjing oth Liao, Xiaoping oth Gong, Gu oth Hu, Junjie oth Fu, Yunxin oth Cai, Wangwei oth Enthalten in Academic Press Xu, Nanqing ELSEVIER Metamorphic 2022 London (DE-627)ELV008152659 volume:30 year:2016 number:2 pages:79-82 extent:4 https://doi.org/10.1016/j.mcp.2016.01.005 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-GGO 38.25 Petrologie: Allgemeines VZ 38.30 Mineralogie VZ 38.32 Geochemie VZ AR 30 2016 2 79-82 4 045F 570 |
| spelling |
10.1016/j.mcp.2016.01.005 doi GBVA2016015000005.pica (DE-627)ELV01953986X (ELSEVIER)S0890-8508(16)30005-6 DE-627 ger DE-627 rakwb eng 570 610 570 DE-600 610 DE-600 550 VZ 38.25 bkl 38.30 bkl 38.32 bkl Lin, Rong verfasserin aut Lack of association between polymorphisms in the SIRT6 gene and longevity in a Chinese population 2016transfer abstract 4 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Sirtuin 6 (SIRT6) has recently been demonstrated to play an important role in the regulation of longevity in mammals. We therefore aimed to determine whether common variations in the SIRT6 gene are associated with human longevity. Five tag single nucleotide polymorphisms (SNPs) across the SIRT6 gene and its 5 kb up-/downstream region, including rs350852, rs350844, rs352493, rs4807546 and rs3760905, have been successfully determined in 616 unrelated Chinese long-lived individuals (LLIs) (mean age: 102.4 ± 2.3 years) and 846 younger controls (mean age: 48.9 ± 10.6 years) from Hainan Island, China. The allele and genotype frequencies of the five SNPs showed no statistically significant difference between the LLIs and controls (all P > 0.05). The five SNPs were in strong linkage disequilibrium and defined seven common haplotypes. Likewise, no association between these haplotypes and longevity was observed (all P > 0.05). The present study reveals that common genetic variations in the SIRT6 gene are not associated with human longevity. Sirtuin 6 (SIRT6) has recently been demonstrated to play an important role in the regulation of longevity in mammals. We therefore aimed to determine whether common variations in the SIRT6 gene are associated with human longevity. Five tag single nucleotide polymorphisms (SNPs) across the SIRT6 gene and its 5 kb up-/downstream region, including rs350852, rs350844, rs352493, rs4807546 and rs3760905, have been successfully determined in 616 unrelated Chinese long-lived individuals (LLIs) (mean age: 102.4 ± 2.3 years) and 846 younger controls (mean age: 48.9 ± 10.6 years) from Hainan Island, China. The allele and genotype frequencies of the five SNPs showed no statistically significant difference between the LLIs and controls (all P > 0.05). The five SNPs were in strong linkage disequilibrium and defined seven common haplotypes. Likewise, no association between these haplotypes and longevity was observed (all P > 0.05). The present study reveals that common genetic variations in the SIRT6 gene are not associated with human longevity. Association study Elsevier SIRT6 Elsevier Longevity Elsevier Polymorphism Elsevier Zhang, Yunxia oth Yan, Dongjing oth Liao, Xiaoping oth Gong, Gu oth Hu, Junjie oth Fu, Yunxin oth Cai, Wangwei oth Enthalten in Academic Press Xu, Nanqing ELSEVIER Metamorphic 2022 London (DE-627)ELV008152659 volume:30 year:2016 number:2 pages:79-82 extent:4 https://doi.org/10.1016/j.mcp.2016.01.005 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-GGO 38.25 Petrologie: Allgemeines VZ 38.30 Mineralogie VZ 38.32 Geochemie VZ AR 30 2016 2 79-82 4 045F 570 |
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10.1016/j.mcp.2016.01.005 doi GBVA2016015000005.pica (DE-627)ELV01953986X (ELSEVIER)S0890-8508(16)30005-6 DE-627 ger DE-627 rakwb eng 570 610 570 DE-600 610 DE-600 550 VZ 38.25 bkl 38.30 bkl 38.32 bkl Lin, Rong verfasserin aut Lack of association between polymorphisms in the SIRT6 gene and longevity in a Chinese population 2016transfer abstract 4 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Sirtuin 6 (SIRT6) has recently been demonstrated to play an important role in the regulation of longevity in mammals. We therefore aimed to determine whether common variations in the SIRT6 gene are associated with human longevity. Five tag single nucleotide polymorphisms (SNPs) across the SIRT6 gene and its 5 kb up-/downstream region, including rs350852, rs350844, rs352493, rs4807546 and rs3760905, have been successfully determined in 616 unrelated Chinese long-lived individuals (LLIs) (mean age: 102.4 ± 2.3 years) and 846 younger controls (mean age: 48.9 ± 10.6 years) from Hainan Island, China. The allele and genotype frequencies of the five SNPs showed no statistically significant difference between the LLIs and controls (all P > 0.05). The five SNPs were in strong linkage disequilibrium and defined seven common haplotypes. Likewise, no association between these haplotypes and longevity was observed (all P > 0.05). The present study reveals that common genetic variations in the SIRT6 gene are not associated with human longevity. Sirtuin 6 (SIRT6) has recently been demonstrated to play an important role in the regulation of longevity in mammals. We therefore aimed to determine whether common variations in the SIRT6 gene are associated with human longevity. Five tag single nucleotide polymorphisms (SNPs) across the SIRT6 gene and its 5 kb up-/downstream region, including rs350852, rs350844, rs352493, rs4807546 and rs3760905, have been successfully determined in 616 unrelated Chinese long-lived individuals (LLIs) (mean age: 102.4 ± 2.3 years) and 846 younger controls (mean age: 48.9 ± 10.6 years) from Hainan Island, China. The allele and genotype frequencies of the five SNPs showed no statistically significant difference between the LLIs and controls (all P > 0.05). The five SNPs were in strong linkage disequilibrium and defined seven common haplotypes. Likewise, no association between these haplotypes and longevity was observed (all P > 0.05). The present study reveals that common genetic variations in the SIRT6 gene are not associated with human longevity. Association study Elsevier SIRT6 Elsevier Longevity Elsevier Polymorphism Elsevier Zhang, Yunxia oth Yan, Dongjing oth Liao, Xiaoping oth Gong, Gu oth Hu, Junjie oth Fu, Yunxin oth Cai, Wangwei oth Enthalten in Academic Press Xu, Nanqing ELSEVIER Metamorphic 2022 London (DE-627)ELV008152659 volume:30 year:2016 number:2 pages:79-82 extent:4 https://doi.org/10.1016/j.mcp.2016.01.005 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-GGO 38.25 Petrologie: Allgemeines VZ 38.30 Mineralogie VZ 38.32 Geochemie VZ AR 30 2016 2 79-82 4 045F 570 |
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10.1016/j.mcp.2016.01.005 doi GBVA2016015000005.pica (DE-627)ELV01953986X (ELSEVIER)S0890-8508(16)30005-6 DE-627 ger DE-627 rakwb eng 570 610 570 DE-600 610 DE-600 550 VZ 38.25 bkl 38.30 bkl 38.32 bkl Lin, Rong verfasserin aut Lack of association between polymorphisms in the SIRT6 gene and longevity in a Chinese population 2016transfer abstract 4 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Sirtuin 6 (SIRT6) has recently been demonstrated to play an important role in the regulation of longevity in mammals. We therefore aimed to determine whether common variations in the SIRT6 gene are associated with human longevity. Five tag single nucleotide polymorphisms (SNPs) across the SIRT6 gene and its 5 kb up-/downstream region, including rs350852, rs350844, rs352493, rs4807546 and rs3760905, have been successfully determined in 616 unrelated Chinese long-lived individuals (LLIs) (mean age: 102.4 ± 2.3 years) and 846 younger controls (mean age: 48.9 ± 10.6 years) from Hainan Island, China. The allele and genotype frequencies of the five SNPs showed no statistically significant difference between the LLIs and controls (all P > 0.05). The five SNPs were in strong linkage disequilibrium and defined seven common haplotypes. Likewise, no association between these haplotypes and longevity was observed (all P > 0.05). The present study reveals that common genetic variations in the SIRT6 gene are not associated with human longevity. Sirtuin 6 (SIRT6) has recently been demonstrated to play an important role in the regulation of longevity in mammals. We therefore aimed to determine whether common variations in the SIRT6 gene are associated with human longevity. Five tag single nucleotide polymorphisms (SNPs) across the SIRT6 gene and its 5 kb up-/downstream region, including rs350852, rs350844, rs352493, rs4807546 and rs3760905, have been successfully determined in 616 unrelated Chinese long-lived individuals (LLIs) (mean age: 102.4 ± 2.3 years) and 846 younger controls (mean age: 48.9 ± 10.6 years) from Hainan Island, China. The allele and genotype frequencies of the five SNPs showed no statistically significant difference between the LLIs and controls (all P > 0.05). The five SNPs were in strong linkage disequilibrium and defined seven common haplotypes. Likewise, no association between these haplotypes and longevity was observed (all P > 0.05). The present study reveals that common genetic variations in the SIRT6 gene are not associated with human longevity. Association study Elsevier SIRT6 Elsevier Longevity Elsevier Polymorphism Elsevier Zhang, Yunxia oth Yan, Dongjing oth Liao, Xiaoping oth Gong, Gu oth Hu, Junjie oth Fu, Yunxin oth Cai, Wangwei oth Enthalten in Academic Press Xu, Nanqing ELSEVIER Metamorphic 2022 London (DE-627)ELV008152659 volume:30 year:2016 number:2 pages:79-82 extent:4 https://doi.org/10.1016/j.mcp.2016.01.005 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-GGO 38.25 Petrologie: Allgemeines VZ 38.30 Mineralogie VZ 38.32 Geochemie VZ AR 30 2016 2 79-82 4 045F 570 |
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10.1016/j.mcp.2016.01.005 doi GBVA2016015000005.pica (DE-627)ELV01953986X (ELSEVIER)S0890-8508(16)30005-6 DE-627 ger DE-627 rakwb eng 570 610 570 DE-600 610 DE-600 550 VZ 38.25 bkl 38.30 bkl 38.32 bkl Lin, Rong verfasserin aut Lack of association between polymorphisms in the SIRT6 gene and longevity in a Chinese population 2016transfer abstract 4 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Sirtuin 6 (SIRT6) has recently been demonstrated to play an important role in the regulation of longevity in mammals. We therefore aimed to determine whether common variations in the SIRT6 gene are associated with human longevity. Five tag single nucleotide polymorphisms (SNPs) across the SIRT6 gene and its 5 kb up-/downstream region, including rs350852, rs350844, rs352493, rs4807546 and rs3760905, have been successfully determined in 616 unrelated Chinese long-lived individuals (LLIs) (mean age: 102.4 ± 2.3 years) and 846 younger controls (mean age: 48.9 ± 10.6 years) from Hainan Island, China. The allele and genotype frequencies of the five SNPs showed no statistically significant difference between the LLIs and controls (all P > 0.05). The five SNPs were in strong linkage disequilibrium and defined seven common haplotypes. Likewise, no association between these haplotypes and longevity was observed (all P > 0.05). The present study reveals that common genetic variations in the SIRT6 gene are not associated with human longevity. Sirtuin 6 (SIRT6) has recently been demonstrated to play an important role in the regulation of longevity in mammals. We therefore aimed to determine whether common variations in the SIRT6 gene are associated with human longevity. Five tag single nucleotide polymorphisms (SNPs) across the SIRT6 gene and its 5 kb up-/downstream region, including rs350852, rs350844, rs352493, rs4807546 and rs3760905, have been successfully determined in 616 unrelated Chinese long-lived individuals (LLIs) (mean age: 102.4 ± 2.3 years) and 846 younger controls (mean age: 48.9 ± 10.6 years) from Hainan Island, China. The allele and genotype frequencies of the five SNPs showed no statistically significant difference between the LLIs and controls (all P > 0.05). The five SNPs were in strong linkage disequilibrium and defined seven common haplotypes. Likewise, no association between these haplotypes and longevity was observed (all P > 0.05). The present study reveals that common genetic variations in the SIRT6 gene are not associated with human longevity. Association study Elsevier SIRT6 Elsevier Longevity Elsevier Polymorphism Elsevier Zhang, Yunxia oth Yan, Dongjing oth Liao, Xiaoping oth Gong, Gu oth Hu, Junjie oth Fu, Yunxin oth Cai, Wangwei oth Enthalten in Academic Press Xu, Nanqing ELSEVIER Metamorphic 2022 London (DE-627)ELV008152659 volume:30 year:2016 number:2 pages:79-82 extent:4 https://doi.org/10.1016/j.mcp.2016.01.005 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-GGO 38.25 Petrologie: Allgemeines VZ 38.30 Mineralogie VZ 38.32 Geochemie VZ AR 30 2016 2 79-82 4 045F 570 |
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We therefore aimed to determine whether common variations in the SIRT6 gene are associated with human longevity. Five tag single nucleotide polymorphisms (SNPs) across the SIRT6 gene and its 5 kb up-/downstream region, including rs350852, rs350844, rs352493, rs4807546 and rs3760905, have been successfully determined in 616 unrelated Chinese long-lived individuals (LLIs) (mean age: 102.4 ± 2.3 years) and 846 younger controls (mean age: 48.9 ± 10.6 years) from Hainan Island, China. The allele and genotype frequencies of the five SNPs showed no statistically significant difference between the LLIs and controls (all P > 0.05). The five SNPs were in strong linkage disequilibrium and defined seven common haplotypes. Likewise, no association between these haplotypes and longevity was observed (all P > 0.05). 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The five SNPs were in strong linkage disequilibrium and defined seven common haplotypes. Likewise, no association between these haplotypes and longevity was observed (all P > 0.05). 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Lack of association between polymorphisms in the SIRT6 gene and longevity in a Chinese population |
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Sirtuin 6 (SIRT6) has recently been demonstrated to play an important role in the regulation of longevity in mammals. We therefore aimed to determine whether common variations in the SIRT6 gene are associated with human longevity. Five tag single nucleotide polymorphisms (SNPs) across the SIRT6 gene and its 5 kb up-/downstream region, including rs350852, rs350844, rs352493, rs4807546 and rs3760905, have been successfully determined in 616 unrelated Chinese long-lived individuals (LLIs) (mean age: 102.4 ± 2.3 years) and 846 younger controls (mean age: 48.9 ± 10.6 years) from Hainan Island, China. The allele and genotype frequencies of the five SNPs showed no statistically significant difference between the LLIs and controls (all P > 0.05). The five SNPs were in strong linkage disequilibrium and defined seven common haplotypes. Likewise, no association between these haplotypes and longevity was observed (all P > 0.05). The present study reveals that common genetic variations in the SIRT6 gene are not associated with human longevity. |
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Sirtuin 6 (SIRT6) has recently been demonstrated to play an important role in the regulation of longevity in mammals. We therefore aimed to determine whether common variations in the SIRT6 gene are associated with human longevity. Five tag single nucleotide polymorphisms (SNPs) across the SIRT6 gene and its 5 kb up-/downstream region, including rs350852, rs350844, rs352493, rs4807546 and rs3760905, have been successfully determined in 616 unrelated Chinese long-lived individuals (LLIs) (mean age: 102.4 ± 2.3 years) and 846 younger controls (mean age: 48.9 ± 10.6 years) from Hainan Island, China. The allele and genotype frequencies of the five SNPs showed no statistically significant difference between the LLIs and controls (all P > 0.05). The five SNPs were in strong linkage disequilibrium and defined seven common haplotypes. Likewise, no association between these haplotypes and longevity was observed (all P > 0.05). The present study reveals that common genetic variations in the SIRT6 gene are not associated with human longevity. |
| abstract_unstemmed |
Sirtuin 6 (SIRT6) has recently been demonstrated to play an important role in the regulation of longevity in mammals. We therefore aimed to determine whether common variations in the SIRT6 gene are associated with human longevity. Five tag single nucleotide polymorphisms (SNPs) across the SIRT6 gene and its 5 kb up-/downstream region, including rs350852, rs350844, rs352493, rs4807546 and rs3760905, have been successfully determined in 616 unrelated Chinese long-lived individuals (LLIs) (mean age: 102.4 ± 2.3 years) and 846 younger controls (mean age: 48.9 ± 10.6 years) from Hainan Island, China. The allele and genotype frequencies of the five SNPs showed no statistically significant difference between the LLIs and controls (all P > 0.05). The five SNPs were in strong linkage disequilibrium and defined seven common haplotypes. Likewise, no association between these haplotypes and longevity was observed (all P > 0.05). The present study reveals that common genetic variations in the SIRT6 gene are not associated with human longevity. |
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