Composite poly(lactic acid)/chitosan nanofibrous scaffolds for cardiac tissue engineering
Fibrous scaffolds with different ratios of poly (lactic acid) (PLA) and chitosan were fabricated by conventional electrospinning. After crosslinking by the glutaraldehyde vapor, the structure, mechanical properties, hydrophilicity, and in-fiber chemical interactions of the scaffolds were investigate...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Liu, Yaowen [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
2017transfer abstract |
|---|
| Schlagwörter: |
|---|
| Umfang: |
8 |
|---|
| Übergeordnetes Werk: |
Enthalten in: Automated DNA hybridization transfer with movable super-paramagnetic microbeads in a microflow reactor - Penchovsky, Robert ELSEVIER, 2019, structure, function and interactions, New York, NY [u.a.] |
|---|---|
| Übergeordnetes Werk: |
volume:103 ; year:2017 ; pages:1130-1137 ; extent:8 |
| Links: |
|---|
| DOI / URN: |
10.1016/j.ijbiomac.2017.05.101 |
|---|
| Katalog-ID: |
ELV019989393 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | ELV019989393 | ||
| 003 | DE-627 | ||
| 005 | 20230625131049.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 180603s2017 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.ijbiomac.2017.05.101 |2 doi | |
| 028 | 5 | 2 | |a GBV00000000000293A.pica |
| 035 | |a (DE-627)ELV019989393 | ||
| 035 | |a (ELSEVIER)S0141-8130(17)30911-X | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 082 | 0 | |a 540 |a 570 | |
| 082 | 0 | 4 | |a 540 |q DE-600 |
| 082 | 0 | 4 | |a 570 |q DE-600 |
| 082 | 0 | 4 | |a 570 |a 610 |q VZ |
| 084 | |a 58.30 |2 bkl | ||
| 084 | |a 50.22 |2 bkl | ||
| 084 | |a 44.09 |2 bkl | ||
| 100 | 1 | |a Liu, Yaowen |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Composite poly(lactic acid)/chitosan nanofibrous scaffolds for cardiac tissue engineering |
| 264 | 1 | |c 2017transfer abstract | |
| 300 | |a 8 | ||
| 336 | |a nicht spezifiziert |b zzz |2 rdacontent | ||
| 337 | |a nicht spezifiziert |b z |2 rdamedia | ||
| 338 | |a nicht spezifiziert |b zu |2 rdacarrier | ||
| 520 | |a Fibrous scaffolds with different ratios of poly (lactic acid) (PLA) and chitosan were fabricated by conventional electrospinning. After crosslinking by the glutaraldehyde vapor, the structure, mechanical properties, hydrophilicity, and in-fiber chemical interactions of the scaffolds were investigated. We found that the fiber diameter decreased with the concentration of chitosan, while mechanical properties and hydrophilicity improved. In addition, we found that scaffolds with aligned fibers have higher mechanical strength and biocompatibility than scaffolds with randomly oriented fibers. In particular, scaffolds with aligned fibers with PLA:chitosan ratios of 7:1 was found to support cardiomyocyte viability, elicit cell elongation, and enhance production of sarcomeric α-actinin and troponin I. Collectively, the data indicate that composite scaffolds consisting of PLA/chitosan fibers have great potential for engineering cardiac tissue, and for accelerating the regeneration of myocardia. | ||
| 520 | |a Fibrous scaffolds with different ratios of poly (lactic acid) (PLA) and chitosan were fabricated by conventional electrospinning. After crosslinking by the glutaraldehyde vapor, the structure, mechanical properties, hydrophilicity, and in-fiber chemical interactions of the scaffolds were investigated. We found that the fiber diameter decreased with the concentration of chitosan, while mechanical properties and hydrophilicity improved. In addition, we found that scaffolds with aligned fibers have higher mechanical strength and biocompatibility than scaffolds with randomly oriented fibers. In particular, scaffolds with aligned fibers with PLA:chitosan ratios of 7:1 was found to support cardiomyocyte viability, elicit cell elongation, and enhance production of sarcomeric α-actinin and troponin I. Collectively, the data indicate that composite scaffolds consisting of PLA/chitosan fibers have great potential for engineering cardiac tissue, and for accelerating the regeneration of myocardia. | ||
| 650 | 7 | |a Poly(lactic acid) |2 Elsevier | |
| 650 | 7 | |a Aligned fibers |2 Elsevier | |
| 650 | 7 | |a Chitosan |2 Elsevier | |
| 700 | 1 | |a Wang, Shuyao |4 oth | |
| 700 | 1 | |a Zhang, Rong |4 oth | |
| 773 | 0 | 8 | |i Enthalten in |n Elsevier |a Penchovsky, Robert ELSEVIER |t Automated DNA hybridization transfer with movable super-paramagnetic microbeads in a microflow reactor |d 2019 |d structure, function and interactions |g New York, NY [u.a.] |w (DE-627)ELV002200198 |
| 773 | 1 | 8 | |g volume:103 |g year:2017 |g pages:1130-1137 |g extent:8 |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.ijbiomac.2017.05.101 |3 Volltext |
| 912 | |a GBV_USEFLAG_U | ||
| 912 | |a GBV_ELV | ||
| 912 | |a SYSFLAG_U | ||
| 912 | |a SSG-OLC-PHA | ||
| 936 | b | k | |a 58.30 |j Biotechnologie |q VZ |
| 936 | b | k | |a 50.22 |j Sensorik |q VZ |
| 936 | b | k | |a 44.09 |j Medizintechnik |q VZ |
| 951 | |a AR | ||
| 952 | |d 103 |j 2017 |h 1130-1137 |g 8 | ||
| 953 | |2 045F |a 540 | ||
| author_variant |
y l yl |
|---|---|
| matchkey_str |
liuyaowenwangshuyaozhangrong:2017----:opstpllciaicioannfboscfodfra |
| hierarchy_sort_str |
2017transfer abstract |
| bklnumber |
58.30 50.22 44.09 |
| publishDate |
2017 |
| allfields |
10.1016/j.ijbiomac.2017.05.101 doi GBV00000000000293A.pica (DE-627)ELV019989393 (ELSEVIER)S0141-8130(17)30911-X DE-627 ger DE-627 rakwb eng 540 570 540 DE-600 570 DE-600 570 610 VZ 58.30 bkl 50.22 bkl 44.09 bkl Liu, Yaowen verfasserin aut Composite poly(lactic acid)/chitosan nanofibrous scaffolds for cardiac tissue engineering 2017transfer abstract 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Fibrous scaffolds with different ratios of poly (lactic acid) (PLA) and chitosan were fabricated by conventional electrospinning. After crosslinking by the glutaraldehyde vapor, the structure, mechanical properties, hydrophilicity, and in-fiber chemical interactions of the scaffolds were investigated. We found that the fiber diameter decreased with the concentration of chitosan, while mechanical properties and hydrophilicity improved. In addition, we found that scaffolds with aligned fibers have higher mechanical strength and biocompatibility than scaffolds with randomly oriented fibers. In particular, scaffolds with aligned fibers with PLA:chitosan ratios of 7:1 was found to support cardiomyocyte viability, elicit cell elongation, and enhance production of sarcomeric α-actinin and troponin I. Collectively, the data indicate that composite scaffolds consisting of PLA/chitosan fibers have great potential for engineering cardiac tissue, and for accelerating the regeneration of myocardia. Fibrous scaffolds with different ratios of poly (lactic acid) (PLA) and chitosan were fabricated by conventional electrospinning. After crosslinking by the glutaraldehyde vapor, the structure, mechanical properties, hydrophilicity, and in-fiber chemical interactions of the scaffolds were investigated. We found that the fiber diameter decreased with the concentration of chitosan, while mechanical properties and hydrophilicity improved. In addition, we found that scaffolds with aligned fibers have higher mechanical strength and biocompatibility than scaffolds with randomly oriented fibers. In particular, scaffolds with aligned fibers with PLA:chitosan ratios of 7:1 was found to support cardiomyocyte viability, elicit cell elongation, and enhance production of sarcomeric α-actinin and troponin I. Collectively, the data indicate that composite scaffolds consisting of PLA/chitosan fibers have great potential for engineering cardiac tissue, and for accelerating the regeneration of myocardia. Poly(lactic acid) Elsevier Aligned fibers Elsevier Chitosan Elsevier Wang, Shuyao oth Zhang, Rong oth Enthalten in Elsevier Penchovsky, Robert ELSEVIER Automated DNA hybridization transfer with movable super-paramagnetic microbeads in a microflow reactor 2019 structure, function and interactions New York, NY [u.a.] (DE-627)ELV002200198 volume:103 year:2017 pages:1130-1137 extent:8 https://doi.org/10.1016/j.ijbiomac.2017.05.101 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 58.30 Biotechnologie VZ 50.22 Sensorik VZ 44.09 Medizintechnik VZ AR 103 2017 1130-1137 8 045F 540 |
| spelling |
10.1016/j.ijbiomac.2017.05.101 doi GBV00000000000293A.pica (DE-627)ELV019989393 (ELSEVIER)S0141-8130(17)30911-X DE-627 ger DE-627 rakwb eng 540 570 540 DE-600 570 DE-600 570 610 VZ 58.30 bkl 50.22 bkl 44.09 bkl Liu, Yaowen verfasserin aut Composite poly(lactic acid)/chitosan nanofibrous scaffolds for cardiac tissue engineering 2017transfer abstract 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Fibrous scaffolds with different ratios of poly (lactic acid) (PLA) and chitosan were fabricated by conventional electrospinning. After crosslinking by the glutaraldehyde vapor, the structure, mechanical properties, hydrophilicity, and in-fiber chemical interactions of the scaffolds were investigated. We found that the fiber diameter decreased with the concentration of chitosan, while mechanical properties and hydrophilicity improved. In addition, we found that scaffolds with aligned fibers have higher mechanical strength and biocompatibility than scaffolds with randomly oriented fibers. In particular, scaffolds with aligned fibers with PLA:chitosan ratios of 7:1 was found to support cardiomyocyte viability, elicit cell elongation, and enhance production of sarcomeric α-actinin and troponin I. Collectively, the data indicate that composite scaffolds consisting of PLA/chitosan fibers have great potential for engineering cardiac tissue, and for accelerating the regeneration of myocardia. Fibrous scaffolds with different ratios of poly (lactic acid) (PLA) and chitosan were fabricated by conventional electrospinning. After crosslinking by the glutaraldehyde vapor, the structure, mechanical properties, hydrophilicity, and in-fiber chemical interactions of the scaffolds were investigated. We found that the fiber diameter decreased with the concentration of chitosan, while mechanical properties and hydrophilicity improved. In addition, we found that scaffolds with aligned fibers have higher mechanical strength and biocompatibility than scaffolds with randomly oriented fibers. In particular, scaffolds with aligned fibers with PLA:chitosan ratios of 7:1 was found to support cardiomyocyte viability, elicit cell elongation, and enhance production of sarcomeric α-actinin and troponin I. Collectively, the data indicate that composite scaffolds consisting of PLA/chitosan fibers have great potential for engineering cardiac tissue, and for accelerating the regeneration of myocardia. Poly(lactic acid) Elsevier Aligned fibers Elsevier Chitosan Elsevier Wang, Shuyao oth Zhang, Rong oth Enthalten in Elsevier Penchovsky, Robert ELSEVIER Automated DNA hybridization transfer with movable super-paramagnetic microbeads in a microflow reactor 2019 structure, function and interactions New York, NY [u.a.] (DE-627)ELV002200198 volume:103 year:2017 pages:1130-1137 extent:8 https://doi.org/10.1016/j.ijbiomac.2017.05.101 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 58.30 Biotechnologie VZ 50.22 Sensorik VZ 44.09 Medizintechnik VZ AR 103 2017 1130-1137 8 045F 540 |
| allfields_unstemmed |
10.1016/j.ijbiomac.2017.05.101 doi GBV00000000000293A.pica (DE-627)ELV019989393 (ELSEVIER)S0141-8130(17)30911-X DE-627 ger DE-627 rakwb eng 540 570 540 DE-600 570 DE-600 570 610 VZ 58.30 bkl 50.22 bkl 44.09 bkl Liu, Yaowen verfasserin aut Composite poly(lactic acid)/chitosan nanofibrous scaffolds for cardiac tissue engineering 2017transfer abstract 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Fibrous scaffolds with different ratios of poly (lactic acid) (PLA) and chitosan were fabricated by conventional electrospinning. After crosslinking by the glutaraldehyde vapor, the structure, mechanical properties, hydrophilicity, and in-fiber chemical interactions of the scaffolds were investigated. We found that the fiber diameter decreased with the concentration of chitosan, while mechanical properties and hydrophilicity improved. In addition, we found that scaffolds with aligned fibers have higher mechanical strength and biocompatibility than scaffolds with randomly oriented fibers. In particular, scaffolds with aligned fibers with PLA:chitosan ratios of 7:1 was found to support cardiomyocyte viability, elicit cell elongation, and enhance production of sarcomeric α-actinin and troponin I. Collectively, the data indicate that composite scaffolds consisting of PLA/chitosan fibers have great potential for engineering cardiac tissue, and for accelerating the regeneration of myocardia. Fibrous scaffolds with different ratios of poly (lactic acid) (PLA) and chitosan were fabricated by conventional electrospinning. After crosslinking by the glutaraldehyde vapor, the structure, mechanical properties, hydrophilicity, and in-fiber chemical interactions of the scaffolds were investigated. We found that the fiber diameter decreased with the concentration of chitosan, while mechanical properties and hydrophilicity improved. In addition, we found that scaffolds with aligned fibers have higher mechanical strength and biocompatibility than scaffolds with randomly oriented fibers. In particular, scaffolds with aligned fibers with PLA:chitosan ratios of 7:1 was found to support cardiomyocyte viability, elicit cell elongation, and enhance production of sarcomeric α-actinin and troponin I. Collectively, the data indicate that composite scaffolds consisting of PLA/chitosan fibers have great potential for engineering cardiac tissue, and for accelerating the regeneration of myocardia. Poly(lactic acid) Elsevier Aligned fibers Elsevier Chitosan Elsevier Wang, Shuyao oth Zhang, Rong oth Enthalten in Elsevier Penchovsky, Robert ELSEVIER Automated DNA hybridization transfer with movable super-paramagnetic microbeads in a microflow reactor 2019 structure, function and interactions New York, NY [u.a.] (DE-627)ELV002200198 volume:103 year:2017 pages:1130-1137 extent:8 https://doi.org/10.1016/j.ijbiomac.2017.05.101 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 58.30 Biotechnologie VZ 50.22 Sensorik VZ 44.09 Medizintechnik VZ AR 103 2017 1130-1137 8 045F 540 |
| allfieldsGer |
10.1016/j.ijbiomac.2017.05.101 doi GBV00000000000293A.pica (DE-627)ELV019989393 (ELSEVIER)S0141-8130(17)30911-X DE-627 ger DE-627 rakwb eng 540 570 540 DE-600 570 DE-600 570 610 VZ 58.30 bkl 50.22 bkl 44.09 bkl Liu, Yaowen verfasserin aut Composite poly(lactic acid)/chitosan nanofibrous scaffolds for cardiac tissue engineering 2017transfer abstract 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Fibrous scaffolds with different ratios of poly (lactic acid) (PLA) and chitosan were fabricated by conventional electrospinning. After crosslinking by the glutaraldehyde vapor, the structure, mechanical properties, hydrophilicity, and in-fiber chemical interactions of the scaffolds were investigated. We found that the fiber diameter decreased with the concentration of chitosan, while mechanical properties and hydrophilicity improved. In addition, we found that scaffolds with aligned fibers have higher mechanical strength and biocompatibility than scaffolds with randomly oriented fibers. In particular, scaffolds with aligned fibers with PLA:chitosan ratios of 7:1 was found to support cardiomyocyte viability, elicit cell elongation, and enhance production of sarcomeric α-actinin and troponin I. Collectively, the data indicate that composite scaffolds consisting of PLA/chitosan fibers have great potential for engineering cardiac tissue, and for accelerating the regeneration of myocardia. Fibrous scaffolds with different ratios of poly (lactic acid) (PLA) and chitosan were fabricated by conventional electrospinning. After crosslinking by the glutaraldehyde vapor, the structure, mechanical properties, hydrophilicity, and in-fiber chemical interactions of the scaffolds were investigated. We found that the fiber diameter decreased with the concentration of chitosan, while mechanical properties and hydrophilicity improved. In addition, we found that scaffolds with aligned fibers have higher mechanical strength and biocompatibility than scaffolds with randomly oriented fibers. In particular, scaffolds with aligned fibers with PLA:chitosan ratios of 7:1 was found to support cardiomyocyte viability, elicit cell elongation, and enhance production of sarcomeric α-actinin and troponin I. Collectively, the data indicate that composite scaffolds consisting of PLA/chitosan fibers have great potential for engineering cardiac tissue, and for accelerating the regeneration of myocardia. Poly(lactic acid) Elsevier Aligned fibers Elsevier Chitosan Elsevier Wang, Shuyao oth Zhang, Rong oth Enthalten in Elsevier Penchovsky, Robert ELSEVIER Automated DNA hybridization transfer with movable super-paramagnetic microbeads in a microflow reactor 2019 structure, function and interactions New York, NY [u.a.] (DE-627)ELV002200198 volume:103 year:2017 pages:1130-1137 extent:8 https://doi.org/10.1016/j.ijbiomac.2017.05.101 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 58.30 Biotechnologie VZ 50.22 Sensorik VZ 44.09 Medizintechnik VZ AR 103 2017 1130-1137 8 045F 540 |
| allfieldsSound |
10.1016/j.ijbiomac.2017.05.101 doi GBV00000000000293A.pica (DE-627)ELV019989393 (ELSEVIER)S0141-8130(17)30911-X DE-627 ger DE-627 rakwb eng 540 570 540 DE-600 570 DE-600 570 610 VZ 58.30 bkl 50.22 bkl 44.09 bkl Liu, Yaowen verfasserin aut Composite poly(lactic acid)/chitosan nanofibrous scaffolds for cardiac tissue engineering 2017transfer abstract 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Fibrous scaffolds with different ratios of poly (lactic acid) (PLA) and chitosan were fabricated by conventional electrospinning. After crosslinking by the glutaraldehyde vapor, the structure, mechanical properties, hydrophilicity, and in-fiber chemical interactions of the scaffolds were investigated. We found that the fiber diameter decreased with the concentration of chitosan, while mechanical properties and hydrophilicity improved. In addition, we found that scaffolds with aligned fibers have higher mechanical strength and biocompatibility than scaffolds with randomly oriented fibers. In particular, scaffolds with aligned fibers with PLA:chitosan ratios of 7:1 was found to support cardiomyocyte viability, elicit cell elongation, and enhance production of sarcomeric α-actinin and troponin I. Collectively, the data indicate that composite scaffolds consisting of PLA/chitosan fibers have great potential for engineering cardiac tissue, and for accelerating the regeneration of myocardia. Fibrous scaffolds with different ratios of poly (lactic acid) (PLA) and chitosan were fabricated by conventional electrospinning. After crosslinking by the glutaraldehyde vapor, the structure, mechanical properties, hydrophilicity, and in-fiber chemical interactions of the scaffolds were investigated. We found that the fiber diameter decreased with the concentration of chitosan, while mechanical properties and hydrophilicity improved. In addition, we found that scaffolds with aligned fibers have higher mechanical strength and biocompatibility than scaffolds with randomly oriented fibers. In particular, scaffolds with aligned fibers with PLA:chitosan ratios of 7:1 was found to support cardiomyocyte viability, elicit cell elongation, and enhance production of sarcomeric α-actinin and troponin I. Collectively, the data indicate that composite scaffolds consisting of PLA/chitosan fibers have great potential for engineering cardiac tissue, and for accelerating the regeneration of myocardia. Poly(lactic acid) Elsevier Aligned fibers Elsevier Chitosan Elsevier Wang, Shuyao oth Zhang, Rong oth Enthalten in Elsevier Penchovsky, Robert ELSEVIER Automated DNA hybridization transfer with movable super-paramagnetic microbeads in a microflow reactor 2019 structure, function and interactions New York, NY [u.a.] (DE-627)ELV002200198 volume:103 year:2017 pages:1130-1137 extent:8 https://doi.org/10.1016/j.ijbiomac.2017.05.101 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 58.30 Biotechnologie VZ 50.22 Sensorik VZ 44.09 Medizintechnik VZ AR 103 2017 1130-1137 8 045F 540 |
| language |
English |
| source |
Enthalten in Automated DNA hybridization transfer with movable super-paramagnetic microbeads in a microflow reactor New York, NY [u.a.] volume:103 year:2017 pages:1130-1137 extent:8 |
| sourceStr |
Enthalten in Automated DNA hybridization transfer with movable super-paramagnetic microbeads in a microflow reactor New York, NY [u.a.] volume:103 year:2017 pages:1130-1137 extent:8 |
| format_phy_str_mv |
Article |
| bklname |
Biotechnologie Sensorik Medizintechnik |
| institution |
findex.gbv.de |
| topic_facet |
Poly(lactic acid) Aligned fibers Chitosan |
| dewey-raw |
540 |
| isfreeaccess_bool |
false |
| container_title |
Automated DNA hybridization transfer with movable super-paramagnetic microbeads in a microflow reactor |
| authorswithroles_txt_mv |
Liu, Yaowen @@aut@@ Wang, Shuyao @@oth@@ Zhang, Rong @@oth@@ |
| publishDateDaySort_date |
2017-01-01T00:00:00Z |
| hierarchy_top_id |
ELV002200198 |
| dewey-sort |
3540 |
| id |
ELV019989393 |
| language_de |
englisch |
| fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">ELV019989393</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230625131049.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">180603s2017 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.ijbiomac.2017.05.101</subfield><subfield code="2">doi</subfield></datafield><datafield tag="028" ind1="5" ind2="2"><subfield code="a">GBV00000000000293A.pica</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)ELV019989393</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(ELSEVIER)S0141-8130(17)30911-X</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">540</subfield><subfield code="a">570</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">540</subfield><subfield code="q">DE-600</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">570</subfield><subfield code="q">DE-600</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">570</subfield><subfield code="a">610</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">58.30</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">50.22</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">44.09</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Liu, Yaowen</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Composite poly(lactic acid)/chitosan nanofibrous scaffolds for cardiac tissue engineering</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2017transfer abstract</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">8</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Fibrous scaffolds with different ratios of poly (lactic acid) (PLA) and chitosan were fabricated by conventional electrospinning. After crosslinking by the glutaraldehyde vapor, the structure, mechanical properties, hydrophilicity, and in-fiber chemical interactions of the scaffolds were investigated. We found that the fiber diameter decreased with the concentration of chitosan, while mechanical properties and hydrophilicity improved. In addition, we found that scaffolds with aligned fibers have higher mechanical strength and biocompatibility than scaffolds with randomly oriented fibers. In particular, scaffolds with aligned fibers with PLA:chitosan ratios of 7:1 was found to support cardiomyocyte viability, elicit cell elongation, and enhance production of sarcomeric α-actinin and troponin I. Collectively, the data indicate that composite scaffolds consisting of PLA/chitosan fibers have great potential for engineering cardiac tissue, and for accelerating the regeneration of myocardia.</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Fibrous scaffolds with different ratios of poly (lactic acid) (PLA) and chitosan were fabricated by conventional electrospinning. After crosslinking by the glutaraldehyde vapor, the structure, mechanical properties, hydrophilicity, and in-fiber chemical interactions of the scaffolds were investigated. We found that the fiber diameter decreased with the concentration of chitosan, while mechanical properties and hydrophilicity improved. In addition, we found that scaffolds with aligned fibers have higher mechanical strength and biocompatibility than scaffolds with randomly oriented fibers. In particular, scaffolds with aligned fibers with PLA:chitosan ratios of 7:1 was found to support cardiomyocyte viability, elicit cell elongation, and enhance production of sarcomeric α-actinin and troponin I. Collectively, the data indicate that composite scaffolds consisting of PLA/chitosan fibers have great potential for engineering cardiac tissue, and for accelerating the regeneration of myocardia.</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Poly(lactic acid)</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Aligned fibers</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Chitosan</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Wang, Shuyao</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Zhang, Rong</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="n">Elsevier</subfield><subfield code="a">Penchovsky, Robert ELSEVIER</subfield><subfield code="t">Automated DNA hybridization transfer with movable super-paramagnetic microbeads in a microflow reactor</subfield><subfield code="d">2019</subfield><subfield code="d">structure, function and interactions</subfield><subfield code="g">New York, NY [u.a.]</subfield><subfield code="w">(DE-627)ELV002200198</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:103</subfield><subfield code="g">year:2017</subfield><subfield code="g">pages:1130-1137</subfield><subfield code="g">extent:8</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1016/j.ijbiomac.2017.05.101</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ELV</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-PHA</subfield></datafield><datafield tag="936" ind1="b" ind2="k"><subfield code="a">58.30</subfield><subfield code="j">Biotechnologie</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="936" ind1="b" ind2="k"><subfield code="a">50.22</subfield><subfield code="j">Sensorik</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="936" ind1="b" ind2="k"><subfield code="a">44.09</subfield><subfield code="j">Medizintechnik</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">103</subfield><subfield code="j">2017</subfield><subfield code="h">1130-1137</subfield><subfield code="g">8</subfield></datafield><datafield tag="953" ind1=" " ind2=" "><subfield code="2">045F</subfield><subfield code="a">540</subfield></datafield></record></collection>
|
| author |
Liu, Yaowen |
| spellingShingle |
Liu, Yaowen ddc 540 ddc 570 bkl 58.30 bkl 50.22 bkl 44.09 Elsevier Poly(lactic acid) Elsevier Aligned fibers Elsevier Chitosan Composite poly(lactic acid)/chitosan nanofibrous scaffolds for cardiac tissue engineering |
| authorStr |
Liu, Yaowen |
| ppnlink_with_tag_str_mv |
@@773@@(DE-627)ELV002200198 |
| format |
electronic Article |
| dewey-ones |
540 - Chemistry & allied sciences 570 - Life sciences; biology 610 - Medicine & health |
| delete_txt_mv |
keep |
| author_role |
aut |
| collection |
elsevier |
| remote_str |
true |
| illustrated |
Not Illustrated |
| topic_title |
540 570 540 DE-600 570 DE-600 570 610 VZ 58.30 bkl 50.22 bkl 44.09 bkl Composite poly(lactic acid)/chitosan nanofibrous scaffolds for cardiac tissue engineering Poly(lactic acid) Elsevier Aligned fibers Elsevier Chitosan Elsevier |
| topic |
ddc 540 ddc 570 bkl 58.30 bkl 50.22 bkl 44.09 Elsevier Poly(lactic acid) Elsevier Aligned fibers Elsevier Chitosan |
| topic_unstemmed |
ddc 540 ddc 570 bkl 58.30 bkl 50.22 bkl 44.09 Elsevier Poly(lactic acid) Elsevier Aligned fibers Elsevier Chitosan |
| topic_browse |
ddc 540 ddc 570 bkl 58.30 bkl 50.22 bkl 44.09 Elsevier Poly(lactic acid) Elsevier Aligned fibers Elsevier Chitosan |
| format_facet |
Elektronische Aufsätze Aufsätze Elektronische Ressource |
| format_main_str_mv |
Text Zeitschrift/Artikel |
| carriertype_str_mv |
zu |
| author2_variant |
s w sw r z rz |
| hierarchy_parent_title |
Automated DNA hybridization transfer with movable super-paramagnetic microbeads in a microflow reactor |
| hierarchy_parent_id |
ELV002200198 |
| dewey-tens |
540 - Chemistry 570 - Life sciences; biology 610 - Medicine & health |
| hierarchy_top_title |
Automated DNA hybridization transfer with movable super-paramagnetic microbeads in a microflow reactor |
| isfreeaccess_txt |
false |
| familylinks_str_mv |
(DE-627)ELV002200198 |
| title |
Composite poly(lactic acid)/chitosan nanofibrous scaffolds for cardiac tissue engineering |
| ctrlnum |
(DE-627)ELV019989393 (ELSEVIER)S0141-8130(17)30911-X |
| title_full |
Composite poly(lactic acid)/chitosan nanofibrous scaffolds for cardiac tissue engineering |
| author_sort |
Liu, Yaowen |
| journal |
Automated DNA hybridization transfer with movable super-paramagnetic microbeads in a microflow reactor |
| journalStr |
Automated DNA hybridization transfer with movable super-paramagnetic microbeads in a microflow reactor |
| lang_code |
eng |
| isOA_bool |
false |
| dewey-hundreds |
500 - Science 600 - Technology |
| recordtype |
marc |
| publishDateSort |
2017 |
| contenttype_str_mv |
zzz |
| container_start_page |
1130 |
| author_browse |
Liu, Yaowen |
| container_volume |
103 |
| physical |
8 |
| class |
540 570 540 DE-600 570 DE-600 570 610 VZ 58.30 bkl 50.22 bkl 44.09 bkl |
| format_se |
Elektronische Aufsätze |
| author-letter |
Liu, Yaowen |
| doi_str_mv |
10.1016/j.ijbiomac.2017.05.101 |
| dewey-full |
540 570 610 |
| title_sort |
composite poly(lactic acid)/chitosan nanofibrous scaffolds for cardiac tissue engineering |
| title_auth |
Composite poly(lactic acid)/chitosan nanofibrous scaffolds for cardiac tissue engineering |
| abstract |
Fibrous scaffolds with different ratios of poly (lactic acid) (PLA) and chitosan were fabricated by conventional electrospinning. After crosslinking by the glutaraldehyde vapor, the structure, mechanical properties, hydrophilicity, and in-fiber chemical interactions of the scaffolds were investigated. We found that the fiber diameter decreased with the concentration of chitosan, while mechanical properties and hydrophilicity improved. In addition, we found that scaffolds with aligned fibers have higher mechanical strength and biocompatibility than scaffolds with randomly oriented fibers. In particular, scaffolds with aligned fibers with PLA:chitosan ratios of 7:1 was found to support cardiomyocyte viability, elicit cell elongation, and enhance production of sarcomeric α-actinin and troponin I. Collectively, the data indicate that composite scaffolds consisting of PLA/chitosan fibers have great potential for engineering cardiac tissue, and for accelerating the regeneration of myocardia. |
| abstractGer |
Fibrous scaffolds with different ratios of poly (lactic acid) (PLA) and chitosan were fabricated by conventional electrospinning. After crosslinking by the glutaraldehyde vapor, the structure, mechanical properties, hydrophilicity, and in-fiber chemical interactions of the scaffolds were investigated. We found that the fiber diameter decreased with the concentration of chitosan, while mechanical properties and hydrophilicity improved. In addition, we found that scaffolds with aligned fibers have higher mechanical strength and biocompatibility than scaffolds with randomly oriented fibers. In particular, scaffolds with aligned fibers with PLA:chitosan ratios of 7:1 was found to support cardiomyocyte viability, elicit cell elongation, and enhance production of sarcomeric α-actinin and troponin I. Collectively, the data indicate that composite scaffolds consisting of PLA/chitosan fibers have great potential for engineering cardiac tissue, and for accelerating the regeneration of myocardia. |
| abstract_unstemmed |
Fibrous scaffolds with different ratios of poly (lactic acid) (PLA) and chitosan were fabricated by conventional electrospinning. After crosslinking by the glutaraldehyde vapor, the structure, mechanical properties, hydrophilicity, and in-fiber chemical interactions of the scaffolds were investigated. We found that the fiber diameter decreased with the concentration of chitosan, while mechanical properties and hydrophilicity improved. In addition, we found that scaffolds with aligned fibers have higher mechanical strength and biocompatibility than scaffolds with randomly oriented fibers. In particular, scaffolds with aligned fibers with PLA:chitosan ratios of 7:1 was found to support cardiomyocyte viability, elicit cell elongation, and enhance production of sarcomeric α-actinin and troponin I. Collectively, the data indicate that composite scaffolds consisting of PLA/chitosan fibers have great potential for engineering cardiac tissue, and for accelerating the regeneration of myocardia. |
| collection_details |
GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA |
| title_short |
Composite poly(lactic acid)/chitosan nanofibrous scaffolds for cardiac tissue engineering |
| url |
https://doi.org/10.1016/j.ijbiomac.2017.05.101 |
| remote_bool |
true |
| author2 |
Wang, Shuyao Zhang, Rong |
| author2Str |
Wang, Shuyao Zhang, Rong |
| ppnlink |
ELV002200198 |
| mediatype_str_mv |
z |
| isOA_txt |
false |
| hochschulschrift_bool |
false |
| author2_role |
oth oth |
| doi_str |
10.1016/j.ijbiomac.2017.05.101 |
| up_date |
2024-07-06T22:55:53.783Z |
| _version_ |
1803872164941660160 |
| fullrecord_marcxml |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">ELV019989393</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230625131049.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">180603s2017 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.ijbiomac.2017.05.101</subfield><subfield code="2">doi</subfield></datafield><datafield tag="028" ind1="5" ind2="2"><subfield code="a">GBV00000000000293A.pica</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)ELV019989393</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(ELSEVIER)S0141-8130(17)30911-X</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">540</subfield><subfield code="a">570</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">540</subfield><subfield code="q">DE-600</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">570</subfield><subfield code="q">DE-600</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">570</subfield><subfield code="a">610</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">58.30</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">50.22</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">44.09</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Liu, Yaowen</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Composite poly(lactic acid)/chitosan nanofibrous scaffolds for cardiac tissue engineering</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2017transfer abstract</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">8</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Fibrous scaffolds with different ratios of poly (lactic acid) (PLA) and chitosan were fabricated by conventional electrospinning. After crosslinking by the glutaraldehyde vapor, the structure, mechanical properties, hydrophilicity, and in-fiber chemical interactions of the scaffolds were investigated. We found that the fiber diameter decreased with the concentration of chitosan, while mechanical properties and hydrophilicity improved. In addition, we found that scaffolds with aligned fibers have higher mechanical strength and biocompatibility than scaffolds with randomly oriented fibers. In particular, scaffolds with aligned fibers with PLA:chitosan ratios of 7:1 was found to support cardiomyocyte viability, elicit cell elongation, and enhance production of sarcomeric α-actinin and troponin I. Collectively, the data indicate that composite scaffolds consisting of PLA/chitosan fibers have great potential for engineering cardiac tissue, and for accelerating the regeneration of myocardia.</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Fibrous scaffolds with different ratios of poly (lactic acid) (PLA) and chitosan were fabricated by conventional electrospinning. After crosslinking by the glutaraldehyde vapor, the structure, mechanical properties, hydrophilicity, and in-fiber chemical interactions of the scaffolds were investigated. We found that the fiber diameter decreased with the concentration of chitosan, while mechanical properties and hydrophilicity improved. In addition, we found that scaffolds with aligned fibers have higher mechanical strength and biocompatibility than scaffolds with randomly oriented fibers. In particular, scaffolds with aligned fibers with PLA:chitosan ratios of 7:1 was found to support cardiomyocyte viability, elicit cell elongation, and enhance production of sarcomeric α-actinin and troponin I. Collectively, the data indicate that composite scaffolds consisting of PLA/chitosan fibers have great potential for engineering cardiac tissue, and for accelerating the regeneration of myocardia.</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Poly(lactic acid)</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Aligned fibers</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Chitosan</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Wang, Shuyao</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Zhang, Rong</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="n">Elsevier</subfield><subfield code="a">Penchovsky, Robert ELSEVIER</subfield><subfield code="t">Automated DNA hybridization transfer with movable super-paramagnetic microbeads in a microflow reactor</subfield><subfield code="d">2019</subfield><subfield code="d">structure, function and interactions</subfield><subfield code="g">New York, NY [u.a.]</subfield><subfield code="w">(DE-627)ELV002200198</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:103</subfield><subfield code="g">year:2017</subfield><subfield code="g">pages:1130-1137</subfield><subfield code="g">extent:8</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1016/j.ijbiomac.2017.05.101</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ELV</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-PHA</subfield></datafield><datafield tag="936" ind1="b" ind2="k"><subfield code="a">58.30</subfield><subfield code="j">Biotechnologie</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="936" ind1="b" ind2="k"><subfield code="a">50.22</subfield><subfield code="j">Sensorik</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="936" ind1="b" ind2="k"><subfield code="a">44.09</subfield><subfield code="j">Medizintechnik</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">103</subfield><subfield code="j">2017</subfield><subfield code="h">1130-1137</subfield><subfield code="g">8</subfield></datafield><datafield tag="953" ind1=" " ind2=" "><subfield code="2">045F</subfield><subfield code="a">540</subfield></datafield></record></collection>
|
| score |
7.4028378 |