Acid-sensitive dextran prodrug: A higher molecular weight makes a better efficacy
• Dextran-based prodrugs with similar drug binding rate were synthesized. • The prodrugs showed intracellular acidity-sensitivity. • The amphiphilic prodrugs self-assembled into micellar nanoparticles. • The molecular weight of dextran backbone could adjust the properties. • A higher molecular weigh...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Li, Di [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
2017 |
|---|
| Schlagwörter: |
|---|
| Umfang: |
9 |
|---|
| Übergeordnetes Werk: |
Enthalten in: Residue co-evolution helps predict interaction sites in α-helical membrane proteins - Zeng, Bo ELSEVIER, 2019, an international journal devoted to scientific and technological aspects of industrially important polysaccharides, Amsterdam [u.a.] |
|---|---|
| Übergeordnetes Werk: |
volume:161 ; year:2017 ; day:1 ; month:04 ; pages:33-41 ; extent:9 |
| Links: |
|---|
| DOI / URN: |
10.1016/j.carbpol.2016.12.070 |
|---|
| Katalog-ID: |
ELV019992912 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | ELV019992912 | ||
| 003 | DE-627 | ||
| 005 | 20230623153059.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 180603s2017 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.carbpol.2016.12.070 |2 doi | |
| 028 | 5 | 2 | |a GBVA2017003000020.pica |
| 035 | |a (DE-627)ELV019992912 | ||
| 035 | |a (ELSEVIER)S0144-8617(16)31455-2 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 082 | 0 | |a 540 |a 660 | |
| 082 | 0 | 4 | |a 540 |q DE-600 |
| 082 | 0 | 4 | |a 660 |q DE-600 |
| 082 | 0 | 4 | |a 540 |q VZ |
| 084 | |a BIODIV |q DE-30 |2 fid | ||
| 084 | |a 42.13 |2 bkl | ||
| 100 | 1 | |a Li, Di |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Acid-sensitive dextran prodrug: A higher molecular weight makes a better efficacy |
| 264 | 1 | |c 2017 | |
| 300 | |a 9 | ||
| 336 | |a nicht spezifiziert |b zzz |2 rdacontent | ||
| 337 | |a nicht spezifiziert |b z |2 rdamedia | ||
| 338 | |a nicht spezifiziert |b zu |2 rdacarrier | ||
| 520 | |a • Dextran-based prodrugs with similar drug binding rate were synthesized. • The prodrugs showed intracellular acidity-sensitivity. • The amphiphilic prodrugs self-assembled into micellar nanoparticles. • The molecular weight of dextran backbone could adjust the properties. • A higher molecular weight endowed prodrug with a higher antitumor efficacy. | ||
| 650 | 7 | |a Chemotherapy |2 Elsevier | |
| 650 | 7 | |a Acid-sensitivity |2 Elsevier | |
| 650 | 7 | |a Synergy and attenuation |2 Elsevier | |
| 650 | 7 | |a Prodrug |2 Elsevier | |
| 650 | 7 | |a Molecular weight |2 Elsevier | |
| 700 | 1 | |a Han, Jiandong |4 oth | |
| 700 | 1 | |a Ding, Jianxun |4 oth | |
| 700 | 1 | |a Chen, Li |4 oth | |
| 700 | 1 | |a Chen, Xuesi |4 oth | |
| 773 | 0 | 8 | |i Enthalten in |n Elsevier Science |a Zeng, Bo ELSEVIER |t Residue co-evolution helps predict interaction sites in α-helical membrane proteins |d 2019 |d an international journal devoted to scientific and technological aspects of industrially important polysaccharides |g Amsterdam [u.a.] |w (DE-627)ELV002183382 |
| 773 | 1 | 8 | |g volume:161 |g year:2017 |g day:1 |g month:04 |g pages:33-41 |g extent:9 |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.carbpol.2016.12.070 |3 Volltext |
| 912 | |a GBV_USEFLAG_U | ||
| 912 | |a GBV_ELV | ||
| 912 | |a SYSFLAG_U | ||
| 912 | |a FID-BIODIV | ||
| 912 | |a SSG-OLC-PHA | ||
| 936 | b | k | |a 42.13 |j Molekularbiologie |q VZ |
| 951 | |a AR | ||
| 952 | |d 161 |j 2017 |b 1 |c 0401 |h 33-41 |g 9 | ||
| 953 | |2 045F |a 540 | ||
| author_variant |
d l dl |
|---|---|
| matchkey_str |
lidihanjiandongdingjianxunchenlichenxues:2017----:cdestvdxrnrduaihroeuawihm |
| hierarchy_sort_str |
2017 |
| bklnumber |
42.13 |
| publishDate |
2017 |
| allfields |
10.1016/j.carbpol.2016.12.070 doi GBVA2017003000020.pica (DE-627)ELV019992912 (ELSEVIER)S0144-8617(16)31455-2 DE-627 ger DE-627 rakwb eng 540 660 540 DE-600 660 DE-600 540 VZ BIODIV DE-30 fid 42.13 bkl Li, Di verfasserin aut Acid-sensitive dextran prodrug: A higher molecular weight makes a better efficacy 2017 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • Dextran-based prodrugs with similar drug binding rate were synthesized. • The prodrugs showed intracellular acidity-sensitivity. • The amphiphilic prodrugs self-assembled into micellar nanoparticles. • The molecular weight of dextran backbone could adjust the properties. • A higher molecular weight endowed prodrug with a higher antitumor efficacy. Chemotherapy Elsevier Acid-sensitivity Elsevier Synergy and attenuation Elsevier Prodrug Elsevier Molecular weight Elsevier Han, Jiandong oth Ding, Jianxun oth Chen, Li oth Chen, Xuesi oth Enthalten in Elsevier Science Zeng, Bo ELSEVIER Residue co-evolution helps predict interaction sites in α-helical membrane proteins 2019 an international journal devoted to scientific and technological aspects of industrially important polysaccharides Amsterdam [u.a.] (DE-627)ELV002183382 volume:161 year:2017 day:1 month:04 pages:33-41 extent:9 https://doi.org/10.1016/j.carbpol.2016.12.070 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV SSG-OLC-PHA 42.13 Molekularbiologie VZ AR 161 2017 1 0401 33-41 9 045F 540 |
| spelling |
10.1016/j.carbpol.2016.12.070 doi GBVA2017003000020.pica (DE-627)ELV019992912 (ELSEVIER)S0144-8617(16)31455-2 DE-627 ger DE-627 rakwb eng 540 660 540 DE-600 660 DE-600 540 VZ BIODIV DE-30 fid 42.13 bkl Li, Di verfasserin aut Acid-sensitive dextran prodrug: A higher molecular weight makes a better efficacy 2017 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • Dextran-based prodrugs with similar drug binding rate were synthesized. • The prodrugs showed intracellular acidity-sensitivity. • The amphiphilic prodrugs self-assembled into micellar nanoparticles. • The molecular weight of dextran backbone could adjust the properties. • A higher molecular weight endowed prodrug with a higher antitumor efficacy. Chemotherapy Elsevier Acid-sensitivity Elsevier Synergy and attenuation Elsevier Prodrug Elsevier Molecular weight Elsevier Han, Jiandong oth Ding, Jianxun oth Chen, Li oth Chen, Xuesi oth Enthalten in Elsevier Science Zeng, Bo ELSEVIER Residue co-evolution helps predict interaction sites in α-helical membrane proteins 2019 an international journal devoted to scientific and technological aspects of industrially important polysaccharides Amsterdam [u.a.] (DE-627)ELV002183382 volume:161 year:2017 day:1 month:04 pages:33-41 extent:9 https://doi.org/10.1016/j.carbpol.2016.12.070 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV SSG-OLC-PHA 42.13 Molekularbiologie VZ AR 161 2017 1 0401 33-41 9 045F 540 |
| allfields_unstemmed |
10.1016/j.carbpol.2016.12.070 doi GBVA2017003000020.pica (DE-627)ELV019992912 (ELSEVIER)S0144-8617(16)31455-2 DE-627 ger DE-627 rakwb eng 540 660 540 DE-600 660 DE-600 540 VZ BIODIV DE-30 fid 42.13 bkl Li, Di verfasserin aut Acid-sensitive dextran prodrug: A higher molecular weight makes a better efficacy 2017 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • Dextran-based prodrugs with similar drug binding rate were synthesized. • The prodrugs showed intracellular acidity-sensitivity. • The amphiphilic prodrugs self-assembled into micellar nanoparticles. • The molecular weight of dextran backbone could adjust the properties. • A higher molecular weight endowed prodrug with a higher antitumor efficacy. Chemotherapy Elsevier Acid-sensitivity Elsevier Synergy and attenuation Elsevier Prodrug Elsevier Molecular weight Elsevier Han, Jiandong oth Ding, Jianxun oth Chen, Li oth Chen, Xuesi oth Enthalten in Elsevier Science Zeng, Bo ELSEVIER Residue co-evolution helps predict interaction sites in α-helical membrane proteins 2019 an international journal devoted to scientific and technological aspects of industrially important polysaccharides Amsterdam [u.a.] (DE-627)ELV002183382 volume:161 year:2017 day:1 month:04 pages:33-41 extent:9 https://doi.org/10.1016/j.carbpol.2016.12.070 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV SSG-OLC-PHA 42.13 Molekularbiologie VZ AR 161 2017 1 0401 33-41 9 045F 540 |
| allfieldsGer |
10.1016/j.carbpol.2016.12.070 doi GBVA2017003000020.pica (DE-627)ELV019992912 (ELSEVIER)S0144-8617(16)31455-2 DE-627 ger DE-627 rakwb eng 540 660 540 DE-600 660 DE-600 540 VZ BIODIV DE-30 fid 42.13 bkl Li, Di verfasserin aut Acid-sensitive dextran prodrug: A higher molecular weight makes a better efficacy 2017 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • Dextran-based prodrugs with similar drug binding rate were synthesized. • The prodrugs showed intracellular acidity-sensitivity. • The amphiphilic prodrugs self-assembled into micellar nanoparticles. • The molecular weight of dextran backbone could adjust the properties. • A higher molecular weight endowed prodrug with a higher antitumor efficacy. Chemotherapy Elsevier Acid-sensitivity Elsevier Synergy and attenuation Elsevier Prodrug Elsevier Molecular weight Elsevier Han, Jiandong oth Ding, Jianxun oth Chen, Li oth Chen, Xuesi oth Enthalten in Elsevier Science Zeng, Bo ELSEVIER Residue co-evolution helps predict interaction sites in α-helical membrane proteins 2019 an international journal devoted to scientific and technological aspects of industrially important polysaccharides Amsterdam [u.a.] (DE-627)ELV002183382 volume:161 year:2017 day:1 month:04 pages:33-41 extent:9 https://doi.org/10.1016/j.carbpol.2016.12.070 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV SSG-OLC-PHA 42.13 Molekularbiologie VZ AR 161 2017 1 0401 33-41 9 045F 540 |
| allfieldsSound |
10.1016/j.carbpol.2016.12.070 doi GBVA2017003000020.pica (DE-627)ELV019992912 (ELSEVIER)S0144-8617(16)31455-2 DE-627 ger DE-627 rakwb eng 540 660 540 DE-600 660 DE-600 540 VZ BIODIV DE-30 fid 42.13 bkl Li, Di verfasserin aut Acid-sensitive dextran prodrug: A higher molecular weight makes a better efficacy 2017 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • Dextran-based prodrugs with similar drug binding rate were synthesized. • The prodrugs showed intracellular acidity-sensitivity. • The amphiphilic prodrugs self-assembled into micellar nanoparticles. • The molecular weight of dextran backbone could adjust the properties. • A higher molecular weight endowed prodrug with a higher antitumor efficacy. Chemotherapy Elsevier Acid-sensitivity Elsevier Synergy and attenuation Elsevier Prodrug Elsevier Molecular weight Elsevier Han, Jiandong oth Ding, Jianxun oth Chen, Li oth Chen, Xuesi oth Enthalten in Elsevier Science Zeng, Bo ELSEVIER Residue co-evolution helps predict interaction sites in α-helical membrane proteins 2019 an international journal devoted to scientific and technological aspects of industrially important polysaccharides Amsterdam [u.a.] (DE-627)ELV002183382 volume:161 year:2017 day:1 month:04 pages:33-41 extent:9 https://doi.org/10.1016/j.carbpol.2016.12.070 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV SSG-OLC-PHA 42.13 Molekularbiologie VZ AR 161 2017 1 0401 33-41 9 045F 540 |
| language |
English |
| source |
Enthalten in Residue co-evolution helps predict interaction sites in α-helical membrane proteins Amsterdam [u.a.] volume:161 year:2017 day:1 month:04 pages:33-41 extent:9 |
| sourceStr |
Enthalten in Residue co-evolution helps predict interaction sites in α-helical membrane proteins Amsterdam [u.a.] volume:161 year:2017 day:1 month:04 pages:33-41 extent:9 |
| format_phy_str_mv |
Article |
| bklname |
Molekularbiologie |
| institution |
findex.gbv.de |
| topic_facet |
Chemotherapy Acid-sensitivity Synergy and attenuation Prodrug Molecular weight |
| dewey-raw |
540 |
| isfreeaccess_bool |
false |
| container_title |
Residue co-evolution helps predict interaction sites in α-helical membrane proteins |
| authorswithroles_txt_mv |
Li, Di @@aut@@ Han, Jiandong @@oth@@ Ding, Jianxun @@oth@@ Chen, Li @@oth@@ Chen, Xuesi @@oth@@ |
| publishDateDaySort_date |
2017-01-01T00:00:00Z |
| hierarchy_top_id |
ELV002183382 |
| dewey-sort |
3540 |
| id |
ELV019992912 |
| language_de |
englisch |
| fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">ELV019992912</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230623153059.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">180603s2017 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.carbpol.2016.12.070</subfield><subfield code="2">doi</subfield></datafield><datafield tag="028" ind1="5" ind2="2"><subfield code="a">GBVA2017003000020.pica</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)ELV019992912</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(ELSEVIER)S0144-8617(16)31455-2</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">540</subfield><subfield code="a">660</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">540</subfield><subfield code="q">DE-600</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">660</subfield><subfield code="q">DE-600</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">540</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">BIODIV</subfield><subfield code="q">DE-30</subfield><subfield code="2">fid</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">42.13</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Li, Di</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Acid-sensitive dextran prodrug: A higher molecular weight makes a better efficacy</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2017</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">9</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">• Dextran-based prodrugs with similar drug binding rate were synthesized. • The prodrugs showed intracellular acidity-sensitivity. • The amphiphilic prodrugs self-assembled into micellar nanoparticles. • The molecular weight of dextran backbone could adjust the properties. • A higher molecular weight endowed prodrug with a higher antitumor efficacy.</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Chemotherapy</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Acid-sensitivity</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Synergy and attenuation</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Prodrug</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Molecular weight</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Han, Jiandong</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Ding, Jianxun</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Chen, Li</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Chen, Xuesi</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="n">Elsevier Science</subfield><subfield code="a">Zeng, Bo ELSEVIER</subfield><subfield code="t">Residue co-evolution helps predict interaction sites in α-helical membrane proteins</subfield><subfield code="d">2019</subfield><subfield code="d">an international journal devoted to scientific and technological aspects of industrially important polysaccharides</subfield><subfield code="g">Amsterdam [u.a.]</subfield><subfield code="w">(DE-627)ELV002183382</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:161</subfield><subfield code="g">year:2017</subfield><subfield code="g">day:1</subfield><subfield code="g">month:04</subfield><subfield code="g">pages:33-41</subfield><subfield code="g">extent:9</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1016/j.carbpol.2016.12.070</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ELV</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">FID-BIODIV</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-PHA</subfield></datafield><datafield tag="936" ind1="b" ind2="k"><subfield code="a">42.13</subfield><subfield code="j">Molekularbiologie</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">161</subfield><subfield code="j">2017</subfield><subfield code="b">1</subfield><subfield code="c">0401</subfield><subfield code="h">33-41</subfield><subfield code="g">9</subfield></datafield><datafield tag="953" ind1=" " ind2=" "><subfield code="2">045F</subfield><subfield code="a">540</subfield></datafield></record></collection>
|
| author |
Li, Di |
| spellingShingle |
Li, Di ddc 540 ddc 660 fid BIODIV bkl 42.13 Elsevier Chemotherapy Elsevier Acid-sensitivity Elsevier Synergy and attenuation Elsevier Prodrug Elsevier Molecular weight Acid-sensitive dextran prodrug: A higher molecular weight makes a better efficacy |
| authorStr |
Li, Di |
| ppnlink_with_tag_str_mv |
@@773@@(DE-627)ELV002183382 |
| format |
electronic Article |
| dewey-ones |
540 - Chemistry & allied sciences 660 - Chemical engineering |
| delete_txt_mv |
keep |
| author_role |
aut |
| collection |
elsevier |
| remote_str |
true |
| illustrated |
Not Illustrated |
| topic_title |
540 660 540 DE-600 660 DE-600 540 VZ BIODIV DE-30 fid 42.13 bkl Acid-sensitive dextran prodrug: A higher molecular weight makes a better efficacy Chemotherapy Elsevier Acid-sensitivity Elsevier Synergy and attenuation Elsevier Prodrug Elsevier Molecular weight Elsevier |
| topic |
ddc 540 ddc 660 fid BIODIV bkl 42.13 Elsevier Chemotherapy Elsevier Acid-sensitivity Elsevier Synergy and attenuation Elsevier Prodrug Elsevier Molecular weight |
| topic_unstemmed |
ddc 540 ddc 660 fid BIODIV bkl 42.13 Elsevier Chemotherapy Elsevier Acid-sensitivity Elsevier Synergy and attenuation Elsevier Prodrug Elsevier Molecular weight |
| topic_browse |
ddc 540 ddc 660 fid BIODIV bkl 42.13 Elsevier Chemotherapy Elsevier Acid-sensitivity Elsevier Synergy and attenuation Elsevier Prodrug Elsevier Molecular weight |
| format_facet |
Elektronische Aufsätze Aufsätze Elektronische Ressource |
| format_main_str_mv |
Text Zeitschrift/Artikel |
| carriertype_str_mv |
zu |
| author2_variant |
j h jh j d jd l c lc x c xc |
| hierarchy_parent_title |
Residue co-evolution helps predict interaction sites in α-helical membrane proteins |
| hierarchy_parent_id |
ELV002183382 |
| dewey-tens |
540 - Chemistry 660 - Chemical engineering |
| hierarchy_top_title |
Residue co-evolution helps predict interaction sites in α-helical membrane proteins |
| isfreeaccess_txt |
false |
| familylinks_str_mv |
(DE-627)ELV002183382 |
| title |
Acid-sensitive dextran prodrug: A higher molecular weight makes a better efficacy |
| ctrlnum |
(DE-627)ELV019992912 (ELSEVIER)S0144-8617(16)31455-2 |
| title_full |
Acid-sensitive dextran prodrug: A higher molecular weight makes a better efficacy |
| author_sort |
Li, Di |
| journal |
Residue co-evolution helps predict interaction sites in α-helical membrane proteins |
| journalStr |
Residue co-evolution helps predict interaction sites in α-helical membrane proteins |
| lang_code |
eng |
| isOA_bool |
false |
| dewey-hundreds |
500 - Science 600 - Technology |
| recordtype |
marc |
| publishDateSort |
2017 |
| contenttype_str_mv |
zzz |
| container_start_page |
33 |
| author_browse |
Li, Di |
| container_volume |
161 |
| physical |
9 |
| class |
540 660 540 DE-600 660 DE-600 540 VZ BIODIV DE-30 fid 42.13 bkl |
| format_se |
Elektronische Aufsätze |
| author-letter |
Li, Di |
| doi_str_mv |
10.1016/j.carbpol.2016.12.070 |
| dewey-full |
540 660 |
| title_sort |
acid-sensitive dextran prodrug: a higher molecular weight makes a better efficacy |
| title_auth |
Acid-sensitive dextran prodrug: A higher molecular weight makes a better efficacy |
| abstract |
• Dextran-based prodrugs with similar drug binding rate were synthesized. • The prodrugs showed intracellular acidity-sensitivity. • The amphiphilic prodrugs self-assembled into micellar nanoparticles. • The molecular weight of dextran backbone could adjust the properties. • A higher molecular weight endowed prodrug with a higher antitumor efficacy. |
| abstractGer |
• Dextran-based prodrugs with similar drug binding rate were synthesized. • The prodrugs showed intracellular acidity-sensitivity. • The amphiphilic prodrugs self-assembled into micellar nanoparticles. • The molecular weight of dextran backbone could adjust the properties. • A higher molecular weight endowed prodrug with a higher antitumor efficacy. |
| abstract_unstemmed |
• Dextran-based prodrugs with similar drug binding rate were synthesized. • The prodrugs showed intracellular acidity-sensitivity. • The amphiphilic prodrugs self-assembled into micellar nanoparticles. • The molecular weight of dextran backbone could adjust the properties. • A higher molecular weight endowed prodrug with a higher antitumor efficacy. |
| collection_details |
GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV SSG-OLC-PHA |
| title_short |
Acid-sensitive dextran prodrug: A higher molecular weight makes a better efficacy |
| url |
https://doi.org/10.1016/j.carbpol.2016.12.070 |
| remote_bool |
true |
| author2 |
Han, Jiandong Ding, Jianxun Chen, Li Chen, Xuesi |
| author2Str |
Han, Jiandong Ding, Jianxun Chen, Li Chen, Xuesi |
| ppnlink |
ELV002183382 |
| mediatype_str_mv |
z |
| isOA_txt |
false |
| hochschulschrift_bool |
false |
| author2_role |
oth oth oth oth |
| doi_str |
10.1016/j.carbpol.2016.12.070 |
| up_date |
2024-07-06T22:56:22.743Z |
| _version_ |
1803872195307372544 |
| fullrecord_marcxml |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">ELV019992912</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230623153059.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">180603s2017 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.carbpol.2016.12.070</subfield><subfield code="2">doi</subfield></datafield><datafield tag="028" ind1="5" ind2="2"><subfield code="a">GBVA2017003000020.pica</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)ELV019992912</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(ELSEVIER)S0144-8617(16)31455-2</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">540</subfield><subfield code="a">660</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">540</subfield><subfield code="q">DE-600</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">660</subfield><subfield code="q">DE-600</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">540</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">BIODIV</subfield><subfield code="q">DE-30</subfield><subfield code="2">fid</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">42.13</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Li, Di</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Acid-sensitive dextran prodrug: A higher molecular weight makes a better efficacy</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2017</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">9</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">• Dextran-based prodrugs with similar drug binding rate were synthesized. • The prodrugs showed intracellular acidity-sensitivity. • The amphiphilic prodrugs self-assembled into micellar nanoparticles. • The molecular weight of dextran backbone could adjust the properties. • A higher molecular weight endowed prodrug with a higher antitumor efficacy.</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Chemotherapy</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Acid-sensitivity</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Synergy and attenuation</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Prodrug</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Molecular weight</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Han, Jiandong</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Ding, Jianxun</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Chen, Li</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Chen, Xuesi</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="n">Elsevier Science</subfield><subfield code="a">Zeng, Bo ELSEVIER</subfield><subfield code="t">Residue co-evolution helps predict interaction sites in α-helical membrane proteins</subfield><subfield code="d">2019</subfield><subfield code="d">an international journal devoted to scientific and technological aspects of industrially important polysaccharides</subfield><subfield code="g">Amsterdam [u.a.]</subfield><subfield code="w">(DE-627)ELV002183382</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:161</subfield><subfield code="g">year:2017</subfield><subfield code="g">day:1</subfield><subfield code="g">month:04</subfield><subfield code="g">pages:33-41</subfield><subfield code="g">extent:9</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1016/j.carbpol.2016.12.070</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ELV</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">FID-BIODIV</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-PHA</subfield></datafield><datafield tag="936" ind1="b" ind2="k"><subfield code="a">42.13</subfield><subfield code="j">Molekularbiologie</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">161</subfield><subfield code="j">2017</subfield><subfield code="b">1</subfield><subfield code="c">0401</subfield><subfield code="h">33-41</subfield><subfield code="g">9</subfield></datafield><datafield tag="953" ind1=" " ind2=" "><subfield code="2">045F</subfield><subfield code="a">540</subfield></datafield></record></collection>
|
| score |
7.399766 |