Bone marrow mesenchymal stromal cell (MSC) gene profiling in chronic myeloid leukemia (CML) patients at diagnosis and in deep molecular response induced by tyrosine kinase inhibitors (TKIs)

• MSCs from CML patients exhibit a gene profiling pattern distinct from normal MSCs. • BMP1, MET, MITF, NANOG, and PDPN mRNAs are upregulated in MSCs from CML patients. • This molecular signature persists in MSCs from CML patients in molecular response. • Our results suggest the persistence of a “mo...
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Autor*in:	Aggoune, Djamel [verfasserIn] Sorel, Nathalie Bonnet, Marie-Laure Goujon, Jean-Michel Tarte, Karin Hérault, Olivier Domenech, Jorge Réa, Delphine Legros, Laurence Johnson-Ansa, Hyacinthe Rousselot, Philippe Cayssials, Emilie Guerci-Bresler, Agnès Bennaceur-Griscelli, Annelise Chomel, Jean-Claude Turhan, Ali G.

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2017

Schlagwörter:	TaqMan low-density array Hematopoietic niche Mesenchymal stromal cells Chronic myeloid leukemia

Umfang:	9

Übergeordnetes Werk:	Enthalten in: N - Li, Danyang ELSEVIER, 2019, clinical and laboratory studies, Amsterdam [u.a.]
Übergeordnetes Werk:	volume:60 ; year:2017 ; pages:94-102 ; extent:9

Links:	Volltext

DOI / URN:	10.1016/j.leukres.2017.07.007

Katalog-ID:	ELV019998090

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allfields	10.1016/j.leukres.2017.07.007 doi GBV00000000000285A.pica (DE-627)ELV019998090 (ELSEVIER)S0145-2126(17)30472-1 DE-627 ger DE-627 rakwb eng 610 610 DE-600 333.7 610 VZ 43.12 bkl 43.13 bkl 44.13 bkl Aggoune, Djamel verfasserin aut Bone marrow mesenchymal stromal cell (MSC) gene profiling in chronic myeloid leukemia (CML) patients at diagnosis and in deep molecular response induced by tyrosine kinase inhibitors (TKIs) 2017 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • MSCs from CML patients exhibit a gene profiling pattern distinct from normal MSCs. • BMP1, MET, MITF, NANOG, and PDPN mRNAs are upregulated in MSCs from CML patients. • This molecular signature persists in MSCs from CML patients in molecular response. • Our results suggest the persistence of a “molecular memory” in CML microenvironment. TaqMan low-density array Elsevier Hematopoietic niche Elsevier Mesenchymal stromal cells Elsevier Chronic myeloid leukemia Elsevier Sorel, Nathalie oth Bonnet, Marie-Laure oth Goujon, Jean-Michel oth Tarte, Karin oth Hérault, Olivier oth Domenech, Jorge oth Réa, Delphine oth Legros, Laurence oth Johnson-Ansa, Hyacinthe oth Rousselot, Philippe oth Cayssials, Emilie oth Guerci-Bresler, Agnès oth Bennaceur-Griscelli, Annelise oth Chomel, Jean-Claude oth Turhan, Ali G. oth Enthalten in Elsevier Science Li, Danyang ELSEVIER N 2019 clinical and laboratory studies Amsterdam [u.a.] (DE-627)ELV002185202 volume:60 year:2017 pages:94-102 extent:9 https://doi.org/10.1016/j.leukres.2017.07.007 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA SSG-OPC-GGO 43.12 Umweltchemie VZ 43.13 Umwelttoxikologie VZ 44.13 Medizinische Ökologie VZ AR 60 2017 94-102 9 045F 610
spelling	10.1016/j.leukres.2017.07.007 doi GBV00000000000285A.pica (DE-627)ELV019998090 (ELSEVIER)S0145-2126(17)30472-1 DE-627 ger DE-627 rakwb eng 610 610 DE-600 333.7 610 VZ 43.12 bkl 43.13 bkl 44.13 bkl Aggoune, Djamel verfasserin aut Bone marrow mesenchymal stromal cell (MSC) gene profiling in chronic myeloid leukemia (CML) patients at diagnosis and in deep molecular response induced by tyrosine kinase inhibitors (TKIs) 2017 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • MSCs from CML patients exhibit a gene profiling pattern distinct from normal MSCs. • BMP1, MET, MITF, NANOG, and PDPN mRNAs are upregulated in MSCs from CML patients. • This molecular signature persists in MSCs from CML patients in molecular response. • Our results suggest the persistence of a “molecular memory” in CML microenvironment. TaqMan low-density array Elsevier Hematopoietic niche Elsevier Mesenchymal stromal cells Elsevier Chronic myeloid leukemia Elsevier Sorel, Nathalie oth Bonnet, Marie-Laure oth Goujon, Jean-Michel oth Tarte, Karin oth Hérault, Olivier oth Domenech, Jorge oth Réa, Delphine oth Legros, Laurence oth Johnson-Ansa, Hyacinthe oth Rousselot, Philippe oth Cayssials, Emilie oth Guerci-Bresler, Agnès oth Bennaceur-Griscelli, Annelise oth Chomel, Jean-Claude oth Turhan, Ali G. oth Enthalten in Elsevier Science Li, Danyang ELSEVIER N 2019 clinical and laboratory studies Amsterdam [u.a.] (DE-627)ELV002185202 volume:60 year:2017 pages:94-102 extent:9 https://doi.org/10.1016/j.leukres.2017.07.007 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA SSG-OPC-GGO 43.12 Umweltchemie VZ 43.13 Umwelttoxikologie VZ 44.13 Medizinische Ökologie VZ AR 60 2017 94-102 9 045F 610
allfields_unstemmed	10.1016/j.leukres.2017.07.007 doi GBV00000000000285A.pica (DE-627)ELV019998090 (ELSEVIER)S0145-2126(17)30472-1 DE-627 ger DE-627 rakwb eng 610 610 DE-600 333.7 610 VZ 43.12 bkl 43.13 bkl 44.13 bkl Aggoune, Djamel verfasserin aut Bone marrow mesenchymal stromal cell (MSC) gene profiling in chronic myeloid leukemia (CML) patients at diagnosis and in deep molecular response induced by tyrosine kinase inhibitors (TKIs) 2017 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • MSCs from CML patients exhibit a gene profiling pattern distinct from normal MSCs. • BMP1, MET, MITF, NANOG, and PDPN mRNAs are upregulated in MSCs from CML patients. • This molecular signature persists in MSCs from CML patients in molecular response. • Our results suggest the persistence of a “molecular memory” in CML microenvironment. TaqMan low-density array Elsevier Hematopoietic niche Elsevier Mesenchymal stromal cells Elsevier Chronic myeloid leukemia Elsevier Sorel, Nathalie oth Bonnet, Marie-Laure oth Goujon, Jean-Michel oth Tarte, Karin oth Hérault, Olivier oth Domenech, Jorge oth Réa, Delphine oth Legros, Laurence oth Johnson-Ansa, Hyacinthe oth Rousselot, Philippe oth Cayssials, Emilie oth Guerci-Bresler, Agnès oth Bennaceur-Griscelli, Annelise oth Chomel, Jean-Claude oth Turhan, Ali G. oth Enthalten in Elsevier Science Li, Danyang ELSEVIER N 2019 clinical and laboratory studies Amsterdam [u.a.] (DE-627)ELV002185202 volume:60 year:2017 pages:94-102 extent:9 https://doi.org/10.1016/j.leukres.2017.07.007 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA SSG-OPC-GGO 43.12 Umweltchemie VZ 43.13 Umwelttoxikologie VZ 44.13 Medizinische Ökologie VZ AR 60 2017 94-102 9 045F 610
allfieldsGer	10.1016/j.leukres.2017.07.007 doi GBV00000000000285A.pica (DE-627)ELV019998090 (ELSEVIER)S0145-2126(17)30472-1 DE-627 ger DE-627 rakwb eng 610 610 DE-600 333.7 610 VZ 43.12 bkl 43.13 bkl 44.13 bkl Aggoune, Djamel verfasserin aut Bone marrow mesenchymal stromal cell (MSC) gene profiling in chronic myeloid leukemia (CML) patients at diagnosis and in deep molecular response induced by tyrosine kinase inhibitors (TKIs) 2017 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • MSCs from CML patients exhibit a gene profiling pattern distinct from normal MSCs. • BMP1, MET, MITF, NANOG, and PDPN mRNAs are upregulated in MSCs from CML patients. • This molecular signature persists in MSCs from CML patients in molecular response. • Our results suggest the persistence of a “molecular memory” in CML microenvironment. TaqMan low-density array Elsevier Hematopoietic niche Elsevier Mesenchymal stromal cells Elsevier Chronic myeloid leukemia Elsevier Sorel, Nathalie oth Bonnet, Marie-Laure oth Goujon, Jean-Michel oth Tarte, Karin oth Hérault, Olivier oth Domenech, Jorge oth Réa, Delphine oth Legros, Laurence oth Johnson-Ansa, Hyacinthe oth Rousselot, Philippe oth Cayssials, Emilie oth Guerci-Bresler, Agnès oth Bennaceur-Griscelli, Annelise oth Chomel, Jean-Claude oth Turhan, Ali G. oth Enthalten in Elsevier Science Li, Danyang ELSEVIER N 2019 clinical and laboratory studies Amsterdam [u.a.] (DE-627)ELV002185202 volume:60 year:2017 pages:94-102 extent:9 https://doi.org/10.1016/j.leukres.2017.07.007 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA SSG-OPC-GGO 43.12 Umweltchemie VZ 43.13 Umwelttoxikologie VZ 44.13 Medizinische Ökologie VZ AR 60 2017 94-102 9 045F 610
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topic_title	610 610 DE-600 333.7 610 VZ 43.12 bkl 43.13 bkl 44.13 bkl Bone marrow mesenchymal stromal cell (MSC) gene profiling in chronic myeloid leukemia (CML) patients at diagnosis and in deep molecular response induced by tyrosine kinase inhibitors (TKIs) TaqMan low-density array Elsevier Hematopoietic niche Elsevier Mesenchymal stromal cells Elsevier Chronic myeloid leukemia Elsevier
topic	ddc 610 ddc 333.7 bkl 43.12 bkl 43.13 bkl 44.13 Elsevier TaqMan low-density array Elsevier Hematopoietic niche Elsevier Mesenchymal stromal cells Elsevier Chronic myeloid leukemia
topic_unstemmed	ddc 610 ddc 333.7 bkl 43.12 bkl 43.13 bkl 44.13 Elsevier TaqMan low-density array Elsevier Hematopoietic niche Elsevier Mesenchymal stromal cells Elsevier Chronic myeloid leukemia
topic_browse	ddc 610 ddc 333.7 bkl 43.12 bkl 43.13 bkl 44.13 Elsevier TaqMan low-density array Elsevier Hematopoietic niche Elsevier Mesenchymal stromal cells Elsevier Chronic myeloid leukemia
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title	Bone marrow mesenchymal stromal cell (MSC) gene profiling in chronic myeloid leukemia (CML) patients at diagnosis and in deep molecular response induced by tyrosine kinase inhibitors (TKIs)
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title_full	Bone marrow mesenchymal stromal cell (MSC) gene profiling in chronic myeloid leukemia (CML) patients at diagnosis and in deep molecular response induced by tyrosine kinase inhibitors (TKIs)
author_sort	Aggoune, Djamel
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author_browse	Aggoune, Djamel
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author-letter	Aggoune, Djamel
doi_str_mv	10.1016/j.leukres.2017.07.007
dewey-full	610 333.7
title_sort	bone marrow mesenchymal stromal cell (msc) gene profiling in chronic myeloid leukemia (cml) patients at diagnosis and in deep molecular response induced by tyrosine kinase inhibitors (tkis)
title_auth	Bone marrow mesenchymal stromal cell (MSC) gene profiling in chronic myeloid leukemia (CML) patients at diagnosis and in deep molecular response induced by tyrosine kinase inhibitors (TKIs)
abstract	• MSCs from CML patients exhibit a gene profiling pattern distinct from normal MSCs. • BMP1, MET, MITF, NANOG, and PDPN mRNAs are upregulated in MSCs from CML patients. • This molecular signature persists in MSCs from CML patients in molecular response. • Our results suggest the persistence of a “molecular memory” in CML microenvironment.
abstractGer	• MSCs from CML patients exhibit a gene profiling pattern distinct from normal MSCs. • BMP1, MET, MITF, NANOG, and PDPN mRNAs are upregulated in MSCs from CML patients. • This molecular signature persists in MSCs from CML patients in molecular response. • Our results suggest the persistence of a “molecular memory” in CML microenvironment.
abstract_unstemmed	• MSCs from CML patients exhibit a gene profiling pattern distinct from normal MSCs. • BMP1, MET, MITF, NANOG, and PDPN mRNAs are upregulated in MSCs from CML patients. • This molecular signature persists in MSCs from CML patients in molecular response. • Our results suggest the persistence of a “molecular memory” in CML microenvironment.
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title_short	Bone marrow mesenchymal stromal cell (MSC) gene profiling in chronic myeloid leukemia (CML) patients at diagnosis and in deep molecular response induced by tyrosine kinase inhibitors (TKIs)
url	https://doi.org/10.1016/j.leukres.2017.07.007
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author2	Sorel, Nathalie Bonnet, Marie-Laure Goujon, Jean-Michel Tarte, Karin Hérault, Olivier Domenech, Jorge Réa, Delphine Legros, Laurence Johnson-Ansa, Hyacinthe Rousselot, Philippe Cayssials, Emilie Guerci-Bresler, Agnès Bennaceur-Griscelli, Annelise Chomel, Jean-Claude Turhan, Ali G.
author2Str	Sorel, Nathalie Bonnet, Marie-Laure Goujon, Jean-Michel Tarte, Karin Hérault, Olivier Domenech, Jorge Réa, Delphine Legros, Laurence Johnson-Ansa, Hyacinthe Rousselot, Philippe Cayssials, Emilie Guerci-Bresler, Agnès Bennaceur-Griscelli, Annelise Chomel, Jean-Claude Turhan, Ali G.
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doi_str	10.1016/j.leukres.2017.07.007
up_date	2024-07-06T22:57:05.799Z
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