Pharmacokinetic evaluation of intrapleural perfusion with hyperthermic chemotherapy using cisplatin in patients with malignant pleural effusion
• Intrapleural perfusion with hyperthermic chemotherapy (IPHC) using CDDP 80mg/m2 for 1h at 43°C was developed for malignant pleural effusion. • In this study, pharmacokinetic and pharmacodynamics evaluations were performed. • AUC of free platinum in the pleural space was 26.3μg/mLxh, which was much...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Sakaguchi, Hirozo [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2017transfer abstract |
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| Schlagwörter: |
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| Umfang: |
5 |
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| Übergeordnetes Werk: |
Enthalten in: Extrinsic factors rather than seed traits mediate strong spatial variation in seed predation - Garrote, Pedro J. ELSEVIER, 2019, journal of the International Association for the Study of Lung Cancer, Amsterdam [u.a.] |
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| Übergeordnetes Werk: |
volume:104 ; year:2017 ; pages:70-74 ; extent:5 |
| Links: |
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| DOI / URN: |
10.1016/j.lungcan.2016.12.015 |
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| 520 | |a • Intrapleural perfusion with hyperthermic chemotherapy (IPHC) using CDDP 80mg/m2 for 1h at 43°C was developed for malignant pleural effusion. • In this study, pharmacokinetic and pharmacodynamics evaluations were performed. • AUC of free platinum in the pleural space was 26.3μg/mLxh, which was much higher than administrating CDDP 80mg/m2 intravenously. This high AUC value and hyperthermic chemotherapy produced complete control of pleural effusion for 3 months after IHPC in all cases. • While, absorption rate of total platinum from the pleural space to the body was 33.8±17.0%, resulting in controllable side effects. | ||
| 520 | |a • Intrapleural perfusion with hyperthermic chemotherapy (IPHC) using CDDP 80mg/m2 for 1h at 43°C was developed for malignant pleural effusion. • In this study, pharmacokinetic and pharmacodynamics evaluations were performed. • AUC of free platinum in the pleural space was 26.3μg/mLxh, which was much higher than administrating CDDP 80mg/m2 intravenously. This high AUC value and hyperthermic chemotherapy produced complete control of pleural effusion for 3 months after IHPC in all cases. • While, absorption rate of total platinum from the pleural space to the body was 33.8±17.0%, resulting in controllable side effects. | ||
| 650 | 7 | |a Lung cancer |2 Elsevier | |
| 650 | 7 | |a Mesothelioma |2 Elsevier | |
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| 650 | 7 | |a Intrapleural perfusion with hyperthermic chemotherapy |2 Elsevier | |
| 650 | 7 | |a Cisplatin |2 Elsevier | |
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10.1016/j.lungcan.2016.12.015 doi GBVA2017006000021.pica (DE-627)ELV020107013 (ELSEVIER)S0169-5002(16)30582-7 DE-627 ger DE-627 rakwb eng 610 610 DE-600 Sakaguchi, Hirozo verfasserin aut Pharmacokinetic evaluation of intrapleural perfusion with hyperthermic chemotherapy using cisplatin in patients with malignant pleural effusion 2017transfer abstract 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • Intrapleural perfusion with hyperthermic chemotherapy (IPHC) using CDDP 80mg/m2 for 1h at 43°C was developed for malignant pleural effusion. • In this study, pharmacokinetic and pharmacodynamics evaluations were performed. • AUC of free platinum in the pleural space was 26.3μg/mLxh, which was much higher than administrating CDDP 80mg/m2 intravenously. This high AUC value and hyperthermic chemotherapy produced complete control of pleural effusion for 3 months after IHPC in all cases. • While, absorption rate of total platinum from the pleural space to the body was 33.8±17.0%, resulting in controllable side effects. • Intrapleural perfusion with hyperthermic chemotherapy (IPHC) using CDDP 80mg/m2 for 1h at 43°C was developed for malignant pleural effusion. • In this study, pharmacokinetic and pharmacodynamics evaluations were performed. • AUC of free platinum in the pleural space was 26.3μg/mLxh, which was much higher than administrating CDDP 80mg/m2 intravenously. This high AUC value and hyperthermic chemotherapy produced complete control of pleural effusion for 3 months after IHPC in all cases. • While, absorption rate of total platinum from the pleural space to the body was 33.8±17.0%, resulting in controllable side effects. Lung cancer Elsevier Mesothelioma Elsevier Pharmacokinetics Elsevier Intrapleural perfusion with hyperthermic chemotherapy Elsevier Cisplatin Elsevier Ishida, H. oth Nitanda, H. oth Yamazaki, N. oth Kaneko, K. oth Kobayashi, Kunihiko oth Enthalten in Elsevier Garrote, Pedro J. ELSEVIER Extrinsic factors rather than seed traits mediate strong spatial variation in seed predation 2019 journal of the International Association for the Study of Lung Cancer Amsterdam [u.a.] (DE-627)ELV002331438 volume:104 year:2017 pages:70-74 extent:5 https://doi.org/10.1016/j.lungcan.2016.12.015 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U AR 104 2017 70-74 5 045F 610 |
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10.1016/j.lungcan.2016.12.015 doi GBVA2017006000021.pica (DE-627)ELV020107013 (ELSEVIER)S0169-5002(16)30582-7 DE-627 ger DE-627 rakwb eng 610 610 DE-600 Sakaguchi, Hirozo verfasserin aut Pharmacokinetic evaluation of intrapleural perfusion with hyperthermic chemotherapy using cisplatin in patients with malignant pleural effusion 2017transfer abstract 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • Intrapleural perfusion with hyperthermic chemotherapy (IPHC) using CDDP 80mg/m2 for 1h at 43°C was developed for malignant pleural effusion. • In this study, pharmacokinetic and pharmacodynamics evaluations were performed. • AUC of free platinum in the pleural space was 26.3μg/mLxh, which was much higher than administrating CDDP 80mg/m2 intravenously. This high AUC value and hyperthermic chemotherapy produced complete control of pleural effusion for 3 months after IHPC in all cases. • While, absorption rate of total platinum from the pleural space to the body was 33.8±17.0%, resulting in controllable side effects. • Intrapleural perfusion with hyperthermic chemotherapy (IPHC) using CDDP 80mg/m2 for 1h at 43°C was developed for malignant pleural effusion. • In this study, pharmacokinetic and pharmacodynamics evaluations were performed. • AUC of free platinum in the pleural space was 26.3μg/mLxh, which was much higher than administrating CDDP 80mg/m2 intravenously. This high AUC value and hyperthermic chemotherapy produced complete control of pleural effusion for 3 months after IHPC in all cases. • While, absorption rate of total platinum from the pleural space to the body was 33.8±17.0%, resulting in controllable side effects. Lung cancer Elsevier Mesothelioma Elsevier Pharmacokinetics Elsevier Intrapleural perfusion with hyperthermic chemotherapy Elsevier Cisplatin Elsevier Ishida, H. oth Nitanda, H. oth Yamazaki, N. oth Kaneko, K. oth Kobayashi, Kunihiko oth Enthalten in Elsevier Garrote, Pedro J. ELSEVIER Extrinsic factors rather than seed traits mediate strong spatial variation in seed predation 2019 journal of the International Association for the Study of Lung Cancer Amsterdam [u.a.] (DE-627)ELV002331438 volume:104 year:2017 pages:70-74 extent:5 https://doi.org/10.1016/j.lungcan.2016.12.015 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U AR 104 2017 70-74 5 045F 610 |
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10.1016/j.lungcan.2016.12.015 doi GBVA2017006000021.pica (DE-627)ELV020107013 (ELSEVIER)S0169-5002(16)30582-7 DE-627 ger DE-627 rakwb eng 610 610 DE-600 Sakaguchi, Hirozo verfasserin aut Pharmacokinetic evaluation of intrapleural perfusion with hyperthermic chemotherapy using cisplatin in patients with malignant pleural effusion 2017transfer abstract 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • Intrapleural perfusion with hyperthermic chemotherapy (IPHC) using CDDP 80mg/m2 for 1h at 43°C was developed for malignant pleural effusion. • In this study, pharmacokinetic and pharmacodynamics evaluations were performed. • AUC of free platinum in the pleural space was 26.3μg/mLxh, which was much higher than administrating CDDP 80mg/m2 intravenously. This high AUC value and hyperthermic chemotherapy produced complete control of pleural effusion for 3 months after IHPC in all cases. • While, absorption rate of total platinum from the pleural space to the body was 33.8±17.0%, resulting in controllable side effects. • Intrapleural perfusion with hyperthermic chemotherapy (IPHC) using CDDP 80mg/m2 for 1h at 43°C was developed for malignant pleural effusion. • In this study, pharmacokinetic and pharmacodynamics evaluations were performed. • AUC of free platinum in the pleural space was 26.3μg/mLxh, which was much higher than administrating CDDP 80mg/m2 intravenously. This high AUC value and hyperthermic chemotherapy produced complete control of pleural effusion for 3 months after IHPC in all cases. • While, absorption rate of total platinum from the pleural space to the body was 33.8±17.0%, resulting in controllable side effects. Lung cancer Elsevier Mesothelioma Elsevier Pharmacokinetics Elsevier Intrapleural perfusion with hyperthermic chemotherapy Elsevier Cisplatin Elsevier Ishida, H. oth Nitanda, H. oth Yamazaki, N. oth Kaneko, K. oth Kobayashi, Kunihiko oth Enthalten in Elsevier Garrote, Pedro J. ELSEVIER Extrinsic factors rather than seed traits mediate strong spatial variation in seed predation 2019 journal of the International Association for the Study of Lung Cancer Amsterdam [u.a.] (DE-627)ELV002331438 volume:104 year:2017 pages:70-74 extent:5 https://doi.org/10.1016/j.lungcan.2016.12.015 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U AR 104 2017 70-74 5 045F 610 |
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10.1016/j.lungcan.2016.12.015 doi GBVA2017006000021.pica (DE-627)ELV020107013 (ELSEVIER)S0169-5002(16)30582-7 DE-627 ger DE-627 rakwb eng 610 610 DE-600 Sakaguchi, Hirozo verfasserin aut Pharmacokinetic evaluation of intrapleural perfusion with hyperthermic chemotherapy using cisplatin in patients with malignant pleural effusion 2017transfer abstract 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • Intrapleural perfusion with hyperthermic chemotherapy (IPHC) using CDDP 80mg/m2 for 1h at 43°C was developed for malignant pleural effusion. • In this study, pharmacokinetic and pharmacodynamics evaluations were performed. • AUC of free platinum in the pleural space was 26.3μg/mLxh, which was much higher than administrating CDDP 80mg/m2 intravenously. This high AUC value and hyperthermic chemotherapy produced complete control of pleural effusion for 3 months after IHPC in all cases. • While, absorption rate of total platinum from the pleural space to the body was 33.8±17.0%, resulting in controllable side effects. • Intrapleural perfusion with hyperthermic chemotherapy (IPHC) using CDDP 80mg/m2 for 1h at 43°C was developed for malignant pleural effusion. • In this study, pharmacokinetic and pharmacodynamics evaluations were performed. • AUC of free platinum in the pleural space was 26.3μg/mLxh, which was much higher than administrating CDDP 80mg/m2 intravenously. This high AUC value and hyperthermic chemotherapy produced complete control of pleural effusion for 3 months after IHPC in all cases. • While, absorption rate of total platinum from the pleural space to the body was 33.8±17.0%, resulting in controllable side effects. Lung cancer Elsevier Mesothelioma Elsevier Pharmacokinetics Elsevier Intrapleural perfusion with hyperthermic chemotherapy Elsevier Cisplatin Elsevier Ishida, H. oth Nitanda, H. oth Yamazaki, N. oth Kaneko, K. oth Kobayashi, Kunihiko oth Enthalten in Elsevier Garrote, Pedro J. ELSEVIER Extrinsic factors rather than seed traits mediate strong spatial variation in seed predation 2019 journal of the International Association for the Study of Lung Cancer Amsterdam [u.a.] (DE-627)ELV002331438 volume:104 year:2017 pages:70-74 extent:5 https://doi.org/10.1016/j.lungcan.2016.12.015 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U AR 104 2017 70-74 5 045F 610 |
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10.1016/j.lungcan.2016.12.015 doi GBVA2017006000021.pica (DE-627)ELV020107013 (ELSEVIER)S0169-5002(16)30582-7 DE-627 ger DE-627 rakwb eng 610 610 DE-600 Sakaguchi, Hirozo verfasserin aut Pharmacokinetic evaluation of intrapleural perfusion with hyperthermic chemotherapy using cisplatin in patients with malignant pleural effusion 2017transfer abstract 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • Intrapleural perfusion with hyperthermic chemotherapy (IPHC) using CDDP 80mg/m2 for 1h at 43°C was developed for malignant pleural effusion. • In this study, pharmacokinetic and pharmacodynamics evaluations were performed. • AUC of free platinum in the pleural space was 26.3μg/mLxh, which was much higher than administrating CDDP 80mg/m2 intravenously. This high AUC value and hyperthermic chemotherapy produced complete control of pleural effusion for 3 months after IHPC in all cases. • While, absorption rate of total platinum from the pleural space to the body was 33.8±17.0%, resulting in controllable side effects. • Intrapleural perfusion with hyperthermic chemotherapy (IPHC) using CDDP 80mg/m2 for 1h at 43°C was developed for malignant pleural effusion. • In this study, pharmacokinetic and pharmacodynamics evaluations were performed. • AUC of free platinum in the pleural space was 26.3μg/mLxh, which was much higher than administrating CDDP 80mg/m2 intravenously. This high AUC value and hyperthermic chemotherapy produced complete control of pleural effusion for 3 months after IHPC in all cases. • While, absorption rate of total platinum from the pleural space to the body was 33.8±17.0%, resulting in controllable side effects. Lung cancer Elsevier Mesothelioma Elsevier Pharmacokinetics Elsevier Intrapleural perfusion with hyperthermic chemotherapy Elsevier Cisplatin Elsevier Ishida, H. oth Nitanda, H. oth Yamazaki, N. oth Kaneko, K. oth Kobayashi, Kunihiko oth Enthalten in Elsevier Garrote, Pedro J. ELSEVIER Extrinsic factors rather than seed traits mediate strong spatial variation in seed predation 2019 journal of the International Association for the Study of Lung Cancer Amsterdam [u.a.] (DE-627)ELV002331438 volume:104 year:2017 pages:70-74 extent:5 https://doi.org/10.1016/j.lungcan.2016.12.015 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U AR 104 2017 70-74 5 045F 610 |
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Extrinsic factors rather than seed traits mediate strong spatial variation in seed predation |
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Sakaguchi, Hirozo |
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Sakaguchi, Hirozo |
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10.1016/j.lungcan.2016.12.015 |
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pharmacokinetic evaluation of intrapleural perfusion with hyperthermic chemotherapy using cisplatin in patients with malignant pleural effusion |
| title_auth |
Pharmacokinetic evaluation of intrapleural perfusion with hyperthermic chemotherapy using cisplatin in patients with malignant pleural effusion |
| abstract |
• Intrapleural perfusion with hyperthermic chemotherapy (IPHC) using CDDP 80mg/m2 for 1h at 43°C was developed for malignant pleural effusion. • In this study, pharmacokinetic and pharmacodynamics evaluations were performed. • AUC of free platinum in the pleural space was 26.3μg/mLxh, which was much higher than administrating CDDP 80mg/m2 intravenously. This high AUC value and hyperthermic chemotherapy produced complete control of pleural effusion for 3 months after IHPC in all cases. • While, absorption rate of total platinum from the pleural space to the body was 33.8±17.0%, resulting in controllable side effects. |
| abstractGer |
• Intrapleural perfusion with hyperthermic chemotherapy (IPHC) using CDDP 80mg/m2 for 1h at 43°C was developed for malignant pleural effusion. • In this study, pharmacokinetic and pharmacodynamics evaluations were performed. • AUC of free platinum in the pleural space was 26.3μg/mLxh, which was much higher than administrating CDDP 80mg/m2 intravenously. This high AUC value and hyperthermic chemotherapy produced complete control of pleural effusion for 3 months after IHPC in all cases. • While, absorption rate of total platinum from the pleural space to the body was 33.8±17.0%, resulting in controllable side effects. |
| abstract_unstemmed |
• Intrapleural perfusion with hyperthermic chemotherapy (IPHC) using CDDP 80mg/m2 for 1h at 43°C was developed for malignant pleural effusion. • In this study, pharmacokinetic and pharmacodynamics evaluations were performed. • AUC of free platinum in the pleural space was 26.3μg/mLxh, which was much higher than administrating CDDP 80mg/m2 intravenously. This high AUC value and hyperthermic chemotherapy produced complete control of pleural effusion for 3 months after IHPC in all cases. • While, absorption rate of total platinum from the pleural space to the body was 33.8±17.0%, resulting in controllable side effects. |
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| title_short |
Pharmacokinetic evaluation of intrapleural perfusion with hyperthermic chemotherapy using cisplatin in patients with malignant pleural effusion |
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https://doi.org/10.1016/j.lungcan.2016.12.015 |
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Ishida, H. Nitanda, H. Yamazaki, N. Kaneko, K. Kobayashi, Kunihiko |
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Ishida, H. Nitanda, H. Yamazaki, N. Kaneko, K. Kobayashi, Kunihiko |
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2024-07-06T16:43:08.073Z |
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