A biophysical approach to quantify skeletal stem cells trans-differentiation as a model for the study of osteoporosis
The stroma of human bone marrow contains a population of skeletal stem cells (hBM-MSC) which are common ancestors, among the others, of osteoblasts and adipocytes. It has been proposed that the imbalance between hBM-MSC osteogenesis and adipogenesis, which naturally accompanies bone marrow senescenc...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Petecchia, L. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2017transfer abstract |
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9 |
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Enthalten in: “We can and should do better” - an interview with the 2020 Nobel prize laureates who revolutionized hepatology - Baumert, Thomas F. ELSEVIER, 2021, an international journal devoted to the physics and chemistry of biological phenomena, Amsterdam [u.a.] |
|---|---|
| Übergeordnetes Werk: |
volume:229 ; year:2017 ; pages:84-92 ; extent:9 |
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10.1016/j.bpc.2017.05.011 |
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| 520 | |a The stroma of human bone marrow contains a population of skeletal stem cells (hBM-MSC) which are common ancestors, among the others, of osteoblasts and adipocytes. It has been proposed that the imbalance between hBM-MSC osteogenesis and adipogenesis, which naturally accompanies bone marrow senescence, may contribute to the development of bone-associated diseases, like osteoporosis. The possibility to reproduce this mechanism in vitro has been demonstrated, providing a good model to disclose the details of the complex bone-fat generation homeostasis. Nevertheless, the lack of a simple approach to quantitatively assess the actual stage of a cellular population hindered the adoption of this in vitro model. | ||
| 520 | |a The stroma of human bone marrow contains a population of skeletal stem cells (hBM-MSC) which are common ancestors, among the others, of osteoblasts and adipocytes. It has been proposed that the imbalance between hBM-MSC osteogenesis and adipogenesis, which naturally accompanies bone marrow senescence, may contribute to the development of bone-associated diseases, like osteoporosis. The possibility to reproduce this mechanism in vitro has been demonstrated, providing a good model to disclose the details of the complex bone-fat generation homeostasis. Nevertheless, the lack of a simple approach to quantitatively assess the actual stage of a cellular population hindered the adoption of this in vitro model. | ||
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10.1016/j.bpc.2017.05.011 doi GBVA2017009000003.pica (DE-627)ELV020198973 (ELSEVIER)S0301-4622(17)30123-0 DE-627 ger DE-627 rakwb eng 540 540 DE-600 610 VZ 44.87 bkl Petecchia, L. verfasserin aut A biophysical approach to quantify skeletal stem cells trans-differentiation as a model for the study of osteoporosis 2017transfer abstract 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The stroma of human bone marrow contains a population of skeletal stem cells (hBM-MSC) which are common ancestors, among the others, of osteoblasts and adipocytes. It has been proposed that the imbalance between hBM-MSC osteogenesis and adipogenesis, which naturally accompanies bone marrow senescence, may contribute to the development of bone-associated diseases, like osteoporosis. The possibility to reproduce this mechanism in vitro has been demonstrated, providing a good model to disclose the details of the complex bone-fat generation homeostasis. Nevertheless, the lack of a simple approach to quantitatively assess the actual stage of a cellular population hindered the adoption of this in vitro model. The stroma of human bone marrow contains a population of skeletal stem cells (hBM-MSC) which are common ancestors, among the others, of osteoblasts and adipocytes. It has been proposed that the imbalance between hBM-MSC osteogenesis and adipogenesis, which naturally accompanies bone marrow senescence, may contribute to the development of bone-associated diseases, like osteoporosis. The possibility to reproduce this mechanism in vitro has been demonstrated, providing a good model to disclose the details of the complex bone-fat generation homeostasis. Nevertheless, the lack of a simple approach to quantitatively assess the actual stage of a cellular population hindered the adoption of this in vitro model. Viti, F. oth Sbrana, F. oth Vassalli, M. oth Gavazzo, P. oth Enthalten in Elsevier Science Baumert, Thomas F. ELSEVIER “We can and should do better” - an interview with the 2020 Nobel prize laureates who revolutionized hepatology 2021 an international journal devoted to the physics and chemistry of biological phenomena Amsterdam [u.a.] (DE-627)ELV006315437 volume:229 year:2017 pages:84-92 extent:9 https://doi.org/10.1016/j.bpc.2017.05.011 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.87 Gastroenterologie VZ AR 229 2017 84-92 9 045F 540 |
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A biophysical approach to quantify skeletal stem cells trans-differentiation as a model for the study of osteoporosis |
| abstract |
The stroma of human bone marrow contains a population of skeletal stem cells (hBM-MSC) which are common ancestors, among the others, of osteoblasts and adipocytes. It has been proposed that the imbalance between hBM-MSC osteogenesis and adipogenesis, which naturally accompanies bone marrow senescence, may contribute to the development of bone-associated diseases, like osteoporosis. The possibility to reproduce this mechanism in vitro has been demonstrated, providing a good model to disclose the details of the complex bone-fat generation homeostasis. Nevertheless, the lack of a simple approach to quantitatively assess the actual stage of a cellular population hindered the adoption of this in vitro model. |
| abstractGer |
The stroma of human bone marrow contains a population of skeletal stem cells (hBM-MSC) which are common ancestors, among the others, of osteoblasts and adipocytes. It has been proposed that the imbalance between hBM-MSC osteogenesis and adipogenesis, which naturally accompanies bone marrow senescence, may contribute to the development of bone-associated diseases, like osteoporosis. The possibility to reproduce this mechanism in vitro has been demonstrated, providing a good model to disclose the details of the complex bone-fat generation homeostasis. Nevertheless, the lack of a simple approach to quantitatively assess the actual stage of a cellular population hindered the adoption of this in vitro model. |
| abstract_unstemmed |
The stroma of human bone marrow contains a population of skeletal stem cells (hBM-MSC) which are common ancestors, among the others, of osteoblasts and adipocytes. It has been proposed that the imbalance between hBM-MSC osteogenesis and adipogenesis, which naturally accompanies bone marrow senescence, may contribute to the development of bone-associated diseases, like osteoporosis. The possibility to reproduce this mechanism in vitro has been demonstrated, providing a good model to disclose the details of the complex bone-fat generation homeostasis. Nevertheless, the lack of a simple approach to quantitatively assess the actual stage of a cellular population hindered the adoption of this in vitro model. |
| collection_details |
GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA |
| title_short |
A biophysical approach to quantify skeletal stem cells trans-differentiation as a model for the study of osteoporosis |
| url |
https://doi.org/10.1016/j.bpc.2017.05.011 |
| remote_bool |
true |
| author2 |
Viti, F. Sbrana, F. Vassalli, M. Gavazzo, P. |
| author2Str |
Viti, F. Sbrana, F. Vassalli, M. Gavazzo, P. |
| ppnlink |
ELV006315437 |
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| hochschulschrift_bool |
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| author2_role |
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| doi_str |
10.1016/j.bpc.2017.05.011 |
| up_date |
2024-07-06T16:58:37.549Z |
| _version_ |
1803849687420108800 |
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7.399642 |