Study the influence of licorice and pomegranate drinks on nicotine metabolism in human urine by LC-orbitrap MS
Nicotine-diet interactions have a particular importance on human health. Some food substances are subject to change hepatic CYP2A6 metabolism rate for nicotine and its levels in smokers consequently. This study investigates the effect of pomegranate and licorice drinks on nicotine metabolism, by a n...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Abu-awwad, Ahmad [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2017transfer abstract |
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| Schlagwörter: |
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| Umfang: |
6 |
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| Übergeordnetes Werk: |
Enthalten in: Monitoring the changes in physicochemical, sensory properties and microbiota of village-type homemade yoghurts along three consecutive back-slopping procedures - Gölbaşι, Gülcan ELSEVIER, 2023, the official analytical journal of the American Association of Pharmaceutical Scientists, New York, NY [u.a.] |
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| Übergeordnetes Werk: |
volume:132 ; year:2017 ; day:5 ; month:01 ; pages:60-65 ; extent:6 |
| Links: |
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| DOI / URN: |
10.1016/j.jpba.2016.09.026 |
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| 245 | 1 | 0 | |a Study the influence of licorice and pomegranate drinks on nicotine metabolism in human urine by LC-orbitrap MS |
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| 520 | |a Nicotine-diet interactions have a particular importance on human health. Some food substances are subject to change hepatic CYP2A6 metabolism rate for nicotine and its levels in smokers consequently. This study investigates the effect of pomegranate and licorice drinks on nicotine metabolism, by a new developed and validated method for simultaneous determination of nicotine with its major metabolites (cotinine and nicotine N-oxide) in human urine, utilizing LC ESI-orbitrap-MS. Twenty-four Jordanian healthy and smoker volunteers were participated in two equal groups, crossover design for each of pomegranate and licorice test drink. In the study periods each group assigned either to drink test juice three times a day or to be avoided from test drink for 7 successive days, and then both groups switched their drink treatment in subsequent period. Early morning urine samples were collected from all volunteers after each period. Nicotine metabolism rate was evaluated from nicotine/cotinine and nicotine/nicotine N-oxide ratios in urine. A consistent trend of increase in metabolism rate for nicotine was observed from urine analysis under pomegranate or licorice drink conditions compared to control conditions. Pomegranate and licorice drinks are increasing the metabolism rate for nicotine in terms of induction effect for hepatic cytochrome p450 enzymes. | ||
| 520 | |a Nicotine-diet interactions have a particular importance on human health. Some food substances are subject to change hepatic CYP2A6 metabolism rate for nicotine and its levels in smokers consequently. This study investigates the effect of pomegranate and licorice drinks on nicotine metabolism, by a new developed and validated method for simultaneous determination of nicotine with its major metabolites (cotinine and nicotine N-oxide) in human urine, utilizing LC ESI-orbitrap-MS. Twenty-four Jordanian healthy and smoker volunteers were participated in two equal groups, crossover design for each of pomegranate and licorice test drink. In the study periods each group assigned either to drink test juice three times a day or to be avoided from test drink for 7 successive days, and then both groups switched their drink treatment in subsequent period. Early morning urine samples were collected from all volunteers after each period. Nicotine metabolism rate was evaluated from nicotine/cotinine and nicotine/nicotine N-oxide ratios in urine. A consistent trend of increase in metabolism rate for nicotine was observed from urine analysis under pomegranate or licorice drink conditions compared to control conditions. Pomegranate and licorice drinks are increasing the metabolism rate for nicotine in terms of induction effect for hepatic cytochrome p450 enzymes. | ||
| 650 | 7 | |a Induction effect |2 Elsevier | |
| 650 | 7 | |a Human urine |2 Elsevier | |
| 650 | 7 | |a Nicotine metabolism |2 Elsevier | |
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| 650 | 7 | |a Licorice |2 Elsevier | |
| 650 | 7 | |a Pomegranate |2 Elsevier | |
| 700 | 1 | |a Arafat, Tawfiq |4 oth | |
| 700 | 1 | |a Schmitz, Oliver J. |4 oth | |
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10.1016/j.jpba.2016.09.026 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001907.pica (DE-627)ELV020321317 (ELSEVIER)S0731-7085(16)30698-7 DE-627 ger DE-627 rakwb eng 630 640 VZ 58.34 bkl 48.61 bkl Abu-awwad, Ahmad verfasserin aut Study the influence of licorice and pomegranate drinks on nicotine metabolism in human urine by LC-orbitrap MS 2017transfer abstract 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Nicotine-diet interactions have a particular importance on human health. Some food substances are subject to change hepatic CYP2A6 metabolism rate for nicotine and its levels in smokers consequently. This study investigates the effect of pomegranate and licorice drinks on nicotine metabolism, by a new developed and validated method for simultaneous determination of nicotine with its major metabolites (cotinine and nicotine N-oxide) in human urine, utilizing LC ESI-orbitrap-MS. Twenty-four Jordanian healthy and smoker volunteers were participated in two equal groups, crossover design for each of pomegranate and licorice test drink. In the study periods each group assigned either to drink test juice three times a day or to be avoided from test drink for 7 successive days, and then both groups switched their drink treatment in subsequent period. Early morning urine samples were collected from all volunteers after each period. Nicotine metabolism rate was evaluated from nicotine/cotinine and nicotine/nicotine N-oxide ratios in urine. A consistent trend of increase in metabolism rate for nicotine was observed from urine analysis under pomegranate or licorice drink conditions compared to control conditions. Pomegranate and licorice drinks are increasing the metabolism rate for nicotine in terms of induction effect for hepatic cytochrome p450 enzymes. Nicotine-diet interactions have a particular importance on human health. Some food substances are subject to change hepatic CYP2A6 metabolism rate for nicotine and its levels in smokers consequently. This study investigates the effect of pomegranate and licorice drinks on nicotine metabolism, by a new developed and validated method for simultaneous determination of nicotine with its major metabolites (cotinine and nicotine N-oxide) in human urine, utilizing LC ESI-orbitrap-MS. Twenty-four Jordanian healthy and smoker volunteers were participated in two equal groups, crossover design for each of pomegranate and licorice test drink. In the study periods each group assigned either to drink test juice three times a day or to be avoided from test drink for 7 successive days, and then both groups switched their drink treatment in subsequent period. Early morning urine samples were collected from all volunteers after each period. Nicotine metabolism rate was evaluated from nicotine/cotinine and nicotine/nicotine N-oxide ratios in urine. A consistent trend of increase in metabolism rate for nicotine was observed from urine analysis under pomegranate or licorice drink conditions compared to control conditions. Pomegranate and licorice drinks are increasing the metabolism rate for nicotine in terms of induction effect for hepatic cytochrome p450 enzymes. Induction effect Elsevier Human urine Elsevier Nicotine metabolism Elsevier LC-orbitrap MS Elsevier Licorice Elsevier Pomegranate Elsevier Arafat, Tawfiq oth Schmitz, Oliver J. oth Enthalten in Science Direct Gölbaşι, Gülcan ELSEVIER Monitoring the changes in physicochemical, sensory properties and microbiota of village-type homemade yoghurts along three consecutive back-slopping procedures 2023 the official analytical journal of the American Association of Pharmaceutical Scientists New York, NY [u.a.] (DE-627)ELV009872493 volume:132 year:2017 day:5 month:01 pages:60-65 extent:6 https://doi.org/10.1016/j.jpba.2016.09.026 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 58.34 Lebensmitteltechnologie VZ 48.61 Tierernährung Tierfutter VZ AR 132 2017 5 0105 60-65 6 |
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10.1016/j.jpba.2016.09.026 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001907.pica (DE-627)ELV020321317 (ELSEVIER)S0731-7085(16)30698-7 DE-627 ger DE-627 rakwb eng 630 640 VZ 58.34 bkl 48.61 bkl Abu-awwad, Ahmad verfasserin aut Study the influence of licorice and pomegranate drinks on nicotine metabolism in human urine by LC-orbitrap MS 2017transfer abstract 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Nicotine-diet interactions have a particular importance on human health. Some food substances are subject to change hepatic CYP2A6 metabolism rate for nicotine and its levels in smokers consequently. This study investigates the effect of pomegranate and licorice drinks on nicotine metabolism, by a new developed and validated method for simultaneous determination of nicotine with its major metabolites (cotinine and nicotine N-oxide) in human urine, utilizing LC ESI-orbitrap-MS. Twenty-four Jordanian healthy and smoker volunteers were participated in two equal groups, crossover design for each of pomegranate and licorice test drink. In the study periods each group assigned either to drink test juice three times a day or to be avoided from test drink for 7 successive days, and then both groups switched their drink treatment in subsequent period. Early morning urine samples were collected from all volunteers after each period. Nicotine metabolism rate was evaluated from nicotine/cotinine and nicotine/nicotine N-oxide ratios in urine. A consistent trend of increase in metabolism rate for nicotine was observed from urine analysis under pomegranate or licorice drink conditions compared to control conditions. Pomegranate and licorice drinks are increasing the metabolism rate for nicotine in terms of induction effect for hepatic cytochrome p450 enzymes. Nicotine-diet interactions have a particular importance on human health. Some food substances are subject to change hepatic CYP2A6 metabolism rate for nicotine and its levels in smokers consequently. This study investigates the effect of pomegranate and licorice drinks on nicotine metabolism, by a new developed and validated method for simultaneous determination of nicotine with its major metabolites (cotinine and nicotine N-oxide) in human urine, utilizing LC ESI-orbitrap-MS. Twenty-four Jordanian healthy and smoker volunteers were participated in two equal groups, crossover design for each of pomegranate and licorice test drink. In the study periods each group assigned either to drink test juice three times a day or to be avoided from test drink for 7 successive days, and then both groups switched their drink treatment in subsequent period. Early morning urine samples were collected from all volunteers after each period. Nicotine metabolism rate was evaluated from nicotine/cotinine and nicotine/nicotine N-oxide ratios in urine. A consistent trend of increase in metabolism rate for nicotine was observed from urine analysis under pomegranate or licorice drink conditions compared to control conditions. Pomegranate and licorice drinks are increasing the metabolism rate for nicotine in terms of induction effect for hepatic cytochrome p450 enzymes. Induction effect Elsevier Human urine Elsevier Nicotine metabolism Elsevier LC-orbitrap MS Elsevier Licorice Elsevier Pomegranate Elsevier Arafat, Tawfiq oth Schmitz, Oliver J. oth Enthalten in Science Direct Gölbaşι, Gülcan ELSEVIER Monitoring the changes in physicochemical, sensory properties and microbiota of village-type homemade yoghurts along three consecutive back-slopping procedures 2023 the official analytical journal of the American Association of Pharmaceutical Scientists New York, NY [u.a.] (DE-627)ELV009872493 volume:132 year:2017 day:5 month:01 pages:60-65 extent:6 https://doi.org/10.1016/j.jpba.2016.09.026 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 58.34 Lebensmitteltechnologie VZ 48.61 Tierernährung Tierfutter VZ AR 132 2017 5 0105 60-65 6 |
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10.1016/j.jpba.2016.09.026 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001907.pica (DE-627)ELV020321317 (ELSEVIER)S0731-7085(16)30698-7 DE-627 ger DE-627 rakwb eng 630 640 VZ 58.34 bkl 48.61 bkl Abu-awwad, Ahmad verfasserin aut Study the influence of licorice and pomegranate drinks on nicotine metabolism in human urine by LC-orbitrap MS 2017transfer abstract 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Nicotine-diet interactions have a particular importance on human health. Some food substances are subject to change hepatic CYP2A6 metabolism rate for nicotine and its levels in smokers consequently. This study investigates the effect of pomegranate and licorice drinks on nicotine metabolism, by a new developed and validated method for simultaneous determination of nicotine with its major metabolites (cotinine and nicotine N-oxide) in human urine, utilizing LC ESI-orbitrap-MS. Twenty-four Jordanian healthy and smoker volunteers were participated in two equal groups, crossover design for each of pomegranate and licorice test drink. In the study periods each group assigned either to drink test juice three times a day or to be avoided from test drink for 7 successive days, and then both groups switched their drink treatment in subsequent period. Early morning urine samples were collected from all volunteers after each period. Nicotine metabolism rate was evaluated from nicotine/cotinine and nicotine/nicotine N-oxide ratios in urine. A consistent trend of increase in metabolism rate for nicotine was observed from urine analysis under pomegranate or licorice drink conditions compared to control conditions. Pomegranate and licorice drinks are increasing the metabolism rate for nicotine in terms of induction effect for hepatic cytochrome p450 enzymes. Nicotine-diet interactions have a particular importance on human health. Some food substances are subject to change hepatic CYP2A6 metabolism rate for nicotine and its levels in smokers consequently. This study investigates the effect of pomegranate and licorice drinks on nicotine metabolism, by a new developed and validated method for simultaneous determination of nicotine with its major metabolites (cotinine and nicotine N-oxide) in human urine, utilizing LC ESI-orbitrap-MS. Twenty-four Jordanian healthy and smoker volunteers were participated in two equal groups, crossover design for each of pomegranate and licorice test drink. In the study periods each group assigned either to drink test juice three times a day or to be avoided from test drink for 7 successive days, and then both groups switched their drink treatment in subsequent period. Early morning urine samples were collected from all volunteers after each period. Nicotine metabolism rate was evaluated from nicotine/cotinine and nicotine/nicotine N-oxide ratios in urine. A consistent trend of increase in metabolism rate for nicotine was observed from urine analysis under pomegranate or licorice drink conditions compared to control conditions. Pomegranate and licorice drinks are increasing the metabolism rate for nicotine in terms of induction effect for hepatic cytochrome p450 enzymes. Induction effect Elsevier Human urine Elsevier Nicotine metabolism Elsevier LC-orbitrap MS Elsevier Licorice Elsevier Pomegranate Elsevier Arafat, Tawfiq oth Schmitz, Oliver J. oth Enthalten in Science Direct Gölbaşι, Gülcan ELSEVIER Monitoring the changes in physicochemical, sensory properties and microbiota of village-type homemade yoghurts along three consecutive back-slopping procedures 2023 the official analytical journal of the American Association of Pharmaceutical Scientists New York, NY [u.a.] (DE-627)ELV009872493 volume:132 year:2017 day:5 month:01 pages:60-65 extent:6 https://doi.org/10.1016/j.jpba.2016.09.026 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 58.34 Lebensmitteltechnologie VZ 48.61 Tierernährung Tierfutter VZ AR 132 2017 5 0105 60-65 6 |
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10.1016/j.jpba.2016.09.026 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001907.pica (DE-627)ELV020321317 (ELSEVIER)S0731-7085(16)30698-7 DE-627 ger DE-627 rakwb eng 630 640 VZ 58.34 bkl 48.61 bkl Abu-awwad, Ahmad verfasserin aut Study the influence of licorice and pomegranate drinks on nicotine metabolism in human urine by LC-orbitrap MS 2017transfer abstract 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Nicotine-diet interactions have a particular importance on human health. Some food substances are subject to change hepatic CYP2A6 metabolism rate for nicotine and its levels in smokers consequently. This study investigates the effect of pomegranate and licorice drinks on nicotine metabolism, by a new developed and validated method for simultaneous determination of nicotine with its major metabolites (cotinine and nicotine N-oxide) in human urine, utilizing LC ESI-orbitrap-MS. Twenty-four Jordanian healthy and smoker volunteers were participated in two equal groups, crossover design for each of pomegranate and licorice test drink. In the study periods each group assigned either to drink test juice three times a day or to be avoided from test drink for 7 successive days, and then both groups switched their drink treatment in subsequent period. Early morning urine samples were collected from all volunteers after each period. Nicotine metabolism rate was evaluated from nicotine/cotinine and nicotine/nicotine N-oxide ratios in urine. A consistent trend of increase in metabolism rate for nicotine was observed from urine analysis under pomegranate or licorice drink conditions compared to control conditions. Pomegranate and licorice drinks are increasing the metabolism rate for nicotine in terms of induction effect for hepatic cytochrome p450 enzymes. Nicotine-diet interactions have a particular importance on human health. Some food substances are subject to change hepatic CYP2A6 metabolism rate for nicotine and its levels in smokers consequently. This study investigates the effect of pomegranate and licorice drinks on nicotine metabolism, by a new developed and validated method for simultaneous determination of nicotine with its major metabolites (cotinine and nicotine N-oxide) in human urine, utilizing LC ESI-orbitrap-MS. Twenty-four Jordanian healthy and smoker volunteers were participated in two equal groups, crossover design for each of pomegranate and licorice test drink. In the study periods each group assigned either to drink test juice three times a day or to be avoided from test drink for 7 successive days, and then both groups switched their drink treatment in subsequent period. Early morning urine samples were collected from all volunteers after each period. Nicotine metabolism rate was evaluated from nicotine/cotinine and nicotine/nicotine N-oxide ratios in urine. A consistent trend of increase in metabolism rate for nicotine was observed from urine analysis under pomegranate or licorice drink conditions compared to control conditions. Pomegranate and licorice drinks are increasing the metabolism rate for nicotine in terms of induction effect for hepatic cytochrome p450 enzymes. Induction effect Elsevier Human urine Elsevier Nicotine metabolism Elsevier LC-orbitrap MS Elsevier Licorice Elsevier Pomegranate Elsevier Arafat, Tawfiq oth Schmitz, Oliver J. oth Enthalten in Science Direct Gölbaşι, Gülcan ELSEVIER Monitoring the changes in physicochemical, sensory properties and microbiota of village-type homemade yoghurts along three consecutive back-slopping procedures 2023 the official analytical journal of the American Association of Pharmaceutical Scientists New York, NY [u.a.] (DE-627)ELV009872493 volume:132 year:2017 day:5 month:01 pages:60-65 extent:6 https://doi.org/10.1016/j.jpba.2016.09.026 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 58.34 Lebensmitteltechnologie VZ 48.61 Tierernährung Tierfutter VZ AR 132 2017 5 0105 60-65 6 |
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10.1016/j.jpba.2016.09.026 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001907.pica (DE-627)ELV020321317 (ELSEVIER)S0731-7085(16)30698-7 DE-627 ger DE-627 rakwb eng 630 640 VZ 58.34 bkl 48.61 bkl Abu-awwad, Ahmad verfasserin aut Study the influence of licorice and pomegranate drinks on nicotine metabolism in human urine by LC-orbitrap MS 2017transfer abstract 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Nicotine-diet interactions have a particular importance on human health. Some food substances are subject to change hepatic CYP2A6 metabolism rate for nicotine and its levels in smokers consequently. This study investigates the effect of pomegranate and licorice drinks on nicotine metabolism, by a new developed and validated method for simultaneous determination of nicotine with its major metabolites (cotinine and nicotine N-oxide) in human urine, utilizing LC ESI-orbitrap-MS. Twenty-four Jordanian healthy and smoker volunteers were participated in two equal groups, crossover design for each of pomegranate and licorice test drink. In the study periods each group assigned either to drink test juice three times a day or to be avoided from test drink for 7 successive days, and then both groups switched their drink treatment in subsequent period. Early morning urine samples were collected from all volunteers after each period. Nicotine metabolism rate was evaluated from nicotine/cotinine and nicotine/nicotine N-oxide ratios in urine. A consistent trend of increase in metabolism rate for nicotine was observed from urine analysis under pomegranate or licorice drink conditions compared to control conditions. Pomegranate and licorice drinks are increasing the metabolism rate for nicotine in terms of induction effect for hepatic cytochrome p450 enzymes. Nicotine-diet interactions have a particular importance on human health. Some food substances are subject to change hepatic CYP2A6 metabolism rate for nicotine and its levels in smokers consequently. This study investigates the effect of pomegranate and licorice drinks on nicotine metabolism, by a new developed and validated method for simultaneous determination of nicotine with its major metabolites (cotinine and nicotine N-oxide) in human urine, utilizing LC ESI-orbitrap-MS. Twenty-four Jordanian healthy and smoker volunteers were participated in two equal groups, crossover design for each of pomegranate and licorice test drink. In the study periods each group assigned either to drink test juice three times a day or to be avoided from test drink for 7 successive days, and then both groups switched their drink treatment in subsequent period. Early morning urine samples were collected from all volunteers after each period. Nicotine metabolism rate was evaluated from nicotine/cotinine and nicotine/nicotine N-oxide ratios in urine. A consistent trend of increase in metabolism rate for nicotine was observed from urine analysis under pomegranate or licorice drink conditions compared to control conditions. Pomegranate and licorice drinks are increasing the metabolism rate for nicotine in terms of induction effect for hepatic cytochrome p450 enzymes. Induction effect Elsevier Human urine Elsevier Nicotine metabolism Elsevier LC-orbitrap MS Elsevier Licorice Elsevier Pomegranate Elsevier Arafat, Tawfiq oth Schmitz, Oliver J. oth Enthalten in Science Direct Gölbaşι, Gülcan ELSEVIER Monitoring the changes in physicochemical, sensory properties and microbiota of village-type homemade yoghurts along three consecutive back-slopping procedures 2023 the official analytical journal of the American Association of Pharmaceutical Scientists New York, NY [u.a.] (DE-627)ELV009872493 volume:132 year:2017 day:5 month:01 pages:60-65 extent:6 https://doi.org/10.1016/j.jpba.2016.09.026 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 58.34 Lebensmitteltechnologie VZ 48.61 Tierernährung Tierfutter VZ AR 132 2017 5 0105 60-65 6 |
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Enthalten in Monitoring the changes in physicochemical, sensory properties and microbiota of village-type homemade yoghurts along three consecutive back-slopping procedures New York, NY [u.a.] volume:132 year:2017 day:5 month:01 pages:60-65 extent:6 |
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Enthalten in Monitoring the changes in physicochemical, sensory properties and microbiota of village-type homemade yoghurts along three consecutive back-slopping procedures New York, NY [u.a.] volume:132 year:2017 day:5 month:01 pages:60-65 extent:6 |
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Monitoring the changes in physicochemical, sensory properties and microbiota of village-type homemade yoghurts along three consecutive back-slopping procedures |
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study the influence of licorice and pomegranate drinks on nicotine metabolism in human urine by lc-orbitrap ms |
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Study the influence of licorice and pomegranate drinks on nicotine metabolism in human urine by LC-orbitrap MS |
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Nicotine-diet interactions have a particular importance on human health. Some food substances are subject to change hepatic CYP2A6 metabolism rate for nicotine and its levels in smokers consequently. This study investigates the effect of pomegranate and licorice drinks on nicotine metabolism, by a new developed and validated method for simultaneous determination of nicotine with its major metabolites (cotinine and nicotine N-oxide) in human urine, utilizing LC ESI-orbitrap-MS. Twenty-four Jordanian healthy and smoker volunteers were participated in two equal groups, crossover design for each of pomegranate and licorice test drink. In the study periods each group assigned either to drink test juice three times a day or to be avoided from test drink for 7 successive days, and then both groups switched their drink treatment in subsequent period. Early morning urine samples were collected from all volunteers after each period. Nicotine metabolism rate was evaluated from nicotine/cotinine and nicotine/nicotine N-oxide ratios in urine. A consistent trend of increase in metabolism rate for nicotine was observed from urine analysis under pomegranate or licorice drink conditions compared to control conditions. Pomegranate and licorice drinks are increasing the metabolism rate for nicotine in terms of induction effect for hepatic cytochrome p450 enzymes. |
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Nicotine-diet interactions have a particular importance on human health. Some food substances are subject to change hepatic CYP2A6 metabolism rate for nicotine and its levels in smokers consequently. This study investigates the effect of pomegranate and licorice drinks on nicotine metabolism, by a new developed and validated method for simultaneous determination of nicotine with its major metabolites (cotinine and nicotine N-oxide) in human urine, utilizing LC ESI-orbitrap-MS. Twenty-four Jordanian healthy and smoker volunteers were participated in two equal groups, crossover design for each of pomegranate and licorice test drink. In the study periods each group assigned either to drink test juice three times a day or to be avoided from test drink for 7 successive days, and then both groups switched their drink treatment in subsequent period. Early morning urine samples were collected from all volunteers after each period. Nicotine metabolism rate was evaluated from nicotine/cotinine and nicotine/nicotine N-oxide ratios in urine. A consistent trend of increase in metabolism rate for nicotine was observed from urine analysis under pomegranate or licorice drink conditions compared to control conditions. Pomegranate and licorice drinks are increasing the metabolism rate for nicotine in terms of induction effect for hepatic cytochrome p450 enzymes. |
| abstract_unstemmed |
Nicotine-diet interactions have a particular importance on human health. Some food substances are subject to change hepatic CYP2A6 metabolism rate for nicotine and its levels in smokers consequently. This study investigates the effect of pomegranate and licorice drinks on nicotine metabolism, by a new developed and validated method for simultaneous determination of nicotine with its major metabolites (cotinine and nicotine N-oxide) in human urine, utilizing LC ESI-orbitrap-MS. Twenty-four Jordanian healthy and smoker volunteers were participated in two equal groups, crossover design for each of pomegranate and licorice test drink. In the study periods each group assigned either to drink test juice three times a day or to be avoided from test drink for 7 successive days, and then both groups switched their drink treatment in subsequent period. Early morning urine samples were collected from all volunteers after each period. Nicotine metabolism rate was evaluated from nicotine/cotinine and nicotine/nicotine N-oxide ratios in urine. A consistent trend of increase in metabolism rate for nicotine was observed from urine analysis under pomegranate or licorice drink conditions compared to control conditions. Pomegranate and licorice drinks are increasing the metabolism rate for nicotine in terms of induction effect for hepatic cytochrome p450 enzymes. |
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Study the influence of licorice and pomegranate drinks on nicotine metabolism in human urine by LC-orbitrap MS |
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