Conditioned reinforcement and locomotor activating effects of caffeine and ethanol combinations in mice
A growing trend among ethanol drinkers, especially young adults, is to combine caffeinated energy drinks with ethanol during a drinking episode. The primary active ingredient of these mixers is caffeine, which may significantly interact with ethanol. We tested the two hypotheses that caffeine would...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Hilbert, Megan L.T. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2013transfer abstract |
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| Umfang: |
6 |
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| Übergeordnetes Werk: |
Enthalten in: Cascade screening and registry for patients with familial hypercholesterolemia in Germany – A follow-up survey - Haack, I.A. ELSEVIER, 2022, Amsterdam [u.a.] |
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| Übergeordnetes Werk: |
volume:110 ; year:2013 ; pages:168-173 ; extent:6 |
| Links: |
|---|
| DOI / URN: |
10.1016/j.pbb.2013.07.008 |
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| 520 | |a A growing trend among ethanol drinkers, especially young adults, is to combine caffeinated energy drinks with ethanol during a drinking episode. The primary active ingredient of these mixers is caffeine, which may significantly interact with ethanol. We tested the two hypotheses that caffeine would enhance ethanol-conditioned place preference and also enhance ethanol-stimulated locomotor activity. The interactive pharmacology of ethanol and caffeine was examined in C57BL/6J (B6) mice in a conditioned place preference procedure with 1.75g/kg ethanol and 3mg/kg caffeine. Additionally, we used B6 mice to evaluate ethanol/caffeine combinations on locomotor activity using 3 doses of ethanol (1.75, 2.5 and 3.25g/kg) and 2 two doses of caffeine (3 and 15mg/kg). Both ethanol and caffeine administered alone increased preference for the drug paired side, although the effect of caffeine was more modest than that of ethanol. The drug combination produced significant place preference itself, but this was not greater than that for ethanol alone. Additionally, the combination of caffeine and ethanol significantly increased locomotion compared to giving either drug alone. The effect was strongest with a stimulatory dose of ethanol (1.75g/kg) and waned with increasing doses of ethanol. Thus, combinations of caffeine and ethanol had significant conditioned reinforcing and locomotor activating effects in mice. | ||
| 520 | |a A growing trend among ethanol drinkers, especially young adults, is to combine caffeinated energy drinks with ethanol during a drinking episode. The primary active ingredient of these mixers is caffeine, which may significantly interact with ethanol. We tested the two hypotheses that caffeine would enhance ethanol-conditioned place preference and also enhance ethanol-stimulated locomotor activity. The interactive pharmacology of ethanol and caffeine was examined in C57BL/6J (B6) mice in a conditioned place preference procedure with 1.75g/kg ethanol and 3mg/kg caffeine. Additionally, we used B6 mice to evaluate ethanol/caffeine combinations on locomotor activity using 3 doses of ethanol (1.75, 2.5 and 3.25g/kg) and 2 two doses of caffeine (3 and 15mg/kg). Both ethanol and caffeine administered alone increased preference for the drug paired side, although the effect of caffeine was more modest than that of ethanol. The drug combination produced significant place preference itself, but this was not greater than that for ethanol alone. Additionally, the combination of caffeine and ethanol significantly increased locomotion compared to giving either drug alone. The effect was strongest with a stimulatory dose of ethanol (1.75g/kg) and waned with increasing doses of ethanol. Thus, combinations of caffeine and ethanol had significant conditioned reinforcing and locomotor activating effects in mice. | ||
| 700 | 1 | |a May, Christina E. |4 oth | |
| 700 | 1 | |a Griffin, William C. |4 oth | |
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10.1016/j.pbb.2013.07.008 doi GBVA2013001000030.pica (DE-627)ELV02159757X (ELSEVIER)S0091-3057(13)00176-7 DE-627 ger DE-627 rakwb eng 540 540 DE-600 610 VZ 44.85 bkl Hilbert, Megan L.T. verfasserin aut Conditioned reinforcement and locomotor activating effects of caffeine and ethanol combinations in mice 2013transfer abstract 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier A growing trend among ethanol drinkers, especially young adults, is to combine caffeinated energy drinks with ethanol during a drinking episode. The primary active ingredient of these mixers is caffeine, which may significantly interact with ethanol. We tested the two hypotheses that caffeine would enhance ethanol-conditioned place preference and also enhance ethanol-stimulated locomotor activity. The interactive pharmacology of ethanol and caffeine was examined in C57BL/6J (B6) mice in a conditioned place preference procedure with 1.75g/kg ethanol and 3mg/kg caffeine. Additionally, we used B6 mice to evaluate ethanol/caffeine combinations on locomotor activity using 3 doses of ethanol (1.75, 2.5 and 3.25g/kg) and 2 two doses of caffeine (3 and 15mg/kg). Both ethanol and caffeine administered alone increased preference for the drug paired side, although the effect of caffeine was more modest than that of ethanol. The drug combination produced significant place preference itself, but this was not greater than that for ethanol alone. Additionally, the combination of caffeine and ethanol significantly increased locomotion compared to giving either drug alone. The effect was strongest with a stimulatory dose of ethanol (1.75g/kg) and waned with increasing doses of ethanol. Thus, combinations of caffeine and ethanol had significant conditioned reinforcing and locomotor activating effects in mice. A growing trend among ethanol drinkers, especially young adults, is to combine caffeinated energy drinks with ethanol during a drinking episode. The primary active ingredient of these mixers is caffeine, which may significantly interact with ethanol. We tested the two hypotheses that caffeine would enhance ethanol-conditioned place preference and also enhance ethanol-stimulated locomotor activity. The interactive pharmacology of ethanol and caffeine was examined in C57BL/6J (B6) mice in a conditioned place preference procedure with 1.75g/kg ethanol and 3mg/kg caffeine. Additionally, we used B6 mice to evaluate ethanol/caffeine combinations on locomotor activity using 3 doses of ethanol (1.75, 2.5 and 3.25g/kg) and 2 two doses of caffeine (3 and 15mg/kg). Both ethanol and caffeine administered alone increased preference for the drug paired side, although the effect of caffeine was more modest than that of ethanol. The drug combination produced significant place preference itself, but this was not greater than that for ethanol alone. Additionally, the combination of caffeine and ethanol significantly increased locomotion compared to giving either drug alone. The effect was strongest with a stimulatory dose of ethanol (1.75g/kg) and waned with increasing doses of ethanol. Thus, combinations of caffeine and ethanol had significant conditioned reinforcing and locomotor activating effects in mice. May, Christina E. oth Griffin, William C. oth Enthalten in Elsevier Science Haack, I.A. ELSEVIER Cascade screening and registry for patients with familial hypercholesterolemia in Germany – A follow-up survey 2022 Amsterdam [u.a.] (DE-627)ELV00002127X volume:110 year:2013 pages:168-173 extent:6 https://doi.org/10.1016/j.pbb.2013.07.008 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.85 Kardiologie Angiologie VZ AR 110 2013 168-173 6 045F 540 |
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10.1016/j.pbb.2013.07.008 doi GBVA2013001000030.pica (DE-627)ELV02159757X (ELSEVIER)S0091-3057(13)00176-7 DE-627 ger DE-627 rakwb eng 540 540 DE-600 610 VZ 44.85 bkl Hilbert, Megan L.T. verfasserin aut Conditioned reinforcement and locomotor activating effects of caffeine and ethanol combinations in mice 2013transfer abstract 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier A growing trend among ethanol drinkers, especially young adults, is to combine caffeinated energy drinks with ethanol during a drinking episode. The primary active ingredient of these mixers is caffeine, which may significantly interact with ethanol. We tested the two hypotheses that caffeine would enhance ethanol-conditioned place preference and also enhance ethanol-stimulated locomotor activity. The interactive pharmacology of ethanol and caffeine was examined in C57BL/6J (B6) mice in a conditioned place preference procedure with 1.75g/kg ethanol and 3mg/kg caffeine. Additionally, we used B6 mice to evaluate ethanol/caffeine combinations on locomotor activity using 3 doses of ethanol (1.75, 2.5 and 3.25g/kg) and 2 two doses of caffeine (3 and 15mg/kg). Both ethanol and caffeine administered alone increased preference for the drug paired side, although the effect of caffeine was more modest than that of ethanol. The drug combination produced significant place preference itself, but this was not greater than that for ethanol alone. Additionally, the combination of caffeine and ethanol significantly increased locomotion compared to giving either drug alone. The effect was strongest with a stimulatory dose of ethanol (1.75g/kg) and waned with increasing doses of ethanol. Thus, combinations of caffeine and ethanol had significant conditioned reinforcing and locomotor activating effects in mice. A growing trend among ethanol drinkers, especially young adults, is to combine caffeinated energy drinks with ethanol during a drinking episode. The primary active ingredient of these mixers is caffeine, which may significantly interact with ethanol. We tested the two hypotheses that caffeine would enhance ethanol-conditioned place preference and also enhance ethanol-stimulated locomotor activity. The interactive pharmacology of ethanol and caffeine was examined in C57BL/6J (B6) mice in a conditioned place preference procedure with 1.75g/kg ethanol and 3mg/kg caffeine. Additionally, we used B6 mice to evaluate ethanol/caffeine combinations on locomotor activity using 3 doses of ethanol (1.75, 2.5 and 3.25g/kg) and 2 two doses of caffeine (3 and 15mg/kg). Both ethanol and caffeine administered alone increased preference for the drug paired side, although the effect of caffeine was more modest than that of ethanol. The drug combination produced significant place preference itself, but this was not greater than that for ethanol alone. Additionally, the combination of caffeine and ethanol significantly increased locomotion compared to giving either drug alone. The effect was strongest with a stimulatory dose of ethanol (1.75g/kg) and waned with increasing doses of ethanol. Thus, combinations of caffeine and ethanol had significant conditioned reinforcing and locomotor activating effects in mice. May, Christina E. oth Griffin, William C. oth Enthalten in Elsevier Science Haack, I.A. ELSEVIER Cascade screening and registry for patients with familial hypercholesterolemia in Germany – A follow-up survey 2022 Amsterdam [u.a.] (DE-627)ELV00002127X volume:110 year:2013 pages:168-173 extent:6 https://doi.org/10.1016/j.pbb.2013.07.008 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.85 Kardiologie Angiologie VZ AR 110 2013 168-173 6 045F 540 |
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10.1016/j.pbb.2013.07.008 doi GBVA2013001000030.pica (DE-627)ELV02159757X (ELSEVIER)S0091-3057(13)00176-7 DE-627 ger DE-627 rakwb eng 540 540 DE-600 610 VZ 44.85 bkl Hilbert, Megan L.T. verfasserin aut Conditioned reinforcement and locomotor activating effects of caffeine and ethanol combinations in mice 2013transfer abstract 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier A growing trend among ethanol drinkers, especially young adults, is to combine caffeinated energy drinks with ethanol during a drinking episode. The primary active ingredient of these mixers is caffeine, which may significantly interact with ethanol. We tested the two hypotheses that caffeine would enhance ethanol-conditioned place preference and also enhance ethanol-stimulated locomotor activity. The interactive pharmacology of ethanol and caffeine was examined in C57BL/6J (B6) mice in a conditioned place preference procedure with 1.75g/kg ethanol and 3mg/kg caffeine. Additionally, we used B6 mice to evaluate ethanol/caffeine combinations on locomotor activity using 3 doses of ethanol (1.75, 2.5 and 3.25g/kg) and 2 two doses of caffeine (3 and 15mg/kg). Both ethanol and caffeine administered alone increased preference for the drug paired side, although the effect of caffeine was more modest than that of ethanol. The drug combination produced significant place preference itself, but this was not greater than that for ethanol alone. Additionally, the combination of caffeine and ethanol significantly increased locomotion compared to giving either drug alone. The effect was strongest with a stimulatory dose of ethanol (1.75g/kg) and waned with increasing doses of ethanol. Thus, combinations of caffeine and ethanol had significant conditioned reinforcing and locomotor activating effects in mice. A growing trend among ethanol drinkers, especially young adults, is to combine caffeinated energy drinks with ethanol during a drinking episode. The primary active ingredient of these mixers is caffeine, which may significantly interact with ethanol. We tested the two hypotheses that caffeine would enhance ethanol-conditioned place preference and also enhance ethanol-stimulated locomotor activity. The interactive pharmacology of ethanol and caffeine was examined in C57BL/6J (B6) mice in a conditioned place preference procedure with 1.75g/kg ethanol and 3mg/kg caffeine. Additionally, we used B6 mice to evaluate ethanol/caffeine combinations on locomotor activity using 3 doses of ethanol (1.75, 2.5 and 3.25g/kg) and 2 two doses of caffeine (3 and 15mg/kg). Both ethanol and caffeine administered alone increased preference for the drug paired side, although the effect of caffeine was more modest than that of ethanol. The drug combination produced significant place preference itself, but this was not greater than that for ethanol alone. Additionally, the combination of caffeine and ethanol significantly increased locomotion compared to giving either drug alone. The effect was strongest with a stimulatory dose of ethanol (1.75g/kg) and waned with increasing doses of ethanol. Thus, combinations of caffeine and ethanol had significant conditioned reinforcing and locomotor activating effects in mice. May, Christina E. oth Griffin, William C. oth Enthalten in Elsevier Science Haack, I.A. ELSEVIER Cascade screening and registry for patients with familial hypercholesterolemia in Germany – A follow-up survey 2022 Amsterdam [u.a.] (DE-627)ELV00002127X volume:110 year:2013 pages:168-173 extent:6 https://doi.org/10.1016/j.pbb.2013.07.008 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.85 Kardiologie Angiologie VZ AR 110 2013 168-173 6 045F 540 |
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10.1016/j.pbb.2013.07.008 doi GBVA2013001000030.pica (DE-627)ELV02159757X (ELSEVIER)S0091-3057(13)00176-7 DE-627 ger DE-627 rakwb eng 540 540 DE-600 610 VZ 44.85 bkl Hilbert, Megan L.T. verfasserin aut Conditioned reinforcement and locomotor activating effects of caffeine and ethanol combinations in mice 2013transfer abstract 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier A growing trend among ethanol drinkers, especially young adults, is to combine caffeinated energy drinks with ethanol during a drinking episode. The primary active ingredient of these mixers is caffeine, which may significantly interact with ethanol. We tested the two hypotheses that caffeine would enhance ethanol-conditioned place preference and also enhance ethanol-stimulated locomotor activity. The interactive pharmacology of ethanol and caffeine was examined in C57BL/6J (B6) mice in a conditioned place preference procedure with 1.75g/kg ethanol and 3mg/kg caffeine. Additionally, we used B6 mice to evaluate ethanol/caffeine combinations on locomotor activity using 3 doses of ethanol (1.75, 2.5 and 3.25g/kg) and 2 two doses of caffeine (3 and 15mg/kg). Both ethanol and caffeine administered alone increased preference for the drug paired side, although the effect of caffeine was more modest than that of ethanol. The drug combination produced significant place preference itself, but this was not greater than that for ethanol alone. Additionally, the combination of caffeine and ethanol significantly increased locomotion compared to giving either drug alone. The effect was strongest with a stimulatory dose of ethanol (1.75g/kg) and waned with increasing doses of ethanol. Thus, combinations of caffeine and ethanol had significant conditioned reinforcing and locomotor activating effects in mice. A growing trend among ethanol drinkers, especially young adults, is to combine caffeinated energy drinks with ethanol during a drinking episode. The primary active ingredient of these mixers is caffeine, which may significantly interact with ethanol. We tested the two hypotheses that caffeine would enhance ethanol-conditioned place preference and also enhance ethanol-stimulated locomotor activity. The interactive pharmacology of ethanol and caffeine was examined in C57BL/6J (B6) mice in a conditioned place preference procedure with 1.75g/kg ethanol and 3mg/kg caffeine. Additionally, we used B6 mice to evaluate ethanol/caffeine combinations on locomotor activity using 3 doses of ethanol (1.75, 2.5 and 3.25g/kg) and 2 two doses of caffeine (3 and 15mg/kg). Both ethanol and caffeine administered alone increased preference for the drug paired side, although the effect of caffeine was more modest than that of ethanol. The drug combination produced significant place preference itself, but this was not greater than that for ethanol alone. Additionally, the combination of caffeine and ethanol significantly increased locomotion compared to giving either drug alone. The effect was strongest with a stimulatory dose of ethanol (1.75g/kg) and waned with increasing doses of ethanol. Thus, combinations of caffeine and ethanol had significant conditioned reinforcing and locomotor activating effects in mice. May, Christina E. oth Griffin, William C. oth Enthalten in Elsevier Science Haack, I.A. ELSEVIER Cascade screening and registry for patients with familial hypercholesterolemia in Germany – A follow-up survey 2022 Amsterdam [u.a.] (DE-627)ELV00002127X volume:110 year:2013 pages:168-173 extent:6 https://doi.org/10.1016/j.pbb.2013.07.008 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.85 Kardiologie Angiologie VZ AR 110 2013 168-173 6 045F 540 |
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10.1016/j.pbb.2013.07.008 doi GBVA2013001000030.pica (DE-627)ELV02159757X (ELSEVIER)S0091-3057(13)00176-7 DE-627 ger DE-627 rakwb eng 540 540 DE-600 610 VZ 44.85 bkl Hilbert, Megan L.T. verfasserin aut Conditioned reinforcement and locomotor activating effects of caffeine and ethanol combinations in mice 2013transfer abstract 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier A growing trend among ethanol drinkers, especially young adults, is to combine caffeinated energy drinks with ethanol during a drinking episode. The primary active ingredient of these mixers is caffeine, which may significantly interact with ethanol. We tested the two hypotheses that caffeine would enhance ethanol-conditioned place preference and also enhance ethanol-stimulated locomotor activity. The interactive pharmacology of ethanol and caffeine was examined in C57BL/6J (B6) mice in a conditioned place preference procedure with 1.75g/kg ethanol and 3mg/kg caffeine. Additionally, we used B6 mice to evaluate ethanol/caffeine combinations on locomotor activity using 3 doses of ethanol (1.75, 2.5 and 3.25g/kg) and 2 two doses of caffeine (3 and 15mg/kg). Both ethanol and caffeine administered alone increased preference for the drug paired side, although the effect of caffeine was more modest than that of ethanol. The drug combination produced significant place preference itself, but this was not greater than that for ethanol alone. Additionally, the combination of caffeine and ethanol significantly increased locomotion compared to giving either drug alone. The effect was strongest with a stimulatory dose of ethanol (1.75g/kg) and waned with increasing doses of ethanol. Thus, combinations of caffeine and ethanol had significant conditioned reinforcing and locomotor activating effects in mice. A growing trend among ethanol drinkers, especially young adults, is to combine caffeinated energy drinks with ethanol during a drinking episode. The primary active ingredient of these mixers is caffeine, which may significantly interact with ethanol. We tested the two hypotheses that caffeine would enhance ethanol-conditioned place preference and also enhance ethanol-stimulated locomotor activity. The interactive pharmacology of ethanol and caffeine was examined in C57BL/6J (B6) mice in a conditioned place preference procedure with 1.75g/kg ethanol and 3mg/kg caffeine. Additionally, we used B6 mice to evaluate ethanol/caffeine combinations on locomotor activity using 3 doses of ethanol (1.75, 2.5 and 3.25g/kg) and 2 two doses of caffeine (3 and 15mg/kg). Both ethanol and caffeine administered alone increased preference for the drug paired side, although the effect of caffeine was more modest than that of ethanol. The drug combination produced significant place preference itself, but this was not greater than that for ethanol alone. Additionally, the combination of caffeine and ethanol significantly increased locomotion compared to giving either drug alone. The effect was strongest with a stimulatory dose of ethanol (1.75g/kg) and waned with increasing doses of ethanol. Thus, combinations of caffeine and ethanol had significant conditioned reinforcing and locomotor activating effects in mice. May, Christina E. oth Griffin, William C. oth Enthalten in Elsevier Science Haack, I.A. ELSEVIER Cascade screening and registry for patients with familial hypercholesterolemia in Germany – A follow-up survey 2022 Amsterdam [u.a.] (DE-627)ELV00002127X volume:110 year:2013 pages:168-173 extent:6 https://doi.org/10.1016/j.pbb.2013.07.008 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.85 Kardiologie Angiologie VZ AR 110 2013 168-173 6 045F 540 |
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Conditioned reinforcement and locomotor activating effects of caffeine and ethanol combinations in mice |
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Cascade screening and registry for patients with familial hypercholesterolemia in Germany – A follow-up survey |
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conditioned reinforcement and locomotor activating effects of caffeine and ethanol combinations in mice |
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Conditioned reinforcement and locomotor activating effects of caffeine and ethanol combinations in mice |
| abstract |
A growing trend among ethanol drinkers, especially young adults, is to combine caffeinated energy drinks with ethanol during a drinking episode. The primary active ingredient of these mixers is caffeine, which may significantly interact with ethanol. We tested the two hypotheses that caffeine would enhance ethanol-conditioned place preference and also enhance ethanol-stimulated locomotor activity. The interactive pharmacology of ethanol and caffeine was examined in C57BL/6J (B6) mice in a conditioned place preference procedure with 1.75g/kg ethanol and 3mg/kg caffeine. Additionally, we used B6 mice to evaluate ethanol/caffeine combinations on locomotor activity using 3 doses of ethanol (1.75, 2.5 and 3.25g/kg) and 2 two doses of caffeine (3 and 15mg/kg). Both ethanol and caffeine administered alone increased preference for the drug paired side, although the effect of caffeine was more modest than that of ethanol. The drug combination produced significant place preference itself, but this was not greater than that for ethanol alone. Additionally, the combination of caffeine and ethanol significantly increased locomotion compared to giving either drug alone. The effect was strongest with a stimulatory dose of ethanol (1.75g/kg) and waned with increasing doses of ethanol. Thus, combinations of caffeine and ethanol had significant conditioned reinforcing and locomotor activating effects in mice. |
| abstractGer |
A growing trend among ethanol drinkers, especially young adults, is to combine caffeinated energy drinks with ethanol during a drinking episode. The primary active ingredient of these mixers is caffeine, which may significantly interact with ethanol. We tested the two hypotheses that caffeine would enhance ethanol-conditioned place preference and also enhance ethanol-stimulated locomotor activity. The interactive pharmacology of ethanol and caffeine was examined in C57BL/6J (B6) mice in a conditioned place preference procedure with 1.75g/kg ethanol and 3mg/kg caffeine. Additionally, we used B6 mice to evaluate ethanol/caffeine combinations on locomotor activity using 3 doses of ethanol (1.75, 2.5 and 3.25g/kg) and 2 two doses of caffeine (3 and 15mg/kg). Both ethanol and caffeine administered alone increased preference for the drug paired side, although the effect of caffeine was more modest than that of ethanol. The drug combination produced significant place preference itself, but this was not greater than that for ethanol alone. Additionally, the combination of caffeine and ethanol significantly increased locomotion compared to giving either drug alone. The effect was strongest with a stimulatory dose of ethanol (1.75g/kg) and waned with increasing doses of ethanol. Thus, combinations of caffeine and ethanol had significant conditioned reinforcing and locomotor activating effects in mice. |
| abstract_unstemmed |
A growing trend among ethanol drinkers, especially young adults, is to combine caffeinated energy drinks with ethanol during a drinking episode. The primary active ingredient of these mixers is caffeine, which may significantly interact with ethanol. We tested the two hypotheses that caffeine would enhance ethanol-conditioned place preference and also enhance ethanol-stimulated locomotor activity. The interactive pharmacology of ethanol and caffeine was examined in C57BL/6J (B6) mice in a conditioned place preference procedure with 1.75g/kg ethanol and 3mg/kg caffeine. Additionally, we used B6 mice to evaluate ethanol/caffeine combinations on locomotor activity using 3 doses of ethanol (1.75, 2.5 and 3.25g/kg) and 2 two doses of caffeine (3 and 15mg/kg). Both ethanol and caffeine administered alone increased preference for the drug paired side, although the effect of caffeine was more modest than that of ethanol. The drug combination produced significant place preference itself, but this was not greater than that for ethanol alone. Additionally, the combination of caffeine and ethanol significantly increased locomotion compared to giving either drug alone. The effect was strongest with a stimulatory dose of ethanol (1.75g/kg) and waned with increasing doses of ethanol. Thus, combinations of caffeine and ethanol had significant conditioned reinforcing and locomotor activating effects in mice. |
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Conditioned reinforcement and locomotor activating effects of caffeine and ethanol combinations in mice |
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