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Hyper-methylation in CpG islands of gene promoters, an epigenetic phenomenon down-regulating gene expression, is directly linked with carcinogenesis. In our laboratory we have analysed, in a series of primary OSCCs with matched normal oral mucosa under alcohol-smoking chronic exposure, the methylati...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Pannone, Giuseppe [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
2013 |
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| Übergeordnetes Werk: |
Enthalten in: Anti-anaerobic activity of a new β-lactamase inhibitor NXL104 in combination with β-lactams and metronidazole - 2012transfer abstract, Amsterdam [u.a.] |
|---|---|
| Übergeordnetes Werk: |
volume:49 ; year:2013 ; day:1 ; month:05 ; pages:8 |
| Links: |
|---|
| DOI / URN: |
10.1016/j.oraloncology.2013.03.018 |
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| 520 | |a Hyper-methylation in CpG islands of gene promoters, an epigenetic phenomenon down-regulating gene expression, is directly linked with carcinogenesis. In our laboratory we have analysed, in a series of primary OSCCs with matched normal oral mucosa under alcohol-smoking chronic exposure, the methylation status of a panel of genes, including hMLH1, CDH1, CDKN2a, MGMT, Rar-β2, SFRP-1, SFRP-2, SFRP-4, SFRP-5, Wif-1 and DKK-3 in order to define an epigenetic fingerprint for the precancer lesions and oral cancers. | ||
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Enthalten in Anti-anaerobic activity of a new β-lactamase inhibitor NXL104 in combination with β-lactams and metronidazole Amsterdam [u.a.] volume:49 year:2013 day:1 month:05 pages:8 |
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Hyper-methylation in CpG islands of gene promoters, an epigenetic phenomenon down-regulating gene expression, is directly linked with carcinogenesis. In our laboratory we have analysed, in a series of primary OSCCs with matched normal oral mucosa under alcohol-smoking chronic exposure, the methylation status of a panel of genes, including hMLH1, CDH1, CDKN2a, MGMT, Rar-β2, SFRP-1, SFRP-2, SFRP-4, SFRP-5, Wif-1 and DKK-3 in order to define an epigenetic fingerprint for the precancer lesions and oral cancers. |
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Hyper-methylation in CpG islands of gene promoters, an epigenetic phenomenon down-regulating gene expression, is directly linked with carcinogenesis. In our laboratory we have analysed, in a series of primary OSCCs with matched normal oral mucosa under alcohol-smoking chronic exposure, the methylation status of a panel of genes, including hMLH1, CDH1, CDKN2a, MGMT, Rar-β2, SFRP-1, SFRP-2, SFRP-4, SFRP-5, Wif-1 and DKK-3 in order to define an epigenetic fingerprint for the precancer lesions and oral cancers. |
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Hyper-methylation in CpG islands of gene promoters, an epigenetic phenomenon down-regulating gene expression, is directly linked with carcinogenesis. In our laboratory we have analysed, in a series of primary OSCCs with matched normal oral mucosa under alcohol-smoking chronic exposure, the methylation status of a panel of genes, including hMLH1, CDH1, CDKN2a, MGMT, Rar-β2, SFRP-1, SFRP-2, SFRP-4, SFRP-5, Wif-1 and DKK-3 in order to define an epigenetic fingerprint for the precancer lesions and oral cancers. |
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