Influence of experimental canine ehrlichiosis on the E-ADA activity and purine levels in serum and possible functional correlations with pathogenesis
The aim of this study was to evaluate adenosine deaminase activity and purines levels in serum of dogs experimentally infected by Ehrlichia canis. Banked serum samples of dogs divided into two groups with five animals each: healthy animals and animals infected by E. canis. The concentration of purin...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Da Silva, Aleksandro S. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2013transfer abstract |
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| Schlagwörter: |
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| Umfang: |
5 |
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| Übergeordnetes Werk: |
Enthalten in: Grain refinement and hardness distribution in cryogenically cooled ferritic stainless steel welds - 2013, an international journal concerned with microbiological diseases of all animals that are useful to man, Amsterdam [u.a.] |
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| Übergeordnetes Werk: |
volume:166 ; year:2013 ; number:3 ; day:25 ; month:10 ; pages:602-606 ; extent:5 |
| Links: |
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| DOI / URN: |
10.1016/j.vetmic.2013.06.033 |
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ELV021950210 |
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| 245 | 1 | 0 | |a Influence of experimental canine ehrlichiosis on the E-ADA activity and purine levels in serum and possible functional correlations with pathogenesis |
| 264 | 1 | |c 2013transfer abstract | |
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| 520 | |a The aim of this study was to evaluate adenosine deaminase activity and purines levels in serum of dogs experimentally infected by Ehrlichia canis. Banked serum samples of dogs divided into two groups with five animals each: healthy animals and animals infected by E. canis. The concentration of purines (adenosine triphosphate (ATP), adenosine diphosphate (ADP), adenosine monophosphate (AMP), adenosine, inosine, hypoxanthine, xanthine and uric acid), and adenosine deaminase (E-ADA) activity in sera were evaluated. Samples were collected on days 12 and 30 post-infection (PI). The E-ADA activity showed a significant reduction on day 12 PI, and increased on day 30 PI in dogs infected with E. canis. On day 12, an increase in seric concentration of ATP, ADP and adenosine was verified, and different levels of hypoxanthine, xanthine and uric acid had a drastic reduction in infected compared healthy dogs (P <0.05). However, on day 30 PI, the levels of seric ADP and AMP decreased, unlike the concentration of xanthine and uric acid that increased significantly in infected dogs (P <0.05). Therefore, the activity of E-ADA and purine levels are altered in experimental canine ehrlichiosis, probably with the purpose of modulating the pathogenesis of the disease related to immune response, oxidative stress and coagulation disorders in acute phase. | ||
| 520 | |a The aim of this study was to evaluate adenosine deaminase activity and purines levels in serum of dogs experimentally infected by Ehrlichia canis. Banked serum samples of dogs divided into two groups with five animals each: healthy animals and animals infected by E. canis. The concentration of purines (adenosine triphosphate (ATP), adenosine diphosphate (ADP), adenosine monophosphate (AMP), adenosine, inosine, hypoxanthine, xanthine and uric acid), and adenosine deaminase (E-ADA) activity in sera were evaluated. Samples were collected on days 12 and 30 post-infection (PI). The E-ADA activity showed a significant reduction on day 12 PI, and increased on day 30 PI in dogs infected with E. canis. On day 12, an increase in seric concentration of ATP, ADP and adenosine was verified, and different levels of hypoxanthine, xanthine and uric acid had a drastic reduction in infected compared healthy dogs (P <0.05). However, on day 30 PI, the levels of seric ADP and AMP decreased, unlike the concentration of xanthine and uric acid that increased significantly in infected dogs (P <0.05). Therefore, the activity of E-ADA and purine levels are altered in experimental canine ehrlichiosis, probably with the purpose of modulating the pathogenesis of the disease related to immune response, oxidative stress and coagulation disorders in acute phase. | ||
| 650 | 7 | |a Adenosine |2 Elsevier | |
| 650 | 7 | |a Ehrlichia canis |2 Elsevier | |
| 650 | 7 | |a Adenosine deaminase |2 Elsevier | |
| 650 | 7 | |a Canine |2 Elsevier | |
| 700 | 1 | |a Munhoz, Thiago D. |4 oth | |
| 700 | 1 | |a Faria, Joice L.M. |4 oth | |
| 700 | 1 | |a Vargas-Hérnandez, Giovanni |4 oth | |
| 700 | 1 | |a Machado, Rosangela Z. |4 oth | |
| 700 | 1 | |a Luz, Nathalia C. |4 oth | |
| 700 | 1 | |a Moritz, Cesar E.J. |4 oth | |
| 700 | 1 | |a Casali, Emerson A. |4 oth | |
| 700 | 1 | |a Bottari, Nathieli B. |4 oth | |
| 700 | 1 | |a Stefani, Lenita M. |4 oth | |
| 700 | 1 | |a Tinucci-Costa, Mirela |4 oth | |
| 773 | 0 | 8 | |i Enthalten in |n Elsevier Science |t Grain refinement and hardness distribution in cryogenically cooled ferritic stainless steel welds |d 2013 |d an international journal concerned with microbiological diseases of all animals that are useful to man |g Amsterdam [u.a.] |w (DE-627)ELV011521430 |
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10.1016/j.vetmic.2013.06.033 doi GBVA2013012000010.pica (DE-627)ELV021950210 (ELSEVIER)S0378-1135(13)00349-0 DE-627 ger DE-627 rakwb eng 630 630 DE-600 Da Silva, Aleksandro S. verfasserin aut Influence of experimental canine ehrlichiosis on the E-ADA activity and purine levels in serum and possible functional correlations with pathogenesis 2013transfer abstract 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The aim of this study was to evaluate adenosine deaminase activity and purines levels in serum of dogs experimentally infected by Ehrlichia canis. Banked serum samples of dogs divided into two groups with five animals each: healthy animals and animals infected by E. canis. The concentration of purines (adenosine triphosphate (ATP), adenosine diphosphate (ADP), adenosine monophosphate (AMP), adenosine, inosine, hypoxanthine, xanthine and uric acid), and adenosine deaminase (E-ADA) activity in sera were evaluated. Samples were collected on days 12 and 30 post-infection (PI). The E-ADA activity showed a significant reduction on day 12 PI, and increased on day 30 PI in dogs infected with E. canis. On day 12, an increase in seric concentration of ATP, ADP and adenosine was verified, and different levels of hypoxanthine, xanthine and uric acid had a drastic reduction in infected compared healthy dogs (P <0.05). However, on day 30 PI, the levels of seric ADP and AMP decreased, unlike the concentration of xanthine and uric acid that increased significantly in infected dogs (P <0.05). Therefore, the activity of E-ADA and purine levels are altered in experimental canine ehrlichiosis, probably with the purpose of modulating the pathogenesis of the disease related to immune response, oxidative stress and coagulation disorders in acute phase. The aim of this study was to evaluate adenosine deaminase activity and purines levels in serum of dogs experimentally infected by Ehrlichia canis. Banked serum samples of dogs divided into two groups with five animals each: healthy animals and animals infected by E. canis. The concentration of purines (adenosine triphosphate (ATP), adenosine diphosphate (ADP), adenosine monophosphate (AMP), adenosine, inosine, hypoxanthine, xanthine and uric acid), and adenosine deaminase (E-ADA) activity in sera were evaluated. Samples were collected on days 12 and 30 post-infection (PI). The E-ADA activity showed a significant reduction on day 12 PI, and increased on day 30 PI in dogs infected with E. canis. On day 12, an increase in seric concentration of ATP, ADP and adenosine was verified, and different levels of hypoxanthine, xanthine and uric acid had a drastic reduction in infected compared healthy dogs (P <0.05). However, on day 30 PI, the levels of seric ADP and AMP decreased, unlike the concentration of xanthine and uric acid that increased significantly in infected dogs (P <0.05). Therefore, the activity of E-ADA and purine levels are altered in experimental canine ehrlichiosis, probably with the purpose of modulating the pathogenesis of the disease related to immune response, oxidative stress and coagulation disorders in acute phase. Adenosine Elsevier Ehrlichia canis Elsevier Adenosine deaminase Elsevier Canine Elsevier Munhoz, Thiago D. oth Faria, Joice L.M. oth Vargas-Hérnandez, Giovanni oth Machado, Rosangela Z. oth Luz, Nathalia C. oth Moritz, Cesar E.J. oth Casali, Emerson A. oth Bottari, Nathieli B. oth Stefani, Lenita M. oth Tinucci-Costa, Mirela oth Enthalten in Elsevier Science Grain refinement and hardness distribution in cryogenically cooled ferritic stainless steel welds 2013 an international journal concerned with microbiological diseases of all animals that are useful to man Amsterdam [u.a.] (DE-627)ELV011521430 volume:166 year:2013 number:3 day:25 month:10 pages:602-606 extent:5 https://doi.org/10.1016/j.vetmic.2013.06.033 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U AR 166 2013 3 25 1025 602-606 5 045F 630 |
| spelling |
10.1016/j.vetmic.2013.06.033 doi GBVA2013012000010.pica (DE-627)ELV021950210 (ELSEVIER)S0378-1135(13)00349-0 DE-627 ger DE-627 rakwb eng 630 630 DE-600 Da Silva, Aleksandro S. verfasserin aut Influence of experimental canine ehrlichiosis on the E-ADA activity and purine levels in serum and possible functional correlations with pathogenesis 2013transfer abstract 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The aim of this study was to evaluate adenosine deaminase activity and purines levels in serum of dogs experimentally infected by Ehrlichia canis. Banked serum samples of dogs divided into two groups with five animals each: healthy animals and animals infected by E. canis. The concentration of purines (adenosine triphosphate (ATP), adenosine diphosphate (ADP), adenosine monophosphate (AMP), adenosine, inosine, hypoxanthine, xanthine and uric acid), and adenosine deaminase (E-ADA) activity in sera were evaluated. Samples were collected on days 12 and 30 post-infection (PI). The E-ADA activity showed a significant reduction on day 12 PI, and increased on day 30 PI in dogs infected with E. canis. On day 12, an increase in seric concentration of ATP, ADP and adenosine was verified, and different levels of hypoxanthine, xanthine and uric acid had a drastic reduction in infected compared healthy dogs (P <0.05). However, on day 30 PI, the levels of seric ADP and AMP decreased, unlike the concentration of xanthine and uric acid that increased significantly in infected dogs (P <0.05). Therefore, the activity of E-ADA and purine levels are altered in experimental canine ehrlichiosis, probably with the purpose of modulating the pathogenesis of the disease related to immune response, oxidative stress and coagulation disorders in acute phase. The aim of this study was to evaluate adenosine deaminase activity and purines levels in serum of dogs experimentally infected by Ehrlichia canis. Banked serum samples of dogs divided into two groups with five animals each: healthy animals and animals infected by E. canis. The concentration of purines (adenosine triphosphate (ATP), adenosine diphosphate (ADP), adenosine monophosphate (AMP), adenosine, inosine, hypoxanthine, xanthine and uric acid), and adenosine deaminase (E-ADA) activity in sera were evaluated. Samples were collected on days 12 and 30 post-infection (PI). The E-ADA activity showed a significant reduction on day 12 PI, and increased on day 30 PI in dogs infected with E. canis. On day 12, an increase in seric concentration of ATP, ADP and adenosine was verified, and different levels of hypoxanthine, xanthine and uric acid had a drastic reduction in infected compared healthy dogs (P <0.05). However, on day 30 PI, the levels of seric ADP and AMP decreased, unlike the concentration of xanthine and uric acid that increased significantly in infected dogs (P <0.05). Therefore, the activity of E-ADA and purine levels are altered in experimental canine ehrlichiosis, probably with the purpose of modulating the pathogenesis of the disease related to immune response, oxidative stress and coagulation disorders in acute phase. Adenosine Elsevier Ehrlichia canis Elsevier Adenosine deaminase Elsevier Canine Elsevier Munhoz, Thiago D. oth Faria, Joice L.M. oth Vargas-Hérnandez, Giovanni oth Machado, Rosangela Z. oth Luz, Nathalia C. oth Moritz, Cesar E.J. oth Casali, Emerson A. oth Bottari, Nathieli B. oth Stefani, Lenita M. oth Tinucci-Costa, Mirela oth Enthalten in Elsevier Science Grain refinement and hardness distribution in cryogenically cooled ferritic stainless steel welds 2013 an international journal concerned with microbiological diseases of all animals that are useful to man Amsterdam [u.a.] (DE-627)ELV011521430 volume:166 year:2013 number:3 day:25 month:10 pages:602-606 extent:5 https://doi.org/10.1016/j.vetmic.2013.06.033 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U AR 166 2013 3 25 1025 602-606 5 045F 630 |
| allfields_unstemmed |
10.1016/j.vetmic.2013.06.033 doi GBVA2013012000010.pica (DE-627)ELV021950210 (ELSEVIER)S0378-1135(13)00349-0 DE-627 ger DE-627 rakwb eng 630 630 DE-600 Da Silva, Aleksandro S. verfasserin aut Influence of experimental canine ehrlichiosis on the E-ADA activity and purine levels in serum and possible functional correlations with pathogenesis 2013transfer abstract 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The aim of this study was to evaluate adenosine deaminase activity and purines levels in serum of dogs experimentally infected by Ehrlichia canis. Banked serum samples of dogs divided into two groups with five animals each: healthy animals and animals infected by E. canis. The concentration of purines (adenosine triphosphate (ATP), adenosine diphosphate (ADP), adenosine monophosphate (AMP), adenosine, inosine, hypoxanthine, xanthine and uric acid), and adenosine deaminase (E-ADA) activity in sera were evaluated. Samples were collected on days 12 and 30 post-infection (PI). The E-ADA activity showed a significant reduction on day 12 PI, and increased on day 30 PI in dogs infected with E. canis. On day 12, an increase in seric concentration of ATP, ADP and adenosine was verified, and different levels of hypoxanthine, xanthine and uric acid had a drastic reduction in infected compared healthy dogs (P <0.05). However, on day 30 PI, the levels of seric ADP and AMP decreased, unlike the concentration of xanthine and uric acid that increased significantly in infected dogs (P <0.05). Therefore, the activity of E-ADA and purine levels are altered in experimental canine ehrlichiosis, probably with the purpose of modulating the pathogenesis of the disease related to immune response, oxidative stress and coagulation disorders in acute phase. The aim of this study was to evaluate adenosine deaminase activity and purines levels in serum of dogs experimentally infected by Ehrlichia canis. Banked serum samples of dogs divided into two groups with five animals each: healthy animals and animals infected by E. canis. The concentration of purines (adenosine triphosphate (ATP), adenosine diphosphate (ADP), adenosine monophosphate (AMP), adenosine, inosine, hypoxanthine, xanthine and uric acid), and adenosine deaminase (E-ADA) activity in sera were evaluated. Samples were collected on days 12 and 30 post-infection (PI). The E-ADA activity showed a significant reduction on day 12 PI, and increased on day 30 PI in dogs infected with E. canis. On day 12, an increase in seric concentration of ATP, ADP and adenosine was verified, and different levels of hypoxanthine, xanthine and uric acid had a drastic reduction in infected compared healthy dogs (P <0.05). However, on day 30 PI, the levels of seric ADP and AMP decreased, unlike the concentration of xanthine and uric acid that increased significantly in infected dogs (P <0.05). Therefore, the activity of E-ADA and purine levels are altered in experimental canine ehrlichiosis, probably with the purpose of modulating the pathogenesis of the disease related to immune response, oxidative stress and coagulation disorders in acute phase. Adenosine Elsevier Ehrlichia canis Elsevier Adenosine deaminase Elsevier Canine Elsevier Munhoz, Thiago D. oth Faria, Joice L.M. oth Vargas-Hérnandez, Giovanni oth Machado, Rosangela Z. oth Luz, Nathalia C. oth Moritz, Cesar E.J. oth Casali, Emerson A. oth Bottari, Nathieli B. oth Stefani, Lenita M. oth Tinucci-Costa, Mirela oth Enthalten in Elsevier Science Grain refinement and hardness distribution in cryogenically cooled ferritic stainless steel welds 2013 an international journal concerned with microbiological diseases of all animals that are useful to man Amsterdam [u.a.] (DE-627)ELV011521430 volume:166 year:2013 number:3 day:25 month:10 pages:602-606 extent:5 https://doi.org/10.1016/j.vetmic.2013.06.033 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U AR 166 2013 3 25 1025 602-606 5 045F 630 |
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10.1016/j.vetmic.2013.06.033 doi GBVA2013012000010.pica (DE-627)ELV021950210 (ELSEVIER)S0378-1135(13)00349-0 DE-627 ger DE-627 rakwb eng 630 630 DE-600 Da Silva, Aleksandro S. verfasserin aut Influence of experimental canine ehrlichiosis on the E-ADA activity and purine levels in serum and possible functional correlations with pathogenesis 2013transfer abstract 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The aim of this study was to evaluate adenosine deaminase activity and purines levels in serum of dogs experimentally infected by Ehrlichia canis. Banked serum samples of dogs divided into two groups with five animals each: healthy animals and animals infected by E. canis. The concentration of purines (adenosine triphosphate (ATP), adenosine diphosphate (ADP), adenosine monophosphate (AMP), adenosine, inosine, hypoxanthine, xanthine and uric acid), and adenosine deaminase (E-ADA) activity in sera were evaluated. Samples were collected on days 12 and 30 post-infection (PI). The E-ADA activity showed a significant reduction on day 12 PI, and increased on day 30 PI in dogs infected with E. canis. On day 12, an increase in seric concentration of ATP, ADP and adenosine was verified, and different levels of hypoxanthine, xanthine and uric acid had a drastic reduction in infected compared healthy dogs (P <0.05). However, on day 30 PI, the levels of seric ADP and AMP decreased, unlike the concentration of xanthine and uric acid that increased significantly in infected dogs (P <0.05). Therefore, the activity of E-ADA and purine levels are altered in experimental canine ehrlichiosis, probably with the purpose of modulating the pathogenesis of the disease related to immune response, oxidative stress and coagulation disorders in acute phase. The aim of this study was to evaluate adenosine deaminase activity and purines levels in serum of dogs experimentally infected by Ehrlichia canis. Banked serum samples of dogs divided into two groups with five animals each: healthy animals and animals infected by E. canis. The concentration of purines (adenosine triphosphate (ATP), adenosine diphosphate (ADP), adenosine monophosphate (AMP), adenosine, inosine, hypoxanthine, xanthine and uric acid), and adenosine deaminase (E-ADA) activity in sera were evaluated. Samples were collected on days 12 and 30 post-infection (PI). The E-ADA activity showed a significant reduction on day 12 PI, and increased on day 30 PI in dogs infected with E. canis. On day 12, an increase in seric concentration of ATP, ADP and adenosine was verified, and different levels of hypoxanthine, xanthine and uric acid had a drastic reduction in infected compared healthy dogs (P <0.05). However, on day 30 PI, the levels of seric ADP and AMP decreased, unlike the concentration of xanthine and uric acid that increased significantly in infected dogs (P <0.05). Therefore, the activity of E-ADA and purine levels are altered in experimental canine ehrlichiosis, probably with the purpose of modulating the pathogenesis of the disease related to immune response, oxidative stress and coagulation disorders in acute phase. Adenosine Elsevier Ehrlichia canis Elsevier Adenosine deaminase Elsevier Canine Elsevier Munhoz, Thiago D. oth Faria, Joice L.M. oth Vargas-Hérnandez, Giovanni oth Machado, Rosangela Z. oth Luz, Nathalia C. oth Moritz, Cesar E.J. oth Casali, Emerson A. oth Bottari, Nathieli B. oth Stefani, Lenita M. oth Tinucci-Costa, Mirela oth Enthalten in Elsevier Science Grain refinement and hardness distribution in cryogenically cooled ferritic stainless steel welds 2013 an international journal concerned with microbiological diseases of all animals that are useful to man Amsterdam [u.a.] (DE-627)ELV011521430 volume:166 year:2013 number:3 day:25 month:10 pages:602-606 extent:5 https://doi.org/10.1016/j.vetmic.2013.06.033 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U AR 166 2013 3 25 1025 602-606 5 045F 630 |
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10.1016/j.vetmic.2013.06.033 doi GBVA2013012000010.pica (DE-627)ELV021950210 (ELSEVIER)S0378-1135(13)00349-0 DE-627 ger DE-627 rakwb eng 630 630 DE-600 Da Silva, Aleksandro S. verfasserin aut Influence of experimental canine ehrlichiosis on the E-ADA activity and purine levels in serum and possible functional correlations with pathogenesis 2013transfer abstract 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The aim of this study was to evaluate adenosine deaminase activity and purines levels in serum of dogs experimentally infected by Ehrlichia canis. Banked serum samples of dogs divided into two groups with five animals each: healthy animals and animals infected by E. canis. The concentration of purines (adenosine triphosphate (ATP), adenosine diphosphate (ADP), adenosine monophosphate (AMP), adenosine, inosine, hypoxanthine, xanthine and uric acid), and adenosine deaminase (E-ADA) activity in sera were evaluated. Samples were collected on days 12 and 30 post-infection (PI). The E-ADA activity showed a significant reduction on day 12 PI, and increased on day 30 PI in dogs infected with E. canis. On day 12, an increase in seric concentration of ATP, ADP and adenosine was verified, and different levels of hypoxanthine, xanthine and uric acid had a drastic reduction in infected compared healthy dogs (P <0.05). However, on day 30 PI, the levels of seric ADP and AMP decreased, unlike the concentration of xanthine and uric acid that increased significantly in infected dogs (P <0.05). Therefore, the activity of E-ADA and purine levels are altered in experimental canine ehrlichiosis, probably with the purpose of modulating the pathogenesis of the disease related to immune response, oxidative stress and coagulation disorders in acute phase. The aim of this study was to evaluate adenosine deaminase activity and purines levels in serum of dogs experimentally infected by Ehrlichia canis. Banked serum samples of dogs divided into two groups with five animals each: healthy animals and animals infected by E. canis. The concentration of purines (adenosine triphosphate (ATP), adenosine diphosphate (ADP), adenosine monophosphate (AMP), adenosine, inosine, hypoxanthine, xanthine and uric acid), and adenosine deaminase (E-ADA) activity in sera were evaluated. Samples were collected on days 12 and 30 post-infection (PI). The E-ADA activity showed a significant reduction on day 12 PI, and increased on day 30 PI in dogs infected with E. canis. On day 12, an increase in seric concentration of ATP, ADP and adenosine was verified, and different levels of hypoxanthine, xanthine and uric acid had a drastic reduction in infected compared healthy dogs (P <0.05). However, on day 30 PI, the levels of seric ADP and AMP decreased, unlike the concentration of xanthine and uric acid that increased significantly in infected dogs (P <0.05). Therefore, the activity of E-ADA and purine levels are altered in experimental canine ehrlichiosis, probably with the purpose of modulating the pathogenesis of the disease related to immune response, oxidative stress and coagulation disorders in acute phase. Adenosine Elsevier Ehrlichia canis Elsevier Adenosine deaminase Elsevier Canine Elsevier Munhoz, Thiago D. oth Faria, Joice L.M. oth Vargas-Hérnandez, Giovanni oth Machado, Rosangela Z. oth Luz, Nathalia C. oth Moritz, Cesar E.J. oth Casali, Emerson A. oth Bottari, Nathieli B. oth Stefani, Lenita M. oth Tinucci-Costa, Mirela oth Enthalten in Elsevier Science Grain refinement and hardness distribution in cryogenically cooled ferritic stainless steel welds 2013 an international journal concerned with microbiological diseases of all animals that are useful to man Amsterdam [u.a.] (DE-627)ELV011521430 volume:166 year:2013 number:3 day:25 month:10 pages:602-606 extent:5 https://doi.org/10.1016/j.vetmic.2013.06.033 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U AR 166 2013 3 25 1025 602-606 5 045F 630 |
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Enthalten in Grain refinement and hardness distribution in cryogenically cooled ferritic stainless steel welds Amsterdam [u.a.] volume:166 year:2013 number:3 day:25 month:10 pages:602-606 extent:5 |
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Da Silva, Aleksandro S. @@aut@@ Munhoz, Thiago D. @@oth@@ Faria, Joice L.M. @@oth@@ Vargas-Hérnandez, Giovanni @@oth@@ Machado, Rosangela Z. @@oth@@ Luz, Nathalia C. @@oth@@ Moritz, Cesar E.J. @@oth@@ Casali, Emerson A. @@oth@@ Bottari, Nathieli B. @@oth@@ Stefani, Lenita M. @@oth@@ Tinucci-Costa, Mirela @@oth@@ |
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Influence of experimental canine ehrlichiosis on the E-ADA activity and purine levels in serum and possible functional correlations with pathogenesis |
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The aim of this study was to evaluate adenosine deaminase activity and purines levels in serum of dogs experimentally infected by Ehrlichia canis. Banked serum samples of dogs divided into two groups with five animals each: healthy animals and animals infected by E. canis. The concentration of purines (adenosine triphosphate (ATP), adenosine diphosphate (ADP), adenosine monophosphate (AMP), adenosine, inosine, hypoxanthine, xanthine and uric acid), and adenosine deaminase (E-ADA) activity in sera were evaluated. Samples were collected on days 12 and 30 post-infection (PI). The E-ADA activity showed a significant reduction on day 12 PI, and increased on day 30 PI in dogs infected with E. canis. On day 12, an increase in seric concentration of ATP, ADP and adenosine was verified, and different levels of hypoxanthine, xanthine and uric acid had a drastic reduction in infected compared healthy dogs (P <0.05). However, on day 30 PI, the levels of seric ADP and AMP decreased, unlike the concentration of xanthine and uric acid that increased significantly in infected dogs (P <0.05). Therefore, the activity of E-ADA and purine levels are altered in experimental canine ehrlichiosis, probably with the purpose of modulating the pathogenesis of the disease related to immune response, oxidative stress and coagulation disorders in acute phase. |
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The aim of this study was to evaluate adenosine deaminase activity and purines levels in serum of dogs experimentally infected by Ehrlichia canis. Banked serum samples of dogs divided into two groups with five animals each: healthy animals and animals infected by E. canis. The concentration of purines (adenosine triphosphate (ATP), adenosine diphosphate (ADP), adenosine monophosphate (AMP), adenosine, inosine, hypoxanthine, xanthine and uric acid), and adenosine deaminase (E-ADA) activity in sera were evaluated. Samples were collected on days 12 and 30 post-infection (PI). The E-ADA activity showed a significant reduction on day 12 PI, and increased on day 30 PI in dogs infected with E. canis. On day 12, an increase in seric concentration of ATP, ADP and adenosine was verified, and different levels of hypoxanthine, xanthine and uric acid had a drastic reduction in infected compared healthy dogs (P <0.05). However, on day 30 PI, the levels of seric ADP and AMP decreased, unlike the concentration of xanthine and uric acid that increased significantly in infected dogs (P <0.05). Therefore, the activity of E-ADA and purine levels are altered in experimental canine ehrlichiosis, probably with the purpose of modulating the pathogenesis of the disease related to immune response, oxidative stress and coagulation disorders in acute phase. |
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The aim of this study was to evaluate adenosine deaminase activity and purines levels in serum of dogs experimentally infected by Ehrlichia canis. Banked serum samples of dogs divided into two groups with five animals each: healthy animals and animals infected by E. canis. The concentration of purines (adenosine triphosphate (ATP), adenosine diphosphate (ADP), adenosine monophosphate (AMP), adenosine, inosine, hypoxanthine, xanthine and uric acid), and adenosine deaminase (E-ADA) activity in sera were evaluated. Samples were collected on days 12 and 30 post-infection (PI). The E-ADA activity showed a significant reduction on day 12 PI, and increased on day 30 PI in dogs infected with E. canis. On day 12, an increase in seric concentration of ATP, ADP and adenosine was verified, and different levels of hypoxanthine, xanthine and uric acid had a drastic reduction in infected compared healthy dogs (P <0.05). However, on day 30 PI, the levels of seric ADP and AMP decreased, unlike the concentration of xanthine and uric acid that increased significantly in infected dogs (P <0.05). Therefore, the activity of E-ADA and purine levels are altered in experimental canine ehrlichiosis, probably with the purpose of modulating the pathogenesis of the disease related to immune response, oxidative stress and coagulation disorders in acute phase. |
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