Evaluation of solubility and partition properties of ampicillin-based ionic liquids
Abstract In order to overcome the problems associated with low water solubility, and consequently low bioavailability of active pharmaceutical ingredients (APIs), herein we explore a modular ionic liquid synthetic strategy for improved APIs. Ionic liquids containing l-ampicillin as active pharmaceut...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Florindo, Catarina [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
2013transfer abstract |
|---|
| Schlagwörter: |
Critical micelle concentrations |
|---|
| Umfang: |
7 |
|---|
| Übergeordnetes Werk: |
Enthalten in: Description d’une cohorte française multicentrique de porteurs asymptomatiques d’anticorps anti-phospholipides - Nigolian, H. ELSEVIER, 2022, New York, NY [u.a.] |
|---|---|
| Übergeordnetes Werk: |
volume:456 ; year:2013 ; number:2 ; day:18 ; month:11 ; pages:553-559 ; extent:7 |
| Links: |
|---|
| DOI / URN: |
10.1016/j.ijpharm.2013.08.010 |
|---|
| Katalog-ID: |
ELV021960526 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | ELV021960526 | ||
| 003 | DE-627 | ||
| 005 | 20230625134540.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 180603s2013 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.ijpharm.2013.08.010 |2 doi | |
| 028 | 5 | 2 | |a GBVA2013012000020.pica |
| 035 | |a (DE-627)ELV021960526 | ||
| 035 | |a (ELSEVIER)S0378-5173(13)00732-1 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 082 | 0 | |a 610 | |
| 082 | 0 | 4 | |a 610 |q DE-600 |
| 082 | 0 | 4 | |a 610 |q VZ |
| 084 | |a 44.61 |2 bkl | ||
| 100 | 1 | |a Florindo, Catarina |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Evaluation of solubility and partition properties of ampicillin-based ionic liquids |
| 264 | 1 | |c 2013transfer abstract | |
| 300 | |a 7 | ||
| 336 | |a nicht spezifiziert |b zzz |2 rdacontent | ||
| 337 | |a nicht spezifiziert |b z |2 rdamedia | ||
| 338 | |a nicht spezifiziert |b zu |2 rdacarrier | ||
| 520 | |a Abstract In order to overcome the problems associated with low water solubility, and consequently low bioavailability of active pharmaceutical ingredients (APIs), herein we explore a modular ionic liquid synthetic strategy for improved APIs. Ionic liquids containing l-ampicillin as active pharmaceutical ingredient anion were prepared using the methodology developed in our previous work, using organic cations selected from substituted ammonium, phosphonium, pyridinium and methylimidazolium salts, with the intent of enhancing the solubility and bioavailability of l-ampicillin forms. In order to evaluate important properties of the synthesized API-ILs, the water solubility at 25°C and 37°C (body temperature) as well as octanol–water partition coefficients (K ow's) and HDPC micelles partition at 25°C were measured. Critical micelle concentrations (CMC's) in water at 25°C and 37°C of the pharmaceutical ionic liquids bearing cations with surfactant properties were also determined from ionic conductivity measurements. | ||
| 520 | |a Abstract In order to overcome the problems associated with low water solubility, and consequently low bioavailability of active pharmaceutical ingredients (APIs), herein we explore a modular ionic liquid synthetic strategy for improved APIs. Ionic liquids containing l-ampicillin as active pharmaceutical ingredient anion were prepared using the methodology developed in our previous work, using organic cations selected from substituted ammonium, phosphonium, pyridinium and methylimidazolium salts, with the intent of enhancing the solubility and bioavailability of l-ampicillin forms. In order to evaluate important properties of the synthesized API-ILs, the water solubility at 25°C and 37°C (body temperature) as well as octanol–water partition coefficients (K ow's) and HDPC micelles partition at 25°C were measured. Critical micelle concentrations (CMC's) in water at 25°C and 37°C of the pharmaceutical ionic liquids bearing cations with surfactant properties were also determined from ionic conductivity measurements. | ||
| 650 | 7 | |a Critical micelle concentrations |2 Elsevier | |
| 650 | 7 | |a Solubility |2 Elsevier | |
| 650 | 7 | |a Bioavailability |2 Elsevier | |
| 650 | 7 | |a Octanol–water partition coefficients |2 Elsevier | |
| 650 | 7 | |a Active pharmaceutical ionic liquids |2 Elsevier | |
| 700 | 1 | |a Araújo, João M.M. |4 oth | |
| 700 | 1 | |a Alves, Filipa |4 oth | |
| 700 | 1 | |a Matos, Carla |4 oth | |
| 700 | 1 | |a Ferraz, Ricardo |4 oth | |
| 700 | 1 | |a Prudêncio, Cristina |4 oth | |
| 700 | 1 | |a Noronha, João Paulo |4 oth | |
| 700 | 1 | |a Petrovski, Željko |4 oth | |
| 700 | 1 | |a Branco, Luís |4 oth | |
| 700 | 1 | |a Rebelo, Luís Paulo N. |4 oth | |
| 700 | 1 | |a Marrucho, Isabel M. |4 oth | |
| 773 | 0 | 8 | |i Enthalten in |n Elsevier |a Nigolian, H. ELSEVIER |t Description d’une cohorte française multicentrique de porteurs asymptomatiques d’anticorps anti-phospholipides |d 2022 |g New York, NY [u.a.] |w (DE-627)ELV008932840 |
| 773 | 1 | 8 | |g volume:456 |g year:2013 |g number:2 |g day:18 |g month:11 |g pages:553-559 |g extent:7 |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.ijpharm.2013.08.010 |3 Volltext |
| 912 | |a GBV_USEFLAG_U | ||
| 912 | |a GBV_ELV | ||
| 912 | |a SYSFLAG_U | ||
| 936 | b | k | |a 44.61 |j Innere Medizin |q VZ |
| 951 | |a AR | ||
| 952 | |d 456 |j 2013 |e 2 |b 18 |c 1118 |h 553-559 |g 7 | ||
| 953 | |2 045F |a 610 | ||
| author_variant |
c f cf |
|---|---|
| matchkey_str |
florindocatarinaarajojoommalvesfilipamat:2013----:vlainfouiiynpriinrprisfmiil |
| hierarchy_sort_str |
2013transfer abstract |
| bklnumber |
44.61 |
| publishDate |
2013 |
| allfields |
10.1016/j.ijpharm.2013.08.010 doi GBVA2013012000020.pica (DE-627)ELV021960526 (ELSEVIER)S0378-5173(13)00732-1 DE-627 ger DE-627 rakwb eng 610 610 DE-600 610 VZ 44.61 bkl Florindo, Catarina verfasserin aut Evaluation of solubility and partition properties of ampicillin-based ionic liquids 2013transfer abstract 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract In order to overcome the problems associated with low water solubility, and consequently low bioavailability of active pharmaceutical ingredients (APIs), herein we explore a modular ionic liquid synthetic strategy for improved APIs. Ionic liquids containing l-ampicillin as active pharmaceutical ingredient anion were prepared using the methodology developed in our previous work, using organic cations selected from substituted ammonium, phosphonium, pyridinium and methylimidazolium salts, with the intent of enhancing the solubility and bioavailability of l-ampicillin forms. In order to evaluate important properties of the synthesized API-ILs, the water solubility at 25°C and 37°C (body temperature) as well as octanol–water partition coefficients (K ow's) and HDPC micelles partition at 25°C were measured. Critical micelle concentrations (CMC's) in water at 25°C and 37°C of the pharmaceutical ionic liquids bearing cations with surfactant properties were also determined from ionic conductivity measurements. Abstract In order to overcome the problems associated with low water solubility, and consequently low bioavailability of active pharmaceutical ingredients (APIs), herein we explore a modular ionic liquid synthetic strategy for improved APIs. Ionic liquids containing l-ampicillin as active pharmaceutical ingredient anion were prepared using the methodology developed in our previous work, using organic cations selected from substituted ammonium, phosphonium, pyridinium and methylimidazolium salts, with the intent of enhancing the solubility and bioavailability of l-ampicillin forms. In order to evaluate important properties of the synthesized API-ILs, the water solubility at 25°C and 37°C (body temperature) as well as octanol–water partition coefficients (K ow's) and HDPC micelles partition at 25°C were measured. Critical micelle concentrations (CMC's) in water at 25°C and 37°C of the pharmaceutical ionic liquids bearing cations with surfactant properties were also determined from ionic conductivity measurements. Critical micelle concentrations Elsevier Solubility Elsevier Bioavailability Elsevier Octanol–water partition coefficients Elsevier Active pharmaceutical ionic liquids Elsevier Araújo, João M.M. oth Alves, Filipa oth Matos, Carla oth Ferraz, Ricardo oth Prudêncio, Cristina oth Noronha, João Paulo oth Petrovski, Željko oth Branco, Luís oth Rebelo, Luís Paulo N. oth Marrucho, Isabel M. oth Enthalten in Elsevier Nigolian, H. ELSEVIER Description d’une cohorte française multicentrique de porteurs asymptomatiques d’anticorps anti-phospholipides 2022 New York, NY [u.a.] (DE-627)ELV008932840 volume:456 year:2013 number:2 day:18 month:11 pages:553-559 extent:7 https://doi.org/10.1016/j.ijpharm.2013.08.010 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 44.61 Innere Medizin VZ AR 456 2013 2 18 1118 553-559 7 045F 610 |
| spelling |
10.1016/j.ijpharm.2013.08.010 doi GBVA2013012000020.pica (DE-627)ELV021960526 (ELSEVIER)S0378-5173(13)00732-1 DE-627 ger DE-627 rakwb eng 610 610 DE-600 610 VZ 44.61 bkl Florindo, Catarina verfasserin aut Evaluation of solubility and partition properties of ampicillin-based ionic liquids 2013transfer abstract 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract In order to overcome the problems associated with low water solubility, and consequently low bioavailability of active pharmaceutical ingredients (APIs), herein we explore a modular ionic liquid synthetic strategy for improved APIs. Ionic liquids containing l-ampicillin as active pharmaceutical ingredient anion were prepared using the methodology developed in our previous work, using organic cations selected from substituted ammonium, phosphonium, pyridinium and methylimidazolium salts, with the intent of enhancing the solubility and bioavailability of l-ampicillin forms. In order to evaluate important properties of the synthesized API-ILs, the water solubility at 25°C and 37°C (body temperature) as well as octanol–water partition coefficients (K ow's) and HDPC micelles partition at 25°C were measured. Critical micelle concentrations (CMC's) in water at 25°C and 37°C of the pharmaceutical ionic liquids bearing cations with surfactant properties were also determined from ionic conductivity measurements. Abstract In order to overcome the problems associated with low water solubility, and consequently low bioavailability of active pharmaceutical ingredients (APIs), herein we explore a modular ionic liquid synthetic strategy for improved APIs. Ionic liquids containing l-ampicillin as active pharmaceutical ingredient anion were prepared using the methodology developed in our previous work, using organic cations selected from substituted ammonium, phosphonium, pyridinium and methylimidazolium salts, with the intent of enhancing the solubility and bioavailability of l-ampicillin forms. In order to evaluate important properties of the synthesized API-ILs, the water solubility at 25°C and 37°C (body temperature) as well as octanol–water partition coefficients (K ow's) and HDPC micelles partition at 25°C were measured. Critical micelle concentrations (CMC's) in water at 25°C and 37°C of the pharmaceutical ionic liquids bearing cations with surfactant properties were also determined from ionic conductivity measurements. Critical micelle concentrations Elsevier Solubility Elsevier Bioavailability Elsevier Octanol–water partition coefficients Elsevier Active pharmaceutical ionic liquids Elsevier Araújo, João M.M. oth Alves, Filipa oth Matos, Carla oth Ferraz, Ricardo oth Prudêncio, Cristina oth Noronha, João Paulo oth Petrovski, Željko oth Branco, Luís oth Rebelo, Luís Paulo N. oth Marrucho, Isabel M. oth Enthalten in Elsevier Nigolian, H. ELSEVIER Description d’une cohorte française multicentrique de porteurs asymptomatiques d’anticorps anti-phospholipides 2022 New York, NY [u.a.] (DE-627)ELV008932840 volume:456 year:2013 number:2 day:18 month:11 pages:553-559 extent:7 https://doi.org/10.1016/j.ijpharm.2013.08.010 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 44.61 Innere Medizin VZ AR 456 2013 2 18 1118 553-559 7 045F 610 |
| allfields_unstemmed |
10.1016/j.ijpharm.2013.08.010 doi GBVA2013012000020.pica (DE-627)ELV021960526 (ELSEVIER)S0378-5173(13)00732-1 DE-627 ger DE-627 rakwb eng 610 610 DE-600 610 VZ 44.61 bkl Florindo, Catarina verfasserin aut Evaluation of solubility and partition properties of ampicillin-based ionic liquids 2013transfer abstract 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract In order to overcome the problems associated with low water solubility, and consequently low bioavailability of active pharmaceutical ingredients (APIs), herein we explore a modular ionic liquid synthetic strategy for improved APIs. Ionic liquids containing l-ampicillin as active pharmaceutical ingredient anion were prepared using the methodology developed in our previous work, using organic cations selected from substituted ammonium, phosphonium, pyridinium and methylimidazolium salts, with the intent of enhancing the solubility and bioavailability of l-ampicillin forms. In order to evaluate important properties of the synthesized API-ILs, the water solubility at 25°C and 37°C (body temperature) as well as octanol–water partition coefficients (K ow's) and HDPC micelles partition at 25°C were measured. Critical micelle concentrations (CMC's) in water at 25°C and 37°C of the pharmaceutical ionic liquids bearing cations with surfactant properties were also determined from ionic conductivity measurements. Abstract In order to overcome the problems associated with low water solubility, and consequently low bioavailability of active pharmaceutical ingredients (APIs), herein we explore a modular ionic liquid synthetic strategy for improved APIs. Ionic liquids containing l-ampicillin as active pharmaceutical ingredient anion were prepared using the methodology developed in our previous work, using organic cations selected from substituted ammonium, phosphonium, pyridinium and methylimidazolium salts, with the intent of enhancing the solubility and bioavailability of l-ampicillin forms. In order to evaluate important properties of the synthesized API-ILs, the water solubility at 25°C and 37°C (body temperature) as well as octanol–water partition coefficients (K ow's) and HDPC micelles partition at 25°C were measured. Critical micelle concentrations (CMC's) in water at 25°C and 37°C of the pharmaceutical ionic liquids bearing cations with surfactant properties were also determined from ionic conductivity measurements. Critical micelle concentrations Elsevier Solubility Elsevier Bioavailability Elsevier Octanol–water partition coefficients Elsevier Active pharmaceutical ionic liquids Elsevier Araújo, João M.M. oth Alves, Filipa oth Matos, Carla oth Ferraz, Ricardo oth Prudêncio, Cristina oth Noronha, João Paulo oth Petrovski, Željko oth Branco, Luís oth Rebelo, Luís Paulo N. oth Marrucho, Isabel M. oth Enthalten in Elsevier Nigolian, H. ELSEVIER Description d’une cohorte française multicentrique de porteurs asymptomatiques d’anticorps anti-phospholipides 2022 New York, NY [u.a.] (DE-627)ELV008932840 volume:456 year:2013 number:2 day:18 month:11 pages:553-559 extent:7 https://doi.org/10.1016/j.ijpharm.2013.08.010 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 44.61 Innere Medizin VZ AR 456 2013 2 18 1118 553-559 7 045F 610 |
| allfieldsGer |
10.1016/j.ijpharm.2013.08.010 doi GBVA2013012000020.pica (DE-627)ELV021960526 (ELSEVIER)S0378-5173(13)00732-1 DE-627 ger DE-627 rakwb eng 610 610 DE-600 610 VZ 44.61 bkl Florindo, Catarina verfasserin aut Evaluation of solubility and partition properties of ampicillin-based ionic liquids 2013transfer abstract 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract In order to overcome the problems associated with low water solubility, and consequently low bioavailability of active pharmaceutical ingredients (APIs), herein we explore a modular ionic liquid synthetic strategy for improved APIs. Ionic liquids containing l-ampicillin as active pharmaceutical ingredient anion were prepared using the methodology developed in our previous work, using organic cations selected from substituted ammonium, phosphonium, pyridinium and methylimidazolium salts, with the intent of enhancing the solubility and bioavailability of l-ampicillin forms. In order to evaluate important properties of the synthesized API-ILs, the water solubility at 25°C and 37°C (body temperature) as well as octanol–water partition coefficients (K ow's) and HDPC micelles partition at 25°C were measured. Critical micelle concentrations (CMC's) in water at 25°C and 37°C of the pharmaceutical ionic liquids bearing cations with surfactant properties were also determined from ionic conductivity measurements. Abstract In order to overcome the problems associated with low water solubility, and consequently low bioavailability of active pharmaceutical ingredients (APIs), herein we explore a modular ionic liquid synthetic strategy for improved APIs. Ionic liquids containing l-ampicillin as active pharmaceutical ingredient anion were prepared using the methodology developed in our previous work, using organic cations selected from substituted ammonium, phosphonium, pyridinium and methylimidazolium salts, with the intent of enhancing the solubility and bioavailability of l-ampicillin forms. In order to evaluate important properties of the synthesized API-ILs, the water solubility at 25°C and 37°C (body temperature) as well as octanol–water partition coefficients (K ow's) and HDPC micelles partition at 25°C were measured. Critical micelle concentrations (CMC's) in water at 25°C and 37°C of the pharmaceutical ionic liquids bearing cations with surfactant properties were also determined from ionic conductivity measurements. Critical micelle concentrations Elsevier Solubility Elsevier Bioavailability Elsevier Octanol–water partition coefficients Elsevier Active pharmaceutical ionic liquids Elsevier Araújo, João M.M. oth Alves, Filipa oth Matos, Carla oth Ferraz, Ricardo oth Prudêncio, Cristina oth Noronha, João Paulo oth Petrovski, Željko oth Branco, Luís oth Rebelo, Luís Paulo N. oth Marrucho, Isabel M. oth Enthalten in Elsevier Nigolian, H. ELSEVIER Description d’une cohorte française multicentrique de porteurs asymptomatiques d’anticorps anti-phospholipides 2022 New York, NY [u.a.] (DE-627)ELV008932840 volume:456 year:2013 number:2 day:18 month:11 pages:553-559 extent:7 https://doi.org/10.1016/j.ijpharm.2013.08.010 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 44.61 Innere Medizin VZ AR 456 2013 2 18 1118 553-559 7 045F 610 |
| allfieldsSound |
10.1016/j.ijpharm.2013.08.010 doi GBVA2013012000020.pica (DE-627)ELV021960526 (ELSEVIER)S0378-5173(13)00732-1 DE-627 ger DE-627 rakwb eng 610 610 DE-600 610 VZ 44.61 bkl Florindo, Catarina verfasserin aut Evaluation of solubility and partition properties of ampicillin-based ionic liquids 2013transfer abstract 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract In order to overcome the problems associated with low water solubility, and consequently low bioavailability of active pharmaceutical ingredients (APIs), herein we explore a modular ionic liquid synthetic strategy for improved APIs. Ionic liquids containing l-ampicillin as active pharmaceutical ingredient anion were prepared using the methodology developed in our previous work, using organic cations selected from substituted ammonium, phosphonium, pyridinium and methylimidazolium salts, with the intent of enhancing the solubility and bioavailability of l-ampicillin forms. In order to evaluate important properties of the synthesized API-ILs, the water solubility at 25°C and 37°C (body temperature) as well as octanol–water partition coefficients (K ow's) and HDPC micelles partition at 25°C were measured. Critical micelle concentrations (CMC's) in water at 25°C and 37°C of the pharmaceutical ionic liquids bearing cations with surfactant properties were also determined from ionic conductivity measurements. Abstract In order to overcome the problems associated with low water solubility, and consequently low bioavailability of active pharmaceutical ingredients (APIs), herein we explore a modular ionic liquid synthetic strategy for improved APIs. Ionic liquids containing l-ampicillin as active pharmaceutical ingredient anion were prepared using the methodology developed in our previous work, using organic cations selected from substituted ammonium, phosphonium, pyridinium and methylimidazolium salts, with the intent of enhancing the solubility and bioavailability of l-ampicillin forms. In order to evaluate important properties of the synthesized API-ILs, the water solubility at 25°C and 37°C (body temperature) as well as octanol–water partition coefficients (K ow's) and HDPC micelles partition at 25°C were measured. Critical micelle concentrations (CMC's) in water at 25°C and 37°C of the pharmaceutical ionic liquids bearing cations with surfactant properties were also determined from ionic conductivity measurements. Critical micelle concentrations Elsevier Solubility Elsevier Bioavailability Elsevier Octanol–water partition coefficients Elsevier Active pharmaceutical ionic liquids Elsevier Araújo, João M.M. oth Alves, Filipa oth Matos, Carla oth Ferraz, Ricardo oth Prudêncio, Cristina oth Noronha, João Paulo oth Petrovski, Željko oth Branco, Luís oth Rebelo, Luís Paulo N. oth Marrucho, Isabel M. oth Enthalten in Elsevier Nigolian, H. ELSEVIER Description d’une cohorte française multicentrique de porteurs asymptomatiques d’anticorps anti-phospholipides 2022 New York, NY [u.a.] (DE-627)ELV008932840 volume:456 year:2013 number:2 day:18 month:11 pages:553-559 extent:7 https://doi.org/10.1016/j.ijpharm.2013.08.010 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 44.61 Innere Medizin VZ AR 456 2013 2 18 1118 553-559 7 045F 610 |
| language |
English |
| source |
Enthalten in Description d’une cohorte française multicentrique de porteurs asymptomatiques d’anticorps anti-phospholipides New York, NY [u.a.] volume:456 year:2013 number:2 day:18 month:11 pages:553-559 extent:7 |
| sourceStr |
Enthalten in Description d’une cohorte française multicentrique de porteurs asymptomatiques d’anticorps anti-phospholipides New York, NY [u.a.] volume:456 year:2013 number:2 day:18 month:11 pages:553-559 extent:7 |
| format_phy_str_mv |
Article |
| bklname |
Innere Medizin |
| institution |
findex.gbv.de |
| topic_facet |
Critical micelle concentrations Solubility Bioavailability Octanol–water partition coefficients Active pharmaceutical ionic liquids |
| dewey-raw |
610 |
| isfreeaccess_bool |
false |
| container_title |
Description d’une cohorte française multicentrique de porteurs asymptomatiques d’anticorps anti-phospholipides |
| authorswithroles_txt_mv |
Florindo, Catarina @@aut@@ Araújo, João M.M. @@oth@@ Alves, Filipa @@oth@@ Matos, Carla @@oth@@ Ferraz, Ricardo @@oth@@ Prudêncio, Cristina @@oth@@ Noronha, João Paulo @@oth@@ Petrovski, Željko @@oth@@ Branco, Luís @@oth@@ Rebelo, Luís Paulo N. @@oth@@ Marrucho, Isabel M. @@oth@@ |
| publishDateDaySort_date |
2013-01-18T00:00:00Z |
| hierarchy_top_id |
ELV008932840 |
| dewey-sort |
3610 |
| id |
ELV021960526 |
| language_de |
englisch |
| fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">ELV021960526</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230625134540.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">180603s2013 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.ijpharm.2013.08.010</subfield><subfield code="2">doi</subfield></datafield><datafield tag="028" ind1="5" ind2="2"><subfield code="a">GBVA2013012000020.pica</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)ELV021960526</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(ELSEVIER)S0378-5173(13)00732-1</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">610</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">DE-600</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">44.61</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Florindo, Catarina</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Evaluation of solubility and partition properties of ampicillin-based ionic liquids</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2013transfer abstract</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">7</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract In order to overcome the problems associated with low water solubility, and consequently low bioavailability of active pharmaceutical ingredients (APIs), herein we explore a modular ionic liquid synthetic strategy for improved APIs. Ionic liquids containing l-ampicillin as active pharmaceutical ingredient anion were prepared using the methodology developed in our previous work, using organic cations selected from substituted ammonium, phosphonium, pyridinium and methylimidazolium salts, with the intent of enhancing the solubility and bioavailability of l-ampicillin forms. In order to evaluate important properties of the synthesized API-ILs, the water solubility at 25°C and 37°C (body temperature) as well as octanol–water partition coefficients (K ow's) and HDPC micelles partition at 25°C were measured. Critical micelle concentrations (CMC's) in water at 25°C and 37°C of the pharmaceutical ionic liquids bearing cations with surfactant properties were also determined from ionic conductivity measurements.</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract In order to overcome the problems associated with low water solubility, and consequently low bioavailability of active pharmaceutical ingredients (APIs), herein we explore a modular ionic liquid synthetic strategy for improved APIs. Ionic liquids containing l-ampicillin as active pharmaceutical ingredient anion were prepared using the methodology developed in our previous work, using organic cations selected from substituted ammonium, phosphonium, pyridinium and methylimidazolium salts, with the intent of enhancing the solubility and bioavailability of l-ampicillin forms. In order to evaluate important properties of the synthesized API-ILs, the water solubility at 25°C and 37°C (body temperature) as well as octanol–water partition coefficients (K ow's) and HDPC micelles partition at 25°C were measured. Critical micelle concentrations (CMC's) in water at 25°C and 37°C of the pharmaceutical ionic liquids bearing cations with surfactant properties were also determined from ionic conductivity measurements.</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Critical micelle concentrations</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Solubility</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Bioavailability</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Octanol–water partition coefficients</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Active pharmaceutical ionic liquids</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Araújo, João M.M.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Alves, Filipa</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Matos, Carla</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Ferraz, Ricardo</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Prudêncio, Cristina</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Noronha, João Paulo</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Petrovski, Željko</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Branco, Luís</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Rebelo, Luís Paulo N.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Marrucho, Isabel M.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="n">Elsevier</subfield><subfield code="a">Nigolian, H. ELSEVIER</subfield><subfield code="t">Description d’une cohorte française multicentrique de porteurs asymptomatiques d’anticorps anti-phospholipides</subfield><subfield code="d">2022</subfield><subfield code="g">New York, NY [u.a.]</subfield><subfield code="w">(DE-627)ELV008932840</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:456</subfield><subfield code="g">year:2013</subfield><subfield code="g">number:2</subfield><subfield code="g">day:18</subfield><subfield code="g">month:11</subfield><subfield code="g">pages:553-559</subfield><subfield code="g">extent:7</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1016/j.ijpharm.2013.08.010</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ELV</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_U</subfield></datafield><datafield tag="936" ind1="b" ind2="k"><subfield code="a">44.61</subfield><subfield code="j">Innere Medizin</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">456</subfield><subfield code="j">2013</subfield><subfield code="e">2</subfield><subfield code="b">18</subfield><subfield code="c">1118</subfield><subfield code="h">553-559</subfield><subfield code="g">7</subfield></datafield><datafield tag="953" ind1=" " ind2=" "><subfield code="2">045F</subfield><subfield code="a">610</subfield></datafield></record></collection>
|
| author |
Florindo, Catarina |
| spellingShingle |
Florindo, Catarina ddc 610 bkl 44.61 Elsevier Critical micelle concentrations Elsevier Solubility Elsevier Bioavailability Elsevier Octanol–water partition coefficients Elsevier Active pharmaceutical ionic liquids Evaluation of solubility and partition properties of ampicillin-based ionic liquids |
| authorStr |
Florindo, Catarina |
| ppnlink_with_tag_str_mv |
@@773@@(DE-627)ELV008932840 |
| format |
electronic Article |
| dewey-ones |
610 - Medicine & health |
| delete_txt_mv |
keep |
| author_role |
aut |
| collection |
elsevier |
| remote_str |
true |
| illustrated |
Not Illustrated |
| topic_title |
610 610 DE-600 610 VZ 44.61 bkl Evaluation of solubility and partition properties of ampicillin-based ionic liquids Critical micelle concentrations Elsevier Solubility Elsevier Bioavailability Elsevier Octanol–water partition coefficients Elsevier Active pharmaceutical ionic liquids Elsevier |
| topic |
ddc 610 bkl 44.61 Elsevier Critical micelle concentrations Elsevier Solubility Elsevier Bioavailability Elsevier Octanol–water partition coefficients Elsevier Active pharmaceutical ionic liquids |
| topic_unstemmed |
ddc 610 bkl 44.61 Elsevier Critical micelle concentrations Elsevier Solubility Elsevier Bioavailability Elsevier Octanol–water partition coefficients Elsevier Active pharmaceutical ionic liquids |
| topic_browse |
ddc 610 bkl 44.61 Elsevier Critical micelle concentrations Elsevier Solubility Elsevier Bioavailability Elsevier Octanol–water partition coefficients Elsevier Active pharmaceutical ionic liquids |
| format_facet |
Elektronische Aufsätze Aufsätze Elektronische Ressource |
| format_main_str_mv |
Text Zeitschrift/Artikel |
| carriertype_str_mv |
zu |
| author2_variant |
j m a jm jma f a fa c m cm r f rf c p cp j p n jp jpn ž p žp l b lb l p n r lpn lpnr i m m im imm |
| hierarchy_parent_title |
Description d’une cohorte française multicentrique de porteurs asymptomatiques d’anticorps anti-phospholipides |
| hierarchy_parent_id |
ELV008932840 |
| dewey-tens |
610 - Medicine & health |
| hierarchy_top_title |
Description d’une cohorte française multicentrique de porteurs asymptomatiques d’anticorps anti-phospholipides |
| isfreeaccess_txt |
false |
| familylinks_str_mv |
(DE-627)ELV008932840 |
| title |
Evaluation of solubility and partition properties of ampicillin-based ionic liquids |
| ctrlnum |
(DE-627)ELV021960526 (ELSEVIER)S0378-5173(13)00732-1 |
| title_full |
Evaluation of solubility and partition properties of ampicillin-based ionic liquids |
| author_sort |
Florindo, Catarina |
| journal |
Description d’une cohorte française multicentrique de porteurs asymptomatiques d’anticorps anti-phospholipides |
| journalStr |
Description d’une cohorte française multicentrique de porteurs asymptomatiques d’anticorps anti-phospholipides |
| lang_code |
eng |
| isOA_bool |
false |
| dewey-hundreds |
600 - Technology |
| recordtype |
marc |
| publishDateSort |
2013 |
| contenttype_str_mv |
zzz |
| container_start_page |
553 |
| author_browse |
Florindo, Catarina |
| container_volume |
456 |
| physical |
7 |
| class |
610 610 DE-600 610 VZ 44.61 bkl |
| format_se |
Elektronische Aufsätze |
| author-letter |
Florindo, Catarina |
| doi_str_mv |
10.1016/j.ijpharm.2013.08.010 |
| dewey-full |
610 |
| title_sort |
evaluation of solubility and partition properties of ampicillin-based ionic liquids |
| title_auth |
Evaluation of solubility and partition properties of ampicillin-based ionic liquids |
| abstract |
Abstract In order to overcome the problems associated with low water solubility, and consequently low bioavailability of active pharmaceutical ingredients (APIs), herein we explore a modular ionic liquid synthetic strategy for improved APIs. Ionic liquids containing l-ampicillin as active pharmaceutical ingredient anion were prepared using the methodology developed in our previous work, using organic cations selected from substituted ammonium, phosphonium, pyridinium and methylimidazolium salts, with the intent of enhancing the solubility and bioavailability of l-ampicillin forms. In order to evaluate important properties of the synthesized API-ILs, the water solubility at 25°C and 37°C (body temperature) as well as octanol–water partition coefficients (K ow's) and HDPC micelles partition at 25°C were measured. Critical micelle concentrations (CMC's) in water at 25°C and 37°C of the pharmaceutical ionic liquids bearing cations with surfactant properties were also determined from ionic conductivity measurements. |
| abstractGer |
Abstract In order to overcome the problems associated with low water solubility, and consequently low bioavailability of active pharmaceutical ingredients (APIs), herein we explore a modular ionic liquid synthetic strategy for improved APIs. Ionic liquids containing l-ampicillin as active pharmaceutical ingredient anion were prepared using the methodology developed in our previous work, using organic cations selected from substituted ammonium, phosphonium, pyridinium and methylimidazolium salts, with the intent of enhancing the solubility and bioavailability of l-ampicillin forms. In order to evaluate important properties of the synthesized API-ILs, the water solubility at 25°C and 37°C (body temperature) as well as octanol–water partition coefficients (K ow's) and HDPC micelles partition at 25°C were measured. Critical micelle concentrations (CMC's) in water at 25°C and 37°C of the pharmaceutical ionic liquids bearing cations with surfactant properties were also determined from ionic conductivity measurements. |
| abstract_unstemmed |
Abstract In order to overcome the problems associated with low water solubility, and consequently low bioavailability of active pharmaceutical ingredients (APIs), herein we explore a modular ionic liquid synthetic strategy for improved APIs. Ionic liquids containing l-ampicillin as active pharmaceutical ingredient anion were prepared using the methodology developed in our previous work, using organic cations selected from substituted ammonium, phosphonium, pyridinium and methylimidazolium salts, with the intent of enhancing the solubility and bioavailability of l-ampicillin forms. In order to evaluate important properties of the synthesized API-ILs, the water solubility at 25°C and 37°C (body temperature) as well as octanol–water partition coefficients (K ow's) and HDPC micelles partition at 25°C were measured. Critical micelle concentrations (CMC's) in water at 25°C and 37°C of the pharmaceutical ionic liquids bearing cations with surfactant properties were also determined from ionic conductivity measurements. |
| collection_details |
GBV_USEFLAG_U GBV_ELV SYSFLAG_U |
| container_issue |
2 |
| title_short |
Evaluation of solubility and partition properties of ampicillin-based ionic liquids |
| url |
https://doi.org/10.1016/j.ijpharm.2013.08.010 |
| remote_bool |
true |
| author2 |
Araújo, João M.M. Alves, Filipa Matos, Carla Ferraz, Ricardo Prudêncio, Cristina Noronha, João Paulo Petrovski, Željko Branco, Luís Rebelo, Luís Paulo N. Marrucho, Isabel M. |
| author2Str |
Araújo, João M.M. Alves, Filipa Matos, Carla Ferraz, Ricardo Prudêncio, Cristina Noronha, João Paulo Petrovski, Željko Branco, Luís Rebelo, Luís Paulo N. Marrucho, Isabel M. |
| ppnlink |
ELV008932840 |
| mediatype_str_mv |
z |
| isOA_txt |
false |
| hochschulschrift_bool |
false |
| author2_role |
oth oth oth oth oth oth oth oth oth oth |
| doi_str |
10.1016/j.ijpharm.2013.08.010 |
| up_date |
2024-07-06T20:51:26.385Z |
| _version_ |
1803864334807334912 |
| fullrecord_marcxml |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">ELV021960526</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230625134540.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">180603s2013 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.ijpharm.2013.08.010</subfield><subfield code="2">doi</subfield></datafield><datafield tag="028" ind1="5" ind2="2"><subfield code="a">GBVA2013012000020.pica</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)ELV021960526</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(ELSEVIER)S0378-5173(13)00732-1</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">610</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">DE-600</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">44.61</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Florindo, Catarina</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Evaluation of solubility and partition properties of ampicillin-based ionic liquids</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2013transfer abstract</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">7</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract In order to overcome the problems associated with low water solubility, and consequently low bioavailability of active pharmaceutical ingredients (APIs), herein we explore a modular ionic liquid synthetic strategy for improved APIs. Ionic liquids containing l-ampicillin as active pharmaceutical ingredient anion were prepared using the methodology developed in our previous work, using organic cations selected from substituted ammonium, phosphonium, pyridinium and methylimidazolium salts, with the intent of enhancing the solubility and bioavailability of l-ampicillin forms. In order to evaluate important properties of the synthesized API-ILs, the water solubility at 25°C and 37°C (body temperature) as well as octanol–water partition coefficients (K ow's) and HDPC micelles partition at 25°C were measured. Critical micelle concentrations (CMC's) in water at 25°C and 37°C of the pharmaceutical ionic liquids bearing cations with surfactant properties were also determined from ionic conductivity measurements.</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract In order to overcome the problems associated with low water solubility, and consequently low bioavailability of active pharmaceutical ingredients (APIs), herein we explore a modular ionic liquid synthetic strategy for improved APIs. Ionic liquids containing l-ampicillin as active pharmaceutical ingredient anion were prepared using the methodology developed in our previous work, using organic cations selected from substituted ammonium, phosphonium, pyridinium and methylimidazolium salts, with the intent of enhancing the solubility and bioavailability of l-ampicillin forms. In order to evaluate important properties of the synthesized API-ILs, the water solubility at 25°C and 37°C (body temperature) as well as octanol–water partition coefficients (K ow's) and HDPC micelles partition at 25°C were measured. Critical micelle concentrations (CMC's) in water at 25°C and 37°C of the pharmaceutical ionic liquids bearing cations with surfactant properties were also determined from ionic conductivity measurements.</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Critical micelle concentrations</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Solubility</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Bioavailability</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Octanol–water partition coefficients</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Active pharmaceutical ionic liquids</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Araújo, João M.M.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Alves, Filipa</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Matos, Carla</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Ferraz, Ricardo</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Prudêncio, Cristina</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Noronha, João Paulo</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Petrovski, Željko</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Branco, Luís</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Rebelo, Luís Paulo N.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Marrucho, Isabel M.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="n">Elsevier</subfield><subfield code="a">Nigolian, H. ELSEVIER</subfield><subfield code="t">Description d’une cohorte française multicentrique de porteurs asymptomatiques d’anticorps anti-phospholipides</subfield><subfield code="d">2022</subfield><subfield code="g">New York, NY [u.a.]</subfield><subfield code="w">(DE-627)ELV008932840</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:456</subfield><subfield code="g">year:2013</subfield><subfield code="g">number:2</subfield><subfield code="g">day:18</subfield><subfield code="g">month:11</subfield><subfield code="g">pages:553-559</subfield><subfield code="g">extent:7</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1016/j.ijpharm.2013.08.010</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ELV</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_U</subfield></datafield><datafield tag="936" ind1="b" ind2="k"><subfield code="a">44.61</subfield><subfield code="j">Innere Medizin</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">456</subfield><subfield code="j">2013</subfield><subfield code="e">2</subfield><subfield code="b">18</subfield><subfield code="c">1118</subfield><subfield code="h">553-559</subfield><subfield code="g">7</subfield></datafield><datafield tag="953" ind1=" " ind2=" "><subfield code="2">045F</subfield><subfield code="a">610</subfield></datafield></record></collection>
|
| score |
7.400326 |