Evaluation of solubility and partition properties of ampicillin-based ionic liquids
Abstract In order to overcome the problems associated with low water solubility, and consequently low bioavailability of active pharmaceutical ingredients (APIs), herein we explore a modular ionic liquid synthetic strategy for improved APIs. Ionic liquids containing l-ampicillin as active pharmaceut...
Ausführliche Beschreibung
Autor*in: |
Florindo, Catarina [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
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2013transfer abstract |
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Schlagwörter: |
Critical micelle concentrations |
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Umfang: |
7 |
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Übergeordnetes Werk: |
Enthalten in: Description d’une cohorte française multicentrique de porteurs asymptomatiques d’anticorps anti-phospholipides - Nigolian, H. ELSEVIER, 2022, New York, NY [u.a.] |
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Übergeordnetes Werk: |
volume:456 ; year:2013 ; number:2 ; day:18 ; month:11 ; pages:553-559 ; extent:7 |
Links: |
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DOI / URN: |
10.1016/j.ijpharm.2013.08.010 |
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ELV021960526 |
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520 | |a Abstract In order to overcome the problems associated with low water solubility, and consequently low bioavailability of active pharmaceutical ingredients (APIs), herein we explore a modular ionic liquid synthetic strategy for improved APIs. Ionic liquids containing l-ampicillin as active pharmaceutical ingredient anion were prepared using the methodology developed in our previous work, using organic cations selected from substituted ammonium, phosphonium, pyridinium and methylimidazolium salts, with the intent of enhancing the solubility and bioavailability of l-ampicillin forms. In order to evaluate important properties of the synthesized API-ILs, the water solubility at 25°C and 37°C (body temperature) as well as octanol–water partition coefficients (K ow's) and HDPC micelles partition at 25°C were measured. Critical micelle concentrations (CMC's) in water at 25°C and 37°C of the pharmaceutical ionic liquids bearing cations with surfactant properties were also determined from ionic conductivity measurements. | ||
520 | |a Abstract In order to overcome the problems associated with low water solubility, and consequently low bioavailability of active pharmaceutical ingredients (APIs), herein we explore a modular ionic liquid synthetic strategy for improved APIs. Ionic liquids containing l-ampicillin as active pharmaceutical ingredient anion were prepared using the methodology developed in our previous work, using organic cations selected from substituted ammonium, phosphonium, pyridinium and methylimidazolium salts, with the intent of enhancing the solubility and bioavailability of l-ampicillin forms. In order to evaluate important properties of the synthesized API-ILs, the water solubility at 25°C and 37°C (body temperature) as well as octanol–water partition coefficients (K ow's) and HDPC micelles partition at 25°C were measured. Critical micelle concentrations (CMC's) in water at 25°C and 37°C of the pharmaceutical ionic liquids bearing cations with surfactant properties were also determined from ionic conductivity measurements. | ||
650 | 7 | |a Critical micelle concentrations |2 Elsevier | |
650 | 7 | |a Solubility |2 Elsevier | |
650 | 7 | |a Bioavailability |2 Elsevier | |
650 | 7 | |a Octanol–water partition coefficients |2 Elsevier | |
650 | 7 | |a Active pharmaceutical ionic liquids |2 Elsevier | |
700 | 1 | |a Araújo, João M.M. |4 oth | |
700 | 1 | |a Alves, Filipa |4 oth | |
700 | 1 | |a Matos, Carla |4 oth | |
700 | 1 | |a Ferraz, Ricardo |4 oth | |
700 | 1 | |a Prudêncio, Cristina |4 oth | |
700 | 1 | |a Noronha, João Paulo |4 oth | |
700 | 1 | |a Petrovski, Željko |4 oth | |
700 | 1 | |a Branco, Luís |4 oth | |
700 | 1 | |a Rebelo, Luís Paulo N. |4 oth | |
700 | 1 | |a Marrucho, Isabel M. |4 oth | |
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10.1016/j.ijpharm.2013.08.010 doi GBVA2013012000020.pica (DE-627)ELV021960526 (ELSEVIER)S0378-5173(13)00732-1 DE-627 ger DE-627 rakwb eng 610 610 DE-600 610 VZ 44.61 bkl Florindo, Catarina verfasserin aut Evaluation of solubility and partition properties of ampicillin-based ionic liquids 2013transfer abstract 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract In order to overcome the problems associated with low water solubility, and consequently low bioavailability of active pharmaceutical ingredients (APIs), herein we explore a modular ionic liquid synthetic strategy for improved APIs. Ionic liquids containing l-ampicillin as active pharmaceutical ingredient anion were prepared using the methodology developed in our previous work, using organic cations selected from substituted ammonium, phosphonium, pyridinium and methylimidazolium salts, with the intent of enhancing the solubility and bioavailability of l-ampicillin forms. In order to evaluate important properties of the synthesized API-ILs, the water solubility at 25°C and 37°C (body temperature) as well as octanol–water partition coefficients (K ow's) and HDPC micelles partition at 25°C were measured. Critical micelle concentrations (CMC's) in water at 25°C and 37°C of the pharmaceutical ionic liquids bearing cations with surfactant properties were also determined from ionic conductivity measurements. Abstract In order to overcome the problems associated with low water solubility, and consequently low bioavailability of active pharmaceutical ingredients (APIs), herein we explore a modular ionic liquid synthetic strategy for improved APIs. Ionic liquids containing l-ampicillin as active pharmaceutical ingredient anion were prepared using the methodology developed in our previous work, using organic cations selected from substituted ammonium, phosphonium, pyridinium and methylimidazolium salts, with the intent of enhancing the solubility and bioavailability of l-ampicillin forms. In order to evaluate important properties of the synthesized API-ILs, the water solubility at 25°C and 37°C (body temperature) as well as octanol–water partition coefficients (K ow's) and HDPC micelles partition at 25°C were measured. Critical micelle concentrations (CMC's) in water at 25°C and 37°C of the pharmaceutical ionic liquids bearing cations with surfactant properties were also determined from ionic conductivity measurements. Critical micelle concentrations Elsevier Solubility Elsevier Bioavailability Elsevier Octanol–water partition coefficients Elsevier Active pharmaceutical ionic liquids Elsevier Araújo, João M.M. oth Alves, Filipa oth Matos, Carla oth Ferraz, Ricardo oth Prudêncio, Cristina oth Noronha, João Paulo oth Petrovski, Željko oth Branco, Luís oth Rebelo, Luís Paulo N. oth Marrucho, Isabel M. oth Enthalten in Elsevier Nigolian, H. ELSEVIER Description d’une cohorte française multicentrique de porteurs asymptomatiques d’anticorps anti-phospholipides 2022 New York, NY [u.a.] (DE-627)ELV008932840 volume:456 year:2013 number:2 day:18 month:11 pages:553-559 extent:7 https://doi.org/10.1016/j.ijpharm.2013.08.010 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 44.61 Innere Medizin VZ AR 456 2013 2 18 1118 553-559 7 045F 610 |
spelling |
10.1016/j.ijpharm.2013.08.010 doi GBVA2013012000020.pica (DE-627)ELV021960526 (ELSEVIER)S0378-5173(13)00732-1 DE-627 ger DE-627 rakwb eng 610 610 DE-600 610 VZ 44.61 bkl Florindo, Catarina verfasserin aut Evaluation of solubility and partition properties of ampicillin-based ionic liquids 2013transfer abstract 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract In order to overcome the problems associated with low water solubility, and consequently low bioavailability of active pharmaceutical ingredients (APIs), herein we explore a modular ionic liquid synthetic strategy for improved APIs. Ionic liquids containing l-ampicillin as active pharmaceutical ingredient anion were prepared using the methodology developed in our previous work, using organic cations selected from substituted ammonium, phosphonium, pyridinium and methylimidazolium salts, with the intent of enhancing the solubility and bioavailability of l-ampicillin forms. In order to evaluate important properties of the synthesized API-ILs, the water solubility at 25°C and 37°C (body temperature) as well as octanol–water partition coefficients (K ow's) and HDPC micelles partition at 25°C were measured. Critical micelle concentrations (CMC's) in water at 25°C and 37°C of the pharmaceutical ionic liquids bearing cations with surfactant properties were also determined from ionic conductivity measurements. Abstract In order to overcome the problems associated with low water solubility, and consequently low bioavailability of active pharmaceutical ingredients (APIs), herein we explore a modular ionic liquid synthetic strategy for improved APIs. Ionic liquids containing l-ampicillin as active pharmaceutical ingredient anion were prepared using the methodology developed in our previous work, using organic cations selected from substituted ammonium, phosphonium, pyridinium and methylimidazolium salts, with the intent of enhancing the solubility and bioavailability of l-ampicillin forms. In order to evaluate important properties of the synthesized API-ILs, the water solubility at 25°C and 37°C (body temperature) as well as octanol–water partition coefficients (K ow's) and HDPC micelles partition at 25°C were measured. Critical micelle concentrations (CMC's) in water at 25°C and 37°C of the pharmaceutical ionic liquids bearing cations with surfactant properties were also determined from ionic conductivity measurements. Critical micelle concentrations Elsevier Solubility Elsevier Bioavailability Elsevier Octanol–water partition coefficients Elsevier Active pharmaceutical ionic liquids Elsevier Araújo, João M.M. oth Alves, Filipa oth Matos, Carla oth Ferraz, Ricardo oth Prudêncio, Cristina oth Noronha, João Paulo oth Petrovski, Željko oth Branco, Luís oth Rebelo, Luís Paulo N. oth Marrucho, Isabel M. oth Enthalten in Elsevier Nigolian, H. ELSEVIER Description d’une cohorte française multicentrique de porteurs asymptomatiques d’anticorps anti-phospholipides 2022 New York, NY [u.a.] (DE-627)ELV008932840 volume:456 year:2013 number:2 day:18 month:11 pages:553-559 extent:7 https://doi.org/10.1016/j.ijpharm.2013.08.010 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 44.61 Innere Medizin VZ AR 456 2013 2 18 1118 553-559 7 045F 610 |
allfields_unstemmed |
10.1016/j.ijpharm.2013.08.010 doi GBVA2013012000020.pica (DE-627)ELV021960526 (ELSEVIER)S0378-5173(13)00732-1 DE-627 ger DE-627 rakwb eng 610 610 DE-600 610 VZ 44.61 bkl Florindo, Catarina verfasserin aut Evaluation of solubility and partition properties of ampicillin-based ionic liquids 2013transfer abstract 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract In order to overcome the problems associated with low water solubility, and consequently low bioavailability of active pharmaceutical ingredients (APIs), herein we explore a modular ionic liquid synthetic strategy for improved APIs. Ionic liquids containing l-ampicillin as active pharmaceutical ingredient anion were prepared using the methodology developed in our previous work, using organic cations selected from substituted ammonium, phosphonium, pyridinium and methylimidazolium salts, with the intent of enhancing the solubility and bioavailability of l-ampicillin forms. In order to evaluate important properties of the synthesized API-ILs, the water solubility at 25°C and 37°C (body temperature) as well as octanol–water partition coefficients (K ow's) and HDPC micelles partition at 25°C were measured. Critical micelle concentrations (CMC's) in water at 25°C and 37°C of the pharmaceutical ionic liquids bearing cations with surfactant properties were also determined from ionic conductivity measurements. Abstract In order to overcome the problems associated with low water solubility, and consequently low bioavailability of active pharmaceutical ingredients (APIs), herein we explore a modular ionic liquid synthetic strategy for improved APIs. Ionic liquids containing l-ampicillin as active pharmaceutical ingredient anion were prepared using the methodology developed in our previous work, using organic cations selected from substituted ammonium, phosphonium, pyridinium and methylimidazolium salts, with the intent of enhancing the solubility and bioavailability of l-ampicillin forms. In order to evaluate important properties of the synthesized API-ILs, the water solubility at 25°C and 37°C (body temperature) as well as octanol–water partition coefficients (K ow's) and HDPC micelles partition at 25°C were measured. Critical micelle concentrations (CMC's) in water at 25°C and 37°C of the pharmaceutical ionic liquids bearing cations with surfactant properties were also determined from ionic conductivity measurements. Critical micelle concentrations Elsevier Solubility Elsevier Bioavailability Elsevier Octanol–water partition coefficients Elsevier Active pharmaceutical ionic liquids Elsevier Araújo, João M.M. oth Alves, Filipa oth Matos, Carla oth Ferraz, Ricardo oth Prudêncio, Cristina oth Noronha, João Paulo oth Petrovski, Željko oth Branco, Luís oth Rebelo, Luís Paulo N. oth Marrucho, Isabel M. oth Enthalten in Elsevier Nigolian, H. ELSEVIER Description d’une cohorte française multicentrique de porteurs asymptomatiques d’anticorps anti-phospholipides 2022 New York, NY [u.a.] (DE-627)ELV008932840 volume:456 year:2013 number:2 day:18 month:11 pages:553-559 extent:7 https://doi.org/10.1016/j.ijpharm.2013.08.010 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 44.61 Innere Medizin VZ AR 456 2013 2 18 1118 553-559 7 045F 610 |
allfieldsGer |
10.1016/j.ijpharm.2013.08.010 doi GBVA2013012000020.pica (DE-627)ELV021960526 (ELSEVIER)S0378-5173(13)00732-1 DE-627 ger DE-627 rakwb eng 610 610 DE-600 610 VZ 44.61 bkl Florindo, Catarina verfasserin aut Evaluation of solubility and partition properties of ampicillin-based ionic liquids 2013transfer abstract 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract In order to overcome the problems associated with low water solubility, and consequently low bioavailability of active pharmaceutical ingredients (APIs), herein we explore a modular ionic liquid synthetic strategy for improved APIs. Ionic liquids containing l-ampicillin as active pharmaceutical ingredient anion were prepared using the methodology developed in our previous work, using organic cations selected from substituted ammonium, phosphonium, pyridinium and methylimidazolium salts, with the intent of enhancing the solubility and bioavailability of l-ampicillin forms. In order to evaluate important properties of the synthesized API-ILs, the water solubility at 25°C and 37°C (body temperature) as well as octanol–water partition coefficients (K ow's) and HDPC micelles partition at 25°C were measured. Critical micelle concentrations (CMC's) in water at 25°C and 37°C of the pharmaceutical ionic liquids bearing cations with surfactant properties were also determined from ionic conductivity measurements. Abstract In order to overcome the problems associated with low water solubility, and consequently low bioavailability of active pharmaceutical ingredients (APIs), herein we explore a modular ionic liquid synthetic strategy for improved APIs. Ionic liquids containing l-ampicillin as active pharmaceutical ingredient anion were prepared using the methodology developed in our previous work, using organic cations selected from substituted ammonium, phosphonium, pyridinium and methylimidazolium salts, with the intent of enhancing the solubility and bioavailability of l-ampicillin forms. In order to evaluate important properties of the synthesized API-ILs, the water solubility at 25°C and 37°C (body temperature) as well as octanol–water partition coefficients (K ow's) and HDPC micelles partition at 25°C were measured. Critical micelle concentrations (CMC's) in water at 25°C and 37°C of the pharmaceutical ionic liquids bearing cations with surfactant properties were also determined from ionic conductivity measurements. Critical micelle concentrations Elsevier Solubility Elsevier Bioavailability Elsevier Octanol–water partition coefficients Elsevier Active pharmaceutical ionic liquids Elsevier Araújo, João M.M. oth Alves, Filipa oth Matos, Carla oth Ferraz, Ricardo oth Prudêncio, Cristina oth Noronha, João Paulo oth Petrovski, Željko oth Branco, Luís oth Rebelo, Luís Paulo N. oth Marrucho, Isabel M. oth Enthalten in Elsevier Nigolian, H. ELSEVIER Description d’une cohorte française multicentrique de porteurs asymptomatiques d’anticorps anti-phospholipides 2022 New York, NY [u.a.] (DE-627)ELV008932840 volume:456 year:2013 number:2 day:18 month:11 pages:553-559 extent:7 https://doi.org/10.1016/j.ijpharm.2013.08.010 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 44.61 Innere Medizin VZ AR 456 2013 2 18 1118 553-559 7 045F 610 |
allfieldsSound |
10.1016/j.ijpharm.2013.08.010 doi GBVA2013012000020.pica (DE-627)ELV021960526 (ELSEVIER)S0378-5173(13)00732-1 DE-627 ger DE-627 rakwb eng 610 610 DE-600 610 VZ 44.61 bkl Florindo, Catarina verfasserin aut Evaluation of solubility and partition properties of ampicillin-based ionic liquids 2013transfer abstract 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract In order to overcome the problems associated with low water solubility, and consequently low bioavailability of active pharmaceutical ingredients (APIs), herein we explore a modular ionic liquid synthetic strategy for improved APIs. Ionic liquids containing l-ampicillin as active pharmaceutical ingredient anion were prepared using the methodology developed in our previous work, using organic cations selected from substituted ammonium, phosphonium, pyridinium and methylimidazolium salts, with the intent of enhancing the solubility and bioavailability of l-ampicillin forms. In order to evaluate important properties of the synthesized API-ILs, the water solubility at 25°C and 37°C (body temperature) as well as octanol–water partition coefficients (K ow's) and HDPC micelles partition at 25°C were measured. Critical micelle concentrations (CMC's) in water at 25°C and 37°C of the pharmaceutical ionic liquids bearing cations with surfactant properties were also determined from ionic conductivity measurements. Abstract In order to overcome the problems associated with low water solubility, and consequently low bioavailability of active pharmaceutical ingredients (APIs), herein we explore a modular ionic liquid synthetic strategy for improved APIs. Ionic liquids containing l-ampicillin as active pharmaceutical ingredient anion were prepared using the methodology developed in our previous work, using organic cations selected from substituted ammonium, phosphonium, pyridinium and methylimidazolium salts, with the intent of enhancing the solubility and bioavailability of l-ampicillin forms. In order to evaluate important properties of the synthesized API-ILs, the water solubility at 25°C and 37°C (body temperature) as well as octanol–water partition coefficients (K ow's) and HDPC micelles partition at 25°C were measured. Critical micelle concentrations (CMC's) in water at 25°C and 37°C of the pharmaceutical ionic liquids bearing cations with surfactant properties were also determined from ionic conductivity measurements. Critical micelle concentrations Elsevier Solubility Elsevier Bioavailability Elsevier Octanol–water partition coefficients Elsevier Active pharmaceutical ionic liquids Elsevier Araújo, João M.M. oth Alves, Filipa oth Matos, Carla oth Ferraz, Ricardo oth Prudêncio, Cristina oth Noronha, João Paulo oth Petrovski, Željko oth Branco, Luís oth Rebelo, Luís Paulo N. oth Marrucho, Isabel M. oth Enthalten in Elsevier Nigolian, H. ELSEVIER Description d’une cohorte française multicentrique de porteurs asymptomatiques d’anticorps anti-phospholipides 2022 New York, NY [u.a.] (DE-627)ELV008932840 volume:456 year:2013 number:2 day:18 month:11 pages:553-559 extent:7 https://doi.org/10.1016/j.ijpharm.2013.08.010 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 44.61 Innere Medizin VZ AR 456 2013 2 18 1118 553-559 7 045F 610 |
language |
English |
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Enthalten in Description d’une cohorte française multicentrique de porteurs asymptomatiques d’anticorps anti-phospholipides New York, NY [u.a.] volume:456 year:2013 number:2 day:18 month:11 pages:553-559 extent:7 |
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Abstract In order to overcome the problems associated with low water solubility, and consequently low bioavailability of active pharmaceutical ingredients (APIs), herein we explore a modular ionic liquid synthetic strategy for improved APIs. Ionic liquids containing l-ampicillin as active pharmaceutical ingredient anion were prepared using the methodology developed in our previous work, using organic cations selected from substituted ammonium, phosphonium, pyridinium and methylimidazolium salts, with the intent of enhancing the solubility and bioavailability of l-ampicillin forms. In order to evaluate important properties of the synthesized API-ILs, the water solubility at 25°C and 37°C (body temperature) as well as octanol–water partition coefficients (K ow's) and HDPC micelles partition at 25°C were measured. Critical micelle concentrations (CMC's) in water at 25°C and 37°C of the pharmaceutical ionic liquids bearing cations with surfactant properties were also determined from ionic conductivity measurements. |
abstractGer |
Abstract In order to overcome the problems associated with low water solubility, and consequently low bioavailability of active pharmaceutical ingredients (APIs), herein we explore a modular ionic liquid synthetic strategy for improved APIs. Ionic liquids containing l-ampicillin as active pharmaceutical ingredient anion were prepared using the methodology developed in our previous work, using organic cations selected from substituted ammonium, phosphonium, pyridinium and methylimidazolium salts, with the intent of enhancing the solubility and bioavailability of l-ampicillin forms. In order to evaluate important properties of the synthesized API-ILs, the water solubility at 25°C and 37°C (body temperature) as well as octanol–water partition coefficients (K ow's) and HDPC micelles partition at 25°C were measured. Critical micelle concentrations (CMC's) in water at 25°C and 37°C of the pharmaceutical ionic liquids bearing cations with surfactant properties were also determined from ionic conductivity measurements. |
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Abstract In order to overcome the problems associated with low water solubility, and consequently low bioavailability of active pharmaceutical ingredients (APIs), herein we explore a modular ionic liquid synthetic strategy for improved APIs. Ionic liquids containing l-ampicillin as active pharmaceutical ingredient anion were prepared using the methodology developed in our previous work, using organic cations selected from substituted ammonium, phosphonium, pyridinium and methylimidazolium salts, with the intent of enhancing the solubility and bioavailability of l-ampicillin forms. In order to evaluate important properties of the synthesized API-ILs, the water solubility at 25°C and 37°C (body temperature) as well as octanol–water partition coefficients (K ow's) and HDPC micelles partition at 25°C were measured. Critical micelle concentrations (CMC's) in water at 25°C and 37°C of the pharmaceutical ionic liquids bearing cations with surfactant properties were also determined from ionic conductivity measurements. |
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