Simultaneous analysis of oxybutynin and its active metabolite N-desethyl oxybutynin in human plasma by stable isotope dilution LC–MS/MS to support a bioequivalence study
Highlights • Selective and rapid LC–MS/MS method for oxybutynin and N-desethyl oxybutynin. • The method employs only 300μL plasma for efficient processing by LLE. • Six endogenous phospholipids were monitored to determine the extraction efficiency. • First report on bioequivalence study in healthy I...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Sharma, Primal [verfasserIn] |
|---|
| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2013 |
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| Schlagwörter: |
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| Umfang: |
12 |
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| Übergeordnetes Werk: |
Enthalten in: Monitoring the changes in physicochemical, sensory properties and microbiota of village-type homemade yoghurts along three consecutive back-slopping procedures - Gölbaşι, Gülcan ELSEVIER, 2023, the official analytical journal of the American Association of Pharmaceutical Scientists, New York, NY [u.a.] |
|---|---|
| Übergeordnetes Werk: |
volume:84 ; year:2013 ; pages:244-255 ; extent:12 |
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10.1016/j.jpba.2013.06.024 |
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| title_sort |
simultaneous analysis of oxybutynin and its active metabolite n-desethyl oxybutynin in human plasma by stable isotope dilution lc–ms/ms to support a bioequivalence study |
| title_auth |
Simultaneous analysis of oxybutynin and its active metabolite N-desethyl oxybutynin in human plasma by stable isotope dilution LC–MS/MS to support a bioequivalence study |
| abstract |
Highlights • Selective and rapid LC–MS/MS method for oxybutynin and N-desethyl oxybutynin. • The method employs only 300μL plasma for efficient processing by LLE. • Six endogenous phospholipids were monitored to determine the extraction efficiency. • First report on bioequivalence study in healthy Indian volunteers. • Method reproducibility was ascertained by incurred sample reanalysis. |
| abstractGer |
Highlights • Selective and rapid LC–MS/MS method for oxybutynin and N-desethyl oxybutynin. • The method employs only 300μL plasma for efficient processing by LLE. • Six endogenous phospholipids were monitored to determine the extraction efficiency. • First report on bioequivalence study in healthy Indian volunteers. • Method reproducibility was ascertained by incurred sample reanalysis. |
| abstract_unstemmed |
Highlights • Selective and rapid LC–MS/MS method for oxybutynin and N-desethyl oxybutynin. • The method employs only 300μL plasma for efficient processing by LLE. • Six endogenous phospholipids were monitored to determine the extraction efficiency. • First report on bioequivalence study in healthy Indian volunteers. • Method reproducibility was ascertained by incurred sample reanalysis. |
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| title_short |
Simultaneous analysis of oxybutynin and its active metabolite N-desethyl oxybutynin in human plasma by stable isotope dilution LC–MS/MS to support a bioequivalence study |
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https://doi.org/10.1016/j.jpba.2013.06.024 |
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Patel, Daxesh P. Sanyal, Mallika Berawala, Hiren Guttikar, Swati Shrivastav, Pranav S. |
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