Neurotensin and neurotensin receptors: Characteristic, structure–activity relationship and pain modulation—A review
Neurotensin (NT) is a tridecapeptide, which – since its discovery in 1973 – has been demonstrated to be involved in the control of various physiological activities in both the central nervous system and in the periphery. Its biological effects are mediated by four receptor types. Exogenously adminis...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Kleczkowska, Patrycja [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2013transfer abstract |
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| Schlagwörter: |
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| Umfang: |
7 |
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| Übergeordnetes Werk: |
Enthalten in: Mexican student-teachers’ “English” language praxicum: Decolonizing attempts - López-Gopar, Mario E. ELSEVIER, 2022, EJP, New York, NY [u.a.] |
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| Übergeordnetes Werk: |
volume:716 ; year:2013 ; number:1 ; day:15 ; month:09 ; pages:54-60 ; extent:7 |
| Links: |
|---|
| DOI / URN: |
10.1016/j.ejphar.2013.03.004 |
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ELV022241612 |
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10.1016/j.ejphar.2013.03.004 doi GBVA2013020000017.pica (DE-627)ELV022241612 (ELSEVIER)S0014-2999(13)00177-5 DE-627 ger DE-627 rakwb eng 610 610 DE-600 370 VZ 5,3 ssgn Kleczkowska, Patrycja verfasserin aut Neurotensin and neurotensin receptors: Characteristic, structure–activity relationship and pain modulation—A review 2013transfer abstract 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Neurotensin (NT) is a tridecapeptide, which – since its discovery in 1973 – has been demonstrated to be involved in the control of various physiological activities in both the central nervous system and in the periphery. Its biological effects are mediated by four receptor types. Exogenously administered NT exerts different behavioral effects, including antinociception. Structure–activity relationship studies performed in recent years resulted in development of several peptidomimetic receptor agonists and non-peptidic receptor antagonists that are useful tools for studies of NT mechanisms in tissue and on cellular level. This may result in design of new generation of analgesics based on neurotensin. NT antinociceptive effects are distinct from opioid analgesia. This creates opportunity of development of hybride analgesics that may simultaneously activate both opioid and NT antinociceptive pathways. Neurotensin (NT) is a tridecapeptide, which – since its discovery in 1973 – has been demonstrated to be involved in the control of various physiological activities in both the central nervous system and in the periphery. Its biological effects are mediated by four receptor types. Exogenously administered NT exerts different behavioral effects, including antinociception. Structure–activity relationship studies performed in recent years resulted in development of several peptidomimetic receptor agonists and non-peptidic receptor antagonists that are useful tools for studies of NT mechanisms in tissue and on cellular level. This may result in design of new generation of analgesics based on neurotensin. NT antinociceptive effects are distinct from opioid analgesia. This creates opportunity of development of hybride analgesics that may simultaneously activate both opioid and NT antinociceptive pathways. Neurotensin receptor Elsevier Pain Elsevier Antinociception Elsevier Neurotensin Elsevier Lipkowski, Andrzej W. oth Enthalten in Elsevier López-Gopar, Mario E. ELSEVIER Mexican student-teachers’ “English” language praxicum: Decolonizing attempts 2022 EJP New York, NY [u.a.] (DE-627)ELV008405875 volume:716 year:2013 number:1 day:15 month:09 pages:54-60 extent:7 https://doi.org/10.1016/j.ejphar.2013.03.004 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U AR 716 2013 1 15 0915 54-60 7 045F 610 |
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10.1016/j.ejphar.2013.03.004 doi GBVA2013020000017.pica (DE-627)ELV022241612 (ELSEVIER)S0014-2999(13)00177-5 DE-627 ger DE-627 rakwb eng 610 610 DE-600 370 VZ 5,3 ssgn Kleczkowska, Patrycja verfasserin aut Neurotensin and neurotensin receptors: Characteristic, structure–activity relationship and pain modulation—A review 2013transfer abstract 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Neurotensin (NT) is a tridecapeptide, which – since its discovery in 1973 – has been demonstrated to be involved in the control of various physiological activities in both the central nervous system and in the periphery. Its biological effects are mediated by four receptor types. Exogenously administered NT exerts different behavioral effects, including antinociception. Structure–activity relationship studies performed in recent years resulted in development of several peptidomimetic receptor agonists and non-peptidic receptor antagonists that are useful tools for studies of NT mechanisms in tissue and on cellular level. This may result in design of new generation of analgesics based on neurotensin. NT antinociceptive effects are distinct from opioid analgesia. This creates opportunity of development of hybride analgesics that may simultaneously activate both opioid and NT antinociceptive pathways. Neurotensin (NT) is a tridecapeptide, which – since its discovery in 1973 – has been demonstrated to be involved in the control of various physiological activities in both the central nervous system and in the periphery. Its biological effects are mediated by four receptor types. Exogenously administered NT exerts different behavioral effects, including antinociception. Structure–activity relationship studies performed in recent years resulted in development of several peptidomimetic receptor agonists and non-peptidic receptor antagonists that are useful tools for studies of NT mechanisms in tissue and on cellular level. This may result in design of new generation of analgesics based on neurotensin. NT antinociceptive effects are distinct from opioid analgesia. This creates opportunity of development of hybride analgesics that may simultaneously activate both opioid and NT antinociceptive pathways. Neurotensin receptor Elsevier Pain Elsevier Antinociception Elsevier Neurotensin Elsevier Lipkowski, Andrzej W. oth Enthalten in Elsevier López-Gopar, Mario E. ELSEVIER Mexican student-teachers’ “English” language praxicum: Decolonizing attempts 2022 EJP New York, NY [u.a.] (DE-627)ELV008405875 volume:716 year:2013 number:1 day:15 month:09 pages:54-60 extent:7 https://doi.org/10.1016/j.ejphar.2013.03.004 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U AR 716 2013 1 15 0915 54-60 7 045F 610 |
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10.1016/j.ejphar.2013.03.004 doi GBVA2013020000017.pica (DE-627)ELV022241612 (ELSEVIER)S0014-2999(13)00177-5 DE-627 ger DE-627 rakwb eng 610 610 DE-600 370 VZ 5,3 ssgn Kleczkowska, Patrycja verfasserin aut Neurotensin and neurotensin receptors: Characteristic, structure–activity relationship and pain modulation—A review 2013transfer abstract 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Neurotensin (NT) is a tridecapeptide, which – since its discovery in 1973 – has been demonstrated to be involved in the control of various physiological activities in both the central nervous system and in the periphery. Its biological effects are mediated by four receptor types. Exogenously administered NT exerts different behavioral effects, including antinociception. Structure–activity relationship studies performed in recent years resulted in development of several peptidomimetic receptor agonists and non-peptidic receptor antagonists that are useful tools for studies of NT mechanisms in tissue and on cellular level. This may result in design of new generation of analgesics based on neurotensin. NT antinociceptive effects are distinct from opioid analgesia. This creates opportunity of development of hybride analgesics that may simultaneously activate both opioid and NT antinociceptive pathways. Neurotensin (NT) is a tridecapeptide, which – since its discovery in 1973 – has been demonstrated to be involved in the control of various physiological activities in both the central nervous system and in the periphery. Its biological effects are mediated by four receptor types. Exogenously administered NT exerts different behavioral effects, including antinociception. Structure–activity relationship studies performed in recent years resulted in development of several peptidomimetic receptor agonists and non-peptidic receptor antagonists that are useful tools for studies of NT mechanisms in tissue and on cellular level. This may result in design of new generation of analgesics based on neurotensin. NT antinociceptive effects are distinct from opioid analgesia. This creates opportunity of development of hybride analgesics that may simultaneously activate both opioid and NT antinociceptive pathways. Neurotensin receptor Elsevier Pain Elsevier Antinociception Elsevier Neurotensin Elsevier Lipkowski, Andrzej W. oth Enthalten in Elsevier López-Gopar, Mario E. ELSEVIER Mexican student-teachers’ “English” language praxicum: Decolonizing attempts 2022 EJP New York, NY [u.a.] (DE-627)ELV008405875 volume:716 year:2013 number:1 day:15 month:09 pages:54-60 extent:7 https://doi.org/10.1016/j.ejphar.2013.03.004 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U AR 716 2013 1 15 0915 54-60 7 045F 610 |
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10.1016/j.ejphar.2013.03.004 doi GBVA2013020000017.pica (DE-627)ELV022241612 (ELSEVIER)S0014-2999(13)00177-5 DE-627 ger DE-627 rakwb eng 610 610 DE-600 370 VZ 5,3 ssgn Kleczkowska, Patrycja verfasserin aut Neurotensin and neurotensin receptors: Characteristic, structure–activity relationship and pain modulation—A review 2013transfer abstract 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Neurotensin (NT) is a tridecapeptide, which – since its discovery in 1973 – has been demonstrated to be involved in the control of various physiological activities in both the central nervous system and in the periphery. Its biological effects are mediated by four receptor types. Exogenously administered NT exerts different behavioral effects, including antinociception. Structure–activity relationship studies performed in recent years resulted in development of several peptidomimetic receptor agonists and non-peptidic receptor antagonists that are useful tools for studies of NT mechanisms in tissue and on cellular level. This may result in design of new generation of analgesics based on neurotensin. NT antinociceptive effects are distinct from opioid analgesia. This creates opportunity of development of hybride analgesics that may simultaneously activate both opioid and NT antinociceptive pathways. Neurotensin (NT) is a tridecapeptide, which – since its discovery in 1973 – has been demonstrated to be involved in the control of various physiological activities in both the central nervous system and in the periphery. Its biological effects are mediated by four receptor types. Exogenously administered NT exerts different behavioral effects, including antinociception. Structure–activity relationship studies performed in recent years resulted in development of several peptidomimetic receptor agonists and non-peptidic receptor antagonists that are useful tools for studies of NT mechanisms in tissue and on cellular level. This may result in design of new generation of analgesics based on neurotensin. NT antinociceptive effects are distinct from opioid analgesia. This creates opportunity of development of hybride analgesics that may simultaneously activate both opioid and NT antinociceptive pathways. Neurotensin receptor Elsevier Pain Elsevier Antinociception Elsevier Neurotensin Elsevier Lipkowski, Andrzej W. oth Enthalten in Elsevier López-Gopar, Mario E. ELSEVIER Mexican student-teachers’ “English” language praxicum: Decolonizing attempts 2022 EJP New York, NY [u.a.] (DE-627)ELV008405875 volume:716 year:2013 number:1 day:15 month:09 pages:54-60 extent:7 https://doi.org/10.1016/j.ejphar.2013.03.004 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U AR 716 2013 1 15 0915 54-60 7 045F 610 |
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Neurotensin and neurotensin receptors: Characteristic, structure–activity relationship and pain modulation—A review |
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Neurotensin and neurotensin receptors: Characteristic, structure–activity relationship and pain modulation—A review |
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Kleczkowska, Patrycja |
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Mexican student-teachers’ “English” language praxicum: Decolonizing attempts |
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neurotensin and neurotensin receptors: characteristic, structure–activity relationship and pain modulation—a review |
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Neurotensin and neurotensin receptors: Characteristic, structure–activity relationship and pain modulation—A review |
| abstract |
Neurotensin (NT) is a tridecapeptide, which – since its discovery in 1973 – has been demonstrated to be involved in the control of various physiological activities in both the central nervous system and in the periphery. Its biological effects are mediated by four receptor types. Exogenously administered NT exerts different behavioral effects, including antinociception. Structure–activity relationship studies performed in recent years resulted in development of several peptidomimetic receptor agonists and non-peptidic receptor antagonists that are useful tools for studies of NT mechanisms in tissue and on cellular level. This may result in design of new generation of analgesics based on neurotensin. NT antinociceptive effects are distinct from opioid analgesia. This creates opportunity of development of hybride analgesics that may simultaneously activate both opioid and NT antinociceptive pathways. |
| abstractGer |
Neurotensin (NT) is a tridecapeptide, which – since its discovery in 1973 – has been demonstrated to be involved in the control of various physiological activities in both the central nervous system and in the periphery. Its biological effects are mediated by four receptor types. Exogenously administered NT exerts different behavioral effects, including antinociception. Structure–activity relationship studies performed in recent years resulted in development of several peptidomimetic receptor agonists and non-peptidic receptor antagonists that are useful tools for studies of NT mechanisms in tissue and on cellular level. This may result in design of new generation of analgesics based on neurotensin. NT antinociceptive effects are distinct from opioid analgesia. This creates opportunity of development of hybride analgesics that may simultaneously activate both opioid and NT antinociceptive pathways. |
| abstract_unstemmed |
Neurotensin (NT) is a tridecapeptide, which – since its discovery in 1973 – has been demonstrated to be involved in the control of various physiological activities in both the central nervous system and in the periphery. Its biological effects are mediated by four receptor types. Exogenously administered NT exerts different behavioral effects, including antinociception. Structure–activity relationship studies performed in recent years resulted in development of several peptidomimetic receptor agonists and non-peptidic receptor antagonists that are useful tools for studies of NT mechanisms in tissue and on cellular level. This may result in design of new generation of analgesics based on neurotensin. NT antinociceptive effects are distinct from opioid analgesia. This creates opportunity of development of hybride analgesics that may simultaneously activate both opioid and NT antinociceptive pathways. |
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Neurotensin and neurotensin receptors: Characteristic, structure–activity relationship and pain modulation—A review |
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