Pleosporin A, an antimalarial cyclodepsipeptide from an elephant dung fungus (BCC 7069)
Abstract Cyclodepsipeptides SCH 217048 (1), SCH 218157 (2), and a new analog, pleosporin A (3), were isolated from cultures of an unidentified elephant dung fungus of the family Pleosporaceae. The structure of 3 was elucidated on the basis of detailed spectroscopic interpretation. The absolute confi...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Isaka, Masahiko [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2014transfer abstract |
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| Umfang: |
3 |
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| Übergeordnetes Werk: |
Enthalten in: Continuing Medical Education Program - 2013, Amsterdam [u.a.] |
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| Übergeordnetes Werk: |
volume:55 ; year:2014 ; number:2 ; day:8 ; month:01 ; pages:469-471 ; extent:3 |
| Links: |
|---|
| DOI / URN: |
10.1016/j.tetlet.2013.11.063 |
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ELV022369457 |
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| 520 | |a Abstract Cyclodepsipeptides SCH 217048 (1), SCH 218157 (2), and a new analog, pleosporin A (3), were isolated from cultures of an unidentified elephant dung fungus of the family Pleosporaceae. The structure of 3 was elucidated on the basis of detailed spectroscopic interpretation. The absolute configurations of 1–3 were determined by chiral column HPLC analysis and Marfey’s method. Cyclodepsipeptides 1–3 exhibited antimalarial activity against Plasmodium falciparum K1 with respective IC50 values of 1.6, 6.4, and 1.6μg/mL, while they did not show cytotoxicity against KB, MCF-7 and NCI-H187 cell-lines or non-cancerous Vero cells at 50μg/mL. | ||
| 520 | |a Abstract Cyclodepsipeptides SCH 217048 (1), SCH 218157 (2), and a new analog, pleosporin A (3), were isolated from cultures of an unidentified elephant dung fungus of the family Pleosporaceae. The structure of 3 was elucidated on the basis of detailed spectroscopic interpretation. The absolute configurations of 1–3 were determined by chiral column HPLC analysis and Marfey’s method. Cyclodepsipeptides 1–3 exhibited antimalarial activity against Plasmodium falciparum K1 with respective IC50 values of 1.6, 6.4, and 1.6μg/mL, while they did not show cytotoxicity against KB, MCF-7 and NCI-H187 cell-lines or non-cancerous Vero cells at 50μg/mL. | ||
| 650 | 7 | |a Antimalarial activity |2 Elsevier | |
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| 700 | 1 | |a Sommai, Sujinda |4 oth | |
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10.1016/j.tetlet.2013.11.063 doi GBVA2014001000018.pica (DE-627)ELV022369457 (ELSEVIER)S0040-4039(13)02010-8 DE-627 ger DE-627 rakwb eng 540 540 DE-600 610 VZ 540 VZ 35.00 bkl Isaka, Masahiko verfasserin aut Pleosporin A, an antimalarial cyclodepsipeptide from an elephant dung fungus (BCC 7069) 2014transfer abstract 3 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Cyclodepsipeptides SCH 217048 (1), SCH 218157 (2), and a new analog, pleosporin A (3), were isolated from cultures of an unidentified elephant dung fungus of the family Pleosporaceae. The structure of 3 was elucidated on the basis of detailed spectroscopic interpretation. The absolute configurations of 1–3 were determined by chiral column HPLC analysis and Marfey’s method. Cyclodepsipeptides 1–3 exhibited antimalarial activity against Plasmodium falciparum K1 with respective IC50 values of 1.6, 6.4, and 1.6μg/mL, while they did not show cytotoxicity against KB, MCF-7 and NCI-H187 cell-lines or non-cancerous Vero cells at 50μg/mL. Abstract Cyclodepsipeptides SCH 217048 (1), SCH 218157 (2), and a new analog, pleosporin A (3), were isolated from cultures of an unidentified elephant dung fungus of the family Pleosporaceae. The structure of 3 was elucidated on the basis of detailed spectroscopic interpretation. The absolute configurations of 1–3 were determined by chiral column HPLC analysis and Marfey’s method. Cyclodepsipeptides 1–3 exhibited antimalarial activity against Plasmodium falciparum K1 with respective IC50 values of 1.6, 6.4, and 1.6μg/mL, while they did not show cytotoxicity against KB, MCF-7 and NCI-H187 cell-lines or non-cancerous Vero cells at 50μg/mL. Antimalarial activity Elsevier Cyclodepsipeptide Elsevier SCH 217048 Elsevier Pleosporaceae Elsevier Coprophilous fungi Elsevier Palasarn, Somporn oth Komwijit, Somjit oth Somrithipol, Sayanh oth Sommai, Sujinda oth Enthalten in Elsevier Science Continuing Medical Education Program 2013 Amsterdam [u.a.] (DE-627)ELV011942339 volume:55 year:2014 number:2 day:8 month:01 pages:469-471 extent:3 https://doi.org/10.1016/j.tetlet.2013.11.063 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 35.00 Chemie: Allgemeines VZ AR 55 2014 2 8 0108 469-471 3 045F 540 |
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10.1016/j.tetlet.2013.11.063 doi GBVA2014001000018.pica (DE-627)ELV022369457 (ELSEVIER)S0040-4039(13)02010-8 DE-627 ger DE-627 rakwb eng 540 540 DE-600 610 VZ 540 VZ 35.00 bkl Isaka, Masahiko verfasserin aut Pleosporin A, an antimalarial cyclodepsipeptide from an elephant dung fungus (BCC 7069) 2014transfer abstract 3 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Cyclodepsipeptides SCH 217048 (1), SCH 218157 (2), and a new analog, pleosporin A (3), were isolated from cultures of an unidentified elephant dung fungus of the family Pleosporaceae. The structure of 3 was elucidated on the basis of detailed spectroscopic interpretation. The absolute configurations of 1–3 were determined by chiral column HPLC analysis and Marfey’s method. Cyclodepsipeptides 1–3 exhibited antimalarial activity against Plasmodium falciparum K1 with respective IC50 values of 1.6, 6.4, and 1.6μg/mL, while they did not show cytotoxicity against KB, MCF-7 and NCI-H187 cell-lines or non-cancerous Vero cells at 50μg/mL. Abstract Cyclodepsipeptides SCH 217048 (1), SCH 218157 (2), and a new analog, pleosporin A (3), were isolated from cultures of an unidentified elephant dung fungus of the family Pleosporaceae. The structure of 3 was elucidated on the basis of detailed spectroscopic interpretation. The absolute configurations of 1–3 were determined by chiral column HPLC analysis and Marfey’s method. Cyclodepsipeptides 1–3 exhibited antimalarial activity against Plasmodium falciparum K1 with respective IC50 values of 1.6, 6.4, and 1.6μg/mL, while they did not show cytotoxicity against KB, MCF-7 and NCI-H187 cell-lines or non-cancerous Vero cells at 50μg/mL. Antimalarial activity Elsevier Cyclodepsipeptide Elsevier SCH 217048 Elsevier Pleosporaceae Elsevier Coprophilous fungi Elsevier Palasarn, Somporn oth Komwijit, Somjit oth Somrithipol, Sayanh oth Sommai, Sujinda oth Enthalten in Elsevier Science Continuing Medical Education Program 2013 Amsterdam [u.a.] (DE-627)ELV011942339 volume:55 year:2014 number:2 day:8 month:01 pages:469-471 extent:3 https://doi.org/10.1016/j.tetlet.2013.11.063 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 35.00 Chemie: Allgemeines VZ AR 55 2014 2 8 0108 469-471 3 045F 540 |
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10.1016/j.tetlet.2013.11.063 doi GBVA2014001000018.pica (DE-627)ELV022369457 (ELSEVIER)S0040-4039(13)02010-8 DE-627 ger DE-627 rakwb eng 540 540 DE-600 610 VZ 540 VZ 35.00 bkl Isaka, Masahiko verfasserin aut Pleosporin A, an antimalarial cyclodepsipeptide from an elephant dung fungus (BCC 7069) 2014transfer abstract 3 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Cyclodepsipeptides SCH 217048 (1), SCH 218157 (2), and a new analog, pleosporin A (3), were isolated from cultures of an unidentified elephant dung fungus of the family Pleosporaceae. The structure of 3 was elucidated on the basis of detailed spectroscopic interpretation. The absolute configurations of 1–3 were determined by chiral column HPLC analysis and Marfey’s method. Cyclodepsipeptides 1–3 exhibited antimalarial activity against Plasmodium falciparum K1 with respective IC50 values of 1.6, 6.4, and 1.6μg/mL, while they did not show cytotoxicity against KB, MCF-7 and NCI-H187 cell-lines or non-cancerous Vero cells at 50μg/mL. Abstract Cyclodepsipeptides SCH 217048 (1), SCH 218157 (2), and a new analog, pleosporin A (3), were isolated from cultures of an unidentified elephant dung fungus of the family Pleosporaceae. The structure of 3 was elucidated on the basis of detailed spectroscopic interpretation. The absolute configurations of 1–3 were determined by chiral column HPLC analysis and Marfey’s method. Cyclodepsipeptides 1–3 exhibited antimalarial activity against Plasmodium falciparum K1 with respective IC50 values of 1.6, 6.4, and 1.6μg/mL, while they did not show cytotoxicity against KB, MCF-7 and NCI-H187 cell-lines or non-cancerous Vero cells at 50μg/mL. Antimalarial activity Elsevier Cyclodepsipeptide Elsevier SCH 217048 Elsevier Pleosporaceae Elsevier Coprophilous fungi Elsevier Palasarn, Somporn oth Komwijit, Somjit oth Somrithipol, Sayanh oth Sommai, Sujinda oth Enthalten in Elsevier Science Continuing Medical Education Program 2013 Amsterdam [u.a.] (DE-627)ELV011942339 volume:55 year:2014 number:2 day:8 month:01 pages:469-471 extent:3 https://doi.org/10.1016/j.tetlet.2013.11.063 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 35.00 Chemie: Allgemeines VZ AR 55 2014 2 8 0108 469-471 3 045F 540 |
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10.1016/j.tetlet.2013.11.063 doi GBVA2014001000018.pica (DE-627)ELV022369457 (ELSEVIER)S0040-4039(13)02010-8 DE-627 ger DE-627 rakwb eng 540 540 DE-600 610 VZ 540 VZ 35.00 bkl Isaka, Masahiko verfasserin aut Pleosporin A, an antimalarial cyclodepsipeptide from an elephant dung fungus (BCC 7069) 2014transfer abstract 3 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Cyclodepsipeptides SCH 217048 (1), SCH 218157 (2), and a new analog, pleosporin A (3), were isolated from cultures of an unidentified elephant dung fungus of the family Pleosporaceae. The structure of 3 was elucidated on the basis of detailed spectroscopic interpretation. The absolute configurations of 1–3 were determined by chiral column HPLC analysis and Marfey’s method. Cyclodepsipeptides 1–3 exhibited antimalarial activity against Plasmodium falciparum K1 with respective IC50 values of 1.6, 6.4, and 1.6μg/mL, while they did not show cytotoxicity against KB, MCF-7 and NCI-H187 cell-lines or non-cancerous Vero cells at 50μg/mL. Abstract Cyclodepsipeptides SCH 217048 (1), SCH 218157 (2), and a new analog, pleosporin A (3), were isolated from cultures of an unidentified elephant dung fungus of the family Pleosporaceae. The structure of 3 was elucidated on the basis of detailed spectroscopic interpretation. The absolute configurations of 1–3 were determined by chiral column HPLC analysis and Marfey’s method. Cyclodepsipeptides 1–3 exhibited antimalarial activity against Plasmodium falciparum K1 with respective IC50 values of 1.6, 6.4, and 1.6μg/mL, while they did not show cytotoxicity against KB, MCF-7 and NCI-H187 cell-lines or non-cancerous Vero cells at 50μg/mL. Antimalarial activity Elsevier Cyclodepsipeptide Elsevier SCH 217048 Elsevier Pleosporaceae Elsevier Coprophilous fungi Elsevier Palasarn, Somporn oth Komwijit, Somjit oth Somrithipol, Sayanh oth Sommai, Sujinda oth Enthalten in Elsevier Science Continuing Medical Education Program 2013 Amsterdam [u.a.] (DE-627)ELV011942339 volume:55 year:2014 number:2 day:8 month:01 pages:469-471 extent:3 https://doi.org/10.1016/j.tetlet.2013.11.063 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 35.00 Chemie: Allgemeines VZ AR 55 2014 2 8 0108 469-471 3 045F 540 |
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10.1016/j.tetlet.2013.11.063 doi GBVA2014001000018.pica (DE-627)ELV022369457 (ELSEVIER)S0040-4039(13)02010-8 DE-627 ger DE-627 rakwb eng 540 540 DE-600 610 VZ 540 VZ 35.00 bkl Isaka, Masahiko verfasserin aut Pleosporin A, an antimalarial cyclodepsipeptide from an elephant dung fungus (BCC 7069) 2014transfer abstract 3 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Cyclodepsipeptides SCH 217048 (1), SCH 218157 (2), and a new analog, pleosporin A (3), were isolated from cultures of an unidentified elephant dung fungus of the family Pleosporaceae. The structure of 3 was elucidated on the basis of detailed spectroscopic interpretation. The absolute configurations of 1–3 were determined by chiral column HPLC analysis and Marfey’s method. Cyclodepsipeptides 1–3 exhibited antimalarial activity against Plasmodium falciparum K1 with respective IC50 values of 1.6, 6.4, and 1.6μg/mL, while they did not show cytotoxicity against KB, MCF-7 and NCI-H187 cell-lines or non-cancerous Vero cells at 50μg/mL. Abstract Cyclodepsipeptides SCH 217048 (1), SCH 218157 (2), and a new analog, pleosporin A (3), were isolated from cultures of an unidentified elephant dung fungus of the family Pleosporaceae. The structure of 3 was elucidated on the basis of detailed spectroscopic interpretation. The absolute configurations of 1–3 were determined by chiral column HPLC analysis and Marfey’s method. Cyclodepsipeptides 1–3 exhibited antimalarial activity against Plasmodium falciparum K1 with respective IC50 values of 1.6, 6.4, and 1.6μg/mL, while they did not show cytotoxicity against KB, MCF-7 and NCI-H187 cell-lines or non-cancerous Vero cells at 50μg/mL. Antimalarial activity Elsevier Cyclodepsipeptide Elsevier SCH 217048 Elsevier Pleosporaceae Elsevier Coprophilous fungi Elsevier Palasarn, Somporn oth Komwijit, Somjit oth Somrithipol, Sayanh oth Sommai, Sujinda oth Enthalten in Elsevier Science Continuing Medical Education Program 2013 Amsterdam [u.a.] (DE-627)ELV011942339 volume:55 year:2014 number:2 day:8 month:01 pages:469-471 extent:3 https://doi.org/10.1016/j.tetlet.2013.11.063 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 35.00 Chemie: Allgemeines VZ AR 55 2014 2 8 0108 469-471 3 045F 540 |
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Pleosporin A, an antimalarial cyclodepsipeptide from an elephant dung fungus (BCC 7069) |
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Abstract Cyclodepsipeptides SCH 217048 (1), SCH 218157 (2), and a new analog, pleosporin A (3), were isolated from cultures of an unidentified elephant dung fungus of the family Pleosporaceae. The structure of 3 was elucidated on the basis of detailed spectroscopic interpretation. The absolute configurations of 1–3 were determined by chiral column HPLC analysis and Marfey’s method. Cyclodepsipeptides 1–3 exhibited antimalarial activity against Plasmodium falciparum K1 with respective IC50 values of 1.6, 6.4, and 1.6μg/mL, while they did not show cytotoxicity against KB, MCF-7 and NCI-H187 cell-lines or non-cancerous Vero cells at 50μg/mL. |
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Abstract Cyclodepsipeptides SCH 217048 (1), SCH 218157 (2), and a new analog, pleosporin A (3), were isolated from cultures of an unidentified elephant dung fungus of the family Pleosporaceae. The structure of 3 was elucidated on the basis of detailed spectroscopic interpretation. The absolute configurations of 1–3 were determined by chiral column HPLC analysis and Marfey’s method. Cyclodepsipeptides 1–3 exhibited antimalarial activity against Plasmodium falciparum K1 with respective IC50 values of 1.6, 6.4, and 1.6μg/mL, while they did not show cytotoxicity against KB, MCF-7 and NCI-H187 cell-lines or non-cancerous Vero cells at 50μg/mL. |
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Abstract Cyclodepsipeptides SCH 217048 (1), SCH 218157 (2), and a new analog, pleosporin A (3), were isolated from cultures of an unidentified elephant dung fungus of the family Pleosporaceae. The structure of 3 was elucidated on the basis of detailed spectroscopic interpretation. The absolute configurations of 1–3 were determined by chiral column HPLC analysis and Marfey’s method. Cyclodepsipeptides 1–3 exhibited antimalarial activity against Plasmodium falciparum K1 with respective IC50 values of 1.6, 6.4, and 1.6μg/mL, while they did not show cytotoxicity against KB, MCF-7 and NCI-H187 cell-lines or non-cancerous Vero cells at 50μg/mL. |
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