HER2 status in lung adenocarcinoma: A comparison of immunohistochemistry, fluorescence in situ hybridization (FISH), dual-ISH, and gene mutations
• We analyzed HER2 alterations in patients with lung adenocarcinoma by using four methods and explored the concordance of these methods. • HER2 protein overexpression, gene amplification, and gene mutations appeared to be uncommon in lung adenocarcinoma. • Cases with HER2 mutations tended to show HE...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Yoshizawa, Akihiko [verfasserIn] |
|---|
| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2014 |
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| Schlagwörter: |
Human epidermal growth factor receptor 2 |
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| Umfang: |
6 |
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| Übergeordnetes Werk: |
Enthalten in: Extrinsic factors rather than seed traits mediate strong spatial variation in seed predation - Garrote, Pedro J. ELSEVIER, 2019, journal of the International Association for the Study of Lung Cancer, Amsterdam [u.a.] |
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| Übergeordnetes Werk: |
volume:85 ; year:2014 ; number:3 ; pages:373-378 ; extent:6 |
| Links: |
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| DOI / URN: |
10.1016/j.lungcan.2014.06.007 |
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ELV022501061 |
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| 520 | |a • We analyzed HER2 alterations in patients with lung adenocarcinoma by using four methods and explored the concordance of these methods. • HER2 protein overexpression, gene amplification, and gene mutations appeared to be uncommon in lung adenocarcinoma. • Cases with HER2 mutations tended to show HER2 gene amplification. • DISH was better than FISH for detection of cases with HER2 amplification. • HER2 gene amplification and mutations should be tested to determine whether patients with lung adenocarcinoma are eligible for administration of new anti-HER2 agents. | ||
| 650 | 7 | |a Immunohistochemistry |2 Elsevier | |
| 650 | 7 | |a Human epidermal growth factor receptor 2 |2 Elsevier | |
| 650 | 7 | |a Fluorescence in situ hybridization |2 Elsevier | |
| 650 | 7 | |a Lung adenocarcinoma |2 Elsevier | |
| 650 | 7 | |a Dual in situ hybridization |2 Elsevier | |
| 650 | 7 | |a Trastuzumab |2 Elsevier | |
| 700 | 1 | |a Sumiyoshi, Shinji |4 oth | |
| 700 | 1 | |a Sonobe, Makoto |4 oth | |
| 700 | 1 | |a Kobayashi, Masashi |4 oth | |
| 700 | 1 | |a Uehara, Takeshi |4 oth | |
| 700 | 1 | |a Fujimoto, Masakazu |4 oth | |
| 700 | 1 | |a Tsuruyama, Tatsuaki |4 oth | |
| 700 | 1 | |a Date, Hiroshi |4 oth | |
| 700 | 1 | |a Haga, Hironori |4 oth | |
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10.1016/j.lungcan.2014.06.007 doi GBVA2014006000012.pica (DE-627)ELV022501061 (ELSEVIER)S0169-5002(14)00265-7 DE-627 ger DE-627 rakwb eng 610 610 DE-600 Yoshizawa, Akihiko verfasserin aut HER2 status in lung adenocarcinoma: A comparison of immunohistochemistry, fluorescence in situ hybridization (FISH), dual-ISH, and gene mutations 2014 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • We analyzed HER2 alterations in patients with lung adenocarcinoma by using four methods and explored the concordance of these methods. • HER2 protein overexpression, gene amplification, and gene mutations appeared to be uncommon in lung adenocarcinoma. • Cases with HER2 mutations tended to show HER2 gene amplification. • DISH was better than FISH for detection of cases with HER2 amplification. • HER2 gene amplification and mutations should be tested to determine whether patients with lung adenocarcinoma are eligible for administration of new anti-HER2 agents. Immunohistochemistry Elsevier Human epidermal growth factor receptor 2 Elsevier Fluorescence in situ hybridization Elsevier Lung adenocarcinoma Elsevier Dual in situ hybridization Elsevier Trastuzumab Elsevier Sumiyoshi, Shinji oth Sonobe, Makoto oth Kobayashi, Masashi oth Uehara, Takeshi oth Fujimoto, Masakazu oth Tsuruyama, Tatsuaki oth Date, Hiroshi oth Haga, Hironori oth Enthalten in Elsevier Garrote, Pedro J. ELSEVIER Extrinsic factors rather than seed traits mediate strong spatial variation in seed predation 2019 journal of the International Association for the Study of Lung Cancer Amsterdam [u.a.] (DE-627)ELV002331438 volume:85 year:2014 number:3 pages:373-378 extent:6 https://doi.org/10.1016/j.lungcan.2014.06.007 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U AR 85 2014 3 373-378 6 045F 610 |
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10.1016/j.lungcan.2014.06.007 doi GBVA2014006000012.pica (DE-627)ELV022501061 (ELSEVIER)S0169-5002(14)00265-7 DE-627 ger DE-627 rakwb eng 610 610 DE-600 Yoshizawa, Akihiko verfasserin aut HER2 status in lung adenocarcinoma: A comparison of immunohistochemistry, fluorescence in situ hybridization (FISH), dual-ISH, and gene mutations 2014 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • We analyzed HER2 alterations in patients with lung adenocarcinoma by using four methods and explored the concordance of these methods. • HER2 protein overexpression, gene amplification, and gene mutations appeared to be uncommon in lung adenocarcinoma. • Cases with HER2 mutations tended to show HER2 gene amplification. • DISH was better than FISH for detection of cases with HER2 amplification. • HER2 gene amplification and mutations should be tested to determine whether patients with lung adenocarcinoma are eligible for administration of new anti-HER2 agents. Immunohistochemistry Elsevier Human epidermal growth factor receptor 2 Elsevier Fluorescence in situ hybridization Elsevier Lung adenocarcinoma Elsevier Dual in situ hybridization Elsevier Trastuzumab Elsevier Sumiyoshi, Shinji oth Sonobe, Makoto oth Kobayashi, Masashi oth Uehara, Takeshi oth Fujimoto, Masakazu oth Tsuruyama, Tatsuaki oth Date, Hiroshi oth Haga, Hironori oth Enthalten in Elsevier Garrote, Pedro J. ELSEVIER Extrinsic factors rather than seed traits mediate strong spatial variation in seed predation 2019 journal of the International Association for the Study of Lung Cancer Amsterdam [u.a.] (DE-627)ELV002331438 volume:85 year:2014 number:3 pages:373-378 extent:6 https://doi.org/10.1016/j.lungcan.2014.06.007 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U AR 85 2014 3 373-378 6 045F 610 |
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10.1016/j.lungcan.2014.06.007 doi GBVA2014006000012.pica (DE-627)ELV022501061 (ELSEVIER)S0169-5002(14)00265-7 DE-627 ger DE-627 rakwb eng 610 610 DE-600 Yoshizawa, Akihiko verfasserin aut HER2 status in lung adenocarcinoma: A comparison of immunohistochemistry, fluorescence in situ hybridization (FISH), dual-ISH, and gene mutations 2014 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • We analyzed HER2 alterations in patients with lung adenocarcinoma by using four methods and explored the concordance of these methods. • HER2 protein overexpression, gene amplification, and gene mutations appeared to be uncommon in lung adenocarcinoma. • Cases with HER2 mutations tended to show HER2 gene amplification. • DISH was better than FISH for detection of cases with HER2 amplification. • HER2 gene amplification and mutations should be tested to determine whether patients with lung adenocarcinoma are eligible for administration of new anti-HER2 agents. Immunohistochemistry Elsevier Human epidermal growth factor receptor 2 Elsevier Fluorescence in situ hybridization Elsevier Lung adenocarcinoma Elsevier Dual in situ hybridization Elsevier Trastuzumab Elsevier Sumiyoshi, Shinji oth Sonobe, Makoto oth Kobayashi, Masashi oth Uehara, Takeshi oth Fujimoto, Masakazu oth Tsuruyama, Tatsuaki oth Date, Hiroshi oth Haga, Hironori oth Enthalten in Elsevier Garrote, Pedro J. ELSEVIER Extrinsic factors rather than seed traits mediate strong spatial variation in seed predation 2019 journal of the International Association for the Study of Lung Cancer Amsterdam [u.a.] (DE-627)ELV002331438 volume:85 year:2014 number:3 pages:373-378 extent:6 https://doi.org/10.1016/j.lungcan.2014.06.007 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U AR 85 2014 3 373-378 6 045F 610 |
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HER2 status in lung adenocarcinoma: A comparison of immunohistochemistry, fluorescence in situ hybridization (FISH), dual-ISH, and gene mutations |
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• We analyzed HER2 alterations in patients with lung adenocarcinoma by using four methods and explored the concordance of these methods. • HER2 protein overexpression, gene amplification, and gene mutations appeared to be uncommon in lung adenocarcinoma. • Cases with HER2 mutations tended to show HER2 gene amplification. • DISH was better than FISH for detection of cases with HER2 amplification. • HER2 gene amplification and mutations should be tested to determine whether patients with lung adenocarcinoma are eligible for administration of new anti-HER2 agents. |
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• We analyzed HER2 alterations in patients with lung adenocarcinoma by using four methods and explored the concordance of these methods. • HER2 protein overexpression, gene amplification, and gene mutations appeared to be uncommon in lung adenocarcinoma. • Cases with HER2 mutations tended to show HER2 gene amplification. • DISH was better than FISH for detection of cases with HER2 amplification. • HER2 gene amplification and mutations should be tested to determine whether patients with lung adenocarcinoma are eligible for administration of new anti-HER2 agents. |
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• We analyzed HER2 alterations in patients with lung adenocarcinoma by using four methods and explored the concordance of these methods. • HER2 protein overexpression, gene amplification, and gene mutations appeared to be uncommon in lung adenocarcinoma. • Cases with HER2 mutations tended to show HER2 gene amplification. • DISH was better than FISH for detection of cases with HER2 amplification. • HER2 gene amplification and mutations should be tested to determine whether patients with lung adenocarcinoma are eligible for administration of new anti-HER2 agents. |
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HER2 status in lung adenocarcinoma: A comparison of immunohistochemistry, fluorescence in situ hybridization (FISH), dual-ISH, and gene mutations |
| url |
https://doi.org/10.1016/j.lungcan.2014.06.007 |
| remote_bool |
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| author2 |
Sumiyoshi, Shinji Sonobe, Makoto Kobayashi, Masashi Uehara, Takeshi Fujimoto, Masakazu Tsuruyama, Tatsuaki Date, Hiroshi Haga, Hironori |
| author2Str |
Sumiyoshi, Shinji Sonobe, Makoto Kobayashi, Masashi Uehara, Takeshi Fujimoto, Masakazu Tsuruyama, Tatsuaki Date, Hiroshi Haga, Hironori |
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ELV002331438 |
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| doi_str |
10.1016/j.lungcan.2014.06.007 |
| up_date |
2024-07-06T22:08:22.433Z |
| _version_ |
1803869175084482560 |
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