Analysis of the KIFAP3 gene in amyotrophic lateral sclerosis: a multicenter survival study
Sporadic amyotrophic lateral sclerosis is a multifactorial disease of environmental and genetic origin. In a previous large multicenter genome wide study, common genetic variation in the Kinesin-Associated Protein 3 (KIFAP3) gene (rs1541160) was reported to have a significant effect on survival in a...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
van Doormaal, Perry T.C. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2014transfer abstract |
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| Schlagwörter: |
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| Umfang: |
2 |
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| Übergeordnetes Werk: |
Enthalten in: Corrigendum to “Electrical and thermal transport properties of Fe–Ni based ternary alloys in the earth's inner core: An ab initio study” [Physics of the Earth and Planetary Interiors - Zidane, Mustapha ELSEVIER, 2021, Amsterdam [u.a.] |
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| Übergeordnetes Werk: |
volume:35 ; year:2014 ; number:10 ; pages:242013-242014 ; extent:2 |
| Links: |
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| DOI / URN: |
10.1016/j.neurobiolaging.2014.04.014 |
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| 520 | |a Sporadic amyotrophic lateral sclerosis is a multifactorial disease of environmental and genetic origin. In a previous large multicenter genome wide study, common genetic variation in the Kinesin-Associated Protein 3 (KIFAP3) gene (rs1541160) was reported to have a significant effect on survival in amyotrophic lateral sclerosis patients. However, this could not be replicated in 3 smaller independent cohorts. We conducted a large multicenter multivariate survival analysis (n = 2362) on the effect of genetic variation in rs1541160. The previously reported beneficial genotype did not show a significant improvement in survival in this patient group. | ||
| 520 | |a Sporadic amyotrophic lateral sclerosis is a multifactorial disease of environmental and genetic origin. In a previous large multicenter genome wide study, common genetic variation in the Kinesin-Associated Protein 3 (KIFAP3) gene (rs1541160) was reported to have a significant effect on survival in amyotrophic lateral sclerosis patients. However, this could not be replicated in 3 smaller independent cohorts. We conducted a large multicenter multivariate survival analysis (n = 2362) on the effect of genetic variation in rs1541160. The previously reported beneficial genotype did not show a significant improvement in survival in this patient group. | ||
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10.1016/j.neurobiolaging.2014.04.014 doi GBVA2014007000027.pica (DE-627)ELV02256943X (ELSEVIER)S0197-4580(14)00316-9 DE-627 ger DE-627 rakwb eng 610 610 DE-600 550 520 VZ 38.70 bkl 39.53 bkl van Doormaal, Perry T.C. verfasserin aut Analysis of the KIFAP3 gene in amyotrophic lateral sclerosis: a multicenter survival study 2014transfer abstract 2 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Sporadic amyotrophic lateral sclerosis is a multifactorial disease of environmental and genetic origin. In a previous large multicenter genome wide study, common genetic variation in the Kinesin-Associated Protein 3 (KIFAP3) gene (rs1541160) was reported to have a significant effect on survival in amyotrophic lateral sclerosis patients. However, this could not be replicated in 3 smaller independent cohorts. We conducted a large multicenter multivariate survival analysis (n = 2362) on the effect of genetic variation in rs1541160. The previously reported beneficial genotype did not show a significant improvement in survival in this patient group. Sporadic amyotrophic lateral sclerosis is a multifactorial disease of environmental and genetic origin. In a previous large multicenter genome wide study, common genetic variation in the Kinesin-Associated Protein 3 (KIFAP3) gene (rs1541160) was reported to have a significant effect on survival in amyotrophic lateral sclerosis patients. However, this could not be replicated in 3 smaller independent cohorts. We conducted a large multicenter multivariate survival analysis (n = 2362) on the effect of genetic variation in rs1541160. The previously reported beneficial genotype did not show a significant improvement in survival in this patient group. Genome-wide association study Elsevier Amyotrophic lateral sclerosis Elsevier Kinesin-associated protein 3 gene Elsevier KIFAP3 Elsevier Ticozzi, Nicola oth Gellera, Cinzia oth Ratti, Antonia oth Taroni, Franco oth Chiò, Adriano oth Calvo, Andrea oth Mora, Gabriele oth Restagno, Gabriella oth Traynor, Bryan J. oth Birve, Anna oth Lemmens, Robin oth van Es, Michael A. oth Saris, Christiaan G.J. oth Blauw, Hylke M. oth van Vught, Paul W.J. oth Groen, Ewout J.N. oth Corrado, Lucia oth Mazzini, Letizia oth Del Bo, Roberto oth Corti, Stefania oth Waibel, Stefan oth Meyer, Thomas oth Ludolph, Albert C. oth Goris, An oth van Damme, Philip oth Robberecht, Wim oth Shatunov, Aleksey oth Fogh, Isabella oth Andersen, Peter M. oth D'Alfonso, Sandra oth Hardiman, Orla oth Cronin, Simon oth Rujescu, Dan oth Al-Chalabi, Ammar oth Landers, John E. oth Silani, Vincenzo oth van den Berg, Leonard H. oth Veldink, Jan H. oth Enthalten in Elsevier Science Zidane, Mustapha ELSEVIER Corrigendum to “Electrical and thermal transport properties of Fe–Ni based ternary alloys in the earth's inner core: An ab initio study” [Physics of the Earth and Planetary Interiors 2021 Amsterdam [u.a.] (DE-627)ELV005660645 volume:35 year:2014 number:10 pages:242013-242014 extent:2 https://doi.org/10.1016/j.neurobiolaging.2014.04.014 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-GGO SSG-OPC-GEO SSG-OPC-AST 38.70 Geophysik: Allgemeines VZ 39.53 Planeten VZ AR 35 2014 10 242013-242014 2 35.2014, 10, 2420.e13-, (2 S.) 045F 610 |
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10.1016/j.neurobiolaging.2014.04.014 doi GBVA2014007000027.pica (DE-627)ELV02256943X (ELSEVIER)S0197-4580(14)00316-9 DE-627 ger DE-627 rakwb eng 610 610 DE-600 550 520 VZ 38.70 bkl 39.53 bkl van Doormaal, Perry T.C. verfasserin aut Analysis of the KIFAP3 gene in amyotrophic lateral sclerosis: a multicenter survival study 2014transfer abstract 2 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Sporadic amyotrophic lateral sclerosis is a multifactorial disease of environmental and genetic origin. In a previous large multicenter genome wide study, common genetic variation in the Kinesin-Associated Protein 3 (KIFAP3) gene (rs1541160) was reported to have a significant effect on survival in amyotrophic lateral sclerosis patients. However, this could not be replicated in 3 smaller independent cohorts. We conducted a large multicenter multivariate survival analysis (n = 2362) on the effect of genetic variation in rs1541160. The previously reported beneficial genotype did not show a significant improvement in survival in this patient group. Sporadic amyotrophic lateral sclerosis is a multifactorial disease of environmental and genetic origin. In a previous large multicenter genome wide study, common genetic variation in the Kinesin-Associated Protein 3 (KIFAP3) gene (rs1541160) was reported to have a significant effect on survival in amyotrophic lateral sclerosis patients. However, this could not be replicated in 3 smaller independent cohorts. We conducted a large multicenter multivariate survival analysis (n = 2362) on the effect of genetic variation in rs1541160. The previously reported beneficial genotype did not show a significant improvement in survival in this patient group. Genome-wide association study Elsevier Amyotrophic lateral sclerosis Elsevier Kinesin-associated protein 3 gene Elsevier KIFAP3 Elsevier Ticozzi, Nicola oth Gellera, Cinzia oth Ratti, Antonia oth Taroni, Franco oth Chiò, Adriano oth Calvo, Andrea oth Mora, Gabriele oth Restagno, Gabriella oth Traynor, Bryan J. oth Birve, Anna oth Lemmens, Robin oth van Es, Michael A. oth Saris, Christiaan G.J. oth Blauw, Hylke M. oth van Vught, Paul W.J. oth Groen, Ewout J.N. oth Corrado, Lucia oth Mazzini, Letizia oth Del Bo, Roberto oth Corti, Stefania oth Waibel, Stefan oth Meyer, Thomas oth Ludolph, Albert C. oth Goris, An oth van Damme, Philip oth Robberecht, Wim oth Shatunov, Aleksey oth Fogh, Isabella oth Andersen, Peter M. oth D'Alfonso, Sandra oth Hardiman, Orla oth Cronin, Simon oth Rujescu, Dan oth Al-Chalabi, Ammar oth Landers, John E. oth Silani, Vincenzo oth van den Berg, Leonard H. oth Veldink, Jan H. oth Enthalten in Elsevier Science Zidane, Mustapha ELSEVIER Corrigendum to “Electrical and thermal transport properties of Fe–Ni based ternary alloys in the earth's inner core: An ab initio study” [Physics of the Earth and Planetary Interiors 2021 Amsterdam [u.a.] (DE-627)ELV005660645 volume:35 year:2014 number:10 pages:242013-242014 extent:2 https://doi.org/10.1016/j.neurobiolaging.2014.04.014 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-GGO SSG-OPC-GEO SSG-OPC-AST 38.70 Geophysik: Allgemeines VZ 39.53 Planeten VZ AR 35 2014 10 242013-242014 2 35.2014, 10, 2420.e13-, (2 S.) 045F 610 |
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10.1016/j.neurobiolaging.2014.04.014 doi GBVA2014007000027.pica (DE-627)ELV02256943X (ELSEVIER)S0197-4580(14)00316-9 DE-627 ger DE-627 rakwb eng 610 610 DE-600 550 520 VZ 38.70 bkl 39.53 bkl van Doormaal, Perry T.C. verfasserin aut Analysis of the KIFAP3 gene in amyotrophic lateral sclerosis: a multicenter survival study 2014transfer abstract 2 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Sporadic amyotrophic lateral sclerosis is a multifactorial disease of environmental and genetic origin. In a previous large multicenter genome wide study, common genetic variation in the Kinesin-Associated Protein 3 (KIFAP3) gene (rs1541160) was reported to have a significant effect on survival in amyotrophic lateral sclerosis patients. However, this could not be replicated in 3 smaller independent cohorts. We conducted a large multicenter multivariate survival analysis (n = 2362) on the effect of genetic variation in rs1541160. The previously reported beneficial genotype did not show a significant improvement in survival in this patient group. Sporadic amyotrophic lateral sclerosis is a multifactorial disease of environmental and genetic origin. In a previous large multicenter genome wide study, common genetic variation in the Kinesin-Associated Protein 3 (KIFAP3) gene (rs1541160) was reported to have a significant effect on survival in amyotrophic lateral sclerosis patients. However, this could not be replicated in 3 smaller independent cohorts. We conducted a large multicenter multivariate survival analysis (n = 2362) on the effect of genetic variation in rs1541160. The previously reported beneficial genotype did not show a significant improvement in survival in this patient group. Genome-wide association study Elsevier Amyotrophic lateral sclerosis Elsevier Kinesin-associated protein 3 gene Elsevier KIFAP3 Elsevier Ticozzi, Nicola oth Gellera, Cinzia oth Ratti, Antonia oth Taroni, Franco oth Chiò, Adriano oth Calvo, Andrea oth Mora, Gabriele oth Restagno, Gabriella oth Traynor, Bryan J. oth Birve, Anna oth Lemmens, Robin oth van Es, Michael A. oth Saris, Christiaan G.J. oth Blauw, Hylke M. oth van Vught, Paul W.J. oth Groen, Ewout J.N. oth Corrado, Lucia oth Mazzini, Letizia oth Del Bo, Roberto oth Corti, Stefania oth Waibel, Stefan oth Meyer, Thomas oth Ludolph, Albert C. oth Goris, An oth van Damme, Philip oth Robberecht, Wim oth Shatunov, Aleksey oth Fogh, Isabella oth Andersen, Peter M. oth D'Alfonso, Sandra oth Hardiman, Orla oth Cronin, Simon oth Rujescu, Dan oth Al-Chalabi, Ammar oth Landers, John E. oth Silani, Vincenzo oth van den Berg, Leonard H. oth Veldink, Jan H. oth Enthalten in Elsevier Science Zidane, Mustapha ELSEVIER Corrigendum to “Electrical and thermal transport properties of Fe–Ni based ternary alloys in the earth's inner core: An ab initio study” [Physics of the Earth and Planetary Interiors 2021 Amsterdam [u.a.] (DE-627)ELV005660645 volume:35 year:2014 number:10 pages:242013-242014 extent:2 https://doi.org/10.1016/j.neurobiolaging.2014.04.014 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-GGO SSG-OPC-GEO SSG-OPC-AST 38.70 Geophysik: Allgemeines VZ 39.53 Planeten VZ AR 35 2014 10 242013-242014 2 35.2014, 10, 2420.e13-, (2 S.) 045F 610 |
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10.1016/j.neurobiolaging.2014.04.014 doi GBVA2014007000027.pica (DE-627)ELV02256943X (ELSEVIER)S0197-4580(14)00316-9 DE-627 ger DE-627 rakwb eng 610 610 DE-600 550 520 VZ 38.70 bkl 39.53 bkl van Doormaal, Perry T.C. verfasserin aut Analysis of the KIFAP3 gene in amyotrophic lateral sclerosis: a multicenter survival study 2014transfer abstract 2 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Sporadic amyotrophic lateral sclerosis is a multifactorial disease of environmental and genetic origin. In a previous large multicenter genome wide study, common genetic variation in the Kinesin-Associated Protein 3 (KIFAP3) gene (rs1541160) was reported to have a significant effect on survival in amyotrophic lateral sclerosis patients. However, this could not be replicated in 3 smaller independent cohorts. We conducted a large multicenter multivariate survival analysis (n = 2362) on the effect of genetic variation in rs1541160. The previously reported beneficial genotype did not show a significant improvement in survival in this patient group. Sporadic amyotrophic lateral sclerosis is a multifactorial disease of environmental and genetic origin. In a previous large multicenter genome wide study, common genetic variation in the Kinesin-Associated Protein 3 (KIFAP3) gene (rs1541160) was reported to have a significant effect on survival in amyotrophic lateral sclerosis patients. However, this could not be replicated in 3 smaller independent cohorts. We conducted a large multicenter multivariate survival analysis (n = 2362) on the effect of genetic variation in rs1541160. The previously reported beneficial genotype did not show a significant improvement in survival in this patient group. Genome-wide association study Elsevier Amyotrophic lateral sclerosis Elsevier Kinesin-associated protein 3 gene Elsevier KIFAP3 Elsevier Ticozzi, Nicola oth Gellera, Cinzia oth Ratti, Antonia oth Taroni, Franco oth Chiò, Adriano oth Calvo, Andrea oth Mora, Gabriele oth Restagno, Gabriella oth Traynor, Bryan J. oth Birve, Anna oth Lemmens, Robin oth van Es, Michael A. oth Saris, Christiaan G.J. oth Blauw, Hylke M. oth van Vught, Paul W.J. oth Groen, Ewout J.N. oth Corrado, Lucia oth Mazzini, Letizia oth Del Bo, Roberto oth Corti, Stefania oth Waibel, Stefan oth Meyer, Thomas oth Ludolph, Albert C. oth Goris, An oth van Damme, Philip oth Robberecht, Wim oth Shatunov, Aleksey oth Fogh, Isabella oth Andersen, Peter M. oth D'Alfonso, Sandra oth Hardiman, Orla oth Cronin, Simon oth Rujescu, Dan oth Al-Chalabi, Ammar oth Landers, John E. oth Silani, Vincenzo oth van den Berg, Leonard H. oth Veldink, Jan H. oth Enthalten in Elsevier Science Zidane, Mustapha ELSEVIER Corrigendum to “Electrical and thermal transport properties of Fe–Ni based ternary alloys in the earth's inner core: An ab initio study” [Physics of the Earth and Planetary Interiors 2021 Amsterdam [u.a.] (DE-627)ELV005660645 volume:35 year:2014 number:10 pages:242013-242014 extent:2 https://doi.org/10.1016/j.neurobiolaging.2014.04.014 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-GGO SSG-OPC-GEO SSG-OPC-AST 38.70 Geophysik: Allgemeines VZ 39.53 Planeten VZ AR 35 2014 10 242013-242014 2 35.2014, 10, 2420.e13-, (2 S.) 045F 610 |
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10.1016/j.neurobiolaging.2014.04.014 doi GBVA2014007000027.pica (DE-627)ELV02256943X (ELSEVIER)S0197-4580(14)00316-9 DE-627 ger DE-627 rakwb eng 610 610 DE-600 550 520 VZ 38.70 bkl 39.53 bkl van Doormaal, Perry T.C. verfasserin aut Analysis of the KIFAP3 gene in amyotrophic lateral sclerosis: a multicenter survival study 2014transfer abstract 2 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Sporadic amyotrophic lateral sclerosis is a multifactorial disease of environmental and genetic origin. In a previous large multicenter genome wide study, common genetic variation in the Kinesin-Associated Protein 3 (KIFAP3) gene (rs1541160) was reported to have a significant effect on survival in amyotrophic lateral sclerosis patients. However, this could not be replicated in 3 smaller independent cohorts. We conducted a large multicenter multivariate survival analysis (n = 2362) on the effect of genetic variation in rs1541160. The previously reported beneficial genotype did not show a significant improvement in survival in this patient group. Sporadic amyotrophic lateral sclerosis is a multifactorial disease of environmental and genetic origin. In a previous large multicenter genome wide study, common genetic variation in the Kinesin-Associated Protein 3 (KIFAP3) gene (rs1541160) was reported to have a significant effect on survival in amyotrophic lateral sclerosis patients. However, this could not be replicated in 3 smaller independent cohorts. We conducted a large multicenter multivariate survival analysis (n = 2362) on the effect of genetic variation in rs1541160. The previously reported beneficial genotype did not show a significant improvement in survival in this patient group. Genome-wide association study Elsevier Amyotrophic lateral sclerosis Elsevier Kinesin-associated protein 3 gene Elsevier KIFAP3 Elsevier Ticozzi, Nicola oth Gellera, Cinzia oth Ratti, Antonia oth Taroni, Franco oth Chiò, Adriano oth Calvo, Andrea oth Mora, Gabriele oth Restagno, Gabriella oth Traynor, Bryan J. oth Birve, Anna oth Lemmens, Robin oth van Es, Michael A. oth Saris, Christiaan G.J. oth Blauw, Hylke M. oth van Vught, Paul W.J. oth Groen, Ewout J.N. oth Corrado, Lucia oth Mazzini, Letizia oth Del Bo, Roberto oth Corti, Stefania oth Waibel, Stefan oth Meyer, Thomas oth Ludolph, Albert C. oth Goris, An oth van Damme, Philip oth Robberecht, Wim oth Shatunov, Aleksey oth Fogh, Isabella oth Andersen, Peter M. oth D'Alfonso, Sandra oth Hardiman, Orla oth Cronin, Simon oth Rujescu, Dan oth Al-Chalabi, Ammar oth Landers, John E. oth Silani, Vincenzo oth van den Berg, Leonard H. oth Veldink, Jan H. oth Enthalten in Elsevier Science Zidane, Mustapha ELSEVIER Corrigendum to “Electrical and thermal transport properties of Fe–Ni based ternary alloys in the earth's inner core: An ab initio study” [Physics of the Earth and Planetary Interiors 2021 Amsterdam [u.a.] (DE-627)ELV005660645 volume:35 year:2014 number:10 pages:242013-242014 extent:2 https://doi.org/10.1016/j.neurobiolaging.2014.04.014 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-GGO SSG-OPC-GEO SSG-OPC-AST 38.70 Geophysik: Allgemeines VZ 39.53 Planeten VZ AR 35 2014 10 242013-242014 2 35.2014, 10, 2420.e13-, (2 S.) 045F 610 |
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Analysis of the KIFAP3 gene in amyotrophic lateral sclerosis: a multicenter survival study |
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Sporadic amyotrophic lateral sclerosis is a multifactorial disease of environmental and genetic origin. In a previous large multicenter genome wide study, common genetic variation in the Kinesin-Associated Protein 3 (KIFAP3) gene (rs1541160) was reported to have a significant effect on survival in amyotrophic lateral sclerosis patients. However, this could not be replicated in 3 smaller independent cohorts. We conducted a large multicenter multivariate survival analysis (n = 2362) on the effect of genetic variation in rs1541160. The previously reported beneficial genotype did not show a significant improvement in survival in this patient group. |
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Sporadic amyotrophic lateral sclerosis is a multifactorial disease of environmental and genetic origin. In a previous large multicenter genome wide study, common genetic variation in the Kinesin-Associated Protein 3 (KIFAP3) gene (rs1541160) was reported to have a significant effect on survival in amyotrophic lateral sclerosis patients. However, this could not be replicated in 3 smaller independent cohorts. We conducted a large multicenter multivariate survival analysis (n = 2362) on the effect of genetic variation in rs1541160. The previously reported beneficial genotype did not show a significant improvement in survival in this patient group. |
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Sporadic amyotrophic lateral sclerosis is a multifactorial disease of environmental and genetic origin. In a previous large multicenter genome wide study, common genetic variation in the Kinesin-Associated Protein 3 (KIFAP3) gene (rs1541160) was reported to have a significant effect on survival in amyotrophic lateral sclerosis patients. However, this could not be replicated in 3 smaller independent cohorts. We conducted a large multicenter multivariate survival analysis (n = 2362) on the effect of genetic variation in rs1541160. The previously reported beneficial genotype did not show a significant improvement in survival in this patient group. |
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